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公开(公告)号:US06689936B1
公开(公告)日:2004-02-10
申请号:US09393483
申请日:1999-09-10
IPC分类号: A01K6700
CPC分类号: C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , A61K49/0006 , A61K49/0008
摘要: The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.
摘要翻译: 本发明提供评估其对皮肤的影响的方法。 本发明还提供具有与皮肤代谢启动子偶联的报告基因的非人转基因动物,例如小鼠。
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公开(公告)号:US07985587B2
公开(公告)日:2011-07-26
申请号:US11701835
申请日:2007-02-02
申请人: Bruce A. Morgan , Jiro Kishimoto , Robert Burgeson
发明人: Bruce A. Morgan , Jiro Kishimoto , Robert Burgeson
IPC分类号: C12N5/00
CPC分类号: C12N5/0627 , A61K8/99 , A61K33/14 , A61K38/18 , A61K48/00 , A61Q7/00 , C12N2500/12 , C12N2501/415 , G01N33/6872 , G01N2333/475 , G01N2500/00
摘要: The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.
摘要翻译: 本发明的特征在于促进受试者的毛发生长的方法。 所述方法包括诱导或模拟Wnt促进的信号转导的作用,例如通过增加Wnt蛋白的水平或施用模拟Wnt促进的信号转导的作用的试剂,例如通过施用氯化锂。 还提供了抑制毛发生长的方法。
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公开(公告)号:US20070074298A1
公开(公告)日:2007-03-29
申请号:US11636078
申请日:2006-12-08
申请人: Jiro Kishimoto , Robert Burgeson
发明人: Jiro Kishimoto , Robert Burgeson
IPC分类号: A01K67/027 , C12Q1/00 , C12N5/06
CPC分类号: A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , C12N2503/02 , C12N2517/02
摘要: The invention describes versican activation and modulation of hair growth, e.g., versican expressing dermal papilla cells exhibit hair induction ability.
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公开(公告)号:US20080286261A1
公开(公告)日:2008-11-20
申请号:US11701835
申请日:2007-02-02
申请人: Bruce A. Morgan , Jiro Kishimoto , Robert Burgeson
发明人: Bruce A. Morgan , Jiro Kishimoto , Robert Burgeson
IPC分类号: A61K39/395 , A61K38/02 , A61K31/7088 , C12N5/00 , A61K35/12 , A61K33/00 , A61K33/14
CPC分类号: C12N5/0627 , A61K8/99 , A61K33/14 , A61K38/18 , A61K48/00 , A61Q7/00 , C12N2500/12 , C12N2501/415 , G01N33/6872 , G01N2333/475 , G01N2500/00
摘要: The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.
摘要翻译: 本发明的特征在于促进受试者的毛发生长的方法。 所述方法包括诱导或模拟Wnt促进的信号转导的作用,例如通过增加Wnt蛋白的水平或施用模拟Wnt促进的信号转导的作用的试剂,例如通过施用氯化锂。 还提供了抑制毛发生长的方法。
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公开(公告)号:US20050271632A1
公开(公告)日:2005-12-08
申请号:US11129215
申请日:2005-05-13
申请人: Bruce Morgan , Jiro Kishimoto , Robert Burgeson
发明人: Bruce Morgan , Jiro Kishimoto , Robert Burgeson
IPC分类号: G01N33/50 , A61K8/99 , A61K33/14 , A61K35/36 , A61K38/00 , A61K38/17 , A61K38/18 , A61K39/395 , A61K45/00 , A61K48/00 , A61P17/14 , A61P39/00 , A61P43/00 , A61Q7/00 , C12N5/02 , C12N5/071 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/68
CPC分类号: C12N5/0627 , A61K8/99 , A61K33/14 , A61K38/18 , A61K48/00 , A61Q7/00 , C12N2500/12 , C12N2501/415 , G01N33/6872 , G01N2333/475 , G01N2500/00
摘要: The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.
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公开(公告)号:US06924141B2
公开(公告)日:2005-08-02
申请号:US09822722
申请日:2001-03-30
申请人: Bruce A. Morgan , Jiro Kishimoto , Robert Burgeson
发明人: Bruce A. Morgan , Jiro Kishimoto , Robert Burgeson
IPC分类号: G01N33/50 , A61K8/99 , A61K33/14 , A61K35/36 , A61K38/00 , A61K38/17 , A61K38/18 , A61K39/395 , A61K45/00 , A61K48/00 , A61P17/14 , A61P39/00 , A61P43/00 , A61Q7/00 , C12N5/02 , C12N5/071 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/68 , C12N5/00
CPC分类号: C12N5/0627 , A61K8/99 , A61K33/14 , A61K38/18 , A61K48/00 , A61Q7/00 , C12N2500/12 , C12N2501/415 , G01N33/6872 , G01N2333/475 , G01N2500/00
摘要: The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.
摘要翻译: 本发明的特征在于促进受试者的毛发生长的方法。 所述方法包括诱导或模拟Wnt促进的信号转导的作用,例如通过增加Wnt蛋白的水平或施用模拟Wnt促进的信号转导的作用的试剂,例如通过施用氯化锂。 还提供了抑制毛发生长的方法。
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公开(公告)号:US07175842B2
公开(公告)日:2007-02-13
申请号:US11129215
申请日:2005-05-13
申请人: Bruce A. Morgan , Jiro Kishimoto , Robert Burgeson
发明人: Bruce A. Morgan , Jiro Kishimoto , Robert Burgeson
IPC分类号: C12N5/00
CPC分类号: C12N5/0627 , A61K8/99 , A61K33/14 , A61K38/18 , A61K48/00 , A61Q7/00 , C12N2500/12 , C12N2501/415 , G01N33/6872 , G01N2333/475 , G01N2500/00
摘要: The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.
摘要翻译: 本发明的特征在于促进受试者的毛发生长的方法。 所述方法包括诱导或模拟Wnt促进的信号转导的作用,例如通过增加Wnt蛋白的水平或施用模拟Wnt促进的信号转导的作用的试剂,例如通过施用氯化锂。 还提供了抑制毛发生长的方法。
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公开(公告)号:US07163679B1
公开(公告)日:2007-01-16
申请号:US09565949
申请日:2000-05-05
申请人: Jiro Kishimoto , Robert Burgeson
发明人: Jiro Kishimoto , Robert Burgeson
CPC分类号: A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , C12N2503/02 , C12N2517/02
摘要: The invention describes versican activation and modulation of hair growth, e.g., versican expressing dermal papilla cells exhibit hair induction ability.
摘要翻译: 本发明描述了多发性激活和调节毛发生长,例如,多核酸表达真皮乳头细胞表现出毛发诱导能力。
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公开(公告)号:US07531625B2
公开(公告)日:2009-05-12
申请号:US10831979
申请日:2004-04-26
申请人: Pamela Olson , Dale Hunter , William Brunken , Manuel Koch , Robert Burgeson
发明人: Pamela Olson , Dale Hunter , William Brunken , Manuel Koch , Robert Burgeson
IPC分类号: C07K14/00
CPC分类号: C07K14/475 , A61K38/00
摘要: β-netrin nucleic acid molecules and polypeptides are provided. Methods of using the β-netrin nucleic acid molecules and polypeptides are also provided.
摘要翻译: 提供β-网蛋白核酸分子和多肽。 还提供了使用β-网蛋白核酸分子和多肽的方法。
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公开(公告)号:US07390634B2
公开(公告)日:2008-06-24
申请号:US09795671
申请日:2001-02-28
申请人: Pamela Olson , Dale Hunter , William Brunken , Manuel Koch , Robert Burgeson
发明人: Pamela Olson , Dale Hunter , William Brunken , Manuel Koch , Robert Burgeson
IPC分类号: C07H21/04
CPC分类号: C07K14/475 , A61K38/00
摘要: β-netrin nucleic acid molecules and polypeptides are provided. Methods of using the β-netrin nucleic acid molecules and polypeptides are also provided.
摘要翻译: 提供β-网蛋白核酸分子和多肽。 还提供了使用β-网蛋白核酸分子和多肽的方法。
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