Peptide Sequences of HIV polypeptides and compositions thereof
    5.
    发明授权
    Peptide Sequences of HIV polypeptides and compositions thereof 有权
    HIV多肽的肽序列及其组合物

    公开(公告)号:US08992934B2

    公开(公告)日:2015-03-31

    申请号:US13526467

    申请日:2012-06-18

    摘要: The present specification discloses an immunogenic composition comprising polypeptide, wherein each of the polypeptides has no more than 100 amino acids, which polypeptides comprises one or more sequences having at least 60% homology with any of SEQ ID 1-4, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-4 that has the same length as the epitope,wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete HIV virus protein.

    摘要翻译: 本说明书公开了包含多肽的免疫原性组合物,其中每个多肽具有不超过100个氨基酸,该多肽包含与SEQ ID 1-4中任一个具有至少60%同源性的一个或多个序列,或包含两个或多个 表位具有7个氨基酸或更多个,每个表位与SEQ ID 1-4中任一个具有与表位相同长度的亚序列具有至少60%的同源性,其中该多肽在表达主要的脊椎动物中具有免疫原性 组织相容性复合体(MHC)等位基因,并且其中所述多肽不是完整的HIV病毒蛋白质。

    Peptide sequences and compositions
    6.
    发明授权
    Peptide sequences and compositions 有权
    肽序列和组成

    公开(公告)号:US08475802B2

    公开(公告)日:2013-07-02

    申请号:US12278728

    申请日:2007-02-05

    摘要: Provided is a polypeptide having no more than 100 amino acids, which polypeptide has one or more sequences having at least 60% homology with any of SEQ ID 1-6, or has two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-6 that has the same length as the epitope: SEQ ID 1DLEALMEWLKTRPILSPLTKGILGFVFTLTVP SEQ ID 2LLYCLMVMYLNPGNYSMQVKLGTLCALCEKQASHS SEQ ID 3DLIFLARSALILRGSVAHKSC SEQ ID 4PGIADIEDLTLLARSMVVVRP SEQ ID 5LLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQ SEQ ID 6IIGILHLILWILDRLFFKCIYRLF wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete influenza virus protein.

    摘要翻译: 提供的多肽具有不超过100个氨基酸,该多肽具有与SEQ ID 1-6中任一个具有至少60%同源性的一个或多个序列,或具有两个或多个具有7个氨基酸或更多个表位的表位,每个表位具有 与SEQ ID 1-6中任一个具有与表位相同长度的亚序列至少60%的同源性:SEQ ID 1 DLEALMEWLKTRPILSPLTKGILGFVFTLTVP SEQ ID 2 LLYCLMVMYLNPGNYSMQVKLGTLCALCEKQASHS SEQ ID 3 DLIFLARSALILRGSVAHKSC SEQ ID 4 PGIADIEDLTLLARSMVVVRP SEQ ID 5 LLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQ SEQ ID 6 IIGILHLILWILDRLFFKCIYRLF其中,所述多肽在表达主要组织相容性复合体(MHC)等位基因的脊椎动物中是免疫原性的,并且其中所述多肽不是完整的流感病毒蛋白质。

    Peptide Sequences and Compositions
    7.
    发明申请
    Peptide Sequences and Compositions 有权
    肽序列和组合物

    公开(公告)号:US20120219575A1

    公开(公告)日:2012-08-30

    申请号:US13465940

    申请日:2012-05-07

    摘要: Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-6, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-6 that has the same length as the epitope: SEQ ID 1 DLEALMEWLKTRPILSPLTKGILGFVFTLTVP SEQ ID 2 LLYCLMVMYLNPGNYSMQVKLGTLCALCEKQASHS SEQ ID 3 DLIFLARSALILRGSVAHKSC SEQ ID 4 PGIADIEDLTLLARSMVVVRP SEQ ID 5 LLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQ SEQ ID 6 IIGILHLILWILDRLFFKCIYRLF wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete influenza virus protein.

    摘要翻译: 提供的多肽具有不超过100个氨基酸,该多肽包含与SEQ ID 1-6中任一个具有至少60%同源性的一个或多个序列,或包含具有7个或更多个氨基酸的两个或多个表位,每个表位具有 与SEQ ID 1-6中任一个具有与表位相同长度的亚序列至少60%的同源性:SEQ ID 1 DLEALMEWLKTRPILSPLTKGILGFVFTLTVP SEQ ID 2 LLYCLMVMYLNPGNYSMQVKLGTLCALCEKQASHS SEQ ID 3 DLIFLARSALILRGSVAHKSC SEQ ID 4 PGIADIEDLTLLARSMVVVRP SEQ ID 5 LLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQ SEQ ID 6 IIGILHLILWILDRLFFKCIYRLF其中,所述多肽在表达主要组织相容性复合体(MHC)等位基因的脊椎动物中是免疫原性的,并且其中所述多肽不是完整的流感病毒蛋白质。

    PEPTIDE SEQUENCES AND COMPOSITIONS
    8.
    发明申请
    PEPTIDE SEQUENCES AND COMPOSITIONS 有权
    肽类序列和组成

    公开(公告)号:US20100297187A1

    公开(公告)日:2010-11-25

    申请号:US12677682

    申请日:2008-09-05

    摘要: Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognising at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40 kDA or less, and wherein the polypeptides are selected independently from: the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.

    摘要翻译: 提供了包含一种或多种多肽的多肽组合物,该多肽在脊椎动物中具有免疫原性,使得它们使脊椎动物产生能够识别节肢动物唾液蛋白质级分中的至少一种表位的免疫系统细胞,其中节肢动物唾液蛋白质级分具有 质量为40kDA或更小,并且其中所述多肽独立地选自:SEQ ID 1-44的多肽序列或来自这些序列的亚序列,所述亚序列具有7个氨基酸或更多个; 或来自与上述一个或多个序列具有85%同源性或更多同源性的多肽序列并且包含在一个或多个以下数据库中:GenBank,蛋白质数据库(PDB),SwissProt,蛋白质信息资源(PIR),蛋白质研究基金会 (PRF)或这些的CDS翻译。

    Peptide sequences and compositions
    9.
    发明授权
    Peptide sequences and compositions 有权
    肽序列和组成

    公开(公告)号:US08986703B2

    公开(公告)日:2015-03-24

    申请号:US12677682

    申请日:2008-09-05

    摘要: Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognizing at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40 kDA or less, and wherein the polypeptides are selected independently from: the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.

    摘要翻译: 提供了包含一种或多种多肽的多肽组合物,该多肽在脊椎动物中具有免疫原性,使得它们使脊椎动物产生能够识别节肢动物唾液蛋白质级分中的至少一种表位的免疫系统细胞,其中节肢动物唾液蛋白质级分具有 质量为40kDA或更小,并且其中所述多肽独立地选自:SEQ ID 1-44的多肽序列或来自这些序列的亚序列,所述亚序列具有7个氨基酸或更多个; 或来自与上述一个或多个序列具有85%同源性或更多同源性的多肽序列并且包含在一个或多个以下数据库中:GenBank,蛋白质数据库(PDB),SwissProt,蛋白质信息资源(PIR),蛋白质研究基金会 (PRF)或这些的CDS翻译。