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公开(公告)号：US20050064526A1
公开(公告)日：2005-03-24
申请号：US10767687
申请日：2004-01-29
申请人： Robert Ulrich , Mark Olson , Sina Bavari
发明人： Robert Ulrich , Mark Olson , Sina Bavari
IPC分类号： C07K14/31 , C12N1/21 , G01N33/554 , C07H21/04 , C12N15/74 , G01N33/569
CPC分类号： C07K14/31
摘要： The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.
摘要翻译： 本发明涉及遗传减毒的超抗原毒素疫苗改变，使得超抗原属性不存在，然而有效识别超抗原并产生适当的免疫应答。 显示减毒的超抗原毒素保护动物免受野生型毒素的攻击。 描述了生产和使用改变的超抗原毒素的方法。
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公开(公告)号：US20130323243A1
公开(公告)日：2013-12-05
申请号：US13882041
申请日：2011-10-28
IPC分类号： A61K39/12
CPC分类号： G01N33/6854 , A61K39/12 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6056 , C07K14/005 , C07K2319/30 , C07K2319/43 , C12N2760/14122 , C12N2760/14134 , G01N33/56983 , G01N2333/08 , G01N2469/20 , G01N2800/26
摘要： This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections.
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公开(公告)号：US20130065943A1
公开(公告)日：2013-03-14
申请号：US13612521
申请日：2012-09-12
申请人： Antonin De Fougerolles , Pamela Tan , Anna Borodovsky , Tatiana Novobrantseva , Sina Bavari , Kelly Lyn Warfield
发明人： Antonin De Fougerolles , Pamela Tan , Anna Borodovsky , Tatiana Novobrantseva , Sina Bavari , Kelly Lyn Warfield
IPC分类号： C12N15/113 , A61P25/00 , A61P37/00 , C12N15/63 , A61P31/14 , A61P31/20 , C12N5/071 , A61K31/713 , A61P31/16
CPC分类号： C12N15/1137 , C12N15/1138 , C12N2310/113 , C12N2310/14 , C12N2310/17 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.
摘要翻译： 本发明涉及用于抑制CD45基因表达的双链核糖核酸（dsRNA）。
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公开(公告)号：US08288525B2
公开(公告)日：2012-10-16
申请号：US12867230
申请日：2009-02-12
申请人： Antonin de Fougerolles , Pamela Tan , Anna Borodovsky , Tatiana Novobrantseva , Sina Bavari , Kelly Lyn Warfield
发明人： Antonin de Fougerolles , Pamela Tan , Anna Borodovsky , Tatiana Novobrantseva , Sina Bavari , Kelly Lyn Warfield
IPC分类号： C12Q1/68
CPC分类号： C12N15/1137 , C12N15/1138 , C12N2310/113 , C12N2310/14 , C12N2310/17 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.
摘要翻译： 本发明涉及用于抑制CD45基因表达的双链核糖核酸（dsRNA）。
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公开(公告)号：US07781183B2
公开(公告)日：2010-08-24
申请号：US11017771
申请日：2004-12-22
申请人： Sina Bavari , Rekha G. Panchal , Ann Hermone , Tam Nguyen , Rick Gussio
发明人： Sina Bavari , Rekha G. Panchal , Ann Hermone , Tam Nguyen , Rick Gussio
IPC分类号： C12Q1/37 , C12N9/50 , C07D233/00 , G01N33/53
CPC分类号： C12Q1/18 , C12Q1/37 , C40B30/02 , G01N2333/32 , G06F19/705
摘要： Disclosed herein is a pharmacophore model for inhibiting anthrax lethal factor protease activity which comprises a first aromatic center A, a second aromatic center B, a first polar center C, a second polar center D, a third polar center E, and a neutral linker F. Also disclosed are small molecules fitting the pharmacophore model and compositions and methods of using thereof.
摘要翻译： 本文公开了用于抑制炭疽致死因子蛋白酶活性的药效团模型，其包含第一芳族中心A，第二芳族中心B，第一极中心C，第二极中心D，第三极中心E和中性接头F 还公开了拟合药效团模型及其使用方法的小分子。
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公开(公告)号：US20090068226A1
公开(公告)日：2009-03-12
申请号：US12151497
申请日：2008-05-07
申请人： Robert G. Ulrich , Mark A. Olson , Sina Bavari
发明人： Robert G. Ulrich , Mark A. Olson , Sina Bavari
IPC分类号： A61K39/085 , C12N15/31 , C12N15/74 , C12N1/00 , C12P21/02 , A61P31/04 , C07K14/195 , G01N33/569 , A61K39/09
CPC分类号： C07K14/31
摘要： The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.
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公开(公告)号：US20060281701A1
公开(公告)日：2006-12-14
申请号：US11433840
申请日：2006-05-11
申请人： David Stein , Patrick Iversen , Sina Bavari , Dwight Weller
发明人： David Stein , Patrick Iversen , Sina Bavari , Dwight Weller
IPC分类号： A61K48/00 , C07H21/02 , C07F9/6533
CPC分类号： C12N15/1131 , C12N2310/11 , C12N2310/31 , C12N2310/32 , C12N2310/3513
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Filoviridae family, and in the treatment of a viral infection. The compounds and methods relate to the treatment of viral infections in mammals including primates by Ebola and Marburg viruses. The antisense antiviral compounds are morpholino oligonucleotides having: a) a nuclease resistant backbone, b) 15-40 nucleotide bases, and c) a targeting sequence of at least 15 bases in length that hybridizes to a target region selected from the following: i) the AUG start site region of VP35, as exemplified by SEQ ID NOS:67-71 or ii) the AUG start site region of VP24, as exemplified by SEQ ID NOS:72-76.
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公开(公告)号：US07049085B2
公开(公告)日：2006-05-23
申请号：US10655450
申请日：2003-09-04
IPC分类号： G01N33/359
CPC分类号： C07K16/1282 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/5308 , G01N33/56911 , G01N2333/33
摘要： Antibodies for binding epitopes of BoNT/A and hybridomas which produce such antibodies are described. The antibodies of the present invention can be used in a method for detecting BoNT/A in a sample and/or in a method for purifying BoNT/A from an impure solution. In addition, the antibodies can be used for passive immunization against BoNT/A intoxication or as intoxication therapy. Another aspect of the invention is a kit for detecting BoNT/A in a sample.
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公开(公告)号：US08710185B2
公开(公告)日：2014-04-29
申请号：US13304835
申请日：2011-11-28
申请人： Robert G. Ulrích , Mark A. Olson , Sina Bavari
发明人： Robert G. Ulrích , Mark A. Olson , Sina Bavari
IPC分类号： C07K14/31
CPC分类号： C07K14/31
摘要： The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.
摘要翻译： 本发明涉及遗传减毒的超抗原毒素疫苗改变，使得超抗原属性不存在，然而有效识别超抗原并产生适当的免疫应答。 显示减毒的超抗原毒素保护动物免受野生型毒素的攻击。 描述了生产和使用改变的超抗原毒素的方法。
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公开(公告)号：US08691859B2
公开(公告)日：2014-04-08
申请号：US11464001
申请日：2006-08-11
申请人： Sina Bavari , Rekha G. Panchal , Rick Gussio
发明人： Sina Bavari , Rekha G. Panchal , Rick Gussio
IPC分类号： A01N43/52 , A61K31/415 , A01N43/76 , A61K31/42 , A01N43/78 , A61K31/425 , A01N43/38 , A61K31/405
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/427 , A61K31/428 , C07D209/10 , C07D209/12 , C07D209/14 , C07D333/56 , C07D333/60 , C07D401/06 , C07D401/12 , C07D403/04 , C07D405/06 , C07D405/14 , C07D407/06 , C07D409/04 , Y02A50/406 , Y02A50/473
摘要： Disclosed herein are methods of inhibiting, reducing or preventing growth of or destroying bacteria of at least one bacterial strain which comprises contacting the bacteria with the compounds disclosed herein. Also disclosed are methods of treating, inhibiting or preventing an infection or intoxication caused by bacteria of at least one bacterial strain in a subject and pharmaceutical and cosmetic compositions comprising the compounds disclosed herein.
摘要翻译： 本文公开了抑制，减少或预防至少一种细菌菌株的生长或破坏细菌的方法，其包括使细菌与本文公开的化合物接触。 还公开了治疗，抑制或预防受试者中至少一种细菌菌株的细菌引起的感染或中毒的方法，以及包含本文公开的化合物的药物和化妆品组合物。
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