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    HCV peptide compositions
    8.
    发明申请
    HCV peptide compositions 审中-公开
    HCV肽组合物

    公开(公告)号：US20050202418A1

    公开(公告)日：2005-09-15

    申请号：US11023183

    申请日：2004-12-28

    申请人： Michael Houghton ,  Qui-Lim Choo ,  George Kuo

    发明人： Michael Houghton ,  Qui-Lim Choo ,  George Kuo

    IPC分类号： A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12Q1/68 ,  C12Q1/70 ,  C07K14/02 ,  C07K16/08

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C07K16/109 ,  C07K2317/21 ,  C07K2319/00 ,  C12N2770/24222 ,  C12Q1/6853 ,  C12Q1/6858 ,  C12Q1/701 ,  C12Q1/707 ,  G01N33/5767 ,  Y02A50/451

    摘要： A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBV), but which are absent from individuals infected with hepatitis A virus, or hepatitis B virus, and also are absent in control individuals. The HCV cDNA sequences lack substantial homology to the sequences of hepatitis delta virus (HDV) and HBV. A comparison of the sequences of amino acids encoded in the HCV cDNA with the sequences of Flaviviruses indicated that HCV may be related to the Flaviviruses. The HCV cDNA sequences and the polypeptides encoded therein are useful as reagents for the detection and therapy of HCV. The reagents provided in the invention are also useful for the isolation of NANBV agent(s), for the propagation of these agents in tissue culture, and for the screening of antiviral agents for HCV.

    摘要翻译： 提供了源自丙型肝炎病毒（HCV）的cDNA序列家族。 这些序列编码与存在于非A非乙型肝炎（NANBV）的个体中存在的抗体免疫反应的抗原，但是在感染甲型肝炎病毒或乙型肝炎病毒的个体中不存在，并且在对照个体中也不存在。 HCV cDNA序列与乙型肝炎病毒（HDV）和HBV的序列缺乏实质同源性。 HCV cDNA编码的氨基酸序列与黄病毒序列的比较表明，HCV可能与黄病毒有关。 HCV cDNA序列及其中编码的多肽可用作检测和治疗HCV的试剂。 本发明中提供的试剂也可用于分离NANBV试剂，用于在组织培养物中繁殖这些试剂，以及筛选用于HCV的抗病毒剂。

    Combinations of hepatitis c virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
    9.
    发明授权
    Combinations of hepatitis c virus (HCV) antigens for use in immunoassays for anti-HCV antibodies 失效
    用于免疫测定抗HCV抗体的丙型肝炎病毒（HCV）抗原的组合

    公开(公告)号：US06312889B1

    公开(公告)日：2001-11-06

    申请号：US08440549

    申请日：1995-05-12

    申请人： Michael Houghton ,  Qui-Lim Choo ,  George Kuo

    发明人： Michael Houghton ,  Qui-Lim Choo ,  George Kuo

    IPC分类号： C12Q170

    CPC分类号： C07K14/005 ,  C12N2770/24222 ,  G01N33/5767 ,  Y10S436/82

    摘要： Combinations of HCV antigens that have a broader range of immunological reactivity than any single HCV antigen. The combinations consist of an antigen from the C domain of the HCV polyprotein, and at least one additional HCV antigen from either the NS3 domain, the NS4 domain, the S domain, or the NS5 domain, and are in the form of a fusion protein, a simple physical mixture, or the individual antigens commonly bound to a solid matrix.

    摘要翻译： 具有比任何单一HCV抗原具有更广泛的免疫反应性的HCV抗原的组合。 该组合由HCV多蛋白C区的抗原和至少一种来自NS3结构域，NS4结构域，S结构域或NS5结构域的另外的HCV抗原组成，并且是融合蛋白的形式 ，简单的物理混合物，或通常与固体基质结合的单个抗原。

    Method of detecting antibodies to HCV
    10.
    发明申请
    Method of detecting antibodies to HCV 审中-公开

    公开(公告)号：US20060292556A1

    公开(公告)日：2006-12-28

    申请号：US11269906

    申请日：2005-11-09

    申请人： Michael Houghton ,  Qui-Lim Choo ,  George Kuo

    发明人： Michael Houghton ,  Qui-Lim Choo ,  George Kuo

    IPC分类号： C12Q1/70

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C07K16/109 ,  C07K2317/21 ,  C07K2319/00 ,  C12N2770/24222 ,  C12Q1/6853 ,  C12Q1/6858 ,  C12Q1/701 ,  C12Q1/707 ,  G01N33/5767 ,  Y02A50/451

    摘要： A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBV), but which are absent from individuals infected with hepatitis A virus, or hepatitis B virus, and also are absent in control individuals. The HCV cDNA sequences lack substantial homology to the sequences of hepatitis delta virus (HDV) and HBV. A comparison of the sequences of amino acids encoded in the HCV cDNA with the sequences of Flaviviruses indicated that HCV may be related to the Flaviviruses. The HCV cDNA sequences and the polypeptides encoded therein are useful as reagents for the detection and therapy of HCV. The reagents provided in the invention are also useful for the isolation of NANBV agent(s), for the propagation of these agents in tissue culture, and for the screening of antiviral agents for HCV.