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公开(公告)号：US20100256047A1
公开(公告)日：2010-10-07
申请号：US12417875
申请日：2009-04-03
申请人： Zara Sieh , David Horwitz , David Price , Peter Krulevitch , Donna Savage , Robert Shartle
发明人： Zara Sieh , David Horwitz , David Price , Peter Krulevitch , Donna Savage , Robert Shartle
CPC分类号： G06F19/3456
摘要： A method for measuring and managing an analyte (e.g., blood glucose) in a bodily fluid includes storing a therapeutic administration protocol in a memory module of an analyte measurement and management device and measuring the analyte in the bodily fluid sample using an analyte measurement module of the device. The method also includes calculating, with a processor module of the device, a recommended therapeutic agent dosage (for example, an insulin dosage) and a recommended administration time for user-activated delivery of the dosage by employing the therapeutic administration protocol. The method further includes displaying the recommended therapeutic agent dosage and administration time to a user on a visual display of the device, delivering a therapeutic agent dosage to the user via a user-activated therapeutic agent delivery device, and detecting the user-activated administration of the therapeutic agent using a delivery device communication module of the device. In addition, the method includes communicating the aforementioned detection to the processor module and/or memory module using the delivery device communication module. The method employs analyte measurement, memory, processor, and delivery device modules, as well as a visual display, and user interface that are integrated as a single hand-held unit.
摘要翻译： 用于测量和管理体液中的分析物（例如，血糖）的方法包括将分析物测量和管理装置的存储器模块中的治疗性给药方案存储在体液样品中，并使用分析物测量模块 装置。 该方法还包括利用该设备的处理器模块，通过使用治疗性给药方案来计算推荐的治疗剂剂量（例如，胰岛素剂量）和用户激活的剂量递送的推荐给药时间。 该方法还包括在设备的视觉显示上向用户显示推荐的治疗剂剂量和给药时间，经由用户激活的治疗剂递送装置向用户递送治疗剂剂量，以及检测用户激活的给药时间 所述治疗剂使用所述装置的递送装置通信模块。 此外，该方法包括使用传送设备通信模块将上述检测传送到处理器模块和/或存储器模块。 该方法采用分析物测量，存储器，处理器和传送设备模块，以及作为单个手持单元集成的可视显示器和用户界面。
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公开(公告)号：US20100016700A1
公开(公告)日：2010-01-21
申请号：US12505007
申请日：2009-07-17
申请人： Zara Sieh , David Horwitz , David Price , Peter Krulevitch , Donna Savage , Robert Shartle
发明人： Zara Sieh , David Horwitz , David Price , Peter Krulevitch , Donna Savage , Robert Shartle
CPC分类号： A61B5/4839 , A61B5/14532 , G06F19/3418 , G06F19/3468 , G16H40/63
摘要： Various embodiments of a diabetes management system are provided. One exemplary system may include an analyte measurement device and a therapeutic agent delivery device. The measurement device includes a measurement unit, display, and first wireless module. The therapeutic agent delivery device has a delivery device housing, delivery mechanism disposed in the housing that delivers a dosage of the agent to the user upon actuation by the user or health care provider, and a second wireless module. The second module, automatically, without prompting from a user or any active input or action by the user, transmits a signal to the first wireless module indicative of: (a) type of therapeutic agent delivered; and (b) amount of therapeutic agent delivered to the user; or (c) type of therapeutic agent device from which the therapeutic agent was administered. Also described are diabetes management devices and methods.
摘要翻译： 提供了糖尿病管理系统的各种实施例。 一个示例性系统可以包括分析物测量装置和治疗剂递送装置。 测量装置包括测量单元，显示器和第一无线模块。 治疗剂递送装置具有输送装置壳体，设置在壳体中的输送机构，其在用户或医疗保健提供者致动时将剂量的剂量递送给使用者，以及第二无线模块。 自动地，第二模块在不提示用户或用户的任何有效输入或动作的情况下，向第一无线模块发送指示：（a）递送的治疗剂的类型; 和（b）递送给使用者的治疗剂量; 或（c）施用治疗剂的治疗剂装置的类型。 还描述了糖尿病管理装置和方法。
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公开(公告)号：US07824333B2
公开(公告)日：2010-11-02
申请号：US11395024
申请日：2006-03-31
申请人： Erik Otto , David Horwitz , Kirk Harmon , Manoj Sharma
发明人： Erik Otto , David Horwitz , Kirk Harmon , Manoj Sharma
IPC分类号： A61B5/00
CPC分类号： G06F19/3456 , G06F19/00 , G16H15/00 , G16H50/20 , G16H50/50
摘要： The present invention relates to methods and systems for monitoring the effectiveness of diabetes treatment. Methods and systems in accordance with the present invention provide information relating to variability of glucose levels and hypoglycemia and hyperglycemia. Such information is based on time-stamped blood glucose data obtained from a meter or the like and actual measurements of HbA1c levels are not required.
摘要翻译： 本发明涉及用于监测糖尿病治疗有效性的方法和系统。 根据本发明的方法和系统提供与葡萄糖水平和低血糖和高血糖的变异性有关的信息。 这样的信息基于从米等获得的时间戳血糖数据，并且不需要HbA1c水平的实际测量。
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公开(公告)号：US20060283108A1
公开(公告)日：2006-12-21
申请号：US11436149
申请日：2006-05-17
申请人： David Horwitz
发明人： David Horwitz
IPC分类号： E04H6/42
CPC分类号： E04F11/1802 , E04F19/026
摘要： A handrail assembly is provided which may be attached to a wall or stairwell using conventional mounting hardware. The handrail consists of a substantially flat panel having a series of grooves on opposite sides of an upper edge and a lower edge of the panel. Within the respective oppositely spaced grooves, a thermoplastic extruded slit tube is inserted into the grooves providing a curved gripping portion of a handrail. The substantially flat panel has exterior surfaces of a thermoplastic polymer, thereby providing a handrail assembly having outer surfaces of a damage resistant, easily repair, long wearing polymer.
摘要翻译： 提供扶手组件，其可以使用传统的安装硬件连接到墙壁或楼梯间隔室。 扶手由在平板的上边缘和下边缘的相对侧上具有一系列凹槽的基本平坦的面板组成。 在各个相对间隔开的槽内，将热塑性挤出的狭缝管插入到提供扶手的弯曲夹持部分的槽中。 基本上平坦的面板具有热塑性聚合物的外表面，从而提供扶手组件，该扶手组件具有抗损坏，容易修复，长期使用的聚合物的外表面。
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公开(公告)号：US20060292164A1
公开(公告)日：2006-12-28
申请号：US11394761
申请日：2006-03-31
申请人： David Horwitz
发明人： David Horwitz
CPC分类号： A61K35/34 , A61K35/17 , A61K39/001 , A61K2039/5158
摘要： Methods of preventing rejection of transplanted tissue. Recipient alloactivated regulatory T cells generated ex vivo are introduced into the recipient before transplantation. Donor antigen is introduced into the recipient after transplantation to boost recipient regulatory T cells.
摘要翻译： 防止移植组织排斥的方法。 在移植前将产生的受体同激活的调节性T细胞引入受体。 在移植后将供者抗原引入受体，以增强受体调节性T细胞。
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公开(公告)号：US20060286067A1
公开(公告)日：2006-12-21
申请号：US11400950
申请日：2006-04-05
申请人： David Horwitz , John Gray
发明人： David Horwitz , John Gray
IPC分类号： A61K35/14 , A61K39/395 , C12N5/08
CPC分类号： C12N5/0636 , A61K35/17 , C12N2501/15 , C12N2501/23
摘要： The invention is generally related to methods of making regulatory T cells and treating autoimmune diseases, including both antibody-mediated and cell-mediated disorders.
摘要翻译： 本发明通常涉及制备调节性T细胞和治疗自身免疫疾病的方法，包括抗体介导的和细胞介导的疾病。
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公开(公告)号：US20060067912A1
公开(公告)日：2006-03-30
申请号：US11241467
申请日：2005-09-30
申请人： David Horwitz
发明人： David Horwitz
IPC分类号： A61K39/395 , A61K38/20 , A61K35/14
CPC分类号： C12N5/0636 , A61K35/17 , C12N2501/15 , C12N2501/23
摘要： The field of the invention is generally related to methods used for the induction of T cells with suppressive activity. More specifically, the methods are used to generate professional regulatory T cells and cytokine-producing T cells with enhanced suppressive activity.
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公开(公告)号：US20100324401A1
公开(公告)日：2010-12-23
申请号：US12854069
申请日：2010-08-10
申请人： Erik OTTO , David Horwitz , Kirk Harmon , Manoj Sharma
发明人： Erik OTTO , David Horwitz , Kirk Harmon , Manoj Sharma
IPC分类号： A61B5/145
摘要： The present invention relates to methods and systems for monitoring the effectiveness of diabetes treatment. Methods and systems in accordance with the present invention provide information relating to variability of glucose levels and hypoglycemia and hyperglycemia. Such information is based on time-stamped blood glucose data obtained from a meter or the like and actual measurements of HbA1c levels are not required.
摘要翻译： 本发明涉及用于监测糖尿病治疗有效性的方法和系统。 根据本发明的方法和系统提供与葡萄糖水平和低血糖和高血糖的变异性有关的信息。 这样的信息基于从米等获得的时间戳血糖数据，并且不需要HbA1c水平的实际测量。
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公开(公告)号：US20070077232A1
公开(公告)日：2007-04-05
申请号：US11538380
申请日：2006-10-03
申请人： Gail Naughton , David Horwitz , Mark Applegate , Joan Zeltinger , Jonathan Mansbridge , Andreas Kern , Lee Landeen , Anthony Ratcliffe , R. Pinney
发明人： Gail Naughton , David Horwitz , Mark Applegate , Joan Zeltinger , Jonathan Mansbridge , Andreas Kern , Lee Landeen , Anthony Ratcliffe , R. Pinney
CPC分类号： A23L33/10 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/35 , A61K35/36 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/39 , A61K45/06 , A61K2800/86 , A61K2800/91 , A61L31/044 , A61L31/047 , A61L31/16 , A61L2300/414 , A61L2430/36 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12N5/0603 , C12N5/0606 , C12N5/0625 , C12N5/0629 , C12N5/0656 , C12N5/069 , C12N2502/1323 , C12P21/00 , A61K2300/00
摘要： Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, formulated with a salve or ointment for topical applications, or, for example, made into or added to surgical glue to accelerate healing of sutures following invasive procedures. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
摘要翻译： 描述了包含调节细胞培养基组合物和使用方法的新产品。 本发明的条件细胞培养基组合物可以由任何已知的定义或未定义的培养基组成，并且可以使用任何真核细胞类型进行调节。 介质可以由基质细胞，实质细胞，间充质干细胞，肝储备细胞，神经干细胞，胰干细胞和/或胚胎干细胞调节。 另外，细胞可以被遗传修饰。 优选三维组织构建体。 一旦本发明的细胞培养基被调节，它可以在任何状态下使用。 条件培养基的物理实施方案包括但不限于液体或固体，冷冻，冻干或干燥成粉末。 另外，介质配制有药学上可接受的载体作为内部给药载体，直接施用于用药膏或软膏配制用于局部应用的食品或产品，或者例如制成或添加到手术胶中 通过侵入性手术加快缝合线愈合。 此外，可以进一步处理介质以浓缩或减少介质中包含的一种或多种因素或组分。
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公开(公告)号：US20060286079A1
公开(公告)日：2006-12-21
申请号：US11507908
申请日：2006-08-21
申请人： David Horwitz
发明人： David Horwitz
IPC分类号： A61K35/14 , A61K39/395 , C12N5/08
CPC分类号： A61K35/17 , C12N5/0636 , C12N2501/15 , C12N2501/23 , C12N2501/599
摘要： The invention is generally related to methods of treating autoimmune diseases, including both antibody-mediated and cell-mediated disorders.
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