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公开(公告)号:US20100331295A1
公开(公告)日:2010-12-30
申请号:US11993806
申请日:2006-06-26
申请人: Brett B Busch , Brenton T. Flatt , Xiao Hui Gu , Shao Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, JR. , Tie Lin Wang , Yinong Xie
发明人: Brett B Busch , Brenton T. Flatt , Xiao Hui Gu , Shao Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, JR. , Tie Lin Wang , Yinong Xie
IPC分类号: A61K31/4155 , C07D409/04 , C07D231/12 , C07D401/04 , C07D413/10 , C07D409/14 , C07D403/10 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/496 , A61P3/06 , A61P3/10 , A61P9/10 , A61P17/10 , A61P25/16 , A61P25/28 , A61P35/00 , A61P29/00 , A61P37/00 , A61P3/04
CPC分类号: C07D233/64 , C07D231/12 , C07D231/22 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/08
摘要: Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3, and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译: 本发明的化合物,例如式Ia,Ib,Ic或Id的化合物及其药学上可接受的盐,异构体和前药,其可用作肝脏X受体活性的调节剂,其中R1,R2,R21,R3 ,和G在本文中定义。 还公开了含有该化合物的药物组合物和使用该化合物的方法。
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2.
公开(公告)号:US07977489B2
公开(公告)日:2011-07-12
申请号:US11577611
申请日:2005-10-21
IPC分类号: C07D277/00
CPC分类号: C07D277/36 , C07D277/34 , C07D277/38 , C07D417/04 , C07D417/12 , C09B23/04
摘要: Compounds of the following general structure for use in compositions and methods for modulating the activity of nuclear receptors are provided: The compounds are useable in compositions and methods for modulating the estrogen related receptors and are agonists, partial agonists, antagonists. or inverse agonists of ERR or ERRα.
摘要翻译: 提供了用于调节核受体活性的组合物和方法中的以下通用结构的化合物:该化合物可用于调节雌激素相关受体的组合物和方法,并且是激动剂,部分激动剂,拮抗剂。 或ERR或ERRα的反向激动剂。
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公开(公告)号:US08703805B2
公开(公告)日:2014-04-22
申请号:US11993806
申请日:2006-06-26
申请人: Brett B. Busch , Brenton T. Flatt , Xiao Hui Gu , Shao Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, Jr. , Tie Lin Wang , Yinong Xie
发明人: Brett B. Busch , Brenton T. Flatt , Xiao Hui Gu , Shao Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, Jr. , Tie Lin Wang , Yinong Xie
IPC分类号: A61K31/4155 , C07D231/12
CPC分类号: C07D233/64 , C07D231/12 , C07D231/22 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/08
摘要: Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3, and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译: 本发明的化合物,例如式Ia,Ib,Ic或Id的化合物及其药学上可接受的盐,异构体和前药,其可用作肝脏X受体活性的调节剂,其中R1,R2,R21,R3 ,和G在本文中定义。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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公开(公告)号:US08569352B2
公开(公告)日:2013-10-29
申请号:US11993529
申请日:2006-06-26
申请人: Brett B. Busch , Brenton T. Flatt , Xiao-Hui Gu , Shao-Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, Jr. , Tie-Lin Wang , Yinong Xie
发明人: Brett B. Busch , Brenton T. Flatt , Xiao-Hui Gu , Shao-Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, Jr. , Tie-Lin Wang , Yinong Xie
IPC分类号: A61K31/4174 , C07D233/64
CPC分类号: C07D233/64 , C07D231/12 , C07D231/22 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/08
摘要: Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3 and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译: 本发明的化合物,例如式IIa,IIb,IIc或IId的化合物及其药学上可接受的盐,异构体和前药可用作肝脏X受体活性的调节剂,其中R1,R2,R21,R3和 G在本文中定义。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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公开(公告)号:US20100075964A1
公开(公告)日:2010-03-25
申请号:US11993529
申请日:2006-06-26
申请人: Brett B. Busch , Brenton T. Flatt , Xiao-Hui Gu , Shao-Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, Jr. , Tie-Lin Wang , Yinong Xie
发明人: Brett B. Busch , Brenton T. Flatt , Xiao-Hui Gu , Shao-Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, Jr. , Tie-Lin Wang , Yinong Xie
IPC分类号: A61K31/5377 , C07D233/54 , A61K31/4164 , C07D401/14 , A61K31/4439 , A61K31/496 , C07D413/14 , A61P3/06 , A61P9/00 , A61P25/00 , A61P35/00
CPC分类号: C07D233/64 , C07D231/12 , C07D231/22 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/08
摘要: Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3 and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译: 本发明的化合物,例如式IIa,IIb,IIc或IId的化合物及其药学上可接受的盐,异构体和前药可用作肝脏X受体活性的调节剂,其中R1,R2,R21,R3和 G在本文中定义。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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公开(公告)号:US20090197870A1
公开(公告)日:2009-08-06
申请号:US11577611
申请日:2005-10-21
IPC分类号: A61K31/55 , A61K31/426 , C07D277/16 , A61K31/5377 , C07D417/12 , C07D417/04 , A61K31/541 , C07D417/14 , A61K31/497 , A61P35/00 , C12N5/06
CPC分类号: C07D277/36 , C07D277/34 , C07D277/38 , C07D417/04 , C07D417/12 , C09B23/04
摘要: Compounds for use in compositions and methods for modulating the activity of nuclear receptors are provided. In particular, compounds for use in compositions and methods for modulating the estrogen related receptors are provided. In one embodiment, the compounds provided herein are ERR modulators. In another embodiment, the compounds provided herein are agonists, partial agonists, antagonists, or inverse agonists of ERR or ERR?. In certain embodiments, the compounds of the invention, as described above in the Summary of the Invention, are compounds of formula (I).
摘要翻译: 提供了用于组合物中的化合物和调节核受体活性的方法。 特别地,提供了用于调节雌激素相关受体的组合物和方法的化合物。 在一个实施方案中,本文提供的化合物是ERR调节剂。 在另一个实施方案中,本文提供的化合物是ERR或ERRα的激动剂,部分激动剂,拮抗剂或反向激动剂。 在某些实施方案中,本发明概述中所述的本发明化合物是式(I)的化合物。
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公开(公告)号:US20080234270A1
公开(公告)日:2008-09-25
申请号:US11572962
申请日:2005-07-30
申请人: Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
发明人: Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
IPC分类号: A61K31/40 , C07D207/34 , C07D403/02 , C07D413/02 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506
CPC分类号: C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译: 提供了调节受体活性的化合物,组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗,预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号:US08367667B2
公开(公告)日:2013-02-05
申请号:US13214665
申请日:2011-08-22
申请人: Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
发明人: Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
IPC分类号: A61K31/40 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506
CPC分类号: C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译: 提供了调节受体活性的化合物,组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗,预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号:US20110301128A1
公开(公告)日:2011-12-08
申请号:US13214665
申请日:2011-08-22
申请人: Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
发明人: Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
IPC分类号: A61K31/635 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/433 , A61K31/4025 , A61K31/4725 , A61K31/4709 , A61K31/506 , A61K31/428 , A61K31/40 , A61K31/519 , A61K31/5377 , A61K31/55 , A61P9/00 , A61P21/00 , A61P17/00 , A61P13/12 , A61P25/00 , A61P19/00 , A61P37/02 , A61P3/00 , A61P35/00 , A61P15/08 , A61P5/00 , A61K31/402
CPC分类号: C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译: 提供了调节受体活性的化合物,组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗,预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号:US08026237B2
公开(公告)日:2011-09-27
申请号:US11572962
申请日:2005-07-30
申请人: Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
发明人: Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
IPC分类号: A61K31/40 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506 , C07D207/34 , C07D403/02 , C07D413/02
CPC分类号: C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译: 提供了调节受体活性的化合物,组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗,预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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