公开(公告)号：US5951863A

公开(公告)日：1999-09-14

申请号：US262421

申请日：1994-06-20

申请人： Robert J. Kruger ,  Warren P Frederick ,  R. Hayes Helgren ,  Mark E. Larkin ,  Joaquin Mayoral ,  Brad A. Schmolesky ,  Roman W Siczek ,  Kenneth J. Timmons

发明人： Robert J. Kruger ,  Warren P Frederick ,  R. Hayes Helgren ,  Mark E. Larkin ,  Joaquin Mayoral ,  Brad A. Schmolesky ,  Roman W Siczek ,  Kenneth J. Timmons

IPC分类号： A61M1/16 ,  A61M1/28 ,  B01D61/02 ,  B01D63/10 ,  B01D63/12 ,  C02F1/44 ,  B01D61/26 ,  A61M1/34 ,  B01D61/08

CPC分类号： B01D63/106 ,  A61M1/1643 ,  A61M1/1662 ,  A61M1/28 ,  A61M1/281 ,  A61M1/284 ,  B01D61/022 ,  B01D63/103 ,  B01D63/12 ,  C02F1/441 ,  A61M2205/3613 ,  B01D2311/08 ,  B01D2313/086 ,  B01D2313/143 ,  B01D2313/24

摘要： Medical drug formulation and delivery system includes a reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom. A second reverse osmosis multilayer assembly is also wound on the core and is in fluid communication with the water treatment chemicals to receive the chemically purified water for purification of at least a second portion thereof. The second reserve osmosis multilayer assembly is in fluid communication with the first outlet so as to permit passage of the second portion of purified water therethrough. In one preferred embodiment, the first and second reverse osmosis assemblies are formed integrally in a side by side configuration. In an alternative embodiment, they are rolled about the core in an interleaf configuration.

摘要翻译： 药物制剂和递送系统包括用于净化来自源的水的反渗透装置，包括具有用于使来自源的水通过的入口的壳体，用于从壳体通过净化水的第一出口和用于通过废物的第二出口 净化后剩余水。 第一反渗透多层组件设置在壳体内，与入口流体连通，用于从源净化至少第一部分水。 水处理化学品可以位于卷绕第一储备渗透多层组件的核心中。 处理化学品与第一反渗透多层组件流体连通以接收第一纯化部分的水并且至少从其中去除化学污染物。 第二反渗透多层组件也缠绕在芯上并且与水处理化学品流体连通以接收用于纯化其至少第二部分的化学净化水。 第二储备渗透多层组件与第一出口流体连通，以允许第二部分净化水通过其中。 在一个优选实施例中，第一和第二反渗透组件以并排构造一体地形成。 在替代实施例中，它们以插页配置围绕核心滚动。

公开(公告)号：US5498338A

公开(公告)日：1996-03-12

申请号：US254014

申请日：1994-06-03

申请人： Robert J. Kruger ,  Warren P. Frederick ,  R. Hayes Helgren ,  Mark E. Larkin ,  Joaquin Mayoral ,  Brad A. Schmolesky ,  Roman W. Siczek ,  Kenneth J. Timmons

发明人： Robert J. Kruger ,  Warren P. Frederick ,  R. Hayes Helgren ,  Mark E. Larkin ,  Joaquin Mayoral ,  Brad A. Schmolesky ,  Roman W. Siczek ,  Kenneth J. Timmons

IPC分类号： A61M1/16 ,  A61M1/28 ,  B01D61/02 ,  B01D63/10 ,  B01D63/12 ,  C02F1/44 ,  B01D61/08

CPC分类号： B01D63/106 ,  A61M1/1643 ,  A61M1/1662 ,  A61M1/28 ,  A61M1/281 ,  A61M1/284 ,  B01D61/022 ,  B01D63/103 ,  B01D63/12 ,  C02F1/441 ,  A61M2205/3613 ,  B01D2311/08 ,  B01D2313/086 ,  B01D2313/143 ,  B01D2313/24

摘要： Medical drug formulation and delivery system includes a reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom. A second reverse osmosis multilayer assembly is also wound on the core and is in fluid communication with the water treatment chemicals to receive the chemically purified water for purification of at least a second portion thereof. The second reserve osmosis multilayer assembly is in fluid communication with the first outlet so as to permit passage of the second portion of purified water therethrough. A method of forming a reverse osmosis device, a peritoneal dialysis treatment system and alternative treatment systems incorporating such a device as well as corresponding methods of treatment are also disclosed.

摘要翻译： 药物制剂和递送系统包括用于净化来自源的水的反渗透装置，包括具有用于使来自源的水通过的入口的壳体，用于从壳体通过净化水的第一出口和用于通过废物的第二出口 净化后剩余水。 第一反渗透多层组件设置在壳体内，与入口流体连通，用于从源净化至少第一部分水。 水处理化学品可以位于卷绕第一储备渗透多层组件的核心中。 处理化学品与第一反渗透多层组件流体连通以接收第一纯化部分的水并且至少从其中去除化学污染物。 第二反渗透多层组件也缠绕在芯上并且与水处理化学品流体连通以接收用于纯化其至少第二部分的化学净化水。 第二储备渗透多层组件与第一出口流体连通，以允许第二部分净化水通过其中。 还公开了形成反渗透装置的方法，腹膜透析治疗系统和包含这种装置的替代治疗系统以及相应的治疗方法。

公开(公告)号：US5312547A

公开(公告)日：1994-05-17

申请号：US846184

申请日：1992-03-04

申请人： Robert J. Kruger ,  Warren P. Frederick ,  William J. Hook ,  Mark E. Larkin ,  Joaquin Mayoral ,  Roman W. Siczek ,  Kenneth J. Timmons ,  Sheldon M. Wecker

发明人： Robert J. Kruger ,  Warren P. Frederick ,  William J. Hook ,  Mark E. Larkin ,  Joaquin Mayoral ,  Roman W. Siczek ,  Kenneth J. Timmons ,  Sheldon M. Wecker

IPC分类号： A61M1/16 ,  A61M1/28 ,  B01D61/02 ,  B01D63/10 ,  B01D63/12 ,  C02F1/44 ,  B01D61/08

CPC分类号： B01D63/106 ,  A61M1/1643 ,  A61M1/1662 ,  A61M1/28 ,  A61M1/281 ,  A61M1/284 ,  B01D61/022 ,  B01D63/103 ,  B01D63/12 ,  C02F1/441 ,  A61M2205/3613 ,  B01D2311/08 ,  B01D2313/086 ,  B01D2313/143 ,  B01D2313/24

摘要： Medical drug formulation and delivery system includes a reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom. A second reverse osmosis multilayer assembly is also wound on the core and is in fluid communication with the water treatment chemicals to receive the chemically purified water for purification of at least a second portion thereof. The second reserve osmosis multilayer assembly is in fluid communication with the first outlet so as to permit passage of the second portion of purified water therethrough. In one preferred embodiment, the first and second reverse osmosis assemblies are formed integrally in a side by side configuration. In an alternative embodiment, they are rolled about the core in an interleaf configuration.

摘要翻译： 药物制剂和递送系统包括用于净化来自源的水的反渗透装置，包括具有用于使来自源的水通过的入口的壳体，用于从壳体通过净化水的第一出口和用于通过废物的第二出口 净化后剩余水。 第一反渗透多层组件设置在壳体内，与入口流体连通，用于从源净化至少第一部分水。 水处理化学品可以位于卷绕第一储备渗透多层组件的核心中。 处理化学品与第一反渗透多层组件流体连通以接收第一纯化部分的水并且至少从其中去除化学污染物。 第二反渗透多层组件也缠绕在芯上并且与水处理化学品流体连通以接收用于纯化其至少第二部分的化学净化水。 第二储备渗透多层组件与第一出口流体连通，以允许第二部分净化水通过其中。 在一个优选实施例中，第一和第二反渗透组件以并排构造一体地形成。 在替代实施例中，它们以插页配置围绕核心滚动。

公开(公告)号：US5352364A

公开(公告)日：1994-10-04

申请号：US990580

申请日：1992-12-15

申请人： Robert J. Kruger ,  Warren P. Frederick ,  Mark E. Larkin ,  Joaquin Mayoral ,  Sheldon M. Wecker

发明人： Robert J. Kruger ,  Warren P. Frederick ,  Mark E. Larkin ,  Joaquin Mayoral ,  Sheldon M. Wecker

IPC分类号： A61M1/16 ,  A61M1/28 ,  B01D61/02 ,  B01D63/10 ,  B01D63/12 ,  C02F1/44 ,  B01D61/08

CPC分类号： B01D63/106 ,  A61M1/1643 ,  A61M1/1662 ,  A61M1/28 ,  A61M1/281 ,  A61M1/284 ,  B01D61/022 ,  B01D63/103 ,  B01D63/12 ,  C02F1/441 ,  A61M2205/3613 ,  B01D2311/08 ,  B01D2313/086 ,  B01D2313/143 ,  B01D2313/24

摘要： A reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom. A second reverse osmosis multilayer assembly is also wound on the core and is in fluid communication with the water treatment chemicals to receive the chemically purified water for purification of at least a second portion thereof. The second reserve osmosis multilayer assembly is in fluid communication with the first outlet so as to permit passage of the second portion of purified water therethrough.

摘要翻译： 一种用于净化来自源的水的反渗透装置，包括具有用于从源通过水的入口的壳体，用于从壳体通过净化水的第一出口和用于净化后剩余的废水通过的第二出口。 第一反渗透多层组件设置在壳体内，与入口流体连通，用于从源净化至少第一部分水。 水处理化学品可以位于卷绕第一储备渗透多层组件的核心中。 处理化学品与第一反渗透多层组件流体连通以接收第一纯化部分的水并且至少从其中去除化学污染物。 第二反渗透多层组件也缠绕在芯上并且与水处理化学品流体连通以接收用于纯化其至少第二部分的化学净化水。 第二储备渗透多层组件与第一出口流体连通，以允许第二部分净化水通过其中。

公开(公告)号：US5437650A

公开(公告)日：1995-08-01

申请号：US371317

申请日：1995-01-11

申请人： Mark E. Larkin ,  Dvid E. Kramer ,  Warren P. Frederick

发明人： Mark E. Larkin ,  Dvid E. Kramer ,  Warren P. Frederick

IPC分类号： A61M25/18 ,  A61M39/04 ,  A61M39/10 ,  A61M25/00 ,  F16L21/06

CPC分类号： A61M39/045 ,  A61M39/1011 ,  A61M2039/1027 ,  A61M2039/1072 ,  Y10S604/905

摘要： A securing collar is used in combination with two tubular flow connectors to prevent the inadvertent disconnection of I.V. tubing sets. The securing collar includes a housing supported by one of the connectors, a radial flange extending from the housing, a tubular collar having a outwardly splayed end, at least two notches that separates the splayed collar into at least two elongated segments, a transition portion on the exterior of the collar, and a sliding annular locking ring. The locking ring slides on the collar from the proximal end over the transition portion to the distal segments so that the annular locking ring forces the splayed and segmented distal portions radially inward to grip the second connector.

摘要翻译： 固定环与两个管状流动连接器组合使用，以防止IV的意外断开。 管套。 所述固定环包括由所述连接器中的一个支撑的壳体，从所述壳体延伸的径向凸缘，具有向外张开的端部的管状套环，至少两个将所述凸起的凸缘分成至少两个细长段的凹口， 轴环的外部和滑动的环形锁定环。 锁定环从过渡部分上的近端在轴环上滑动到远侧段，使得环形锁定环径向向内迫使张开的和分段的远端部分夹紧第二连接器。

公开(公告)号：US5507733A

公开(公告)日：1996-04-16

申请号：US353048

申请日：1994-12-09

申请人： Mark E. Larkin ,  David E. Kramer ,  Warren P. Frederick

发明人： Mark E. Larkin ,  David E. Kramer ,  Warren P. Frederick

IPC分类号： A61M25/18 ,  A61M39/04 ,  A61M39/10 ,  A61M25/00 ,  F16L21/06

CPC分类号： A61M39/045 ,  A61M39/1011 ,  A61M2039/1027 ,  A61M2039/1072 ,  Y10S604/905

摘要： A securable collar is used with two connectors to prevent the inadvertent disconnection of IV tubing sets. The securable collar includes a housing supported by one of the connectors, a radial flange extending from the housing, a collar having a frustum-shape, two notches that separate the collar into two longitudinal segments, a transition portion on the exterior of the collar, and a sliding annular locking ring. The locking ring slides on the collar from a small diameter portion over the transition portion to a larger diameter portion. The annular locking ring compresses the larger diameter portion to pivot the longitudinal segments radially inward at the radial flange to grip the second connector.

摘要翻译： 使用两个连接器安装一个可靠的套环，以防止IV管套的意外断开。 可固定套环包括由一个连接器支撑的壳体，从壳体延伸的径向凸缘，具有平截头体形状的套环，两个凹槽，其将套环分成两个纵向段，在套环的外部上的过渡部分， 和滑动环形锁定环。 锁定环在套环上从过渡部分上的小直径部分滑动到较大直径部分。 环形锁定环压缩较大直径的部分，以使径向凸缘的径向向内径向枢转以夹持第二连接器。

公开(公告)号：US06906709B1

公开(公告)日：2005-06-14

申请号：US10083962

申请日：2002-02-26

申请人： Mark E. Larkin ,  Anita D. D'Amico

发明人： Mark E. Larkin ,  Anita D. D'Amico

IPC分类号： G06T15/00 ,  H04L29/06

CPC分类号： H04L63/1433 ,  H04L63/1441 ,  H04L63/20

摘要： A method of visualizing the impact of security flaws or breaches in a network. A 3-D visualization tool that simulates 3-D space on a monitor interfaces with a security database which relationally associates security events with the network elements affected thereby. The security events are visually depicted in a first section of simulated 3-D space and the network elements are depicted in a second section of simulated 3-D space. Relationship lines are drawn between displayed categories of security events and the displayed network elements in order to aid an analyst to visualize the impact of security breaches on the organization. Various other properties of the network elements may also be displayed such as the role of the network device within the organization, and the business functions of the organization.

摘要翻译： 一种可视化网络中安全漏洞或漏洞的影响的方法。 3-D可视化工具，其模拟监视器上的3-D空间与安全数据库的接口，该安全数据库将安全事件与受此影响的网络元素进行关联。 在模拟3-D空间的第一部分中可视地描绘安全事件，并且网络元件被描绘在模拟的3-D空间的第二部分中。 在显示的安全事件类别和显示的网络元素之间绘制关系线，以帮助分析师将安全漏洞对组织的影响视觉化。 还可以显示网络元件的各种其他属性，例如组织内的网络设备的作用以及组织的业务功能。

公开(公告)号：US5328041A

公开(公告)日：1994-07-12

申请号：US85697

申请日：1993-06-30

申请人： William J. Hook ,  Mark E. Larkin

发明人： William J. Hook ,  Mark E. Larkin

IPC分类号： B65D51/00 ,  B65D39/00 ,  B65D41/20

CPC分类号： B65D51/002

摘要： A stopper assembly for sealing the open end of a container and usable with a blunt entry device includes an elastomeric stopper having an annular flange portion, a hollow plug portion, and a thin diaphragm portion, the flange portion covering and abutting the open end of the container, the plug portion depending from the inner circumference of the flange portion and sealingly engaging the interior of the open end of the container, and the diaphragm portion spanning the center portion of the annular flange portion. A metal ferrule for securing the stopper to the container has an annular top portion and an annular skirt portion for engagement with the exterior of the container.

摘要翻译： 用于密封容器的开口端并且可用于钝进入装置的止动器组件包括具有环形凸缘部分，中空塞部分和薄膜部分的弹性止动件，所述凸缘部分覆盖并邻接所述开口端 容器，插头部分从凸缘部分的内圆周伸出并密封地接合容器的开口端的内部，并且隔膜部分跨越环形凸缘部分的中心部分。 用于将止动件固定到容器的金属套圈具有环形顶部和用于与容器的外部接合的环形裙部。

公开(公告)号：US4757911A

公开(公告)日：1988-07-19

申请号：US806782

申请日：1985-12-09

申请人： Mark E. Larkin ,  Edward S. Tripp ,  John S. Ziegler

发明人： Mark E. Larkin ,  Edward S. Tripp ,  John S. Ziegler

IPC分类号： B65D47/36 ,  A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61J1/20 ,  A61J3/00 ,  B65D41/02

CPC分类号： A61J1/2089 ,  A61J1/10 ,  A61J1/2041 ,  A61J1/2072

摘要： A thin flexible fluid-tight cover of PVC is bonded to a rigid port of a diluent container which is to be subjected to heat sterilization. The cover includes an outer flange for bonding to a complementary surface around the port, and a removable section for spanning the port. The removable section includes a central flexible diaphragm portion and a cylindrical wall portion. The diaphragm portion has at least one annular convolution whereby the diaphragm section is axially expandable by flexing of the convolution. A tear line is provided in a frangible section which joins the cylindrical wall portion to the outer flange. The cylindrical wall portion of the cover is disposed adjacent the outer surfaces of an abutment wall on the port to provide stress relief against rupture of the tear line from stresses generated in the cover during sterilization. A narrow post element is located adjacent the wall portion for concentrating manual pulling forces from an attached pull ring to a limited segment of the tear line.

摘要翻译： PVC的薄柔性流体密封盖结合到要进行加热灭菌的稀释剂容器的刚性端口上。 该盖包括用于粘合到端口周围的互补表面的外凸缘和用于跨越端口的可移除部分。 可移除部分包括中心柔性膜部分和圆柱形壁部分。 隔膜部分具有至少一个环形卷积，其中隔膜部分通过卷曲的弯曲而可轴向膨胀。 撕裂线设置在将圆筒形壁部连接到外凸缘的易碎部分中。 盖的圆柱形壁部分邻近端口上的邻接壁的外表面设置，以提供应力消除，以防止撕裂线从灭菌期间在盖中产生的应力破裂。 狭窄的柱元件邻近壁部分定位，用于将来自附接的拉环的手动拉力集中到撕裂线的有限部分。

公开(公告)号：USD291491S

公开(公告)日：1987-08-18

申请号：US680015

申请日：1984-12-10

申请人： Mark E. Larkin

设计人： Mark E. Larkin