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    Processes for producing polymer coatings through surface polymerization
    1.
    发明申请
    Processes for producing polymer coatings through surface polymerization 失效
    通过表面聚合生产聚合物涂层的方法

    公开(公告)号：US20080145516A1

    公开(公告)日：2008-06-19

    申请号：US12070275

    申请日：2008-02-14

    申请人： Robert A. Herrmann ,  Frederick H. Strickler ,  Wendy Naimark ,  Peter L. Dayton

    发明人： Robert A. Herrmann ,  Frederick H. Strickler ,  Wendy Naimark ,  Peter L. Dayton

    IPC分类号： B05D3/10 ,  A61F2/82

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/606

    摘要： A medical device with a therapeutic agent-releasing polymer coating. The medical device is provided by a method that comprises: (a) attaching at least one reactive species to a medical device surface, which reactive species leads to chain growth polymerization in the presence of monomer; (b) contacting the reactive species with at least one monomer species, thereby forming a polymer coating on the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating. The therapeutic agent may be incorporated during formation of the polymer coating or after formation of the polymer coating. The at least one reactive species can comprise, for example, a free radical species, a carbanion species. a carbocation species, a Ziegler-Natta polymerization complex, a metallocene complex, and/or an atom transfer radical polymerization initiator. Alternatively, the medical device is provided by a process comprising: (a) immobilizing least one polymerization catalyst at a medical device surface, which polymerization catalyst leads to polymerization in the presence of monomer; (b) contacting the medical device surface with at least one monomer species, thereby forming a polymer coating at the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating.

    摘要翻译： 具有治疗剂释放聚合物涂层的医疗装置。 该医疗装置由一种方法提供，该方法包括：（a）将至少一种反应性物质附着到医疗器械表面上，该反应性物质在单体存在下导致链增长聚合; （b）使反应性物质与至少一种单体物质接触，从而在医疗装置的表面上形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。 治疗剂可以在形成聚合物涂层期间或在形成聚合物涂层之后引入。 至少一种反应性物质可以包含例如自由基物质，碳负离子物质。 碳阳离子种类，齐格勒 - 纳塔聚合络合物，茂金属络合物和/或原子转移自由基聚合引发剂。 或者，医疗装置由包括以下步骤的方法提供：（a）在医疗器械表面固定最少一种聚合催化剂，该聚合催化剂在单体存在下导致聚合; （b）使医疗器械表面与至少一种单体物质接触，从而在医疗装置的表面形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。

    Processes for producing polymer coatings through surface polymerization
    2.
    发明授权
    Processes for producing polymer coatings through surface polymerization 失效
    通过表面聚合生产聚合物涂层的方法

    公开(公告)号：US07931932B2

    公开(公告)日：2011-04-26

    申请号：US12070275

    申请日：2008-02-14

    申请人： Robert A. Herrmann ,  Frederick H. Strickler ,  Wendy Naimark ,  Peter L. Dayton

    发明人： Robert A. Herrmann ,  Frederick H. Strickler ,  Wendy Naimark ,  Peter L. Dayton

    IPC分类号： B05D3/06 ,  C08F2/46 ,  C08F295/00 ,  A61F2/06

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/606

    摘要： A medical device with a therapeutic agent-releasing polymer coating. The medical device is provided by a method that comprises: (a) attaching at least one reactive species to a medical device surface, which reactive species leads to chain growth polymerization in the presence of monomer; (b) contacting the reactive species with at least one monomer species, thereby forming a polymer coating on the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating. The therapeutic agent may be incorporated during formation of the polymer coating or after formation of the polymer coating. The at least one reactive species can comprise, for example, a free radical species, a carbanion species, a carbocation species, a Ziegler-Natta polymerization complex, a metallocene complex, and/or an atom transfer radical polymerization initiator. Alternatively, the medical device is provided by a process comprising: (a) immobilizing least one polymerization catalyst at a medical device surface, which polymerization catalyst leads to polymerization in the presence of monomer; (b) contacting the medical device surface with at least one monomer species, thereby forming a polymer coating at the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating.

    摘要翻译： 具有治疗剂释放聚合物涂层的医疗装置。 该医疗装置由一种方法提供，该方法包括：（a）将至少一种反应性物质附着到医疗器械表面上，该反应性物质在单体存在下导致链增长聚合; （b）使反应性物质与至少一种单体物质接触，从而在医疗装置的表面上形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。 治疗剂可以在形成聚合物涂层期间或在形成聚合物涂层之后引入。 至少一种反应性物质可以包括例如自由基物质，碳负离子物质，碳阳离子物质，齐格勒 - 纳塔聚合配合物，茂金属络合物和/或原子转移自由基聚合引发剂。 或者，医疗装置由包括以下步骤的方法提供：（a）在医疗器械表面固定最少一种聚合催化剂，该聚合催化剂在单体存在下导致聚合; （b）使医疗器械表面与至少一种单体物质接触，从而在医疗装置的表面形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。

    Medical devices having polymeric regions that contain fluorocarbon-containing block copolymers
    3.
    发明授权
    Medical devices having polymeric regions that contain fluorocarbon-containing block copolymers 有权
    具有含有含氟烃嵌段共聚物的聚合物区域的医疗装置

    公开(公告)号：US08034874B2

    公开(公告)日：2011-10-11

    申请号：US11285885

    申请日：2005-11-23

    申请人： Frederick H. Strickler ,  Ronald A. Sahatjian

    发明人： Frederick H. Strickler ,  Ronald A. Sahatjian

    IPC分类号： C08L53/00 ,  A61F2/06 ,  A61F2/24

    CPC分类号： C08L53/00 ,  C08F293/00 ,  C08F293/005 ,  C09D153/00

    摘要： In one aspect, the present invention provides implantable or insertable medical devices, which contain at least one polymeric region. The polymeric region contains at least one fluorocarbon-containing block copolymer, which, in turn, contains (a) at least one fluorocarbon-containing, low glass transition temperature (low Tg) copolymer chain and (b) at least one glass transition temperature (high Tg) polymer chain.

    摘要翻译： 在一个方面，本发明提供了可植入或可插入的医疗装置，其包含至少一个聚合物区域。 聚合物区域含有至少一种含氟烃嵌段共聚物，其又包含（a）至少一种含碳氟化合物，低玻璃化转变温度（低Tg）共聚物链和（b）至少一个玻璃化转变温度 高Tg）聚合物链。

    Medical devices having improved mechanical performance
    4.
    发明授权
    Medical devices having improved mechanical performance 有权
    医疗器械具有改善的机械性能

    公开(公告)号：US07897170B2

    公开(公告)日：2011-03-01

    申请号：US11809459

    申请日：2007-06-01

    申请人： Frederick H. Strickler ,  Mark Boden

    发明人： Frederick H. Strickler ,  Mark Boden

    IPC分类号： A61F13/00

    CPC分类号： A61L27/16 ,  A61L29/041 ,  A61L31/048 ,  C08L53/00

    摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided that contain at least one covalently crosslinked polymeric region, which contains at least one block copolymer comprising at least one low Tg block and at least one high Tg block.

    摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含至少一个共价交联的聚合物区域，其含有至少一个包含至少一个低Tg嵌段和至少一个高Tg嵌段的嵌段共聚物。

    MEDICAL DEVICES HAVING IMPROVED PERFORMANCE
    6.
    发明申请
    MEDICAL DEVICES HAVING IMPROVED PERFORMANCE 有权
    具有改进性能的医疗器械

    公开(公告)号：US20110144276A1

    公开(公告)日：2011-06-16

    申请号：US13034249

    申请日：2011-02-24

    申请人： Shaina Brito ,  Frederick H. Strickler

    发明人： Shaina Brito ,  Frederick H. Strickler

    IPC分类号： C08F299/00 ,  C08F214/18 ,  C08F228/02

    CPC分类号： A61L31/048 ,  A61L27/16 ,  A61L29/041 ,  C08F293/00 ,  C08L53/02

    摘要： In accordance with various aspects of the invention, implantable and insertable medical devices are provided, which contain one or more polymeric regions. In one aspect, the polymeric regions comprise (a) a block copolymer that comprises a polyaromatic block and a polyalkene block admixed with (b) a sulfonated high Tg polymer. In another aspect, the polymeric regions comprise a block copolymer that comprises (a) a sulfonated polymer block and (b) fluorinated polymer block.

    摘要翻译： 根据本发明的各个方面，提供了可植入和可插入的医疗装置，其包含一个或多个聚合物区域。 在一个方面，聚合物区域包含（a）嵌段共聚物，其包含与（b）磺化的高Tg聚合物混合的多芳族嵌段和聚烯烃嵌段。 另一方面，聚合物区域包含嵌段共聚物，其包含（a）磺化聚合物嵌段和（b）氟化聚合物嵌段。

    Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents
    7.
    发明授权
    Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents 有权
    含有接受共聚物的植入式或可插入医疗器械用于治疗剂的控制递送

    公开(公告)号：US07357940B2

    公开(公告)日：2008-04-15

    申请号：US10632413

    申请日：2003-07-31

    申请人： Robert E. Richard ,  Frederick H. Strickler

    发明人： Robert E. Richard ,  Frederick H. Strickler

    IPC分类号： A61F13/00

    CPC分类号： A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  C08L51/00

    摘要： Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region that controls the release of the therapeutic agent upon administration to a patient. The polymer release region comprises a graft copolymer, which further comprises a main chain and a plurality of side chains. One of (a) the main chain and (b) the side chains corresponds to a rubbery phase within the release region at ambient temperatures, while the other corresponds to a hard phase within the release layer at ambient temperatures. Typically, the graft copolymer will comprise one glass transition temperature below ambient temperature and another second glass transition temperature above ambient temperature. Also described are methods for forming the above graft copolymers, methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices, as well as methods for making the above devices.

    摘要翻译： 描述了可植入或可插入的医疗装置。 医疗装置包括（a）治疗剂和（b）控制治疗剂在给予患者时释放的聚合物释放区域。 聚合物释放区域包括接枝共聚物，其还包含主链和多个侧链。 （a）主链和（b）侧链对应于环境温度下释放区内的橡胶相，而另一个对应于在环境温度下释放层内的硬相。 通常，接枝共聚物将包括低于环境温度的一个玻璃化转变温度和高于环境温度的另一个第二玻璃化转变温度。 还描述了形成上述接枝共聚物的方法，使用上述可植入或可插入的医疗装置向患者施用治疗剂的方法，以及制备上述装置的方法。