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    Biological fluid constituent sampling and measurement devices and methods
    2.
    发明授权
    Biological fluid constituent sampling and measurement devices and methods 有权
    生物流体成分采样和测量装置及方法

    公开(公告)号：US06875613B2

    公开(公告)日：2005-04-05

    申请号：US09879188

    申请日：2001-06-12

    申请人： Robert Shartle ,  Koon-wah Leong ,  Ernest J. Kiser

    发明人： Robert Shartle ,  Koon-wah Leong ,  Ernest J. Kiser

    IPC分类号： G01N33/48 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/15 ,  A61B5/151 ,  A61B17/062 ,  G01N27/28 ,  G01N27/327 ,  G01N33/487

    CPC分类号： A61B5/1486 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150984 ,  A61B5/15142 ,  A61B5/15186 ,  A61B5/157 ,  A61B2562/0295 ,  Y10T436/144444

    摘要： A device for accessing biological fluid, sampling biological fluid constituents and determining the concentration of at least one target constituent within the accessed biological fluid is provided. The device has at least one micro-piercing member used to penetrate the skin to a selected depth and to access biological fluid, a constituent sampling means and a constituent measuring means. The constituent sampling means comprises a constituent transfer medium, such as a hydrophilic gel material, by which sampled constituents are transferred from the micro-piercing member to the measuring means. The measuring means includes an electrochemical cell having at least one porous electrode through which at least one sampled constituent is caused to enter into the electrochemical cell. Methods of sampling constituents within the skin and measuring the sampled constituents, as well as kits for practicing the invention are provided.

    摘要翻译： 提供了用于访问生物流体的装置，取样生物流体成分并确定所访问的生物流体中至少一种目标成分的浓度。 该装置具有至少一个微穿刺构件，用于将皮肤穿透到选定的深度并且访问生物流体，构成采样装置和构成测量装置。 组分采样装置包括诸如亲水性凝胶材料的组成转印介质，通过该组分转移介质将取样的组分从微穿孔构件转移到测量装置。 测量装置包括具有至少一个多孔电极的电化学电池，使至少一个采样成分进入电化学电池。 提供了对皮肤内的成分进行取样并测量取样成分的方法，以及用于实施本发明的试剂盒。

    Analyte Measurement and Management Device and Associated Methods
    4.
    发明申请
    Analyte Measurement and Management Device and Associated Methods 审中-公开
    分析物测量和管理装置及相关方法

    公开(公告)号：US20100256047A1

    公开(公告)日：2010-10-07

    申请号：US12417875

    申请日：2009-04-03

    申请人： Zara Sieh ,  David Horwitz ,  David Price ,  Peter Krulevitch ,  Donna Savage ,  Robert Shartle

    发明人： Zara Sieh ,  David Horwitz ,  David Price ,  Peter Krulevitch ,  Donna Savage ,  Robert Shartle

    IPC分类号： A61K38/28 ,  A61P3/10 ,  G06F19/00

    CPC分类号： G06F19/3456

    摘要： A method for measuring and managing an analyte (e.g., blood glucose) in a bodily fluid includes storing a therapeutic administration protocol in a memory module of an analyte measurement and management device and measuring the analyte in the bodily fluid sample using an analyte measurement module of the device. The method also includes calculating, with a processor module of the device, a recommended therapeutic agent dosage (for example, an insulin dosage) and a recommended administration time for user-activated delivery of the dosage by employing the therapeutic administration protocol. The method further includes displaying the recommended therapeutic agent dosage and administration time to a user on a visual display of the device, delivering a therapeutic agent dosage to the user via a user-activated therapeutic agent delivery device, and detecting the user-activated administration of the therapeutic agent using a delivery device communication module of the device. In addition, the method includes communicating the aforementioned detection to the processor module and/or memory module using the delivery device communication module. The method employs analyte measurement, memory, processor, and delivery device modules, as well as a visual display, and user interface that are integrated as a single hand-held unit.

    摘要翻译： 用于测量和管理体液中的分析物（例如，血糖）的方法包括将分析物测量和管理装置的存储器模块中的治疗性给药方案存储在体液样品中，并使用分析物测量模块 装置。 该方法还包括利用该设备的处理器模块，通过使用治疗性给药方案来计算推荐的治疗剂剂量（例如，胰岛素剂量）和用户激活的剂量递送的推荐给药时间。 该方法还包括在设备的视觉显示上向用户显示推荐的治疗剂剂量和给药时间，经由用户激活的治疗剂递送装置向用户递送治疗剂剂量，以及检测用户激活的给药时间 所述治疗剂使用所述装置的递送装置通信模块。 此外，该方法包括使用传送设备通信模块将上述检测传送到处理器模块和/或存储器模块。 该方法采用分析物测量，存储器，处理器和传送设备模块，以及作为单个手持单元集成的可视显示器和用户界面。

    ANALYTE MEASUREMENT AND MANAGEMENT DEVICE AND ASSOCIATED METHODS
    5.
    发明申请
    ANALYTE MEASUREMENT AND MANAGEMENT DEVICE AND ASSOCIATED METHODS 审中-公开
    分析测量和管理设备及相关方法

    公开(公告)号：US20100016700A1

    公开(公告)日：2010-01-21

    申请号：US12505007

    申请日：2009-07-17

    申请人： Zara Sieh ,  David Horwitz ,  David Price ,  Peter Krulevitch ,  Donna Savage ,  Robert Shartle

    发明人： Zara Sieh ,  David Horwitz ,  David Price ,  Peter Krulevitch ,  Donna Savage ,  Robert Shartle

    IPC分类号： A61B5/00 ,  G06F3/048 ,  H04L9/32 ,  G08B1/08 ,  G06F15/16 ,  G06N5/02

    CPC分类号： A61B5/4839 ,  A61B5/14532 ,  G06F19/3418 ,  G06F19/3468 ,  G16H40/63

    摘要： Various embodiments of a diabetes management system are provided. One exemplary system may include an analyte measurement device and a therapeutic agent delivery device. The measurement device includes a measurement unit, display, and first wireless module. The therapeutic agent delivery device has a delivery device housing, delivery mechanism disposed in the housing that delivers a dosage of the agent to the user upon actuation by the user or health care provider, and a second wireless module. The second module, automatically, without prompting from a user or any active input or action by the user, transmits a signal to the first wireless module indicative of: (a) type of therapeutic agent delivered; and (b) amount of therapeutic agent delivered to the user; or (c) type of therapeutic agent device from which the therapeutic agent was administered. Also described are diabetes management devices and methods.

    摘要翻译： 提供了糖尿病管理系统的各种实施例。 一个示例性系统可以包括分析物测量装置和治疗剂递送装置。 测量装置包括测量单元，显示器和第一无线模块。 治疗剂递送装置具有输送装置壳体，设置在壳体中的输送机构，其在用户或医疗保健提供者致动时将剂量的剂量递送给使用者，以及第二无线模块。 自动地，第二模块在不提示用户或用户的任何有效输入或动作的情况下，向第一无线模块发送指示：（a）递送的治疗剂的类型; 和（b）递送给使用者的治疗剂量; 或（c）施用治疗剂的治疗剂装置的类型。 还描述了糖尿病管理装置和方法。

    Biological fluid constituent sampling and measurement devices
    6.
    发明授权
    Biological fluid constituent sampling and measurement devices 有权
    生物流体成分采样和测量装置

    公开(公告)号：US07361307B2

    公开(公告)日：2008-04-22

    申请号：US10886789

    申请日：2004-07-07

    申请人： Robert Shartle ,  Koon-wah Leong ,  Ernest J. Kiser

    发明人： Robert Shartle ,  Koon-wah Leong ,  Ernest J. Kiser

    IPC分类号： G01N33/48

    CPC分类号： A61B5/1486 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150984 ,  A61B5/15142 ,  A61B5/15186 ,  A61B5/157 ,  A61B2562/0295 ,  Y10T436/144444

    摘要： A device for accessing biological fluid, sampling biological fluid constituents and determining the concentration of at least one target constituent within the accessed biological fluid is provided. The device has at least one micro-piercing member used to penetrate the skin to a selected depth and to access biological fluid, a constituent sampling means and a constituent measuring means. The constituent sampling means comprises a constituent transfer medium, such as a hydrophilic gel material, by which sampled constituents are transferred from the micro-piercing member to the measuring means. The measuring means includes an electrochemical cell having at least one porous electrode through which at least one sampled constituent is caused to enter into the electrochemical cell. Methods of sampling constituents within the skin and measuring the sampled constituents, as well as kits for practicing the invention are provided.

    摘要翻译： 提供了用于访问生物流体的装置，取样生物流体成分并确定所访问的生物流体中至少一种目标成分的浓度。 该装置具有至少一个微穿刺构件，用于将皮肤穿透到选定的深度并且访问生物流体，构成采样装置和构成测量装置。 组分采样装置包括诸如亲水性凝胶材料的组成转印介质，通过该组分转移介质将取样的组分从微穿孔构件转移到测量装置。 测量装置包括具有至少一个多孔电极的电化学电池，使至少一个采样成分进入电化学电池。 提供了对皮肤内的成分进行取样并测量取样成分的方法，以及用于实施本发明的试剂盒。

    Capillary stop-flow junction having improved stability against accidental fluid flow
    8.
    发明授权
    Capillary stop-flow junction having improved stability against accidental fluid flow 失效
    毛细管停止流动接头具有提高的防止意外流体流动的稳定性

    公开(公告)号：US5230866A

    公开(公告)日：1993-07-27

    申请号：US663217

    申请日：1991-03-01

    申请人： Robert Shartle ,  Donald Besemer ,  Michael Gorin

    发明人： Robert Shartle ,  Donald Besemer ,  Michael Gorin

    IPC分类号： G01N35/08 ,  B01L3/00 ,  G01N1/38 ,  G01N33/04 ,  G01N37/00

    CPC分类号： B01L3/502723 ,  G01N1/38 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0457 ,  B01L2400/0683 ,  B01L2400/0688 ,  B01L2400/0694 ,  B01L3/502738 ,  G01N33/04 ,  Y10T436/111666 ,  Y10T436/25625 ,  Y10T436/2575

    摘要： A capillary stop-flow junction located in a housing at an end of a capillary passageway used to transport a liquid and at the beginning of a non-capillary internal chamber in the housing, in which the stop-flow junction contains an improvement which comprises 1) means for selectively trapping a gas in the capillary passageway and non-capillary chamber, wherein when the means for trapping is activated and the liquid enters the capillary passageway, the gas is compressed by the liquid as the liquid flows through the capillary channel and stops flowing at the stop-flow junction; or 2) a stop-flow nozzle surrounding the capillary passageway and projecting into the chamber; or 3) the stop-flow junction being formed from a single housing body member; or 4) a rupture junction in the capillary pathway, wherein the rupture junction is a stop-flow junction providing less maximum available back pressure than the capillary stop-flow junction. Diluters capable of serial dilution that use the stop-flow junctions of the invention are also described.

    摘要翻译： 位于毛细管通道的端部处的壳体中的毛细管停止流动接头，用于输送液体并且在壳体中的非毛细管内部室的开始处，其中止动接合处包含改进，其包括1 用于选择性地捕集毛细管通道和非毛细管腔中的气体的装置，其中当用于捕集的装置被激活并且液体进入毛细通道时，当液体流过毛细通道并停止时，气体被液体压缩 在止流口处流动; 或2）围绕毛细管通道并突出到腔室中的止流喷嘴; 或3）由一个壳体主体部件形成的止动接合部; 或4）毛细管路径中的断裂连接处，其中所述断裂连接处是提供比所述毛细管停止流动结点更少的最大可用背压的止动结。 还描述了能够连续稀释使用本发明的止流结的稀释剂。

    Open-ended conical tube for recovering cells from a microfludic chip
    9.
    发明授权
    Open-ended conical tube for recovering cells from a microfludic chip 有权

    公开(公告)号：US10130951B2

    公开(公告)日：2018-11-20

    申请号：US14428252

    申请日：2013-09-11

    申请人： Robert Shartle ,  Behrad Vahidi ,  William M. Strauss

    发明人： Robert Shartle ,  Behrad Vahidi ,  William M. Strauss

    IPC分类号： B01L3/00 ,  B01D21/26

    摘要： Provided are devices for recovery of cells from a microfluidic device. In particular, provided are open-ended conical tubes for recovery of cells from a microfluidic device and methods of use. In some embodiments, the open-ended conical tubes comprise: i) a nipple portion (7), wherein the nipple portion (7) comprises a length in the range of 0.2 to 0.3 inches, a diameter in the range of 0.2 to 0.3 inches, wherein the nipple portion (7) comprises a narrow orifice; ii) a conical portion (5) attached to and in fluid communication with the nipple portion, wherein the conical portion (5) has a length in the range of 1.0 to 1.5 inches and the angle of the outer surface of the conical portion (5) of the tube in relation to the outer surface of a cylindrical portion (1) of the tube is between 30° to 45° , wherein an outer circumferential surface of the conical portion (5) is attached to a flange (6) comprising a cylindrical cavity (12), wherein the cylindrical cavity (12) is formed into the surface of the flange (6), and the flange (6) is attached to the outer circumferential surface of the conical portion (5) of the tube such that the opening of the cylindrical cavity (12) extends perpendicularly with respect to the longitudinal axis of the tube, wherein a cap of a PCR tube fits into the cylindrical cavity (12) in the flange (6); iii) the cylindrical portion (1) attached to and in fluid communication with the conical portion (5) and having an axis substantially co-linear with an axis of the conical portion (5), wherein the cylindrical portion (1) comprises a wide orifice and threads (8) on the outer surface abutting the wide orifice to accommodate a cap for the conical tube, wherein the cylindrical portion (1) comprises a length in the range of 2.2 to 2.8 inches, an outer diameter in the range of 1.10 to 1.19 inches along its entire length and an inner diameter configured to accommodate one or more microfluidic chips or slides.