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1.发明授权公开(公告)号：US07892205B2
公开(公告)日：2011-02-22
申请号：US10455298
申请日：2003-06-06
申请人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
发明人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
IPC分类号： A61M37/00
CPC分类号： A61M11/06 , A61M25/0054 , A61M2025/0057
摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
摘要翻译： 本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。 微粉化治疗剂以气溶胶形式或干粉形式递送。 本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制 将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。
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公开(公告)号：US20060029720A1
公开(公告)日：2006-02-09
申请号：US10909408
申请日：2004-08-03
申请人： Anastasia Panos , Wendy Naimark , Maria Palasis , Toby Freyman , Samuel Epstein
发明人： Anastasia Panos , Wendy Naimark , Maria Palasis , Toby Freyman , Samuel Epstein
CPC分类号： B05C5/0208 , A61F2/86 , A61F2002/072 , A61L31/08 , A61L31/10 , A61L2420/02 , B05C13/025 , B05D1/002 , B05D1/26 , B05D1/30
摘要： Methods and apparatus for coating at least a portion of the surface of medical devices using an injection coating device are disclosed. In one embodiment, the invention includes a coating method wherein an orifice of the injection coating device is placed adjacent a vertically positioned medical device, coating material is ejected from the orifice onto the medical device, and the coating material gravitationally flows downward coating the medical device. In another embodiment, an orifice of an injection coating device is positioned adjacent a horizontally positioned medical device to gravitationally flow and deposit coating material onto the medical device. These methods may be used to apply one or more coating materials, simultaneously or in sequence. In another embodiment, multiple injection coating devices may be utilized. In certain embodiments of the invention, the coating materials include therapeutic or biologically active agents.
摘要翻译： 公开了使用注射涂覆装置涂覆医疗装置的表面的至少一部分的方法和装置。 在一个实施方案中，本发明包括一种涂覆方法，其中注射涂覆装置的孔口邻近垂直定位的医疗装置放置，涂层材料从孔口喷射到医疗装置上，并且涂覆材料重力地向下流动涂覆医疗装置 。 在另一个实施例中，注射涂覆装置的孔口邻近水平定位的医疗装置定位以重力地流动并将涂层材料沉积到医疗装置上。 这些方法可以同时或按顺序施用一种或多种涂料。 在另一个实施例中，可以使用多个注射涂覆装置。 在本发明的某些实施方案中，涂层材料包括治疗或生物活性剂。
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公开(公告)号：US20070055352A1
公开(公告)日：2007-03-08
申请号：US11221647
申请日：2005-09-07
申请人： Wendy Naimark , Peter Shank , Maria Palasis , Toby Freyman , Anastasia Panos , Samuel Epstein , Alexandra Rousseau
发明人： Wendy Naimark , Peter Shank , Maria Palasis , Toby Freyman , Anastasia Panos , Samuel Epstein , Alexandra Rousseau
IPC分类号： A61F2/90
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2220/0008 , A61F2230/0013 , A61F2250/0068 , A61L2300/606
摘要： A medical device for: delivering a therapeutic agent to a body lumen is described. The device may generally be a stent with an inner sidewall surface and an outer sidewall surface, with a plurality of struts having a plurality of openings therein. An inner and outer layer may be applied to the stent, forming pockets within at least a portion of the openings. The pockets may be filled with at least one therapeutic agent. The pockets may take a variety of shapes and sizes, and may be designed for release or rupture in variety of ways.
摘要翻译： 描述了用于将治疗剂递送到体腔的医疗装置。 该装置通常可以是具有内侧壁表面和外侧壁表面的支架，多个支柱在其中具有多个开口。 内层和外层可以施加到支架上，在开口的至少一部分内形成袋。 口袋可以填充有至少一种治疗剂。 口袋可以采取各种形状和尺寸，并且可以设计为以各种方式释放或破裂。
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4.发明申请公开(公告)号：US20110130715A1
公开(公告)日：2011-06-02
申请号：US13022217
申请日：2011-02-07
申请人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
发明人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
IPC分类号： A61M5/00
CPC分类号： A61M11/06 , A61M25/0054 , A61M2025/0057
摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
摘要翻译： 本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。 微粉化治疗剂以气溶胶形式或干粉形式递送。 本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制 将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。
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5.发明授权公开(公告)号：US08235937B2
公开(公告)日：2012-08-07
申请号：US13022217
申请日：2011-02-07
申请人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
发明人： Maria Palasis , Wendy Naimark , Toby Freyman , Samuel Epstein
IPC分类号： A61M31/00
CPC分类号： A61M11/06 , A61M25/0054 , A61M2025/0057
摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
摘要翻译： 本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。 微粉化治疗剂以气溶胶形式或干粉形式递送。 本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制 将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。
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公开(公告)号：US08808364B2
公开(公告)日：2014-08-19
申请号：US13240792
申请日：2011-09-22
申请人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
发明人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。
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公开(公告)号：US07517338B2
公开(公告)日：2009-04-14
申请号：US11038241
申请日：2005-01-21
申请人： Toby Freyman , Maria Palasis , Wendy Naimark , William J. Shaw
发明人： Toby Freyman , Maria Palasis , Wendy Naimark , William J. Shaw
CPC分类号： A61M25/0068 , A61B2017/00247 , A61B2018/00392 , A61M25/0071 , A61M25/0074 , A61M25/0084 , A61M25/10 , A61M2025/0058 , A61M2025/0076 , A61M2025/0079 , A61M2025/0085 , A61M2025/0681
摘要： Embodiments of the present invention regard the delivery of therapeutic. One such apparatus may comprise multiple, independently-activated, injection devices for the delivery of therapeutic or other substances. This apparatus may include a first catheter; a second catheter in the first catheter and a multiple delivery member injection device. This multiple delivery member may include an expandable member and a plurality of injection elements. A third catheter may be positioned in the second catheter. This third catheter may have a distal end connected to a wall of the expandable member and a plurality of filling tubes connected to an distal end of the third catheter. In some of the embodiments each of the injection elements may hold a pressurized therapeutic prior to release of the therapeutic.
摘要翻译： 本发明的实施方案涉及治疗的递送。 一种这样的装置可以包括用于递送治疗剂或其它物质的多个独立激活的注射装置。 该装置可以包括第一导管; 第一导管中的第二导管和多个递送部件注射装置。 该多个传送构件可以包括可扩张构件和多个注射元件。 第三导管可以定位在第二导管中。 该第三导管可以具有连接到可扩张构件的壁的远端和连接到第三导管的远端的多个填充管。 在一些实施方案中，每个注射元件可以在释放治疗剂之前保持加压治疗。
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公开(公告)号：US20070065414A1
公开(公告)日：2007-03-22
申请号：US11227278
申请日：2005-09-16
申请人： Toby Freyman , Maria Palasis , Wendy Naimark
发明人： Toby Freyman , Maria Palasis , Wendy Naimark
CPC分类号： A61M25/10 , A61K31/28 , A61K31/7076 , A61K35/28 , A61K45/00 , A61K45/06 , A61K2300/00 , A61M5/1407 , A61M2025/1052 , A61M2210/125
摘要： The present invention provides a method comprising administering cells by infusion through a blood vessel and administering a vasodilator, a vascular enhancer, or both. In accordance with one embodiment, the delivery of stem cells to the myocardium by intracoronary infusion is improved by administration of one or more vasodilators and/or vascular permeability enhancers prior to or at the time of cell therapy.
摘要翻译： 本发明提供了一种方法，其包括通过血管输注施用细胞并施用血管扩张剂，血管增强剂或两者。 根据一个实施方案，通过在细胞治疗之前或期间通过施用一种或多种血管扩张剂和/或血管通透性增强剂来改善通过冠状动脉内输注将干细胞递送至心肌。
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公开(公告)号：US20060195059A1
公开(公告)日：2006-08-31
申请号：US11038241
申请日：2005-01-21
申请人： Toby Freyman , Maria Palasis , Wendy Naimark , William Shaw
发明人： Toby Freyman , Maria Palasis , Wendy Naimark , William Shaw
IPC分类号： A61M29/00
CPC分类号： A61M25/0068 , A61B2017/00247 , A61B2018/00392 , A61M25/0071 , A61M25/0074 , A61M25/0084 , A61M25/10 , A61M2025/0058 , A61M2025/0076 , A61M2025/0079 , A61M2025/0085 , A61M2025/0681
摘要： Embodiments of the present invention regard the delivery of therapeutic. One such apparatus may comprise multiple, independently-activated, injection devices for the delivery of therapeutic or other substances. This apparatus may include a first catheter; a second catheter in the first catheter and a multiple delivery member injection device. This multiple delivery member may include an expandable member and a plurality of injection elements. A third catheter may be positioned in the second catheter. This third catheter may have a distal end connected to a wall of the expandable member and a plurality of filling tubes connected to an distal end of the third catheter. In some of the embodiments each of the injection elements may hold a pressurized therapeutic prior to release of the therapeutic.
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10.发明申请Decullularized extracellular matrix of conditioned body tissues and uses thereof 审中-公开条状体组织的脱细胞细胞外基质及其用途公开(公告)号：US20050181016A1
公开(公告)日：2005-08-18
申请号：US11076328
申请日：2005-03-10
申请人： Toby Freyman , Wendy Naimark , Maria Palasis
发明人： Toby Freyman , Wendy Naimark , Maria Palasis
CPC分类号： A61L27/3683 , A61K35/12 , A61L27/3633 , A61L2430/40 , C12N5/0679 , C12N2510/00
摘要： The invention is directed to an apparatus, such as a medical device, having a surface coated or covered with a decellularized extracellular matrix or having a component comprising the decellularized extracellular matrix for implantation into a subject, preferably a human. In one embodiment of the invention, a decellularized extracellular matrix is used to form a bodily implant such as a vein, an artery, an esophagus, or a ventricular restraining device. In some embodiments of the invention, the decellularized extracellular matrix is configured to be a time released therapeutic. In another embodiment of the invention, a decellularized extracellular matrix forms an aneurysm treatment device, such as an aneurysm coil, a seal, a pouch, or a filler. In a further embodiment of the invention, decellularized extracellular matrix is used to embolize lesions, tumors, or vessels. Methods for making the tissue regeneration scaffold and methods for manufacturing a coated or covered medical device having a component comprising decellularized extracellular matrix of body tissues are also provided.
摘要翻译： 本发明涉及一种诸如医疗装置的装置，其具有被脱细胞的细胞外基质包被或覆盖的表面，或具有包含用于植入受试者，优选人的脱细胞的细胞外基质的组分。 在本发明的一个实施方案中，使用脱细胞的细胞外基质形成诸如静脉，动脉，食管或心室抑制装置的身体植入物。 在本发明的一些实施方案中，脱细胞的细胞外基质被配置为时间释放的治疗剂。 在本发明的另一个实施方案中，脱细胞的细胞外基质形成动脉瘤治疗装置，例如动脉瘤线圈，密封件，小袋或填充物。 在本发明的另一个实施方案中，脱细胞的细胞外基质用于栓塞病变，肿瘤或血管。 还提供了用于制备组织再生支架的方法和用于制造具有包含身体组织的脱细胞的细胞外基质的组分的涂覆或覆盖的医疗装置的方法。
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