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19 条记录 (耗时 0.052 秒)

    Method of promoting graft survival with anti-tissue factor antibodies
    1.
    发明申请
    Method of promoting graft survival with anti-tissue factor antibodies 审中-公开
    用抗组织因子抗体促进移植物存活的方法

    公开(公告)号：US20050106147A1

    公开(公告)日：2005-05-19

    申请号：US10928291

    申请日：2004-08-27

    申请人： Robert Jordan ,  Susan Tam ,  Janet Davis ,  Mark Zimmerman ,  Gang Xu ,  Norma Kenyon

    发明人： Robert Jordan ,  Susan Tam ,  Janet Davis ,  Mark Zimmerman ,  Gang Xu ,  Norma Kenyon

    IPC分类号： A61K20060101 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  C07K16/00 ,  C07K16/36 ,  C12P21/08

    CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/70

    摘要： The present invention is directed to a method of using function blocking tissue factor antibodies to enhance graft survival in mammals. Function blocking antibodies having the effect of blocking activated tissue factor (TF), TF and its ligand FVII as either the inactive TF:FVII or active TF:FVIIa complex, or block the formation of the TF:FVIIa:FX ternary complex are useful in the method. These properties provide a therapy that has directed action towards thrombotic events involving tissue-plasma interactions but does not prevent the intrinsic pathway for coagulation. Activated TF arises on cells, tissues, and organs during or after transplantation and is a major cause of graft loss.

    摘要翻译： 本发明涉及使用功能阻断组织因子抗体增强哺乳动物的移植物存活的方法。 具有阻断活化组织因子（TF），TF及其配体FVII作为无活性TF：FVII或活性TF：FVIIa复合物或阻断TF：FVIIa：FX三元复合物形成的作用的功能阻断抗体可用于 方法。 这些性质提供了一种治疗方法，其针对涉及组织 - 血浆相互作用的血栓形成事件发挥作用，但并不阻止凝固的内在途径。 活化的TF在移植期间或移植后在细胞，组织和器官上产生，并且是移植物损失的主要原因。

    Integral abradable seals
    5.
    发明申请
    Integral abradable seals 有权
    整体耐磨密封件

    公开(公告)号：US20100151183A1

    公开(公告)日：2010-06-17

    申请号：US12316991

    申请日：2008-12-17

    申请人： Janet Davis ,  David Marshall ,  Olivier Sudre

    发明人： Janet Davis ,  David Marshall ,  Olivier Sudre

    IPC分类号： D03D27/00 ,  B32B7/02

    CPC分类号： D03D25/005 ,  B32B3/30 ,  B32B5/024 ,  B32B5/26 ,  B32B9/005 ,  B32B2262/105 ,  B32B2262/106 ,  B32B2307/554 ,  B32B2581/00 ,  B32B2605/18 ,  Y10T428/23914 ,  Y10T428/23957 ,  Y10T428/23979 ,  Y10T428/23986 ,  Y10T428/24992 ,  Y10T428/24996 ,  Y10T428/249967

    摘要： Devices, systems and methods for fabricating improved ceramic composite turbine shrouds with abradable seals are disclosed. A high temperature seal with an abradable coating is provided. The seal comprises a three-dimensional, high-density woven composite base structure recessed below the abradable coating, with loops incorporated in and protruding from the base structure. The abradable coating is integrally attached to the base structure via the loops. Additionally, a graded density seal is provided with a three-dimensional, low-density woven composite structure. The low-density structure is abradable. A three-dimensional, high-density woven composite base structure is recessed below the low-density structure, with the low-density structure integrally attached to the base structure via weaving.

    摘要翻译： 公开了用于制造具有可磨损密封件的改进的陶瓷复合涡轮机护罩的装置，系统和方法。 提供了具有耐磨涂层的高温密封。 密封件包括在可磨损涂层下面凹陷的三维，高密度织造复合基底结构，其中结合到基部结构中并从基部结构突出。 可磨损涂层通过环一体地附接到基底结构。 此外，分级密度密封件设置有三维低密度编织复合结构。 低密度结构是可磨损的。 三维，高密度织造复合基底结构凹陷在低密度结构下方，低密度结构通过编织整体连接到基座结构。

    Multi-compartment delivery system
    9.
    发明申请
    Multi-compartment delivery system 审中-公开
    多隔间输送系统

    公开(公告)号：US20060153894A1

    公开(公告)日：2006-07-13

    申请号：US11170410

    申请日：2005-06-29

    申请人： Ragae Ghabrial ,  Ramie Fung ,  Alireza Rezania ,  Janet Davis

    发明人： Ragae Ghabrial ,  Ramie Fung ,  Alireza Rezania ,  Janet Davis

    IPC分类号： A61K38/18 ,  A61F2/00

    CPC分类号： A61L27/38 ,  A61K35/44 ,  A61K38/1866 ,  A61L27/40 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/43 ,  A61K2300/00

    摘要： This invention provides devices designed to effectively deliver multiple biological entities in combination for tissue engineering. In particular, the present invention provides devices capable of delivering cells or clusters of cells, such as islets of Langerhans, in combination with a therapeutic compound, such as an angiogenic growth factor, for the purpose of transplantation. The devices of the present invention are composed of at least two compartments that are designed independently and processed separately in order to accommodate different requirements of the biological entities. The compartments of the present device can be combined prior to or at the time of implantation, such that the therapeutic released from one compartment provides some benefit to cells hosted by another compartment to promote or improve their proliferation, differentiation, survival, or functionality.

    摘要翻译： 本发明提供设计成有效地将多个生物实体组合用于组织工程的装置。 特别地，本发明提供了能够将诸如胰岛的细胞或簇的细胞与诸如血管生成生长因子等治疗性化合物结合用于移植目的的装置。 本发明的装置由至少两个独立设计并分开处理的隔室组成，以适应不同生物实体的要求。 本装置的隔室可以在植入之前或在植入时组合，使得从一个隔室释放的治疗剂为由另一隔室托管的细胞提供一些益处以促进或改善其增殖，分化，存活或功能。