公开(公告)号：US4533500A

公开(公告)日：1985-08-06

申请号：US476295

申请日：1983-03-17

申请人： Yves Chauvin ,  Dominique Commereuc ,  Andre Hirschauer ,  Dominique Reffet ,  Robert Stern

发明人： Yves Chauvin ,  Dominique Commereuc ,  Andre Hirschauer ,  Dominique Reffet ,  Robert Stern

IPC分类号： C07C233/46 ,  C09F5/00 ,  C09F7/00 ,  C11C3/00

CPC分类号： C07C233/46

摘要： N-acyliminodiacetic acids are manufactured by reacting formaldehyde or a formaldehyde generator compound with a N-unsubstituted amide or a generator thereof and with carbon monoxide in contact with a carbonylation catalyst, for example, a cobalt compound, the ratio of the aldehyde groups to the amide groups being at least 2:1. The formaldehyde generator can be a polymeric form of formaldehyde and the amide generator can be a carboxylic ester, acid or anhydride.

摘要翻译： N-酰基亚氨基二乙酸是通过使甲醛或甲醛发生剂化合物与N-未取代的酰胺或其发生剂和与羰基化催化剂例如钴化合物接触的一氧化碳反应制备的，醛基与 酰胺基团为至少2:1。 甲醛发生器可以是甲醛的聚合形式，酰胺发生剂可以是羧酸酯，酸或酸酐。

公开(公告)号：US4264515A

公开(公告)日：1981-04-28

申请号：US103774

申请日：1979-12-14

申请人： Robert Stern ,  Andre Hirschauer ,  Dominique Commereuc ,  Yves Chauvin

发明人： Robert Stern ,  Andre Hirschauer ,  Dominique Commereuc ,  Yves Chauvin

IPC分类号： C07C233/45 ,  C07C102/00

CPC分类号： C07C233/45

摘要： A N-acyl .alpha.-amino acid is manufactured by reacting an unsaturated vegetable oil or a C.sub.8 -C.sub.30 mono-olefinic compound with an amide, carbon monoxide and hydrogen, in the presence of a cobalt catalyst. The process is operated in one step, providing for an increased selectivity as compared with a two-step process.

摘要翻译： 通过使不饱和植物油或C 8 -C 30单烯烃化合物与酰胺，一氧化碳和氢气在钴催化剂存在下反应制备N-酰基α-氨基酸。 该方法在一个步骤中操作，与两步法相比提供了增加的选择性。

公开(公告)号：US06452029B1

公开(公告)日：2002-09-17

申请号：US09362217

申请日：1999-07-28

申请人： Gérard Hillion ,  Hélène Olivier ,  Katja Siepen ,  Dominique Commereuc ,  Robert Stern

发明人： Gérard Hillion ,  Hélène Olivier ,  Katja Siepen ,  Dominique Commereuc ,  Robert Stern

IPC分类号： C09F706

CPC分类号： C10M105/34 ,  C07C67/303 ,  C07C67/347 ,  C07C69/24 ,  C07C69/587

摘要： A nickel catalytic system that makes it possible to obtain branched compounds from fatty substances by reacting simple olefins on polyunsaturated esters, which may or may not be conjugated, is described. The compounds that are obtained may be hydrogenated and used as lubricant bases or may be transformed according to known procedures into compounds of acid, alcohol, amine or amide type, used in varied applications.

摘要翻译： 描述了一种镍催化体系，其可以通过在多不饱和酯上反应简单的烯烃从脂肪物质获得支链化合物，其可以或可以不共轭。 获得的化合物可以被氢化并用作润滑剂基质，或者可以根据已知的方法转化成用于各种应用的酸，醇，胺或酰胺型的化合物。

公开(公告)号：US4038295A

公开(公告)日：1977-07-26

申请号：US545189

申请日：1975-01-29

申请人： Robert Stern ,  Eugene Ucciani ,  Andre Hirschauer ,  Georges Cecchi

发明人： Robert Stern ,  Eugene Ucciani ,  Andre Hirschauer ,  Georges Cecchi

IPC分类号： B01J31/00 ,  C11C3/12

CPC分类号： C11C3/12

摘要： Highly unsaturated oils of vegetable or animal origin are selectively hydenated to less highly unsaturated oils using a catalytic composition obtained by dissolving a compound of a metal selected from the IB, IV B to VII B or VIII groups in an unsaturated oil and then adding thereto an organic derivative or hydride of a metal from groups I A, II A, II B or III A, in the absence of a stabilizing solvent.

公开(公告)号：US5476956A

公开(公告)日：1995-12-19

申请号：US232984

申请日：1994-04-25

申请人： Gerard Hillion ,  Robert Stern ,  Abakar Kotoko ,  Yves Chauvin

发明人： Gerard Hillion ,  Robert Stern ,  Abakar Kotoko ,  Yves Chauvin

IPC分类号： B01J27/13 ,  B01J31/16 ,  C07B37/02 ,  C07B61/00 ,  C07C2/04 ,  C07C2/38 ,  C07C11/12 ,  C07C67/347 ,  C07C69/65 ,  C09F7/06

CPC分类号： C07C2/04 ,  C07B37/02 ,  C07C67/347 ,  C07C2531/22

摘要： Co dimerization is conducted of at least one monoolefin, for example a monoolefinic hydrocarbon such as ethylene, propylene or 1-butene, a halogenated monoolefin such as vinyl chloride, or an olefinic functional compound such as methyl acrylate, acrylonitrile, allyl acetate or vinyl acetate, with at least one polyolefin containing at least two conjugated or unconjugated ethylene bonds, for example a diene hydrocarbon such as 1,3-butadiene, piperylene, or isoprene or a polyolefin containing a carboxylic function, such as a fatty acid or a fatty acid ester having 14 to 24 carbon atoms in the fatty chain derived, for example, from a natural oil. The reaction is carried out in the presence of a catalytic system having general formula [RhX.sub.4 ][YR.sub.4 ] where X represents a halogen ion or a SO.sub.4.sup.--, SO.sub.3.sup.-, OH.sup.-, OR.sup.- or R.sup.- group, at least one X being a halogen ion, Y represents a nitrogen atom or a phosphorous atom, and R represents an alkyl, cycloalkyl, alkenyl, aryl, alkylaryl, polystyryl, alkyl polystyryl or acyl radical.

摘要翻译： Co二聚化由至少一种单烯烃，例如单烯烃如乙烯，丙烯或1-丁烯，卤代单烯烃如氯乙烯或烯属官能化合物如丙烯酸甲酯，丙烯腈，乙酸烯丙酯或乙酸乙烯酯 与至少一种含有至少两个共轭或非共轭的乙烯键的聚烯烃，例如二烯烃如1,3-丁二烯，戊间二烯或异戊二烯或含有羧酸官能团的聚烯烃如脂肪酸或脂肪酸 在脂肪链中具有14至24个碳原子的酯衍生自例如天然油。 该反应在具有通式[RhX4] [YR4]的催化体系存在下进行，其中X表示卤素离子或SO 4 - ，SO 3 - ，OH-，OR-或R-基团，至少一个X 作为卤素离子，Y表示氮原子或磷原子，R表示烷基，环烷基，烯基，芳基，烷基芳基，聚苯乙烯基，烷基聚苯乙烯基或酰基。

公开(公告)号：US5434282A

公开(公告)日：1995-07-18

申请号：US231706

申请日：1994-04-22

申请人： Robert Stern ,  Gerard Hillion ,  Abakar Kotoko ,  Yves Chauvin

发明人： Robert Stern ,  Gerard Hillion ,  Abakar Kotoko ,  Yves Chauvin

IPC分类号： B01J31/22 ,  B01J31/24 ,  C07B61/00 ,  C07C51/353 ,  C07C51/36 ,  C07C53/126 ,  C07C57/03 ,  C07C67/303 ,  C07C67/347 ,  C07C69/24 ,  C07C69/30 ,  C07C69/533 ,  C07C69/587 ,  C10M105/24 ,  C10M105/34 ,  C10M105/38 ,  C07C67/03

CPC分类号： C07C69/587 ,  C07C51/353 ,  C07C53/126 ,  C07C67/347

摘要： A novel family of chemical compounds derived from fatty compounds has two branches of two carbon atoms on the linear chain and general formula C.sub.21 H.sub.39 COOR where R represents a hydrogen atom, a lower alkyl radical or a glyceryl radical. Particular compounds for consideration have the following formulae:(C.sub.2 H.sub.5).sub.2 C.sub.17 H.sub.29 COOR (I)(C.sub.2 H.sub.5)(C.sub.2 H.sub.4)C.sub.17 H.sub.30 COOR (II)and(C.sub.2 H.sub.5)(C.sub.2 H.sub.3)C.sub.17 H.sub.31 COOR (III)also compounds with the following formulae derived from partial or total hydrogenation of the above:(C.sub.2 H.sub.5).sub.2 C.sub.17 H.sub.31 COOR (IV)(C.sub.2 h.sub.5)(C.sub.2 h.sub.4)C.sub.17 H.sub.32 COOR (V)andti (C.sub.2 H.sub.5).sub.2 C.sub.17 H.sub.33 COOR (VI)Compounds with formulae (I), (II) and (III) may be produced by addition of ethylene to compositions comprising mainly diunsaturated C.sub.18 fatty acids; or to lower alkyl or glyceryl esters of these acids, originating in particular from natural oils, in the presence of a catalytic system containing anionic rhodium of the type [RhX.sub.4 ].sup.- YR'.sub.4 where X is preferably a halide anion; Y is a nitrogen N.sup.+ or phosphorous P.sup.+ atom and R.sup.' is preferably a hydrocarbon group.Compositions in accordance with the invention can be used as base compositions for lubricants or emulsifying agents.

摘要翻译： 衍生自脂肪族化合物的化学化合物的新型家族在直链上具有两个碳原子的分支，通式为C 21 H 39 COOR，其中R表示氢原子，低级烷基或甘油基。 考虑的具体化合物具有下式：（C 2 H 5）2 C 17 H 29 COOR（I）（C 2 H 5）（C 2 H 4）C 17 H 30 COOR（II）和（C 2 H 5）（C 2 H 3）C 17 H 31 COOR 上述:( C2H5）2C17H31COOR（Ⅳ）（C2h5）（C2h4）C17H32COOR（Ⅴ）和（C2H5）2C17H33COOR（VI）式（Ⅰ），（Ⅱ）和（Ⅲ）化合物可以通过加入乙烯 主要包含二不饱和C18脂肪酸的组合物; 或者在含有[RhX4] -YR'4类型的阴离子铑的催化体系存在下，将这些酸的烷基或甘油酯特别地衍生自天然油，其中X优选为卤化物阴离子; Y是氮N +或磷P +原子，R'优选为烃基。 根据本发明的组合物可用作润滑剂或乳化剂的基础组合物。

公开(公告)号：US20140339840A1

公开(公告)日：2014-11-20

申请号：US13986619

申请日：2013-05-20

申请人： Robert Stern

发明人： Robert Stern

IPC分类号： A47J43/28

CPC分类号： A47J43/283

摘要： Tongs for manipulating shish-kebob on a barbeque grill, the tongs having two arms, the two arms being in parallel relationship at an insulated handle end which includes the pivot point at one end, the arms diverging at the opposing end of the handle end, to form two opposing spaced apart arms having kebob engaging ends, each end having an aperture there through, the apertures engaging the ends of the skewer, the tongs then being compressed so that the kebob engaging ends engage the outer food items on the skewer preventing their rotation so that the kebob may be either flipped for even cooking on the opposing side, or removed from the grill for consumption without endangering the fingers of the user.

摘要翻译： 用于在烧烤格栅上操作shish-kebob的钳子，钳子具有两个臂，两个臂在绝缘手柄端处平行关系，其包括在一端的枢转点，臂在手柄端的相对端处发散， 以形成两个相对的间隔开的臂，其具有接头端部，每个端部具有通孔的孔，所述孔接合扦子的端部，然后钳子被压缩，使得肠壁接合端接合串上的外部食物，从而防止它们 旋转，使得可以将小桶翻转以便在相对侧进行烹饪，或者从烤架中取出以消费，而不会危及用户的手指。

公开(公告)号：US20140002075A1

公开(公告)日：2014-01-02

申请号：US13988813

申请日：2011-11-28

申请人： Alexander Lin ,  Carolyn Mountford ,  Saadallah Ramadan ,  Robert Stern

发明人： Alexander Lin ,  Carolyn Mountford ,  Saadallah Ramadan ,  Robert Stern

IPC分类号： G01R33/483

CPC分类号： G01R33/483 ,  A61B5/055 ,  A61B5/4064 ,  A61B2503/00 ,  A61B2503/04 ,  A61B2503/10 ,  G01R33/485

摘要： A method for producing a biomarker indicative of a repetitive head injury in a subject using a magnetic resonance imaging (MRI) system is provided. Two-dimensional spectroscopic data is acquired from a subject using an MRI system. From the two-dimensional spectroscopic data, a two-dimensional spectrum is produced. The two-dimensional spectrum contains spectral information indicated by a first spectral dimension and a second spectral dimension. Such a two-dimensional spectrum may include diagonal peaks and off-diagonal, or cross-peaks. In such an instance, each cross peak may indicate, for example, scalar coupling between the two protons it connects on the diagonal. However, depending on the type of method used, different types of coupling may also be present. Using the two-dimensional spectrum, a biomarker indicative of repetitive head injury in the subject is identified, and may be used to produce a report indicating a status or regression of a neurological dysfunction.

摘要翻译： 提供了使用磁共振成像（MRI）系统来产生指示受试者的重复性头部损伤的生物标志物的方法。 使用MRI系统从受试者获取二维光谱数据。 从二维光谱数据生成二维光谱。 二维光谱包含由第一光谱维度和第二光谱维度指示的光谱信息。 这样的二维光谱可以包括对角峰和非对角线或交叉峰。 在这种情况下，每个交叉峰值可以表示例如它在对角线上连接的两个质子之间的标量耦合。 然而，根据所使用的方法的类型，也可以存在不同类型的耦合。 使用二维光谱，鉴定出指示受试者重复性头部损伤的生物标志物，并且可用于产生指示神经功能障碍的状态或消退的报告。

公开(公告)号：US07539656B2

公开(公告)日：2009-05-26

申请号：US09798964

申请日：2001-03-06

申请人： Raya Fratkina ,  Monica Anderson ,  Mark A. Angel ,  Max Copperman ,  Scott B. Huffman ,  David Kay ,  Robert Stern

发明人： Raya Fratkina ,  Monica Anderson ,  Mark A. Angel ,  Max Copperman ,  Scott B. Huffman ,  David Kay ,  Robert Stern

IPC分类号： G06F17/00 ,  G06F17/30 ,  G06N5/00

CPC分类号： G06F17/30654 ,  G06F17/30873 ,  G06N5/042 ,  Y10S707/99933 ,  Y10S707/99945

摘要： A method and system are disclosed for retrieving information through the use of a multi-stage interaction with a client to identify particular knowledge content associated with a knowledge map. The present invention is an application program running on a server accessed via the world-wide web or other data network using standard Internet protocols, a web browser and web server software. In addition to an automated portion, the present invention allows a human dialog designer to model the way the system elicits information, giving a human feel to the dialog and a better customer experience. In operation, users start a dialog by directing their web browser to a designated web page. This web page asks the user some initial questions that are then passed to a dialog engine. The dialog engine then applies its methods and algorithms to a knowledge map, using dialog control information\ and the user's responses to provide feedback to the user. The feedback may include follow-up questions, relevant documents, and instructions to the user (e.g., instructions to contact a human customer service representative). This dialog engine response is rendered as a web page and returned to the user's web browser. The user can then respond further to the follow-up questions he or she is presented, and the cycle repeats. The invention can be implemented so that it can interact with customers through a wide variety of communication channels including the Internet, wireless devices (e.g., telephone, pager, etc.), handheld devices such as a Personal Data Assistant (PDA), email, and via a telephone where the automated system is delivered using an interactive voice response (IVR) and/or speech-recognition system.

摘要翻译： 公开了一种用于通过使用与客户端的多阶段交互来检索信息以识别与知识图相关联的特定知识内容的方法和系统。 本发明是在通过世界范围的网络或其他数据网络使用标准互联网协议访问的服务器上运行的应用程序，网络浏览器和web服务器软件。 除了自动化部分之外，本发明允许人对话设计者对系统引出信息的方式进行建模，给出对人的感觉和更好的客户体验。 在操作中，用户通过将其浏览器指向指定的网页来开始对话。 该网页向用户询问一些初始问题，然后传递给对话框引擎。 然后，对话框引擎将其方法和算法应用于知识图，使用对话控制信息\和用户的响应来向用户提供反馈。 反馈可以包括对用户的后续问题，相关文档和指令（例如，联系人类客户服务代表的指令）。 此对话框引擎响应呈现为网页并返回到用户的Web浏览器。 用户可以进一步响应他或她所呈现的后续问题，循环重复。 可以实现本发明，使得其可以通过包括因特网，无线设备（例如，电话，寻呼机等），诸如个人数据助理（PDA），电子邮件等手持设备的各种通信信道与客户进行交互， 以及通过使用交互式语音响应（IVR）和/或语音识别系统传送自动系统的电话。

公开(公告)号：US07148201B2

公开(公告)日：2006-12-12

申请号：US09795914

申请日：2001-02-27

申请人： Robert Stern ,  Gregory I. Frost ,  Anthony Csóka ,  Tim M. Wong

发明人： Robert Stern ,  Gregory I. Frost ,  Anthony Csóka ,  Tim M. Wong

IPC分类号： A61K31/70 ,  A01N63/00 ,  C12N15/63 ,  A61K38/43 ,  G01N33/53

CPC分类号： C12Y302/01035 ,  A61K38/00 ,  C07K16/40 ,  C12N9/16 ,  C12N9/2474 ,  C12Y302/01036 ,  G01N33/573

摘要： The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is based on the discovery of a method for identifying antibodies that specifically bind native hpHAse (anti-native hpHAse antibodies), and anti-native hpHAse antibodies identified by this screening method. The invention also features an assay for sensitive detection of HAse activity using biotinylated hyaluronic acid (bHA). Purification and characterization of hpHAse lead to the inventors' additional discovery that hpHAse is encoded by the LuCa-1 gene, which gene is present in the human chromosome at 3p21.3, a region associated with tumor suppression. The invention additionally features methods of treating tumor-bearing patients by administration of hpHAse and/or transformation of cells with hpHAse-encoding DNA.