公开(公告)号：US08992750B1

公开(公告)日：2015-03-31

申请号：US13933697

申请日：2013-07-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Terry A. Beaty ,  Eric R. Diebold ,  Abner D. Joseph ,  Randall K. Riggles

IPC: G01N27/00 ,  G01N27/07 ,  G01N27/02

CPC classification number: G01N27/02 ,  G01N27/3272

Abstract: Embodiments of the invention include a test strip with a sample chamber opening spanning the width of the test strip at the sampling end and including a portion of the lateral sides at that end. The chamber is vertically bounded by upper and lower substrate layers, horizontally bounded by the front face of a spacer layer, and open on the remaining sides. The test strip fills rapidly and requires small sample volumes. Both 1-up and 2-up manufacturing techniques for producing such test strips eliminate registration and alignment steps, and other techniques relating to the 2-up technique (simultaneously manufacturing test strips arranged in multiple columns) are also disclosed.

Abstract translation: 本发明的实施例包括具有样品室开口的测试条，其跨越采样端处的测试条的宽度，并且包括在该端的侧面的一部分。 该室由上下基板层垂直界定，水平地由间隔层的前表面限定，并在其余的侧面上敞开。 测试条快速填充并需要较小的样品体积。 还公开了用于生产这种测试条的1-up和2-up制造技术消除了对准和对准步骤，并且还公开了与2层技术相关的其它技术（同时制造布置在多列中的测试条）。

公开(公告)号：US20130105074A1

公开(公告)日：2013-05-02

申请号：US13712072

申请日：2012-12-12

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Randall K. Riggles ,  Eric R. Diebold ,  Abner D. Joseph ,  Terry A. Beaty

IPC: G01N27/327

CPC classification number: G01N27/327 ,  B01L3/502707 ,  B01L2200/0684 ,  B01L2300/0645 ,  B01L2300/0825 ,  B01L2400/0406 ,  G01N27/3272 ,  Y10T156/1084

Abstract: Some embodiments of the invention include a 2-up manufacturing technique for producing test strips to reduce costs, reduce waste, and increase output. Other techniques relating to the 2-up technique, such as simultaneously manufacturing test strips arranged in multiple columns, are also disclosed. Yet other techniques include cutting through the upper and lower substrates to form an overhang of either the upper or the lower substrate. Other embodiments include a dual-use biosensor in which a user can apply a sample of bodily fluid to both test strips simultaneously.

Abstract translation: 本发明的一些实施方案包括用于生产测试条以降低成本，减少浪费并增加产量的2层制造技术。 还公开了与双向技术相关的其它技术，例如同时制造布置在多列中的测试条。 其他技术包括切割上下基板以形成上基板或下基板的突出端。 其他实施方案包括双用途生物传感器，其中使用者可以同时将两个测试条的体液样品施加。

公开(公告)号：US20140262773A1

公开(公告)日：2014-09-18

申请号：US13837083

申请日：2013-03-15

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Randall K. Riggles ,  Abner D. Joseph ,  Scott E. Carpenter ,  Harvey E. Buck, JR. ,  Georgeta C. Lica ,  Terry A. Beaty

IPC: G01N27/413

CPC classification number: G01N27/3272

Abstract: A biosensor including a capillary chamber having an inner boundary, a working electrode including an effective working electrode portion positioned within the capillary chamber, and a counter electrode including an effective counter electrode portion positioned within the capillary chamber, and with the working and counter electrodes each having a neck that constitutes the sole portion of the electrodes that extends across the inner boundary and out of the capillary chamber. In one embodiment, the effective working electrode portion defines an average working electrode width, and the working electrode neck defines a working electrode neck width that is reduced relative to the average working electrode width. In another embodiment, a ratio between the area of the effective working electrode portion exposed to the capillary chamber and the area of the effective counter electrode portion exposed to the capillary chamber is substantially constant as a position of the inner boundary of the capillary chamber is varied along a length of the working and counter electrode necks.

Abstract translation: 一种生物传感器，包括具有内边界的毛细管腔，包括位于毛细管腔内的有效工作电极部分的工作电极以及包括位于毛细管腔内的有效对电极部分的对电极，以及每个 具有构成电极的唯一部分的颈部，该颈部延伸穿过内部边界并且从毛细管腔中延伸出来。 在一个实施例中，有效工作电极部分限定平均工作电极宽度，并且工作电极颈部限定相对于平均工作电极宽度减小的工作电极颈部宽度。 在另一个实施例中，暴露于毛细管腔室的有效工作电极部分的面积与暴露于毛细管腔室的有效对置电极部分的面积之间的比例基本上是恒定的，因为毛细管腔的内边界的位置是变化的 沿着工作和对电极颈部的长度。

公开(公告)号：USD698459S1

公开(公告)日：2014-01-28

申请号：US29443313

申请日：2013-01-16

Applicant: Roche Diagnostics Operations, Inc.

Designer： Frank A. Chan ,  Abner D. Joseph

公开(公告)号：US20130190579A1

公开(公告)日：2013-07-25

申请号：US13795227

申请日：2013-03-12

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Abner D. Joseph ,  Brian A. Heald

IPC: F21V33/00 ,  A61B5/1455 ,  A61B10/00 ,  G01N1/10

CPC classification number: G01N33/49 ,  A61B5/1455 ,  A61B10/0045 ,  C12Q1/006 ,  F21V33/0068 ,  G01N1/10 ,  G01N33/48785 ,  G01N33/52 ,  G01N33/66 ,  Y10T436/144444

Abstract: A test strip with a sample chamber is secured to a meter. The sample chamber in the portion of the test strip that extends out of the meter is illuminated by transmitting light from a light source inside the meter internally through the test strip towards the sample chamber. By way of analogy, the test strip acts in a fashion similar to a fiber optic cable or optical wave guide by transmitting the light from the meter to the remotely located sample chamber that extends outside the meter. The user is then able to easily see the sample chamber of the test strip in dark conditions so that the user is able to readily align the sample chamber with the drop of fluid on the skin as well as view the sample chamber in order to ensure proper filling. The light also illuminates a test strip slot into which the test strip is inserted.

Abstract translation: 带有样品室的测试条固定在仪表上。 通过将来自仪器内部的光源的光透过测试条朝向样品室传送来自测量仪器外延的测试条部分中的样品室。 通过类推，测试条以与光纤电缆或光波导相似的方式通过将来自仪表的光传输到延伸到仪表外部的位于远处的样品室。 使用者然后能够在黑暗的条件下容易地看到测试条的样品室，使得用户能够容易地将样品室与皮肤上的一滴液体对准，并且观察样品室以确保适当 填充。 灯也照亮测试条插入的测试条槽。

公开(公告)号：US20150076010A1

公开(公告)日：2015-03-19

申请号：US14542755

申请日：2014-11-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： John T. Austera ,  Terry A. Beaty ,  Abner D. Joseph ,  Nathan E. Manlove ,  Steven K. Moore ,  James L. Pauley, JR. ,  Randall K. Riggles

IPC: G01N27/327 ,  G01N33/487

CPC classification number: G01N27/3272 ,  G01N33/48771

Abstract: An analyte test sensor strip is disclosed having information coded thereon as well as a method of forming the same and conducting an analyte test using the analyte test sensor strip. Information relating to an attribute of the strip or batch/lot of strips may be coded based on resistance values pertaining to electrical aspects of the strip, such as a primary resistive element and a secondary resistive element, the secondary resistive element having one of a plurality of states defined by a location of a closed tap to form a unique resistive path for the secondary resistive element that includes a portion of the primary resistive element depending on the location of the closed tap. The states may be formed on the strip by a secondary processing step in the manufacture of the strip in which a plurality of taps are severed leaving only one tap in a closed state.

Abstract translation: 公开了一种分析物测试传感器带，其具有编码信息的方法以及其形成方法，并使用分析物测试传感器条进行分析物测试。 可以基于条带的电气方面的电阻值（例如主要电阻元件和次级电阻元件）来编码与条带或批/条带的属性有关的信息，次电阻元件具有多个 的状态由闭合抽头的位置限定，以形成用于辅助电阻元件的唯一电阻性通路，该电阻元件包括主电阻元件的一部分，取决于封闭抽头的位置。 这些状态可以通过二次加工步骤形成在条带的制造中，其中多个抽头被切断，在关闭状态下仅留下一个龙头。

公开(公告)号：US08765482B2

公开(公告)日：2014-07-01

申请号：US13795227

申请日：2013-03-12

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Abner D. Joseph ,  Brian A. Heald

IPC: G01N33/66 ,  G01N33/49 ,  G01N33/52 ,  C12Q1/00 ,  A61B5/1455

CPC classification number: G01N33/49 ,  A61B5/1455 ,  A61B10/0045 ,  C12Q1/006 ,  F21V33/0068 ,  G01N1/10 ,  G01N33/48785 ,  G01N33/52 ,  G01N33/66 ,  Y10T436/144444

Abstract: A test strip with a sample chamber is secured to a meter. The sample chamber in the portion of the test strip that extends out of the meter is illuminated by transmitting light from a light source inside the meter internally through the test strip towards the sample chamber. By way of analogy, the test strip acts in a fashion similar to a fiber optic cable or optical wave guide by transmitting the light from the meter to the remotely located sample chamber that extends outside the meter. The user is then able to easily see the sample chamber of the test strip in dark conditions so that the user is able to readily align the sample chamber with the drop of fluid on the skin as well as view the sample chamber in order to ensure proper filling. The light also illuminates a test strip slot into which the test strip is inserted.

Abstract translation: 带有样品室的测试条固定在仪表上。 通过将来自仪器内部的光源的光透过测试条朝向样品室传送来自测量仪器外延的测试条部分中的样品室。 通过类推，测试条以与光纤电缆或光波导相似的方式通过将来自仪表的光传输到延伸到仪表外部的位于远处的样品室。 使用者然后能够在黑暗的条件下容易地看到测试条的样品室，使得用户能够容易地将样品室与皮肤上的一滴液体对准，并且观察样品室以确保适当 填充。 灯也照亮测试条插入的测试条槽。