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    Enantioselective enzymatic aminolysis of a racemic 2-isoxazolylacetate alkyl ester
    1.
    发明授权
    Enantioselective enzymatic aminolysis of a racemic 2-isoxazolylacetate alkyl ester 失效
    外消旋2-异恶唑乙酸烷基酯的对映选择性酶解

    公开(公告)号：US06624311B2

    公开(公告)日：2003-09-23

    申请号：US10039972

    申请日：2001-10-25

    申请人： Robert DiCosimo ,  Philip Ma ,  Jaan A. Pesti

    发明人： Robert DiCosimo ,  Philip Ma ,  Jaan A. Pesti

    IPC分类号： C07D26104

    CPC分类号： C12P41/001 ,  C07D261/04 ,  C12P17/14

    摘要： The present invention relates to a process for the enantioselective enzymatic aminolysis of racemic 2-[3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetate ((R/S)-I) by methyl N&agr;-Boc-L-&agr;,&bgr;-diaminoproprionate.p-toluenesulfonic acid. More specifically, this invention pertains to a process for the enantioselective enzymatic aminolysis of racemic isobutyl 2-[3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]-acetate by methyl N&agr;-Boc-L-&agr;,&bgr;-diaminoproprionate.p-toluene sulfonic acid to produce (R)-methyl-3-[[[3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetyl]amino]-N-(butoxycarbonyl)-L-alanine, an intermediate in the preparation of roxifiban, an isoxazoline-based platelet glycoprotein IIb/IIIa antagonist which has activity as an antithrombotic agent.

    摘要翻译： 本发明涉及外消旋的2- [3-（4-氰基苯基）-4,5-二氢-5-异恶唑基]乙酸酯（（R / S）-I）的对映选择性酶促氨基化方法由Nalpha-Boc -L-α，β-二氨基丙酸酯对甲苯磺酸。 更具体地，本发明涉及通过Nalpha-Boc-L-α甲基对外消旋异丁基2- [3-（4-氰基苯基）-4,5-二氢-5-异恶唑基] - 乙酸酯的对映选择性酶解的方法， （R） - 甲基-3 - [[[3-（4-氰基苯基）-4,5-二氢-5-异恶唑基]乙酰基]氨基] -N-（丁氧基羰基） L-丙氨酸，罗非昔布的制备中间体，一种具有作为抗血栓形成剂活性的异恶唑啉类血小板糖蛋白IIb / IIIa拮抗剂。

    Production of peracids using an enzyme having perhydrolysis activity
    2.
    发明授权
    Production of peracids using an enzyme having perhydrolysis activity 有权
    使用具有过水解活性的酶生产过酸

    公开(公告)号：US08518675B2

    公开(公告)日：2013-08-27

    申请号：US11943872

    申请日：2007-11-21

    申请人： Robert DiCosimo ,  John E. Gavagan ,  Mark S. Payne ,  Frederick B. Cooling, III

    发明人： Robert DiCosimo ,  John E. Gavagan ,  Mark S. Payne ,  Frederick B. Cooling, III

    IPC分类号： C12P7/40 ,  C12N9/14

    CPC分类号： C12P7/40 ,  A61L2/186 ,  C12P7/62

    摘要： A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided.

    摘要翻译： 提供了从羧酸酯制备过氧羧酸的方法。 更具体地说，羧酸酯与无机过氧化物如过氧化氢在具有过水解活性的酶催化剂存在下反应。 基于保守的结构特征，本发明的过水解酶催化剂被分类为碳水化合物酯酶家族7（CE-7）的成员。 此外，提供包含通过本文所述方法生产的过酸的消毒剂制剂。

    Control of enzymatic peracid generation
    4.
    发明授权
    Control of enzymatic peracid generation 失效
    控制酶过氧酸生成

    公开(公告)号：US08389575B2

    公开(公告)日：2013-03-05

    申请号：US13354486

    申请日：2012-01-20

    申请人： Robert DiCosimo ,  Mark Scott Payne ,  Eugenia Costa Hann

    发明人： Robert DiCosimo ,  Mark Scott Payne ,  Eugenia Costa Hann

    IPC分类号： A01N37/00 ,  C12P7/40 ,  C12N9/14

    CPC分类号： C12N9/18 ,  C11D3/0047 ,  C11D3/38636 ,  C11D3/38681 ,  C11D3/3945 ,  C11D3/48

    摘要： A process is provided for producing target concentrations of peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity under conditions where control of reaction pH by selection of buffer concentration and concentration of perhydrolase and reactants produces a targeted concentration of peroxycarboxylic acids. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided, as are corresponding methods of use.

    摘要翻译： 提供了从羧酸酯生产过氧羧酸的目标浓度的方法。 更具体地说，羧酸酯与无机过氧化物如过氧化氢反应，在具有过水解活性的酶催化剂的存在下，通过选择缓冲液浓度和过水解酶和反应物的浓度来控制反应pH产生目标浓度 的过氧羧酸。 基于保守的结构特征，本发明的过水解酶催化剂被分类为碳水化合物酯酶家族7（CE-7）的成员。 此外，提供包含通过本文所述方法生产的过酸的消毒剂制剂，以及相应的使用方法。