公开(公告)号：US4794252A

公开(公告)日：1988-12-27

申请号：US72019

申请日：1987-07-10

申请人： Robert H. Bateman ,  David S. Jones

发明人： Robert H. Bateman ,  David S. Jones

IPC分类号： G01N27/62 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10 ,  H01J49/12 ,  H01J49/00

CPC分类号： H01J49/049 ,  G01N30/726 ,  H01J49/0445 ,  H01J49/12

摘要： The invention provides a mass spectrometer for the analysis of a sample dissolved in a fluid, and in particular a spectrometer for the analysis of high molecular weight compounds in the eluent of a liquid chromatograph. The fluid to be analyzed is at least partly vaporized and sprayed into the cathode dark space of a glow discharge. Ions characteristic of the sample are extracted from the discharge and subsequently mass analyzed. conveniently, spraying into the cathode dark space is achieved by making the cathode electrode of the discharge comprise the spraying means through which the fluid is sprayed. Little fragmentation of the high mass ions is caused by the process, and the invention extends the range of compounds which can be analyzed in comparison with similar prior art thermospray type mass spectrometers.

摘要翻译： 本发明提供了用于分析溶解在流体中的样品的质谱仪，特别是用于在液相色谱仪的洗脱液中分析高分子量化合物的光谱仪。 要分析的流体至少部分蒸发并喷射到辉光放电的阴极暗空间中。 从放电中提取样品的离子特征，随后进行质量分析。 方便地，通过使排出物的阴极电极包括通过其喷射流体的喷射装置来实现向阴极黑暗空间的喷射。 通过该方法引起高质量离子的小碎裂，并且与现有技术的热喷涂型质谱仪相比，本发明扩展了可分析的化合物的范围。

公开(公告)号：US06229142B1

公开(公告)日：2001-05-08

申请号：US09381774

申请日：1999-12-17

申请人： Robert H. Bateman ,  Anthony J. Gilbert ,  Thomas O. Merren ,  John B. Hoyes ,  Jonathan C. Cottrell

发明人： Robert H. Bateman ,  Anthony J. Gilbert ,  Thomas O. Merren ,  John B. Hoyes ,  Jonathan C. Cottrell

IPC分类号： H01J4940

CPC分类号： H01J49/0036 ,  H01J49/025 ,  H01J49/40

摘要： An ion detector (27) for use in a time-of-flight mass spectrometer (1) is disclosed. The ion detector (27), which has an extended dynamic range, comprises collection electrodes (36, 38; 39) of different surface areas. In one embodiment the collection electrodes (36, 38; 39) are formed in an array consisting of a larger plate-like collection electrode (36, 38) and a smaller plate-like collection electrode (39). Microchannel multiplier plates (31, 32) may be arranged in front of the collection electrodes (36, 38; 39). In an alternative embodiment the collection electrodes consist of a grid (42) or, more preferably, a wire electrode (50) disposed in front of a plate-like electrode (43).

摘要翻译： 公开了一种用于飞行时间质谱仪（1）的离子检测器（27）。 具有扩展动态范围的离子检测器（27）包括具有不同表面积的收集电极（36,38; 39）。 在一个实施例中，收集电极（36,38; 39）形成为由更大的板状收集电极（36,38）和较小的板状收集电极（39）组成的阵列。 微通道乘法器板（31,32）可以布置在收集电极（36,38; 39）的前面。 在替代实施例中，收集电极由布置在板状电极（43）的前面的格栅（42）或更优选的线电极（50）组成。

公开(公告)号：US5661298A

公开(公告)日：1997-08-26

申请号：US649795

申请日：1996-05-17

申请人： Robert H. Bateman

发明人： Robert H. Bateman

IPC分类号： H01J49/28 ,  H01J49/30

CPC分类号： H01J49/30 ,  H01J49/282

摘要： A mass spectrometer is provided having a plurality of analyzers and including at least one magnetic sector analyzer and, typically, an orthogonal-acceleration time-of-flight mass analyzer. Bypass means are provided so that by switching of the direction of the ion beam, the magnetic sector analyzer may be bypassed and the time-of-flight analyzer used either to analyse the beam of ions from the source or daughter ions produced by fragmentation of that beam.

摘要翻译： 提供了具有多个分析器并且包括至少一个磁性扇区分析仪和通常是正交加速度飞行时间质量分析器的质谱仪。 提供了旁路装置，使得通过切换离子束的方向，可以绕过磁性扇区分析仪，并且飞行时间分析仪用于分析来自源或子离子的离子束 光束。

公开(公告)号：US09093254B2

公开(公告)日：2015-07-28

申请号：US13264574

申请日：2010-04-14

申请人： Kasper D. Rand ,  John R. Engen ,  Robert H. Bateman

发明人： Kasper D. Rand ,  John R. Engen ,  Robert H. Bateman

IPC分类号： H01J49/00

CPC分类号： H01J49/0077

摘要： A mass spectrometer (MS) that is adapted to allow rapid gas-phase hydrogen/deuterium exchange (HDX) labeling of ions in one or more traveling wave ion guides (TWIGs) with or without ion mobility separation. The addition of isotopic labeling by gas-phase HDX offers a sensitive alternative dimension for conformational detection, which enables high resolution detection of gaseous conformations based on shape and surface reactivity. Gas-phase, isotopic HDX labeling or “curtain” labeling, can be performed by infusing a reactive, isotopic labeling gas, e.g., ND3, into one or more of the traveling-ion wave guides (TWIG) in the MS. Analyte ions retained in the potential wells of a traveling wave generated by one or more of the TWIGs can be isotopic labeled at adjustable gas pressures. Labeling times can also be controlled by adjusting the speed of the traveling wave and can be performed within milliseconds of ionizations, probing protein conformations present in solution.

摘要翻译： 一种质谱仪（MS），其适于允许在具有或不具有离子迁移率分离的一个或多个行波离子导向器（TWIG）中的离子快速气相氢/氘交换（HDX）标记。 通过气相HDX添加同位素标记为构象检测提供了敏感的替代尺寸，可根据形状和表面反应性进行气相构象的高分辨率检测。 可以通过将反应性同位素标记气体例如ND3注入到MS中的一个或多个行进离子波导（TWIG）中来进行气相，同位素HDX标记或“窗帘”标记。 保留在由一个或多个TWIG产生的行波的势阱中的分析物离子可以在可调节的气体压力下进行同位素标记。 标记时间也可以通过调整行波的速度来控制，并且可以在毫秒的电离范围内进行，探测溶液中存在的蛋白质构象。

公开(公告)号：US4727249A

公开(公告)日：1988-02-23

申请号：US863356

申请日：1986-05-15

申请人： Robert H. Bateman ,  Peter Burns, deceased

发明人： Robert H. Bateman ,  Peter Burns, deceased

IPC分类号： H01J49/30 ,  B01D59/44

CPC分类号： H01J49/30

摘要： The invention relates to a mass spectrometer having a magnetic sector analyzer in which the magnetic field is developed neither by a permanent magnet nor by an electromagnet having the conventional ferromagnetic core. In particular, the spectrometer has a magnetic sector analyzer through which ions of a mass-to-charge ratio selected by said analyzer may travel along a substantially circular trajectory disposed in a first plane, said analyzer comprising at least two electrical conductor portions of substantially circular arcuate form, respectively of greater and smaller radius than said circular trajectory and disposed on radially opposite sides of a curved plane which is aligned with said circular trajectory and perpendicular to said first plane, and wherein substantially all of the magnetic flux generated by the passage of electrical current through said conductor portions passes only through non-ferromagnetic materials.

摘要翻译： 本发明涉及一种具有磁性扇形分析仪的质谱仪，其中磁场既不由永磁体也不由具有常规铁磁性核心的电磁体显影。 特别地，光谱仪具有磁性分析器，通过该磁性分析器，由所述分析仪选择的质荷比的离子可以沿着设置在第一平面中的基本上圆形的轨迹行进，所述分析器包括至少两个基本圆形的电导体部分 分别具有比所述圆形轨迹更大和更小的半径的弧形形状，并且设置在与所述圆形轨迹对齐并垂直于所述第一平面的曲面的径向相对侧上，并且其中基本上全部由通过 通过所述导体部分的电流仅通过非铁磁材料。

公开(公告)号：US4723076A

公开(公告)日：1988-02-02

申请号：US862623

申请日：1986-05-13

申请人： Robert H. Bateman

发明人： Robert H. Bateman

IPC分类号： H01J49/32

CPC分类号： H01J49/32

摘要： There is provided a mass spectrometer having at least three analyser sectors of the electrostatic or magnetic types, at least one sector being of the electrostatic type and at least one further sector being of the magnetic type. The spectrometer includes a focusing sector array having at least three analyzer sectors, the sectors of the array being dimensioned and positioned so as to cooperate to form a velocity- and direction- focused image. The sectors of the array are dimensioned and positioned as to form no velocity focused image within the array. One sector of said array is disposed adjacent to and between two sectors of the other type.

摘要翻译： 提供了一种质谱仪，其具有静电或磁性类型的至少三个分析器扇区，至少一个扇区是静电型的，并且至少一个另外的扇区是磁性类型。 光谱仪包括具有至少三个分析器扇区的聚焦扇区阵列，阵列的扇区的尺寸和位置被设计成协作以形成速度和方向聚焦的图像。 阵列的扇区的尺寸和位置被定义为在阵列内不形成速度聚焦的图像。 所述阵列的一个扇区被布置成与另一种类型的两个扇区相邻并且在两个扇区之间。

公开(公告)号：US20120032073A1

公开(公告)日：2012-02-09

申请号：US13264574

申请日：2010-04-14

申请人： Kasper D. Rand ,  John R. Engen ,  Robert H. Bateman

发明人： Kasper D. Rand ,  John R. Engen ,  Robert H. Bateman

IPC分类号： H01J49/10 ,  H01J49/26

CPC分类号： H01J49/0077

摘要： A mass spectrometer (MS) that is adapted to allow rapid gas-phase hydrogen/deuterium exchange (HDX) labeling of ions in one or more traveling wave ion guides (TWIGs) with or without ion mobility separation. The addition of isotopic labeling by gas-phase HDX offers a sensitive alternative dimension for conformational detection, which enables high resolution detection of gaseous conformations based on shape and surface reactivity. Gas-phase, isotopic HDX labeling or “curtain” labeling, can be performed by infusing a reactive, isotopic labeling gas, e.g., ND3, into one or more of the traveling-ion wave guides (TWIG) in the MS. Analyte ions retained in the potential wells of a traveling wave generated by one or more of the TWIGs can be isotopic labeled at adjustable gas pressures. Labeling times can also be controlled by adjusting the speed of the traveling wave and can be performed within milliseconds of ionizations, probing protein conformations present in solution.

摘要翻译： 一种质谱仪（MS），其适于允许在具有或不具有离子迁移率分离的一个或多个行波离子导向器（TWIG）中的离子快速气相氢/氘交换（HDX）标记。 通过气相HDX添加同位素标记为构象检测提供了敏感的替代尺寸，可根据形状和表面反应性进行气相构象的高分辨率检测。 可以通过将反应性同位素标记气体例如ND3注入到MS中的一个或多个行进离子波导（TWIG）中来进行气相，同位素HDX标记或“窗帘”标记。 保留在由一个或多个TWIG产生的行波的势阱中的分析物离子可以在可调节的气体压力下进行同位素标记。 标记时间也可以通过调整行波的速度来控制，并且可以在毫秒的电离范围内进行，探测溶液中存在的蛋白质构象。

公开(公告)号：US06756587B1

公开(公告)日：2004-06-29

申请号：US09381778

申请日：2000-02-22

申请人： Robert H. Bateman ,  Anthony J. Gilbert ,  Thomas O. Merren ,  John B. Hoyes ,  Jonathan C. Cottrell

发明人： Robert H. Bateman ,  Anthony J. Gilbert ,  Thomas O. Merren ,  John B. Hoyes ,  Jonathan C. Cottrell

IPC分类号： B01D5944

CPC分类号： H01J49/0036 ,  H01J49/025 ,  H01J49/40

摘要： An ion detector (27) for use in a time-of-flight mass spectrometer (1) is disclosed. The ion detector (27), which has an extended dynamic range, comprises at least one microchannel plate electron multiplier (42, 32) together with first and second collection electrodes (36, 38; 39). The second collection electrode (36, 38) is arranged such that in receives more electrons per ion entering the ion detector (27) than the first collection electrode (39). In one embodiment the collection electrodes (36, 38; 39) are formed in an array consisting of a larger plate-like collection electrode (36, 38) and a smaller plate-like collection electrode (39). In an alternative embodiment a second microchannel plate electron multiplier is arranged between the first collection electrode (46) and the second collection electrode (47). In this embodiment the first collection electrode consists either of a grid electrode (42) or more preferably of a wire electrode, and the second collection electrode consists of a plate-like electrode (43).

摘要翻译： 公开了一种用于飞行时间质谱仪（1）的离子检测器（27）。 具有扩展动态范围的离子检测器（27）与第一和第二收集电极（36,38; 39）一起包括至少一个微通道板电子倍增器（42,32）。 第二收集电极（36,38）被布置为使得每进入离子检测器（27）的离子比第一收集电极（39）接收更多的电子。 在一个实施例中，收集电极（36,38; 39）形成为由更大的板状收集电极（36,38）和较小的板状收集电极（39）组成的阵列。 在替代实施例中，第二微通道板电子倍增器布置在第一收集电极（46）和第二收集电极（47）之间。 在本实施例中，第一采集电极由栅电极（42）或更优选线电极组成，第二采集电极由板状电极（43）组成。

公开(公告)号：US06410915B1

公开(公告)日：2002-06-25

申请号：US09335116

申请日：1999-06-17

申请人： Robert H. Bateman ,  John A. Hickson

发明人： Robert H. Bateman ,  John A. Hickson

IPC分类号： H01J4926

CPC分类号： H01J49/0431 ,  G01N30/466 ,  G01N30/7266 ,  G01N2030/628 ,  H01J49/107

摘要： An electrospray and/or atmospheric pressure ionization mass spectrometer includes an evacuated chamber, a sampling region within which is maintained a pressure greater than in the evacuation chamber, a sampling orifice that communicates between the sampling region and the evacuation chamber, and a mass analyzer that receives charged particles along a first axis through the sampling orifice from the sampling region into the evacuated chamber. A plurality of charged-particle jet generators, each having an associated jet axis, are adapted to be alternatively, selectively aligned such that a respective jet axis intersects with the first axis associated with the mass analyzer. This alignment is performed through the use of a hollow member which functions to guide charged particles through the sampling orifice to the evacuated chamber and, subsequently, to the mass analyzer.

摘要翻译： 电喷雾和/或大气压电离质谱仪包括抽真空室，其中保持比抽真空室大的压力的采样区域，在取样区域和排气室之间连通的采样孔，以及质量分析器， 沿着第一轴将带电粒子从采样区域接收到抽真空室中。 多个带有相关联的射流轴的带电粒子射流发生器适于可选择地对准，使得相应的射流轴线与与质量分析器相关联的第一轴线相交。 该对准是通过使用中空构件进行的，中空构件用于将带电粒子引导通过采样孔到达真空室，随后引导到质量分析器。

公开(公告)号：US5198666A

公开(公告)日：1993-03-30

申请号：US777355

申请日：1991-12-02

申请人： Robert H. Bateman

发明人： Robert H. Bateman

IPC分类号： G21K1/087 ,  H01J49/02 ,  H01J49/32 ,  H01J49/48

CPC分类号： H01J49/48 ,  H01J49/025 ,  H01J49/326

摘要： The invention typically provides a double focusing mass spectrometer comprising an ion source (55), an ion momentum analyzer (56), a multichannel detector (58) and a multielectrode electrostatic ion-energy analyzer (57), wherein the energy dispersing field is generated by arrays of electrodes disposed in groups above and below the ion beam. By appropriate selection of the potentials applied to the electrodes, the focusing properties of the analyzer can be changed, allowing different extents of the mass spectrum to be accurately focused on the face of the detector (58) as it is tilted by the actuator (61) at different angles to the ion beam (64) emerging from the analyzer (57). This enables the spectrometer to simultaneously record either a small part of a mass spectrum at high resolution or a larger part at a lower resolution. Alternative arrangements of the detector which allow a similar result to be obtained are also disclosed.