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67 条记录 (耗时 0.049 秒)

    Novel factor viia inhibiting compounds
    1.
    发明申请
    Novel factor viia inhibiting compounds 审中-公开
    新型因子viia抑制化合物

    公开(公告)号：US20060084614A1

    公开(公告)日：2006-04-20

    申请号：US10541347

    申请日：2004-01-05

    申请人： Robert Eckl ,  Lutz Weber ,  Christian Oefner

    发明人： Robert Eckl ,  Lutz Weber ,  Christian Oefner

    IPC分类号： A61K31/704 ,  C07H17/00

    CPC分类号： C07H15/203 ,  A61K31/7034

    摘要： The present invention relates to new compounds of formula (I): These compounds are very effective factor VIIa inhibitors and are therefore of interest in the treatment and/or prevention of thromboses, stroke, heart attack, inflammation, arteriosclerosis and tumour conditions.

    摘要翻译： 本发明涉及式（I）的新化合物：这些化合物是非常有效的因子VIIa抑制剂，因此对治疗和/或预防血栓形成，中风，心脏病发作，炎症，动脉硬化和肿瘤状况感兴趣。

    Apparatus for transporting a fluid within a channel leg of a microfluidic element
    3.
    发明授权
    Apparatus for transporting a fluid within a channel leg of a microfluidic element 有权

    公开(公告)号：US10315197B2

    公开(公告)日：2019-06-11

    申请号：US13375837

    申请日：2010-05-14

    申请人： Lutz Weber

    发明人： Lutz Weber

    IPC分类号： B01L3/00

    摘要： The invention relates to an apparatus for transporting a fluid in a channel leg of a microfluidic element, especially of a flow cell. According to the invention, a pressure source for pressurizing a front end face (42) in transport direction of the liquid which completely fills the channel leg in cross section is provided. The pressure source preferably comprises a closed space (17; 22; 34; 36, 38, 40), in which a compressed gas, for example air, is compressible by moving the front end face (42) of the fluid transported in the channel leg.

    FLUID RESERVOIR
    5.
    发明申请
    FLUID RESERVOIR 有权
    流体储存

    公开(公告)号：US20120187117A1

    公开(公告)日：2012-07-26

    申请号：US13383355

    申请日：2010-06-07

    申请人： Lutz Weber

    发明人： Lutz Weber

    IPC分类号： B65D25/02 ,  B65D25/38 ,  B65B3/02 ,  B65D6/00

    CPC分类号： B65D81/268 ,  B01L3/502707 ,  B01L3/52 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2300/0867 ,  B01L2400/0481 ,  B01L2400/0683 ,  B65D75/36 ,  B65D81/266

    摘要： The invention relates to a fluid reservoir, in particular a fluid reservoir to be integrated into a miniaturized flow cell, comprising a reservoir space, which is enclosed by two bodies (6,7) that lie against each other in a fluid-tight manner. According to the invention, in addition to a stored liquid (9), a solid filling body (12) that fills the remaining reservoir space is arranged in the reservoir space. A part of the reservoir space filled by the stored liquid is preferably bounded predominately by one of the two bodies (6,7) and the solid filling body (12).

    摘要翻译： 本发明涉及一种流体储存器，特别是集成在小型化流动池中的流体储存器，其包括储存空间，该储存空间由流体密封的彼此相对的两个主体（6,7）封闭。 根据本发明，除了储存的液体（9）之外，填充剩余的储存空间的固体填充体（12）设置在储存空间中。 由储存液体填充的储存空间的一部分优选主要由两个主体（6,7）和固体填充体（12）中的一个限定。

    Micropump and method for the production thereof
    7.
    发明授权
    Micropump and method for the production thereof 有权
    Micropump及其生产方法

    公开(公告)号：US07771176B2

    公开(公告)日：2010-08-10

    申请号：US10527207

    申请日：2003-09-04

    申请人： Lutz Weber

    发明人： Lutz Weber

    IPC分类号： F04B17/03 ,  F04B53/10 ,  F16K15/14

    CPC分类号： F04B53/1062 ,  F04B43/046 ,  Y10T137/7895

    摘要： The invention relates to a micropump comprising a pump membrane (5) which can be moved by modifying the volume of a pump chamber which is adjacent to the pump membrane (5) and a base part (1), also comprising two valves which are arranged in recesses (10,11) in the base part and react to the pressure in the pump chamber in order to alternately open and close an inlet channel (8) and an outlet channel (9) for a medium to be pumped. According to the invention, the valves are formed by functioning valve modules (40,41) without any common components. The pre-manufactured valve modules, base modules comprising the base part and hose connections (2,3) and actuator modules comprising the actuator and the membrane are combined in order to produce said micropumps.

    摘要翻译： 本发明涉及一种包括泵膜（5）的微型泵，该泵膜可以通过改变与泵膜（5）相邻的泵室的容积和一个基部（1）来移动，该基座部分还包括两个阀， 在基部中的凹部（10,11）中，并且与泵室中的压力作出反应，以交替地打开和关闭待泵送的介质的入口通道（8）和出口通道（9）。 根据本发明，阀由功能不同的阀组件（40,41）组成。 包括基部和软管连接件（2,3）的预制阀模块，包括致动器和膜的致动器模块的基本模块被组合以便产生所述微型泵。

    Methods and Compositions for Detecting Receptor Ligand Mimetics
    9.
    发明申请
    Methods and Compositions for Detecting Receptor Ligand Mimetics 有权
    检测受体配体模拟物的方法和组成

    公开(公告)号：US20100111930A1

    公开(公告)日：2010-05-06

    申请号：US12514328

    申请日：2007-11-09

    申请人： Vladimir Khazak ,  Lutz Weber

    发明人： Vladimir Khazak ,  Lutz Weber

    IPC分类号： A61K39/395 ,  C12Q1/02 ,  C07F9/06 ,  A61K31/66 ,  A61P35/04

    CPC分类号： G01N33/5041 ,  A61K31/66 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/57423 ,  G01N2500/04

    摘要： A method to determine the utility of small molecules as functional replacements (mimetics) for protein receptor ligands is described. The method uses cellular biological assays on a systematic array of compounds, comprising known protein receptor ligands and other biologically active molecules to determine if a proposed small molecule is a functional equivalent of a receptor ligand, having therapeutic utility as a pharmaceutically relevant and useful agent either alone or in combination with other molecules.

    摘要翻译： 描述了确定小分子作为蛋白质受体配体的功能替代物（模拟物）的效用的方法。 该方法在系统化的化合物阵列上使用细胞生物测定法，其包括已知的蛋白质受体配体和其他生物活性分子，以确定所提出的小分子是否是受体配体的功能等同物，具有作为药学上相关和有用的药剂的治疗效用 单独或与其他分子组合。