利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

136 条记录 (耗时 0.028 秒)

    Non-linear optical tomography of turbid media
    2.
    发明授权
    Non-linear optical tomography of turbid media 失效
    浑浊介质的非线性光学层析成像

    公开(公告)号：US06208886B1

    公开(公告)日：2001-03-27

    申请号：US09054743

    申请日：1998-04-03

    申请人： Robert R. Alfano ,  Yici Guo ,  Feng Liu ,  Ping Pei Ho

    发明人： Robert R. Alfano ,  Yici Guo ,  Feng Liu ,  Ping Pei Ho

    IPC分类号： A61B500

    CPC分类号： A61B5/0073 ,  A61B5/4519

    摘要： An apparatus utilizing non-linear optical signals for use in constructing a three-dimensional tomographic map of an in vivo biological tissue for medical disease detection purposes. In one embodiment, said apparatus comprises a stage for supporting the in vivo biological tissue; a laser for illuminating the in vivo biological tissue with a focused beam of laser light, the light emerging from the in vivo biological tissue comprising fundamental light, harmonic wave light, and fluorescence due to multi-photon excitation; a filter for selectively passing only at least one of the harmonic wave light and the fluorescence; one or more detectors for individually detecting each of the harmonic wave light and the fluorescence selectively passed; and a mechanism for moving the laser relative to the stage in x, y and z directions.

    摘要翻译： 一种利用非线性光信号用于构建用于医学疾病检测目的的体内生物组织的三维断层图的装置。 在一个实施方案中，所述装置包括用于支撑体内生物组织的载物台; 用聚焦光束照射体内生物组织的激光，从体内生物组织出射的光包括基本光，谐波光和由于多光子激发引起的荧光; 用于选择性地仅通过谐波光和荧光中的至少一个的滤光器; 一个或多个检测器，用于单独检测每个谐波光和选择性地通过的荧光; 以及用于在x，y和z方向上相对于舞台移动激光的机构。

    Time-resolved diffusion tomographic 2D and 3D imaging in highly scattering turbid media
    3.
    发明授权
    Time-resolved diffusion tomographic 2D and 3D imaging in highly scattering turbid media 失效
    在高散射混浊介质中的时间分辨扩散断层扫描2D和3D成像

    公开(公告)号：US5931789A

    公开(公告)日：1999-08-03

    申请号：US797028

    申请日：1997-02-07

    申请人： Robert R. Alfano ,  Wei Cai ,  Feng Liu ,  Melvin Lax ,  Bidyut B. Das

    发明人： Robert R. Alfano ,  Wei Cai ,  Feng Liu ,  Melvin Lax ,  Bidyut B. Das

    IPC分类号： A61B5/00 ,  G01N21/47

    CPC分类号： A61B5/7257 ,  A61B5/0073 ,  G01N21/4795 ,  A61B5/0091

    摘要： A method for imaging objects in highly scattering turbid media. According to one embodiment of the invention, the method involves using a plurality of intersecting source/detectors sets and time-resolving equipment to generate a plurality of time-resolved intensity curves for the diffusive component of light emergent from the medium. For each of the curves, the intensities at a plurality of times are then inputted into the following inverse reconstruction algorithm to form an image of the medium: ##EQU1## wherein W is a matrix relating output at source and detector positions r.sub.s and r.sub.d, at time t, to position r, .LAMBDA. is a regularization matrix, chosen for convenience to be diagonal, but selected in a way related to the ratio of the noise, to fluctuations in the absorption (or diffusion) X.sub.j that we are trying to determine:.LAMBDA..sub.ij =.lambda..sub.j .delta..sub.ij with .lambda..sub.j = / Y is the data collected at the detectors, and X.sup.k is the kth iterate toward the desired absoption information. An algorithm, which combines a two dimensional (2D) matrix inversion with a one-dimensional (1D) Fourier transform inversion is used to obtain images of three dimensional hidden objects in turbid scattering media.

    摘要翻译： 一种用于在高散射混浊介质中成像物体的方法。 根据本发明的一个实施例，该方法包括使用多个相交的源/检测器组和时间分辨设备来产生用于从介质出射的光的漫射分量的多个时间分辨强度曲线。 对于每个曲线，多个时间的强度然后被输入到以下逆重建算法中以形成介质的图像：其中W是在时间t处将源的输出和检测器位置rs和rd相关联的矩阵， 为了定位r，LAMBDA是一个正则化矩阵，为方便起见选择为对角线，但以与噪声的比值与我们试图确定的吸收（或扩散）Xj的波动相关的方式进行选择： LAMBDA ij = lambda j delta ij，其中λj = / Y是在检测器处收集的数据，Xk是朝向期望的吸收信息的第k次迭代。 将二维（2D）矩阵求逆与一维（1D）傅里叶变换反演相结合的算法用于获取浑浊散射介质中三维隐藏物体的图像。

    Microscope imaging inside highly scattering media
    4.
    发明授权
    Microscope imaging inside highly scattering media 失效
    高分散介质下的显微镜成像

    公开(公告)号：US06215587B1

    公开(公告)日：2001-04-10

    申请号：US08659615

    申请日：1996-06-06

    申请人： Robert R. Alfano ,  Gordon E. Anderson ,  Feng Liu

    发明人： Robert R. Alfano ,  Gordon E. Anderson ,  Feng Liu

    IPC分类号： G02B2100

    CPC分类号： G02B21/0072 ,  G02B21/00 ,  G02B21/0084 ,  G02B21/06

    摘要： A method and system for imaging a small object in or behind a highly scattering medium comprises a laser source for illuminating the object with an ultrashort collimated beam of light and a novel microscope for forming a magnified image of the object using light emergent from the highly scattering medium, the emergent light consisting of a scattered component and a non-scattered component. The novel microscope comprises an objective, an eyepiece and an aperture centered at the back focal plane of the objective. The aperture, which may be of a fixed or variable size and controlled electronically or by a computer serves to spatially filter the scattered light component of the light emergent from the highly scattering medium. The system may also comprise a streak camera or similar time resolving device positioned at the image plane of the microscope for temporally filtering the scattered light component of the light emergent from the highly scattering medium.

    摘要翻译： 用于对高散射介质中或其后面的小物体进行成像的方法和系统包括用于以超短准直光束照射物体的激光源和用于使用来自高散射的光的光形成物体的放大图像的新型显微镜 介质，由散射组分和非分散组分组成的出射光。 该新型显微镜包括物镜，目镜和以物镜的后焦平面为中心的光圈。 可以具有固定或可变尺寸并且由电子控制或通过计算机控制的孔用于空间地过滤来自高度散射介质的出射光的散射光分量。 系统还可以包括位于显微镜的图像平面上的条纹相机或类似的时间分辨装置，用于对来自高度散射介质的出射光的散射光分量进行时间过滤。

    Time-resolved diffusion tomographic imaging in highly scattering turbid media
    5.
    发明授权
    Time-resolved diffusion tomographic imaging in highly scattering turbid media 失效
    在高散射混浊介质中的时间分辨扩散断层成像

    公开(公告)号：US5813988A

    公开(公告)日：1998-09-29

    申请号：US618471

    申请日：1996-03-18

    申请人： Robert R. Alfano ,  Wei Cai ,  Feng Liu ,  Melvin Lax ,  Bidyut B. Das

    发明人： Robert R. Alfano ,  Wei Cai ,  Feng Liu ,  Melvin Lax ,  Bidyut B. Das

    IPC分类号： A61B5/00 ,  G01N21/47

    CPC分类号： A61B5/0073 ,  G01N21/4795 ,  A61B5/0091

    摘要： A method for imaging objects in highly scattering turbid media. According to one embodiment of the invention, the method involves using a plurality of intersecting source/detectors sets and time-resolving equipment to generate a plurality of time-resolved intensity curves for the diffusive component of light emergent from the medium. For each of the curves, the intensities at a plurality of times are then inputted into the following inverse reconstruction algorithm to form an image of the medium: X.sup.(k+1).spsp.T =�Y.sup.T W+X.sup.(k).spsp.T .LAMBDA.!�W.sup.T W+.LAMBDA.!.sup.-1 wherein W is a matrix relating output at detector position r.sub.d, at time t, to source at position r.sub.s, .LAMBDA. is a regularization matrix, chosen for convenience to be diagonal, but selected in a way related to the ratio of the noise, to fluctuations in the absorption (or diffusion) X.sub.j that we are trying to determine: .LAMBDA..sub.ij =.lambda..sub.j .delta..sub.ij with .lambda..sub.j = / Here Y is the data collected at the detectors, and X.sup.k is the kth iterate toward the desired absoption information.

    摘要翻译： 一种用于在高散射混浊介质中成像物体的方法。 根据本发明的一个实施例，该方法包括使用多个相交的源/检测器组和时间分辨设备来产生用于从介质出射的光的漫射分量的多个时间分辨强度曲线。 对于每个曲线，多个时间的强度然后被输入到以下逆重建算法中以形成介质的图像：X（k + 1）T = [YTW + X（k）T LAMBDA] [WTW + LAMBDA] -1其中W是将检测器位置rd，时间t处的输出与位置rs处的源相关的矩阵，LAMBDA是为了方便对角线选择的正则化矩阵，但是以与 噪声，nn>我们试图确定的吸收（或扩散）Xj的波动：LAMBDA ij = lambda j delta ij与lambda j = / 这里Y是在 检测器和Xk是朝向期望的吸收信息的第k次迭代。

    Ultrafast optical imaging of objects in or behind scattering media
    6.
    发明授权
    Ultrafast optical imaging of objects in or behind scattering media 失效
    散射介质中或其后的物体的超快光学成像

    公开(公告)号：US5710429A

    公开(公告)日：1998-01-20

    申请号：US419623

    申请日：1995-04-06

    申请人： Robert R. Alfano ,  Feng Liu ,  Quan-Zhen Wang ,  Ping P. Ho ,  Leming M. Wang ,  Xiangchun Liang

    发明人： Robert R. Alfano ,  Feng Liu ,  Quan-Zhen Wang ,  Ping P. Ho ,  Leming M. Wang ,  Xiangchun Liang

    IPC分类号： G01N21/49 ,  G01N21/59

    CPC分类号： G01N21/49

    摘要： A system for imaging an object in or behind a highly scattering medium includes a light source for illuminating the highly scattering medium with a beam of light. The light emerging form the highly scattering medium consists of a ballistic component, snake-like component and a diffuse component. A 4F Fourier imaging system including a Fourier spatial filter located at 2F is used to form a time gated image of the emerging light, the time gated image consisting primarily of the ballistic component and the snake-like component.

    摘要翻译： 用于对高散射介质中或其后面的物体进行成像的系统包括用光束照射高散射介质的光源。 由高弹性介质形成的光由弹道组件，蛇形部件和扩散部件组成。 使用包括位于2F的傅立叶空间滤波器的4F傅立叶成像系统来形成新出现的光的时间门控图像，时间门控图像主要由弹道分量和蛇形分量组成。

    Continuous diode laser stimulated Raman gain/loss vibrational microscope
    7.
    发明授权
    Continuous diode laser stimulated Raman gain/loss vibrational microscope 有权

    公开(公告)号：US10433731B2

    公开(公告)日：2019-10-08

    申请号：US15243207

    申请日：2016-08-22

    申请人： Robert R. Alfano

    发明人： Robert R. Alfano ,  Lingyan Shi ,  Yury Budansky

    IPC分类号： A61B5/00 ,  G01N21/65

    摘要： There is a need for a compact instrument and microscope that maps the vibration fingerprints of biomolecules and chemicals in a sample such as brain, breast, cervix, and arteries. One can use spontaneous Raman scattering to accomplish this; however, the problem is low scattering efficiency to 10−5. With the availability of continuous wave diode laser at numerous wavelengths from 375 nm-1800 nm for parametric nonlinear difference vibrational mixing to enhance Stimulated Raman process within materials. A seed beam at Raman frequency is used with pump laser beam. In this way one can map in 2D and 3D images of the vibrations associate with disease changes. Scanning a pair of laser beams can map the location of vibrations within cells, smears, membranes, arteries, and tissues of animal and human.

    Spatial frequency spectrometer for and method of detection of spatial structures in materials
    8.
    发明授权
    Spatial frequency spectrometer for and method of detection of spatial structures in materials 有权

    公开(公告)号：US09804088B2

    公开(公告)日：2017-10-31

    申请号：US14580892

    申请日：2014-12-23

    申请人： Robert R. Alfano ,  Yang Pu

    发明人： Robert R. Alfano ,  Yang Pu

    IPC分类号： G01B9/02 ,  G01N21/47

    CPC分类号： G01N21/4788

    摘要： Spatial frequency spectra from periodic, aperiodic and quasi-random structures in materials are shown and used to detect differences among objects via internal coding from the spatial frequencies. The method is applied to different grades of human tissues for a new form of histology and pathology, and to detect art forgeries and coding boxes, money and papers and gems. The randomness of material structures on surface and at depths near surface can be detected from the spatial spectrum. In tissue spectral features from normal to different stages of cancer in tissue for ex vivo and in vivo applications can be recognized by different spectral fingerprints content of the spatial frequency. Similarly, the painting for the strokes of artist is different. A new type of instrument is described to analyze materials as a Spatial Frequency Spectrometer.

    Compact electromagnetic-radiation antenna
    9.
    发明授权
    Compact electromagnetic-radiation antenna 有权

    公开(公告)号：US09620858B2

    公开(公告)日：2017-04-11

    申请号：US14218864

    申请日：2014-03-18

    申请人： Robert R. Alfano

    发明人： Robert R. Alfano ,  M. Yu Sharonov

    IPC分类号： H01Q7/06 ,  H01Q7/08 ,  H01Q1/36

    CPC分类号： H01Q7/08 ,  H01Q1/36 ,  H01Q7/06 ,  Y10T29/49016

    摘要： A compact random media size antenna employing random magnetic and dielectrics nm to mm range size particles in polymer hosts is used to transfer E & M oscillations in 1 kHz to 900 Mhz range using a 1 cm to 1 meter length antenna. This is achieved by using small size particles and a random mean path length of E & M wavefront travel in and about a core tube of effective length matching Leff=L2/2ltr, equivalent to λ/2 for transmitting and receiving E & M radiation, where L is the physical size of the antenna, ltris the transport scattering random walk length between particles and λ is the frequency wavelength.