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1.发明授权Detection of ligand-antiligand complex formation by electromagnetically detectable bulk property measurement 失效通过电磁可检测的体积特性测量检测配体 - 抗配体复合物形成公开(公告)号：US07011948B2
公开(公告)日：2006-03-14
申请号：US10198465
申请日：2002-07-17
申请人： Robert G. Chapman , Pejman Ghanouni , Igor Shmulevich , David Balaban , Joseph A. Heanue , Andrew P. May , Nikolai Sharkov
发明人： Robert G. Chapman , Pejman Ghanouni , Igor Shmulevich , David Balaban , Joseph A. Heanue , Andrew P. May , Nikolai Sharkov
CPC分类号： G01N33/53 , Y10S977/924
摘要： Disclosed are methods for analyzing molecular binding events in which the formation of ligand/antiligand complexes can be directly detected in a mixture without requiring separation of the components of the mixture from each other by measuring bulk properties of the mixture (i.e., properties that have contributions from several or all of the components present in the mixture). Using these techniques, it is possible to screen libraries without labeling either the target antiligand or ligand. The invention also provides a method for determining the strength of ligand/antiligand binding by further analysis of the same signals.
摘要翻译： 公开了用于分析分子结合事件的方法，其中可以在混合物中直接检测配体/反配体配合物的形成，而不需要通过测量混合物的体积特性（即具有贡献的性质）来将混合物的组分彼此分离 来自混合物中存在的几种或全部组分）。 使用这些技术，可以筛选文库而不标记靶抗配体或配体。 本发明还提供了通过进一步分析相同信号来确定配体/抗配体结合强度的方法。
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公开(公告)号：US08755866B2
公开(公告)日：2014-06-17
申请号：US11381443
申请日：2006-05-03
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/10 , G01J3/2823 , G01J3/4406 , G01N21/6408 , G01N2201/0826 , G01N2201/0833
摘要： A system and method for optical lymph node mapping. The system is useful for guiding sentinel lymph node biopsy surgeries. A contrast agent that includes a fluorescent dye is injected near the site of a malignancy. The contrast agent drains into the lymphatic system, collecting in a sentinel node or nodes. The system utilizes one or more low-power continuous-wave lasers or light-emitting diodes modulated with a digital code sequence to probe the tissue suspected of containing the sentinel node. When the light is incident near the sentinel node, it will excite fluorescence from the dye. A portion of the scattered fluorescent light is captured with one or more photo-detectors. A correlation of the photo-detector signal and the digital code sequence is calculated to produce an estimate of the distribution of flight times for photons traveling from a given source to a given detector. The flight time distributions are used along with the measured amplitudes to reconstruct a map of contrast agent location within the tissue.
摘要翻译： 一种用于光学淋巴结图谱的系统和方法。 该系统可用于引导前哨淋巴结活检。 包含荧光染料的造影剂在恶性肿瘤部位附近注射。 造影剂排入淋巴系统，收集在前哨节点或节点。 该系统利用一个或多个低功率连续波激光器或用数字代码序列调制的发光二极管来探测怀疑含有前哨节点的组织。 当光在哨兵节点附近入射时，它会激发染料的荧光。 一部分散射的荧光被一个或多个光电探测器捕获。 计算光检测器信号和数字码序列的相关性，以产生从给定源到给定检测器的光子的飞行时间分布的估计。 飞行时间分布与测量的振幅一起使用以重建组织内造影剂位置的图。
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公开(公告)号：US20090112046A1
公开(公告)日：2009-04-30
申请号：US11925200
申请日：2007-10-26
申请人： Paul A. Lovoi , Joseph A. Heanue
发明人： Paul A. Lovoi , Joseph A. Heanue
IPC分类号： A61N5/00
CPC分类号： A61N5/1001 , A61N5/1014 , A61N5/1015
摘要： A brachytherapy applicator and method of use involve a source guide that assumes a desired curving, non-linear configuration when inserted into an inflated balloon of the applicator. A flexible source catheter follows the shape of the source guide when inserted into the balloon. Radiation dose received in various tissue areas can be better controlled using the invention, and the ratio of cavity surface dose to prescription depth dose can be lowered. With rotation of the curving source guide coupled with translation of the source via longitudinal movement of the catheter, the applicator can approximate a spherical source, through either stepped or continuous movement of the source and source guide.
摘要翻译： 近距离放射治疗施放器和使用方法涉及当将插入到施放器的充气气球中时呈现期望的弯曲非线性构造的源引导件。 当插入气球时，柔性源导管遵循源引导件的形状。 可以使用本发明更好地控制在各组织区域中接收的辐射剂量，并且可以降低腔表面剂量与处方深度剂量的比例。 随着通过导管的纵向移动与源的平移耦合的弯曲源引导件的旋转，施加器可以通过源和引导件的阶梯式或连续移动近似球形源。
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公开(公告)号：US20120323109A1
公开(公告)日：2012-12-20
申请号：US13598324
申请日：2012-08-29
IPC分类号： A61B6/00
CPC分类号： G01N21/6456 , A61B5/0059 , A61B5/0071 , A61B5/0086 , G01N21/4795
摘要： A system and method for measuring photons utilizing a low-power light source modulated with a code sequence to interrogate a sample of interest. Preferably a portion of the scattered light from the sample is detected by a photo-detector. A correlation of the photo-detector signal and the code sequence produces an estimate of the distribution of flight times for photons traveling from the source to the detector.
摘要翻译： 一种利用利用码序列调制的低功率光源来测量光子的系统和方法来询问感兴趣的样本。 优选地，通过光检测器检测来自样品的一部分散射光。 光检测器信号和代码序列的相关性产生从源到检测器的光子的飞行时间分布的估计。
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5.发明申请SYSTEM AND METHOD FOR DETERMINING ELECTRODE-TISSUE CONTACT BASED ON AMPLITUDE MODULATION OF SENSED SIGNAL 有权基于感应信号振幅调制的电极组织接触测定系统及方法公开(公告)号：US20120238897A1
公开(公告)日：2012-09-20
申请号：US13423034
申请日：2012-03-16
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B18/1492 , A61B2090/065
摘要： Methods and systems for monitoring contact between a medical probe and tissue are provided. A medical probe is introduced into a patient adjacent the tissue. An electrical parameter, e.g., electrical admittance, is measuring between a first electrode located on the medical probe and a second electrode remote from the first electrode. The electrical parameter is amplitude modulated in response to a physiological cycle of the patient. Contact between the medical probe and the tissue is detected based on the amplitude modulation of the measured electrical parameter.
摘要翻译： 提供了用于监测医疗探针和组织之间接触的方法和系统。 将医用探针引入邻近组织的患者。 诸如电导纳的电参数是在位于医用探针上的第一电极和远离第一电极的第二电极之间进行测量。 电参数响应于患者的生理周期进行幅度调制。 基于所测量的电参数的幅度调制来检测医用探针与组织之间的接触。
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6.发明授权System and method for determining electrode-tissue contact based on amplitude modulation of sensed signal 有权基于感测信号的幅度调制确定电极 - 组织接触的系统和方法公开(公告)号：US08160690B2
公开(公告)日：2012-04-17
申请号：US11762778
申请日：2007-06-14
IPC分类号： A61B5/05
CPC分类号： A61B5/053 , A61B18/1492 , A61B2090/065
摘要： Methods and systems for monitoring contact between a medical probe and tissue are provided. A medical probe is introduced into a patient adjacent the tissue. An electrical parameter, e.g., electrical admittance, is measured between a first electrode located on the medical probe and a second electrode remote from the first electrode. The electrical parameter is amplitude modulated in response to a physiological cycle of the patient. Contact between the medical probe and the tissue is detected based on the amplitude modulation of the measured electrical parameter.
摘要翻译： 提供了用于监测医疗探针和组织之间接触的方法和系统。 将医用探针引入邻近组织的患者。 在位于医疗探针上的第一电极和远离第一电极的第二电极之间测量电参数，例如电导纳。 电参数响应于患者的生理周期进行幅度调制。 基于所测量的电参数的幅度调制来检测医用探针与组织之间的接触。
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公开(公告)号：US08269964B2
公开(公告)日：2012-09-18
申请号：US11381450
申请日：2006-05-03
IPC分类号： G01J3/30
CPC分类号： G01N21/6456 , A61B5/0059 , A61B5/0071 , A61B5/0086 , G01N21/4795
摘要： A system and method for measuring photons utilizing a low-power light source modulated with a code sequence to interrogate a sample of interest. Preferably a portion of the scattered light from the sample is detected by a photo-detector. A correlation of the photo-detector signal and the code sequence produces an estimate of the distribution of flight times for photons traveling from the source to the detector.
摘要翻译： 一种利用利用码序列调制的低功率光源来测量光子的系统和方法来询问感兴趣的样本。 优选地，通过光检测器检测来自样品的一部分散射光。 光检测器信号和代码序列的相关性产生从源到检测器的光子的飞行时间分布的估计。
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公开(公告)号：US08050384B2
公开(公告)日：2011-11-01
申请号：US12251298
申请日：2008-10-14
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/10 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1084 , A61N2005/1059 , A61N2005/1091 , A61N2005/1098
摘要： A small tabletop stationary five-degree of freedom device such as a “robot” is used to define the treatment region by tracing the region under direct visualization and then to precisely deliver the treatment plan created by an automatic planning system by positioning a single low energy radiation source, or a plurality of low energy sources connected to each other in a predetermined parallel or similar geometry, each source equipped with blocking and attenuation mechanisms, at a plurality of positions in a planar fashion across or through a selected treatment field, thereby delivering a plurality of parallel overlapping beams indexed on a millimeter or submillimeter grid such that a concentration of dose is achieved at a variable depth in tissue relative to the dose where the radiation first enters the tissue and can be used to treat regions on or below the surface of tissue, in a cavity and underlying region created following a surgical resection, on or below the surface of an internal cavity, hollow viscus, or lumen, or deep in tissue adjacent to an inserted probe or conduit or catheter. By generating a plurality of overlapping beams indexed on a millimeter or submillimeter grid that converge on a target volume loaded with gold nanoparticles, a tumorcidal dose of radiation can be delivered in as little as a single session to tumor cells but not to normal cells within or outside the treatment volume. This approach also makes it possible to deliver serial radiosurgical treatments.
摘要翻译： 使用诸如“机器人”的小桌面固定式五自由度装置通过在直接可视化下跟踪该区域来定义治疗区域，然后通过定位单个低能量来精确地传递由自动规划系统创建的治疗计划 辐射源或多个以预定的平行或相似几何形状彼此连接的低能量源，每个源在平面形式的多个位置处配备有阻挡和衰减机制，跨越或通过选定的治疗区域，由此递送 多个平行的重叠光束在毫米或亚毫米格栅上分度，使得在组织中相对于辐射首先进入组织的剂量可变深度处实现剂量浓度，并可用于治疗表面上或表面下方的区域 的组织，在腔内和在手术切除后创建的下面的区域，在int的表面上或下方 内腔，中空粘液或内腔，或与插入的探针或导管或导管相邻的组织深部。 通过产生在毫米或亚毫米网格上分度的多个重叠波束，其聚集在装载有金纳米颗粒的靶体上，可将肿瘤剂量的辐射以少量单次递送至肿瘤细胞，但不能递送至肿瘤细胞内的正常细胞， 治疗量以外。 这种方法也可以提供串联放射治疗。
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9.发明申请公开(公告)号：US20080214887A1
公开(公告)日：2008-09-04
申请号：US12082492
申请日：2008-04-10
IPC分类号： A61M36/04
CPC分类号： A61N5/1014 , A61M2025/1063 , A61N5/1015 , A61N5/1048 , A61N2005/1018
摘要： A brachytherapy applicator and method of use involve source guides that assume a desired curving, non-linear configuration. A flexible source catheter follows the shape of the source guides when inserted therein. Radiation dose received in various tissue areas can be better controlled using the invention, and the ratio of cavity surface dose to prescription depth dose can be lowered. With sequential manipulation of the source via movement of the catheter, the applicator can deliver radiotherapy to a treatment plan with local variation to prevent overdose, through either stepped or continuous movement of the source. Source guides can be fixed in position and arranged in bowed configuration around a generally central balloon axis, either attached to the balloon wall or not, and the series of off-center guides can be used to shape the dose delivered.
摘要翻译： 近距离放射疗法施加器和使用方法包括采用期望的弯曲非线性构造的源引导件。 当插入其中时，柔性源导管遵循源极引导件的形状。 可以使用本发明更好地控制在各组织区域中接收的辐射剂量，并且可以降低腔表面剂量与处方深度剂量的比例。 通过导管的运动对源进行顺序操作，施用器可以将放射治疗递送到具有局部变化的治疗计划，以通过源的逐步或连续运动来防止过量。 源引导件可以被固定在适当位置并且围绕一般中心的气球轴线以弓形的形式布置，或者附接到球囊壁，并且可以使用一系列偏心导向器来调整所输送的剂量。
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公开(公告)号：US06175611B1
公开(公告)日：2001-01-16
申请号：US09167318
申请日：1998-10-06
IPC分类号： A61B603
CPC分类号： G01T1/243 , H01L27/14676
摘要： An x-ray detector, useful in x-ray imaging systems constructed from a single piece of silicon and a photon sensing crystal, and comprises a plurality of detector elements, each of the plurality of detector elements comprising a plurality of detector sub-elements. A plurality of x-ray detectors are arranged in a multi-dimensional array, each array of detectors tiered with respect to the next array of detectors. A compact electronics circuitry is also provided. The compact electronics circuitry is contained in each of the plurality of detector sub-elements. The compact electronics circuitry comprises a photon sensor, an amplifier, a discriminator and a digital-to-analog converter. Finally, a method for generating x-ray transmissiveness information is also provided.
摘要翻译： 一种x射线检测器，可用于由单片硅和光子感测晶体构成的x射线成像系统中，并且包括多个检测器元件，多个检测器元件中的每一个包括多个检测器子元件。 多个x射线检测器被布置成多维阵列，每个检测器阵列相对于下一个检测器阵列分层。 还提供了紧凑的电子电路。 紧凑型电子电路包含在多个检测器子元件中的每一个中。 紧凑的电子电路包括光子传感器，放大器，鉴别器和数模转换器。 最后，还提供了一种用于产生x射线透射信息的方法。
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