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公开(公告)号：US20080145516A1
公开(公告)日：2008-06-19
申请号：US12070275
申请日：2008-02-14
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/606
摘要： A medical device with a therapeutic agent-releasing polymer coating. The medical device is provided by a method that comprises: (a) attaching at least one reactive species to a medical device surface, which reactive species leads to chain growth polymerization in the presence of monomer; (b) contacting the reactive species with at least one monomer species, thereby forming a polymer coating on the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating. The therapeutic agent may be incorporated during formation of the polymer coating or after formation of the polymer coating. The at least one reactive species can comprise, for example, a free radical species, a carbanion species. a carbocation species, a Ziegler-Natta polymerization complex, a metallocene complex, and/or an atom transfer radical polymerization initiator. Alternatively, the medical device is provided by a process comprising: (a) immobilizing least one polymerization catalyst at a medical device surface, which polymerization catalyst leads to polymerization in the presence of monomer; (b) contacting the medical device surface with at least one monomer species, thereby forming a polymer coating at the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating.
摘要翻译： 具有治疗剂释放聚合物涂层的医疗装置。 该医疗装置由一种方法提供，该方法包括：（a）将至少一种反应性物质附着到医疗器械表面上，该反应性物质在单体存在下导致链增长聚合; （b）使反应性物质与至少一种单体物质接触，从而在医疗装置的表面上形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。 治疗剂可以在形成聚合物涂层期间或在形成聚合物涂层之后引入。 至少一种反应性物质可以包含例如自由基物质，碳负离子物质。 碳阳离子种类，齐格勒 - 纳塔聚合络合物，茂金属络合物和/或原子转移自由基聚合引发剂。 或者，医疗装置由包括以下步骤的方法提供：（a）在医疗器械表面固定最少一种聚合催化剂，该聚合催化剂在单体存在下导致聚合; （b）使医疗器械表面与至少一种单体物质接触，从而在医疗装置的表面形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。
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公开(公告)号：US07931932B2
公开(公告)日：2011-04-26
申请号：US12070275
申请日：2008-02-14
IPC分类号： B05D3/06 , C08F2/46 , C08F295/00 , A61F2/06
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/606
摘要： A medical device with a therapeutic agent-releasing polymer coating. The medical device is provided by a method that comprises: (a) attaching at least one reactive species to a medical device surface, which reactive species leads to chain growth polymerization in the presence of monomer; (b) contacting the reactive species with at least one monomer species, thereby forming a polymer coating on the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating. The therapeutic agent may be incorporated during formation of the polymer coating or after formation of the polymer coating. The at least one reactive species can comprise, for example, a free radical species, a carbanion species, a carbocation species, a Ziegler-Natta polymerization complex, a metallocene complex, and/or an atom transfer radical polymerization initiator. Alternatively, the medical device is provided by a process comprising: (a) immobilizing least one polymerization catalyst at a medical device surface, which polymerization catalyst leads to polymerization in the presence of monomer; (b) contacting the medical device surface with at least one monomer species, thereby forming a polymer coating at the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating.
摘要翻译： 具有治疗剂释放聚合物涂层的医疗装置。 该医疗装置由一种方法提供，该方法包括：（a）将至少一种反应性物质附着到医疗器械表面上，该反应性物质在单体存在下导致链增长聚合; （b）使反应性物质与至少一种单体物质接触，从而在医疗装置的表面上形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。 治疗剂可以在形成聚合物涂层期间或在形成聚合物涂层之后引入。 至少一种反应性物质可以包括例如自由基物质，碳负离子物质，碳阳离子物质，齐格勒 - 纳塔聚合配合物，茂金属络合物和/或原子转移自由基聚合引发剂。 或者，医疗装置由包括以下步骤的方法提供：（a）在医疗器械表面固定最少一种聚合催化剂，该聚合催化剂在单体存在下导致聚合; （b）使医疗器械表面与至少一种单体物质接触，从而在医疗装置的表面形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。
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3.发明申请THERAPEUTIC AGENT DELIVERY FOR THE TREATMENT OF ASTHMA VIA IMPLANTABLE AND INSERTABLE MEDICAL DEVICES 审中-公开通过可植入和插入式医疗器械治疗哮喘的治疗药物公开(公告)号：US20120231047A1
公开(公告)日：2012-09-13
申请号：US13480227
申请日：2012-05-24
申请人： Robert A. Herrmann , John J. Damarati , Sepideh Hashemi , Wendy Naimark , Barry N. Gellman , Robert Rioux , Alexandra Rousseau , Raymond Lareau
发明人： Robert A. Herrmann , John J. Damarati , Sepideh Hashemi , Wendy Naimark , Barry N. Gellman , Robert Rioux , Alexandra Rousseau , Raymond Lareau
IPC分类号： A61K31/56 , A61K47/02 , A61P11/06 , A61M37/00 , A61P35/00 , A61P21/02 , A61M25/10 , A61K9/00 , A61P29/00
CPC分类号： A61K31/573
摘要： Methods for the treatment of asthma are provided, which comprise: (a) providing an implantable or insertable medical device that comprises an asthma treatment agent; and (b) inserting or implanting the medical device within the lungs (e.g., the trachea or the bronchial tree) of a patient, whereupon the therapeutic agent is delivered to the patient in an amount effective to reduce or eliminate the symptoms of asthma. Also disclosed herein are medical devices and kits for carrying out such methods.
摘要翻译： 提供了治疗哮喘的方法，其包括：（a）提供包含哮喘治疗剂的可植入或可插入的医疗装置; 和（b）将医疗装置插入或植入患者的肺部（例如，气管或支气管树）中，于是将治疗剂以有效减少或消除哮喘症状的量递送给患者。 本文还公开了用于执行这些方法的医疗装置和套件。
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公开(公告)号：US06780849B2
公开(公告)日：2004-08-24
申请号：US09745226
申请日：2000-12-21
申请人： Robert A. Herrmann , Wendy Naimark
发明人： Robert A. Herrmann , Wendy Naimark
IPC分类号： A01N4304
CPC分类号： A61L29/16 , A61K45/06 , A61L15/44 , A61L31/16 , A61L2300/114 , A61L2300/416 , C07C243/42 , C07J41/0055 , Y10T436/104165
摘要： Novel nitric-oxide releasing lipid molecules are provided which comprise a lipid molecule selected from (a) phosphoglycerides, (b) lipids having a sphingosine base as a backbone, (c) monoacylglyerols, (d) diacylglycerols, (e) glycosylacylglycerols, wherein the lipid molecole is provided with a nitric-oxide contianing group which comprises a (a) a —S—N═O moiety, (b) a —O—N═O moiety, or (c) a moiety. Also provided are methods of forming such nitric oxide releasing lipid molecules. Various pharmaceutical compositions, topical liquids and drug delivery systems comprising the ntric-oxide releasing lipid molecules are also described. Further provided are methods for therapeutically administering nitric oxide to patients, methods for treating or preventing various conditions, methods for promoting wound healing and methods for reducing the cells present in an atherosclerotic lesion which methods utilize the nitric-oxide releasing lipid molecules.
摘要翻译： 提供新的一氧化氮释放脂质分子，其包含选自（a）磷酸甘油酯，（b）具有鞘氨醇碱作为主链的脂质的脂质分子，（c）单酰基甘醇，（d）二酰基甘油，（e）糖基酰基甘油，其中 提供了含有（a）-SN = O部分，（b）-ON = O部分或（c）amoiety的一氧化氮连续基团的脂质痣醇。 还提供了形成这种一氧化氮释放脂质分子的方法。 还描述了包含释放氧化氮的脂质分子的各种药物组合物，局部液体和药物递送系统。 还提供了向患者治疗性给予一氧化氮的方法，用于治疗或预防各种病症的方法，用于促进伤口愈合的方法以及减少存在于动脉粥样硬化病变中的细胞的方法，该方法利用释放一氧化氮的脂质分子。
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5.发明申请Therapeutic agent delivery for the treatment of asthma via implantable and insertable medical devices 审中-公开通过可植入和可插入的医疗设备治疗哮喘的治疗剂递送公开(公告)号：US20080051702A1
公开(公告)日：2008-02-28
申请号：US11726608
申请日：2007-03-22
申请人： Robert A. Herrmann , John J. Damarati , Sepideh Hashemi , Wendy Naimark , Barry N. Gellman , Robert Rioux , Alexandra Rousseau , Raymond Lareau
发明人： Robert A. Herrmann , John J. Damarati , Sepideh Hashemi , Wendy Naimark , Barry N. Gellman , Robert Rioux , Alexandra Rousseau , Raymond Lareau
IPC分类号： A61K31/573
CPC分类号： A61K31/573
摘要： Methods for the treatment of asthma are provided, which comprise: (a) providing an implantable or insertable medical device that comprises an asthma treatment agent; and (b) inserting or implanting the medical device within the lungs (e.g., the trachea or the bronchial tree) of a patient, whereupon the therapeutic agent is delivered to the patient in an amount effective to reduce or eliminate the symptoms of asthma. Also disclosed herein are medical devices and kits for carrying out such methods.
摘要翻译： 提供了治疗哮喘的方法，其包括：（a）提供包含哮喘治疗剂的可植入或可插入的医疗装置; 和（b）将医疗装置插入或植入患者的肺部（例如，气管或支气管树）中，于是将治疗剂以有效减少或消除哮喘症状的量递送给患者。 本文还公开了用于执行这些方法的医疗装置和套件。
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公开(公告)号：US07696247B2
公开(公告)日：2010-04-13
申请号：US10885055
申请日：2004-07-06
申请人： Robert A. Herrmann , Wendy Naimark
发明人： Robert A. Herrmann , Wendy Naimark
IPC分类号： A61K31/20 , A01N33/26 , C07C205/00 , C07C207/00 , C07C241/00 , C07C243/00
CPC分类号： A61L29/16 , A61K45/06 , A61L15/44 , A61L31/16 , A61L2300/114 , A61L2300/416 , C07C243/42 , C07J41/0055 , Y10T436/104165
摘要： Novel nitric-oxide releasing lipid molecules are provided which comprise a lipid molecule selected from (a) phosphoglycerides, (b) lipids having a sphingosine base as a backbone, (c) monoacylglyerols, (d) diacylglycerols, (e) glycosylacylglycerols, and (f) sterol compounds of the formula: where R is a branched aliphatic chain of eight or more carbon atoms, wherein the lipid molecule is provided with a nitric-oxide containing group which comprises (a) a —S—N═O moiety, (b) a —O—N═O moiety, or (c) a a moiety. Also provided are methods of forming such nitric oxide releasing lipid molecules. Various pharmaceutical compositions, topical liquids and drug delivery systems comprising the nitric-oxide releasing lipid molecules are also described. Further provided are methods for therapeutically administering nitric oxide to patients, methods of treating or preventing various conditions, methods for promoting wound healing and methods of reducing the cells present in an atherosclerotic lesion, which methods utilize the nitric-oxide releasing lipid molecules.
摘要翻译： 提供新的一氧化氮释放脂质分子，其包含选自（a）磷酸甘油酯，（b）具有鞘氨醇碱作为主链的脂质的脂质分子，（c）单酰基甘醇，（d）二酰基甘油，（e）糖基酰基甘油和（ f）下式的甾醇化合物：其中R是具有8个或更多个碳原子的支链脂族链，其中所述脂质分子具有含一氧化氮的基团，其包含（a）-S-N = O部分，（ b）-O-N = O部分，或（c）aa部分。 还提供了形成这种一氧化氮释放脂质分子的方法。 还描述了包含释放一氧化氮的脂质分子的各种药物组合物，局部液体和药物递送系统。 还提供了向患者治疗性给予一氧化氮的方法，治疗或预防各种病症的方法，促进伤口愈合的方法以及减少存在于动脉粥样硬化病变中的细胞的方法，该方法利用释放一氧化氮的脂质分子。
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公开(公告)号：US20100062055A1
公开(公告)日：2010-03-11
申请号：US12619782
申请日：2009-11-17
申请人： Robert A. Herrmann , Wendy Naimark
发明人： Robert A. Herrmann , Wendy Naimark
CPC分类号： A61L29/16 , A61K45/06 , A61L15/44 , A61L31/16 , A61L2300/114 , A61L2300/416 , C07C243/42 , C07J41/0055 , Y10T436/104165
摘要： Novel nitric-oxide releasing lipid molecules are provided which comprise a lipid molecule selected from (a) phosphoglycerides, (b) lipids having a sphingosine base as a backbone, (c) monoacylglyerols, (d) diacylglycerols, (e) glycosylacylglycerols, and (f) sterol compounds of the formula: where R is a branched aliphatic chain of eight or more carbon atoms, wherein the lipid molecule is provided with a nitric-oxide containing group which comprises (a) a —S—N═O moiety, (b) a —O—N═O moiety, or (c) a moiety. Also provided are methods of forming such nitric oxide releasing lipid molecules. Various pharmaceutical compositions, topical liquids and drug delivery systems comprising the nitric-oxide releasing lipid molecules are also described. Further provided are methods for therapeutically administering nitric oxide to patients, methods of treating or preventing various conditions, methods for promoting wound healing and methods of reducing the cells present in an atherosclerotic lesion, which methods utilize the nitric-oxide releasing lipid molecules.
摘要翻译： 提供新的一氧化氮释放脂质分子，其包含选自（a）磷酸甘油酯，（b）具有鞘氨醇碱作为主链的脂质的脂质分子，（c）单酰基甘醇，（d）二酰基甘油，（e）糖基酰基甘油和（ f）下式的甾醇化合物：其中R是具有8个或更多个碳原子的支链脂族链，其中所述脂质分子具有含一氧化氮的基团，其包含（a）-S-N = O部分，（ b）-O-N = O部分，或（c）部分。 还提供了形成这种一氧化氮释放脂质分子的方法。 还描述了包含释放一氧化氮的脂质分子的各种药物组合物，局部液体和药物递送系统。 还提供了向患者治疗性给予一氧化氮的方法，治疗或预防各种病症的方法，促进伤口愈合的方法以及减少存在于动脉粥样硬化病变中的细胞的方法，该方法利用释放一氧化氮的脂质分子。
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公开(公告)号：US08808364B2
公开(公告)日：2014-08-19
申请号：US13240792
申请日：2011-09-22
申请人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
发明人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。
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9.发明授权公开(公告)号：US07892205B2
公开(公告)日：2011-02-22
申请号：US10455298
申请日：2003-06-06
申请人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
发明人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
IPC分类号： A61M37/00
CPC分类号： A61M11/06 , A61M25/0054 , A61M2025/0057
摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
摘要翻译： 本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。 微粉化治疗剂以气溶胶形式或干粉形式递送。 本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制 将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。
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公开(公告)号：US07517338B2
公开(公告)日：2009-04-14
申请号：US11038241
申请日：2005-01-21
申请人： Toby Freyman , Maria Palasis , Wendy Naimark , William J. Shaw
发明人： Toby Freyman , Maria Palasis , Wendy Naimark , William J. Shaw
CPC分类号： A61M25/0068 , A61B2017/00247 , A61B2018/00392 , A61M25/0071 , A61M25/0074 , A61M25/0084 , A61M25/10 , A61M2025/0058 , A61M2025/0076 , A61M2025/0079 , A61M2025/0085 , A61M2025/0681
摘要： Embodiments of the present invention regard the delivery of therapeutic. One such apparatus may comprise multiple, independently-activated, injection devices for the delivery of therapeutic or other substances. This apparatus may include a first catheter; a second catheter in the first catheter and a multiple delivery member injection device. This multiple delivery member may include an expandable member and a plurality of injection elements. A third catheter may be positioned in the second catheter. This third catheter may have a distal end connected to a wall of the expandable member and a plurality of filling tubes connected to an distal end of the third catheter. In some of the embodiments each of the injection elements may hold a pressurized therapeutic prior to release of the therapeutic.
摘要翻译： 本发明的实施方案涉及治疗的递送。 一种这样的装置可以包括用于递送治疗剂或其它物质的多个独立激活的注射装置。 该装置可以包括第一导管; 第一导管中的第二导管和多个递送部件注射装置。 该多个传送构件可以包括可扩张构件和多个注射元件。 第三导管可以定位在第二导管中。 该第三导管可以具有连接到可扩张构件的壁的远端和连接到第三导管的远端的多个填充管。 在一些实施方案中，每个注射元件可以在释放治疗剂之前保持加压治疗。
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