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公开(公告)号：US6075031A
公开(公告)日：2000-06-13
申请号：US914887
申请日：1997-08-19
IPC分类号： A61K38/28 , A61K31/00 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/395 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/415 , A61K31/4168 , A61K31/4172 , A61K31/495 , A61K31/64 , A61K31/675 , A61K31/685 , A61P3/00 , A61P3/10 , G06G7/48 , G06G7/58 , A61K31/505 , A61K31/185 , A61K31/295
CPC分类号： A61K31/661 , A61K31/197 , A61K31/198 , A61K31/397 , A61K31/401 , A61K31/4168 , A61K31/4172 , A61K31/495 , A61K31/662 , A61K31/663 , A61K31/675
摘要： The present invention relates to the use of creatine compounds including cyclocreatine and creatine phosphate for treating or preventing a metabolic disorder consisting of hyperglycemia, insulin dependent diabetes mellitus, impaired glucose tolerance, hyperinsulinemia, insulin insensitivity, diabetes related diseases in a patient experiencing said disorder. The creatine compounds which can be used in the present method include (1) analogues of creatine which can act as substrates or substrate analogues for the enzyme creatine kinase; (2) compounds which can act as activators or inhibitors of creatine kinase; (3) compounds which can modulate the creatine transporter (4) N-phosphocreatine analogues bearing transferable or non-transferable moieties which mimic the N-phosphoryl group. (5) compounds which modify the association of creatine kinase with other cellular components.
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2.发明授权Methods of inhibiting undesirable cell growth using a combination of a cyclocreatine compound and a hyperplastic inhibitory agent 失效使用环磷酸化合物和增生性抑制剂的组合来抑制不期望的细胞生长的方法
公开(公告)号：US5676978A
公开(公告)日：1997-10-14
申请号：US185438
申请日：1994-01-21
IPC分类号： A61K31/195 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/505 , A61K31/66 , A61K31/675 , A61K38/00 , A61K48/00 , C07C257/14 , C07C311/51 , C07D207/22 , C07D233/06 , C07D233/46 , C07D233/48 , C07D233/88 , C07D487/04 , C07F9/22 , C07F9/6506 , C07K14/82 , C12N9/12 , C12N15/113 , C12Q1/50 , G01N33/574 , A61K33/24 , A61K31/35 , A61K31/65
CPC分类号： A61K31/685 , A61K31/195 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/505 , A61K31/66 , A61K31/675 , A61K31/70 , C07C257/14 , C07C311/51 , C07D207/22 , C07D233/06 , C07D233/46 , C07D233/48 , C07D233/88 , C07D487/04 , C07F9/222 , C07F9/65061 , C07K14/82 , C12N15/1137 , C12N9/12 , C12Q1/50 , C12Y207/0102 , C12Y207/03002 , C12Y207/04003 , C12Y406/01001 , G01N33/57484 , A61K38/00 , A61K48/00 , G01N2333/01
摘要： The present invention provides for the use of creatine compounds and hyperplastic inhibitory agents for prophylactic and/or therapeutic treatments of undesirable cell growth, e.g. tumors. The present invention provides methods of using creatine compounds, in combination with a hyperplastic inhibitory agent, to inhibit the growth of undesirable cells in a subject. The present invention is based, at least in part, on the discovery that creatine compounds and hyperplastic inhibitory agents, such as inhibitory agents, additively and synergistically combine to inhibit cell growth. The present invention further pertains to compositions for inhibiting undesirable cell growth in a subject. The compositions of the present invention include an effective amount of the creatine compound and a hyperplastic inhibitory agent in a pharmaceutically acceptable carrier. Other aspects of the invention include packaged creatine compounds and inhibitory agents. The packaged compounds and agents also include instructions for using the creatine compound/inhibitory agent combination for inhibiting undesirable cell growth in a patient or instructions for using the compounds and agents, in selected quantities, in a pharmaceutically acceptable carrier.
摘要翻译： 本发明提供了肌酸化合物和增生性抑制剂用于预防和/或治疗不期望的细胞生长的用途，例如， 肿瘤。 本发明提供了使用与增生性抑制剂组合的肌酸化合物抑制受试者中不想要的细胞生长的方法。 本发明至少部分地基于发现肌酸化合物和增生性抑制剂，例如抑制剂，相加地并协同地组合以抑制细胞生长。 本发明还涉及用于抑制受试者中不需要的细胞生长的组合物。 本发明的组合物在药学上可接受的载体中包含有效量的肌酸化合物和增生性抑制剂。 本发明的其它方面包括包装的肌酸化合物和抑制剂。 包装的化合物和试剂还包括使用肌酸化合物/抑制剂组合来抑制患者中不期望的细胞生长的说明书或使用选定量的化合物和试剂在药学上可接受的载体中的说明书。
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公开(公告)号：US5295944A
公开(公告)日：1994-03-22
申请号：US699761
申请日：1991-05-14
CPC分类号： A61K38/42 , A61K2121/00
摘要： A method is disclosed treating a tumor in a host by administering an ultrapurified polymerized hemoglobin solution to the host and thereafter administering ionizing radiation, such as X-rays, to the tumor. In a particularly preferred embodiment, the hemoglobin is bovine hemoglobin.
摘要翻译： 公开了一种方法，其通过向该宿主施用超纯化聚合血红蛋白溶液，然后向该肿瘤施用诸如X射线的电离辐射，来治疗宿主中的肿瘤。 在特别优选的实施方案中，血红蛋白是牛血红蛋白。
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公开(公告)号：US5776898A
公开(公告)日：1998-07-07
申请号：US477110
申请日：1995-06-07
IPC分类号： A61K38/42 , A61K38/17 , C07K14/47 , C07K14/805
CPC分类号： A61K38/42 , Y10S514/908 , Y10S530/829
摘要： A method is disclosed treating a tumor in a host by administering a nonemulsified ultrapurified polymerized hemoglobin solution to the host and also administering a chemotherapeutic agent to the host. In a particularly preferred embodiment, the hemoglobin is bovine hemoglobin.
摘要翻译： 公开了通过向宿主施用非乳化的超纯化聚合血红蛋白溶液并且向宿主施用化学治疗剂来治疗宿主中的肿瘤的方法。 在特别优选的实施方案中，血红蛋白是牛血红蛋白。
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公开(公告)号：US5833974A
公开(公告)日：1998-11-10
申请号：US632795
申请日：1996-04-17
申请人： Beverly A. Teicher
发明人： Beverly A. Teicher
摘要： A method of increasing the effective life of oxygen-delivery agents is described. The method involves administering an oxygen-enriched atmosphere to a subject that has received the oxygen-delivery agent at a predetermined time.
摘要翻译： 描述了增加给氧剂的有效寿命的方法。 该方法包括在预定时间内向已经接受给氧剂的受试者施用富氧气氛。
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公开(公告)号：US4985416A
公开(公告)日：1991-01-15
申请号：US322768
申请日：1989-03-13
申请人： Beverly A. Teicher
发明人： Beverly A. Teicher
IPC分类号： A61K31/28 , A61K31/282 , A61K31/655 , A61K33/24 , A61K41/00 , A61P35/00
CPC分类号： A61K41/0038 , A61K31/655 , A61K33/24
摘要： Complexes having the structure ##STR1## in which R, R.sub.1, R.sub.2, R.sub.3 represent lower alkyl groups are cytotoxic to tumor cells in mammals and enhance the killing effect of radiation and heat.
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公开(公告)号：US5679638A
公开(公告)日：1997-10-21
申请号：US94501
申请日：1993-07-20
IPC分类号： A61K38/42 , A61K38/17 , C07K14/47 , C07K14/805
CPC分类号： A61K38/42 , Y10S514/908 , Y10S530/829
摘要： A method is disclosed treating a tumor in a host by administering a nonemulsified ultrapurified polymerized hemoglobin solution to the host and also administering a chemotherapeutic agent to the host. In a particularly preferred embodiment, the hemoglobin is bovine hemoglobin.
摘要翻译： 公开了通过向宿主施用非乳化的超纯化聚合血红蛋白溶液并且向宿主施用化学治疗剂来治疗宿主中的肿瘤的方法。 在特别优选的实施方案中，血红蛋白是牛血红蛋白。
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公开(公告)号：US5502214A
公开(公告)日：1996-03-26
申请号：US93763
申请日：1993-07-19
IPC分类号： C07C46/06 , C07C225/28 , C07D203/14 , C07D205/04 , C07D295/116 , C07D205/00 , C07C50/02 , C07D229/00
CPC分类号： C07D203/14 , C07C225/28 , C07C46/06 , C07D205/04 , C07D295/116
摘要： The present invention relates to 1,2-benzoquinones; methods of preparation of 1,2-benzoquinones that include preparation of 4,5-substituted-1,2-benzoquinones in a one-pot reaction; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such benzoquinones.
摘要翻译： 本发明涉及1,2-苯醌; 制备1,2-苯醌的方法，包括在一锅反应中制备4,5-取代的1,2-苯醌; 以及使用或包含一种或多种这样的苯醌的治疗方法和药物组合物。
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9.发明授权Selective isotopic labeling of spin labels for electron spin resonance spectroscopy 失效电子自旋共振光谱自旋标记的选择性同位素标记
公开(公告)号：US5431901A
公开(公告)日：1995-07-11
申请号：US227793
申请日：1988-08-03
IPC分类号： A61K49/20 , C07B60/00 , C07D207/46 , C07D211/94
CPC分类号： A61K49/20 , C07B61/02 , C07D207/46 , Y10T436/24
摘要： Selective isotopic-labeling of spin label compounds, used in electron spin resonance spectroscopy to detect, measure and monitor the presence of paramagnetic species, increases the sensitivity of the electron spin resonance technique in assays for paramagnetic species, such as the determination of oxygen tension in solution or in a biological sample, like a living organism. Spin label compounds, such as nitroxides, like 3-carbamoyl-2,2,5,5-tetramethyl-3-pyrroline-1-yloxyl (CTPO), are selectively, but not completely, isotopically-labeled, such as partially deuterated, to increase the sensitivity and reliability of assays employing electron spin resonance spectroscopic measurements.
摘要翻译： 用于电子自旋共振光谱法的自旋标记化合物的选择性同位素标记用于检测，测量和监测顺磁性物质的存在，增加了电子自旋共振技术在顺磁性物质的测定中的灵敏度，例如测定氧气张力 溶液或生物样品，如活体。 旋转标记化合物，例如硝基氧，如3-氨基甲酰基-2,2,5,5-四甲基-3-吡咯啉-1-基氧基（CTPO），是选择性但不完全同位素标记的，例如部分氘代， 以提高使用电子自旋共振光谱测量的测定的灵敏度和可靠性。
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公开(公告)号：US5196413A
公开(公告)日：1993-03-23
申请号：US660904
申请日：1991-02-27
CPC分类号： A61K31/28 , C07F15/0093 , C09B69/06
摘要： A (+)-charged dye transition metal complex, particularly a complex of platinum and a (+)-charged dye such as rhodamine 123. These products demonstrate antitumor and radio-sensitizing activity.
摘要翻译： （+）带电的染料过渡金属络合物，特别是铂和（+） - 带电染料如罗丹明123的络合物。这些产品表现出抗肿瘤和放射增敏活性。
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