公开(公告)号：US20060233745A1

公开(公告)日：2006-10-19

申请号：US11301138

申请日：2005-12-12

申请人： Riley Rees ,  Jiyoun Kim ,  Daniel Remick ,  Belinda Adamson

发明人： Riley Rees ,  Jiyoun Kim ,  Daniel Remick ,  Belinda Adamson

IPC分类号： A61K48/00 ,  A61K38/19 ,  C12N5/08 ,  C12M1/00

CPC分类号： A61K38/1808 ,  A61K35/12 ,  A61K38/2006 ,  A61L15/40 ,  A61L15/44 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/64 ,  C12N5/0629 ,  C12N5/0645 ,  C12N2510/02 ,  C12N2531/00

摘要： The present invention relates to devices, systems and methods for treating tumors. In particular, the present invention relates to enclosures housing cell-coated supports for promoting regression of tumors, such as cancerous tumors, papillomas, and warts. In preferred embodiments, the present invention provides methods of promoting tumor regression employing enclosures secreting therapeutic proteins.

公开(公告)号：US07056503B2

公开(公告)日：2006-06-06

申请号：US09962059

申请日：2001-09-25

申请人： Riley Rees ,  Jiyoun Kim ,  Daniel Remick ,  Belinda Adamson

发明人： Riley Rees ,  Jiyoun Kim ,  Daniel Remick ,  Belinda Adamson

IPC分类号： A61K48/00 ,  A61K9/70 ,  C12N15/63 ,  C12N15/00 ,  C12N5/00

CPC分类号： A61K38/1808 ,  A61K35/12 ,  A61K38/2006 ,  A61L15/40 ,  A61L15/44 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/64 ,  C12N5/0629 ,  C12N5/0645 ,  C12N2510/02 ,  C12N2531/00

摘要： The present invention relates to devices, systems and methods for treating tumors. In particular, the present invention relates to enclosures housing cell-coated supports for promoting regression of tumors, such as cancerous tumors, papillomas, and warts. In preferred embodiments, the present invention provides methods of promoting tumor regression employing enclosures secreting therapeutic proteins.

公开(公告)号：US06890552B2

公开(公告)日：2005-05-10

申请号：US10178342

申请日：2002-06-25

申请人： Riley S. Rees ,  Cynthia Marcelo ,  Belinda Adamson ,  Lenore Rhodes ,  Beverly Marchant ,  William J. Lindblad ,  Robert Gilmont ,  Warren Garner ,  Cynthia Zuccaro ,  Thomas E. Taddonio

发明人： Riley S. Rees ,  Cynthia Marcelo ,  Belinda Adamson ,  Lenore Rhodes ,  Beverly Marchant ,  William J. Lindblad ,  Robert Gilmont ,  Warren Garner ,  Cynthia Zuccaro ,  Thomas E. Taddonio

IPC分类号： A61K35/12 ,  A61K38/00 ,  A61L15/40 ,  A61L27/38 ,  A61L27/56 ,  A61L27/60 ,  C12N5/071 ,  A61F13/00 ,  A01N25/34 ,  A61K9/14 ,  A61K9/20

CPC分类号： A61L15/40 ,  A61K35/12 ,  A61K38/00 ,  A61L27/3813 ,  A61L27/56 ,  A61L27/60 ,  C12N5/0629 ,  C12N2510/00 ,  C12N2510/02 ,  C12N2531/00 ,  C12N2533/54 ,  Y10T442/2525

摘要： Devices and methods for enhancing the healing of wounds, especially chronic wounds (e.g., diabetic wounds), involving the use of keratinocytes are described. Keratinocytes are grown on a transplantable solid support (e.g., collagen-coated beads), and the keratinocyte-coated solid support is placed in an enclosure. The enclosure, in turn, is placed in the wound for use as an interactive wound healing promoter.

摘要翻译： 描述了涉及使用角化细胞的用于增强伤口愈合的装置和方法，特别是慢性伤口（例如，糖尿病性伤口）。 将角质细胞在可移植的固体支持物（例如胶原包被的珠粒）上生长，并将角质细胞包被的固体支持物置于外壳中。 外壳又被置于伤口中用作交互伤口愈合促进剂。

公开(公告)号：US06299898B2

公开(公告)日：2001-10-09

申请号：US09747742

申请日：2000-12-22

申请人： Riley S. Rees ,  Cynthia Marcelo ,  Belinda Adamson ,  Lenore Rhodes ,  Beverly Marchant ,  William Lindblad ,  Robert Gilmont ,  Warren Garner ,  Cynthia Zuccaro ,  Thomas E. Taddonio

发明人： Riley S. Rees ,  Cynthia Marcelo ,  Belinda Adamson ,  Lenore Rhodes ,  Beverly Marchant ,  William Lindblad ,  Robert Gilmont ,  Warren Garner ,  Cynthia Zuccaro ,  Thomas E. Taddonio

IPC分类号： A61K970

CPC分类号： A61L15/40 ,  A61K35/12 ,  A61K38/00 ,  A61L27/3813 ,  A61L27/56 ,  A61L27/60 ,  C12N5/0629 ,  C12N2510/00 ,  C12N2510/02 ,  C12N2531/00 ,  C12N2533/54 ,  Y10T442/2525

摘要： Devices and methods for enhancing the healing of wounds, especially chronic wounds (e.g., diabetic wounds), involving the use of keratinocytes are described. Keratinocytes are grown on a transplantable solid support (e.g., collagen-coated beads), and the keratinocyte-coated solid support is placed in an enclosure. The enclosure, in turn, is placed in the wound for use as an interactive wound healing promoter.

公开(公告)号：US5972332A

公开(公告)日：1999-10-26

申请号：US840804

申请日：1997-04-16

申请人： Riley S. Rees ,  Cynthia Marcelo ,  Belinda Adamson ,  Lenore Rhodes ,  Beverly Marchant ,  William Lindblad ,  Robert Gilmont ,  Warren Garner ,  Cynthia Zuccaro ,  Thomas E. Taddonio

发明人： Riley S. Rees ,  Cynthia Marcelo ,  Belinda Adamson ,  Lenore Rhodes ,  Beverly Marchant ,  William Lindblad ,  Robert Gilmont ,  Warren Garner ,  Cynthia Zuccaro ,  Thomas E. Taddonio

IPC分类号： A61K35/12 ,  A61K38/00 ,  A61L15/40 ,  A61L27/38 ,  A61L27/56 ,  A61L27/60 ,  C12N5/071 ,  C12N5/00 ,  C12N11/04 ,  A01N63/00 ,  A61F13/00

CPC分类号： A61L15/40 ,  A61L27/3813 ,  A61L27/56 ,  A61L27/60 ,  C12N5/0629 ,  A61K35/12 ,  A61K38/00 ,  C12N2510/00 ,  C12N2510/02 ,  C12N2531/00 ,  C12N2533/54 ,  Y10T442/2525

摘要： Devices and methods for enhancing the healing of wounds, especially chronic wounds (e.g., diabetic wounds), are provided involving the use of keratinocytes. Keratinocytes are grown on a transplantable solid support (e.g., collagen-coated beads), and the keratinocyte-coated solid support is placed in an enclosure. The enclosure, in turn, is placed in the wound for use as an interactive wound healing promoter. After the enclosure is placed in a wound, the wound may be covered with a dressing. The enclosure is degradable or non-degradable, and is constructed from a membrane or a porous polyester mesh material having pores that are either too small or large enough for keratinocytes to cross. A means may be attached to the enclosure to enable removing the enclosure from a wound.

摘要翻译： 提供用于增强伤口愈合的装置和方法，特别是慢性伤口（例如，糖尿病性伤口），涉及角质形成细胞的使用。 将角质细胞在可移植的固体支持物（例如胶原包被的珠粒）上生长，并将角质细胞包被的固体支持物置于外壳中。 外壳又被置于伤口中用作交互伤口愈合促进剂。 将外壳放置在伤口中之后，可以用敷料覆盖伤口。 外壳是可降解的或不可降解的，并且由膜或多孔聚酯网状物质构成，其孔具有足够小或足够大以使角质形成细胞交叉的孔。 一种装置可以附接到外壳，以便能够从伤口移除外壳。

公开(公告)号：US06440452B2

公开(公告)日：2002-08-27

申请号：US09919516

申请日：2001-07-31

申请人： Riley S. Rees ,  Cynthia Marcelo ,  Belinda Adamson ,  Lenore Rhodes ,  Beverly Marchant ,  William Lindblad ,  Robert Gilmont ,  Warren Garner ,  Cynthia Zuccaro ,  Thomas E. Taddonio

发明人： Riley S. Rees ,  Cynthia Marcelo ,  Belinda Adamson ,  Lenore Rhodes ,  Beverly Marchant ,  William Lindblad ,  Robert Gilmont ,  Warren Garner ,  Cynthia Zuccaro ,  Thomas E. Taddonio

IPC分类号： A61K970

CPC分类号： A61L15/40 ,  A61K35/12 ,  A61K38/00 ,  A61L27/3813 ,  A61L27/56 ,  A61L27/60 ,  C12N5/0629 ,  C12N2510/00 ,  C12N2510/02 ,  C12N2531/00 ,  C12N2533/54 ,  Y10T442/2525

摘要： Devices and methods for enhancing the healing of wounds, especially chronic wounds (e.g., diabetic wounds), involving the use of keratinocytes are described. Keratinocytes are grown on a transplantable solid support (e.g., collagen-coated beads), and the keratinocyte-coated solid support is placed in an enclosure. The enclosure, in turn, is placed in the wound for use as an interactive wound healing promoter.

摘要翻译： 描述了涉及使用角化细胞的用于增强伤口愈合的装置和方法，特别是慢性伤口（例如，糖尿病性伤口）。 将角质细胞在可移植的固体支持物（例如胶原包被的珠粒）上生长，并将角质细胞包被的固体支持物置于外壳中。 外壳又被置于伤口中用作交互伤口愈合促进剂。

公开(公告)号：US06197330B1

公开(公告)日：2001-03-06

申请号：US09338413

申请日：1999-06-22

申请人： Riley S. Rees ,  Cynthia Marcelo ,  Belinda Adamson ,  Lenore Rhodes ,  Beverly Marchant ,  William Lindblad ,  Robert Gilmont ,  Warren Garner ,  Cynthia Zuccaro ,  Thomas E. Taddonio

发明人： Riley S. Rees ,  Cynthia Marcelo ,  Belinda Adamson ,  Lenore Rhodes ,  Beverly Marchant ,  William Lindblad ,  Robert Gilmont ,  Warren Garner ,  Cynthia Zuccaro ,  Thomas E. Taddonio

IPC分类号： A61K970

CPC分类号： A61L15/40 ,  A61K35/12 ,  A61K38/00 ,  A61L27/3813 ,  A61L27/56 ,  A61L27/60 ,  C12N5/0629 ,  C12N2510/00 ,  C12N2510/02 ,  C12N2531/00 ,  C12N2533/54 ,  Y10T442/2525

摘要： Devices and methods for enhancing the healing of wounds, especially chronic wounds (e.g., diabetic wounds), involving the use of keratinocytes are described. Keratinocytes are grown on a transplantable solid support (e.g., collagen-coated beads), and the keratinocyte-coated solid support is placed in an enclosure. The enclosure, in turn, is placed in the wound for use as an interactive wound healing promoter.

摘要翻译： 描述了涉及使用角化细胞的用于增强伤口愈合的装置和方法，特别是慢性伤口（例如，糖尿病性伤口）。 将角质细胞在可移植的固体支持物（例如胶原包被的珠粒）上生长，并将角质细胞包被的固体支持物置于外壳中。 外壳又被置于伤口中用作交互伤口愈合促进剂。