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    Efficient classification, manipulation, and control of network transmissions by associating network flows with rule based functions
    1.
    发明授权
    Efficient classification, manipulation, and control of network transmissions by associating network flows with rule based functions 失效
    通过将网络流量与基于规则的功能相关联，有效地分类，操纵和控制网络传输

    公开(公告)号：US06519636B2

    公开(公告)日：2003-02-11

    申请号：US09181376

    申请日：1998-10-28

    申请人： Robert Engel ,  Tsipora P. Barzilai ,  Dilip Dinkar Kandlur ,  Ashish Mehra

    发明人： Robert Engel ,  Tsipora P. Barzilai ,  Dilip Dinkar Kandlur ,  Ashish Mehra

    IPC分类号： G06F15173

    CPC分类号： H04L47/10 ,  H04L47/20 ,  H04L47/21 ,  H04L47/22 ,  H04L47/2416 ,  H04L47/2441 ,  H04L63/02 ,  H04L63/0227 ,  H04L63/0263 ,  H04L69/22

    摘要： A computer connected to one or more networks through appropriate network interfaces is used to classify, manipulate, and/or control communications, e.g., packets sent and/or received over the network by one or more applications executing in the computer. Each application is connected to the network through one or more sockets to enable this communication. The computer also comprises one or more rule sets of one or more rules. A socket set of one or more of the sockets is associated with only one of the rule sets. The rules in the rule set are used to control one or more of the packets communicated by the applications communicating over the socket(s) associated with the respective rule set. Rules can be added to the rule set, deleted from the rule set, or modified in order to classify, manipulate, and/or control the communication of the packets, e.g. to control the rate at which the packets are sent or to provide certain security functions.

    摘要翻译： 通过适当的网络接口连接到一个或多个网络的计算机被用于通过在计算机中执行的一个或多个应用来分类，操纵和/或控制通信，例如通过网络发送和/或接收的分组。 每个应用程序通过一个或多个套接字连接到网络，以实现此通信。 计算机还包括一个或多个规则集合的一个或多个规则。 一个或多个套接字的套接字集仅与规则集中的一个相关联。 规则集中的规则用于控制通过与相应规则集相关联的套接字通信的应用传送的一个或多个分组。 可以将规则添加到规则集中，从规则集中删除或修改，以便分类，操纵和/或控制分组的通信，例如。 以控制分组发送的速率或提供某些安全功能。

    METHOD FOR NAVIGATING AN UNDERSEA VEHICLE
    2.
    发明申请
    METHOD FOR NAVIGATING AN UNDERSEA VEHICLE 有权
    用于航行下车的方法

    公开(公告)号：US20100106349A1

    公开(公告)日：2010-04-29

    申请号：US12531834

    申请日：2008-02-07

    申请人： Dirk Rathjen ,  Armin Schmiegel ,  Robert Engel

    发明人： Dirk Rathjen ,  Armin Schmiegel ,  Robert Engel

    IPC分类号： G05D1/04 ,  G01C21/00 ,  G01S5/18

    CPC分类号： G01S15/025 ,  G01C21/00 ,  G01S5/186

    摘要： In a method for navigating an undersea vehicle (12), navigation data about position, orientation, and absolute vehicle speed of the undersea vehicle (12) are determined from measurement data delivered by navigation sensors (17) via a navigation filter (18) which incorporates the measurement values of a Doppler log (14). To achieve a highly accurate tracking of the course taken by the undersea vehicle (12), particularly during submerging and surfacing phases, the stretch of water (10) traversed by the undersea vehicle (12) is divided into regions (13) which at least in the vertically oriented z-axis have a finite dimension within a Cartesian coordinate system (11). During the voyage of the undersea vehicle (12), the flow rates in the stretch of water (10) in relation to the individual spatial layers (13) are determined and stored from the relative vehicle speeds measured by the Doppler log (14) in successive measurement processes, and from the absolute vehicle speeds issued continuously by the navigation filter (18). The stored flow rates are input into the navigation filter (18) (FIG. 1) in accordance with the respective spatial layer (13) reached by the undersea vehicle (12).

    摘要翻译： 在用于导航水下车辆（12）的方法中，从由导航传感器（17）经由导航过滤器（18）传送的测量数据确定关于水下车辆（12）的位置，方向和绝对车辆速度的导航数据，导航过滤器（18） 并入多普勒日志的测量值（14）。 为了实现对海底车辆（12）所采取的过程的高度精确跟踪，特别是在浸没和铺面阶段期间，由水下车辆（12）穿过的水（10）的伸展被分成至少至少 在垂直取向的z轴中，在笛卡尔坐标系（11）内具有有限的尺寸。 在海底车辆（12）的航行期间，根据多普勒日志（14）测量的相对车辆速度来确定和存储相对于各个空间层（13）的水（10）的流速 连续的测量过程，以及由导航过滤器（18）连续发出的绝对车辆速度。 存储的流量根据由水下车辆（12）到达的相应的空间层（13）被输入到导航过滤器（18）（图1）中。

    Method of producing nanoparticle suspensions
    3.
    发明授权
    Method of producing nanoparticle suspensions 有权
    制备纳米颗粒悬浮液的方法

    公开(公告)号：US09296685B2

    公开(公告)日：2016-03-29

    申请号：US13583536

    申请日：2011-03-07

    申请人： Robert Engel ,  Wolfgang Gerlinger ,  Stefan Braese ,  Thierry Muller ,  Christina Belenki ,  Heike P. Schuchmann ,  Marion Gedrat

    发明人： Robert Engel ,  Wolfgang Gerlinger ,  Stefan Braese ,  Thierry Muller ,  Christina Belenki ,  Heike P. Schuchmann ,  Marion Gedrat

    IPC分类号： C07C69/36 ,  C07C271/08 ,  B01F17/00 ,  C07C69/38 ,  C07C233/56

    CPC分类号： C07C271/08 ,  B01F17/0007 ,  B01F17/0021 ,  C07C69/36 ,  C07C69/38 ,  C07C233/56

    摘要： Method of producing a nanoparticle suspension with the steps (i) preparation of an emulsion of a disperse polar phase, where the aqueous phase comprises one or more precursor substances forming the nanoparticles, in a continuous organic phase in the presence of an emulsifier stabilizing the emulsion, (ii) conversion of the one or more precursor substances to nanoparticles in the disperse aqueous phase, (iii) breaking of the emulsion and phase separation, where the nanoparticle suspension is obtained as one phase, (iv) separation off of the nanoparticle suspension, (v) optionally isolation of the nanoparticles from the nanoparticle suspension, wherein the emulsifier is selected from compounds of the general formula (I) in which X is O, NH, Y is C(O), NH, R is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 6 to 30 carbon atoms and R1 is hydrogen or C1-C4-alkyl, and R2 is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 1 to 30 carbon atoms, preferably 6 to 30 carbon atoms, R3 is C1-C4-alkyl, n is 0 or 1, and the breaking of the emulsion is effected by splitting the emulsifier.

    摘要翻译： 制备纳米颗粒悬浮液的方法，步骤（i）制备分散极性相的乳液，其中水相包含一种或多种形成纳米颗粒的前体物质，在连续的有机相中，在稳定乳液的乳化剂存在下 ，（ii）将一种或多种前体物质转化为分散水相中的纳米颗粒，（iii）破乳和相分离，其中纳米颗粒悬浮液作为一相获得，（iv）将纳米颗粒悬浮液分离 ，（v）任选地从纳米颗粒悬浮液中分离纳米颗粒，其中所述乳化剂选自X为O，NH，Y为C（O），NH，R为饱和的或通式 具有6至30个碳原子的单或多不饱和的直链或支链烃基，R 1是氢或C 1 -C 4 - 烷基，R 2是饱和或单不饱和或多不饱和的直链或支链烃 具有1至30个碳原子，优选6至30个碳原子的二烷基，R 3是C 1 -C 4 - 烷基，n是0或1，并且通过分裂乳化剂来实现乳液的断裂。

    METHOD OF PRODUCING NANOPARTICLE SUSPENSIONS
    4.
    发明申请
    METHOD OF PRODUCING NANOPARTICLE SUSPENSIONS 有权
    制备纳米悬浮液的方法

    公开(公告)号：US20120329888A1

    公开(公告)日：2012-12-27

    申请号：US13583536

    申请日：2011-03-07

    申请人： Robert Engel ,  Wolfgang Gerlinger ,  Stefan Braese ,  Thierry Muller ,  Christina Belenki ,  Heike P. Schuchmann ,  Marion Gedrat

    发明人： Robert Engel ,  Wolfgang Gerlinger ,  Stefan Braese ,  Thierry Muller ,  Christina Belenki ,  Heike P. Schuchmann ,  Marion Gedrat

    IPC分类号： B01J13/00 ,  C07C69/36 ,  C07C69/38 ,  C07C233/56 ,  C07C271/12

    CPC分类号： C07C271/08 ,  B01F17/0007 ,  B01F17/0021 ,  C07C69/36 ,  C07C69/38 ,  C07C233/56

    摘要： Method of producing a nanoparticle suspension with the steps (i) preparation of an emulsion of a disperse polar phase, where the aqueous phase comprises one or more precursor substances forming the nanoparticles, in a continuous organic phase in the presence of an emulsifier stabilizing the emulsion, (ii) conversion of the one or more precursor substances to nanoparticles in the disperse aqueous phase, (iii) breaking of the emulsion and phase separation, where the nanoparticle suspension is obtained as one phase, (iv) separation off of the nanoparticle suspension, (v) optionally isolation of the nanoparticles from the nanoparticle suspension, wherein the emulsifier is selected from compounds of the general formula (I) in which X is O, NH, Y is C(O), NH, R is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 6 to 30 carbon atoms and R1 is hydrogen or C1-C4-alkyl, and R2 is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 1 to 30 carbon atoms, preferably 6 to 30 carbon atoms, R3 is C1-C4-alkyl, n is 0 or 1, and the breaking of the emulsion is effected by splitting the emulsifier.

    摘要翻译： 制备纳米颗粒悬浮液的方法，步骤（i）制备分散极性相的乳液，其中水相包含一种或多种形成纳米颗粒的前体物质，在连续的有机相中，在稳定乳液的乳化剂存在下 ，（ii）将一种或多种前体物质转化为分散水相中的纳米颗粒，（iii）破乳和相分离，其中纳米颗粒悬浮液作为一相获得，（iv）将纳米颗粒悬浮液分离 ，（v）任选地从纳米颗粒悬浮液中分离纳米颗粒，其中所述乳化剂选自X为O，NH，Y为C（O），NH，R为饱和的或通式 具有6至30个碳原子的单或多不饱和的直链或支链烃基，R 1是氢或C 1 -C 4 - 烷基，R 2是饱和或单不饱和或多不饱和的直链或支链烃 具有1至30个碳原子，优选6至30个碳原子的二烷基，R 3是C 1 -C 4 - 烷基，n是0或1，并且通过分裂乳化剂来实现乳液的断裂。

    QUATERNARY AMMONIUM FUNCTIONALIZED GLYCODENDRIMERS, METHODS FOR THE PRODUCTION AND USE THEREOF
    5.
    发明申请
    QUATERNARY AMMONIUM FUNCTIONALIZED GLYCODENDRIMERS, METHODS FOR THE PRODUCTION AND USE THEREOF 有权
    季铵盐功能性糖苷，其生产方法及其用途

    公开(公告)号：US20090196847A1

    公开(公告)日：2009-08-06

    申请号：US12282496

    申请日：2007-03-12

    申请人： Mary Cloninger ,  Robert Engel

    发明人： Mary Cloninger ,  Robert Engel

    IPC分类号： A01N33/12 ,  C08G69/48 ,  C08G65/48 ,  C08G77/00 ,  A01P1/00 ,  A61P29/00 ,  A61K31/785 ,  A61P17/00

    CPC分类号： A61K31/787 ,  Y02A50/473

    摘要： The present invention provides novel antimicrobial agents that are quaternary ammonium functionalized glycodendrimers. In one embodiment, the quaternary ammonium functionalized glycodendrimers are compounds of Formula (I): (Q+−-S-L)z-DnX− wherein: D is a dendrimer; n is the generation number of the functionalized dendrimer; z is an integer less than or equal to 2(n+2); L is a linking group; Q+ represents a quaternary ammonium moiety; and S represents a carbohydrate moiety. The present invention further provides formulations containing the antimicrobial agents of the invention, methods of making the agents and formulations of the invention, and methods of using the same as effective and/or broad spectrum antimicrobial agents. The agents and formulations of the invention find use in medicine, for the treatment of various inflammatory conditions or diseases, for example, and have numerous industrial applications. (Q+−-S-L)z-DnX−  (I)

    摘要翻译： 本发明提供了新颖的抗菌剂，它们是季铵官能化的缔结缔合体。 在一个实施方案中，季铵官能化的甘氨酸衍生物是式（I）的化合物：（Q + -S-L）z-DnX-其中：D是树枝状大分子; n是官能化树枝状聚合物的代数; z是小于或等于2（n + 2）的整数; L是连接基团; Q +表示季铵部分; S表示碳水化合物部分。 本发明还提供了含有本发明的抗微生物剂，制备本发明的试剂和制剂的方法的制剂，以及将其用作有效和/或广谱抗微生物剂的方法。 本发明的药剂和制剂可用于医药，例如用于治疗各种炎性病症或疾病，并具有许多工业应用。 （Q + -SL）z-DnX-（I）<？in-line-formula description =“In-line formula”end =“lead”？ end =“tail”？>

    ANTIMICROBIAL SURFACES
    6.
    发明申请
    ANTIMICROBIAL SURFACES 有权
    抗菌表面

    公开(公告)号：US20060199758A1

    公开(公告)日：2006-09-07

    申请号：US11420666

    申请日：2006-05-26

    申请人： Robert Engel ,  JaimeLee Cohen ,  Karin Fincher

    发明人： Robert Engel ,  JaimeLee Cohen ,  Karin Fincher

    IPC分类号： A61K38/39 ,  A61K31/717 ,  A61K31/4745

    CPC分类号： D06M13/338 ,  A01N25/34 ,  A01N33/12 ,  A01N43/32 ,  A01N57/34 ,  D06M13/285 ,  D06M13/46 ,  D21H21/36 ,  A01N25/10 ,  A01N2300/00

    摘要： The invention relates to an antimicrobial surface having the formula SS-(V+2-W)X wherein: SS represents a solid surface, said solid surface comprising hydroxyl groups attached to a carbon atom in the unmodified state thereof; V+2 represents a doubly positively charged moiety having the formula —+NR2-T-NR2+—, or 1,4-diazoniabicyclo[2.2.2]octane; T represents a saturated or unsaturated straight-chain hydrocarbon having 1-24 carbon atoms; R represents a saturated or unsaturated hydrocarbon group having 1-24 carbon atoms; phenyl; or benzyl; W represents a saturated or unsaturated straight-chain hydrocarbon having 10-24 carbon atoms; and X represents an anion that balances the charge of V wherein a nitrogen atom of V replaces at least some of the hydroxyl groups.

    摘要翻译： 本发明涉及一种抗微生物表面，其具有式<βin-line-formula description =“In-line Formulas”end =“lead”→> SS-（V SUP +2W） 其中：SS表示固体表面，所述固体表面包含在未改性状态下连接到碳原子上的羟基; V 2 + 2表示具有下式的双正电荷的部分： - NR 2 -T-NR 2 - 或1,4-二氮鎓双环[2.2.2]辛烷; T表示具有1-24个碳原子的饱和或不饱和直链烃; R表示具有1-24个碳原子的饱和或不饱和烃基; 苯基; 或苄基; W表示具有10-24个碳原子的饱和或不饱和直链烃; 并且X表示平衡V的电荷的阴离子，其中V的氮原子取代至少一些羟基。

    Methods for modulating ion channels
    10.
    发明授权
    Methods for modulating ion channels 有权
    调节离子通道的方法

    公开(公告)号：US08143254B2

    公开(公告)日：2012-03-27

    申请号：US11884628

    申请日：2006-02-17

    申请人： Geoffrey W. Abbott ,  Robert Engel ,  JaimeLee Iolani Rizzo

    发明人： Geoffrey W. Abbott ,  Robert Engel ,  JaimeLee Iolani Rizzo

    IPC分类号： A01N43/58

    CPC分类号： A61K31/455 ,  A61K31/4162 ,  A61K31/46

    摘要： In one embodiment, the invention provides an ion having the formula: (I) In another embodiment, the invention provides a method for modulating potassium, sodium, and cyclic nucleotide-modulated ion channels in a mammal in need thereof. In a further embodiment, the invention provides a method for modulating ligand-gated ion channels or transient receptor potential channels in a mammal in need thereof. The methods comprise administering an ion having the formula described above.

    摘要翻译： 在一个实施方案中，本发明提供了具有下式的离子：（I）在另一个实施方案中，本发明提供了在有需要的哺乳动物中调节钾，钠和环核苷酸调节的离子通道的方法。 在另一个实施方案中，本发明提供了在有需要的哺乳动物中调节配体门控离子通道或瞬时受体潜在通道的方法。 所述方法包括施用具有上述式的离子。