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    Soluble Nanoparticles as Delivery Systems for Prodrugs
    1.
    发明申请
    Soluble Nanoparticles as Delivery Systems for Prodrugs 审中-公开
    可溶性纳米颗粒作为前药的递送系统

    公开(公告)号：US20120164230A1

    公开(公告)日：2012-06-28

    申请号：US12115709

    申请日：2008-05-06

    申请人： Rodney Feazell ,  Nozomi Nakayama-Ratchford ,  Hongjie Dai ,  Stephen J. Lippard

    发明人： Rodney Feazell ,  Nozomi Nakayama-Ratchford ,  Hongjie Dai ,  Stephen J. Lippard

    IPC分类号： A61K31/282 ,  C08B37/02 ,  C07K5/09 ,  C07K16/00 ,  C12N5/071 ,  C07F15/00 ,  A61K9/18 ,  B82Y5/00

    CPC分类号： A61K31/282 ,  B82Y5/00 ,  C07F15/0093 ,  C08B37/0021

    摘要： Compounds and methods are disclosed in which a prodrug can be delivered in an elevated oxidative state to cells by means of graphitic nanoparticles to which the prodrug is attached by a hydrophilic polymer and which have been made soluble by a hydrophilic polymer, such as PEG. The graphitic nanoparticle may be a single walled carbon nanotube (SWNT). The prodrug may be a DNA-binding metal-based drug. Exemplified is a platinum(IV) complex c,c,t-[Pt(NH3)2Cl2(OEt)(O2CCH2CH2CO2H)], which is nearly nontoxic to testicular cancer cells, but displays a significantly enhanced cytotoxicity profile when attached to the surface of amine-functionalized soluble SWNTs. An amine functionality on the hydrophilic polymer may be used to link the prodrug.

    摘要翻译： 公开了化合物和方法，其中前药可以通过石墨纳米颗粒以升高的氧化态递送至前体药物通过亲水性聚合物连接并且已经通过亲水性聚合物如PEG所溶解。 石墨纳米颗粒可以是单壁碳纳米管（SWNT）。 前药可以是基于DNA结合金属的药物。 示例是铂（IV）络合物c，c，t- [Pt（NH 3）2 Cl 2（OEt）（O 2 CCH 2 CH 2 CO 2 H）]，其对睾丸癌细胞几乎无毒，但当附着于睾丸癌细胞表面时显示出显着增强的细胞毒性特征 胺官能化的可溶性SWNT。 亲水性聚合物上的胺官能团可用于连接前体药物。

    Carbon nanotube devices
    8.
    发明授权
    Carbon nanotube devices 有权
    碳纳米管装置

    公开(公告)号：US07166325B2

    公开(公告)日：2007-01-23

    申请号：US10299610

    申请日：2002-11-18

    申请人： Hongjie Dai ,  Jing Kong

    发明人： Hongjie Dai ,  Jing Kong

    IPC分类号： C23C16/26 ,  C01B31/02

    CPC分类号： B82B1/00 ,  B82B3/00 ,  C01B32/162 ,  C01B2202/02 ,  G01N27/127 ,  G01Q70/12 ,  G11C13/025 ,  G11C17/16 ,  G11C17/165 ,  Y10S427/102 ,  Y10S977/742 ,  Y10S977/746 ,  Y10S977/842 ,  Y10S977/843 ,  Y10S977/876 ,  Y10S977/894 ,  Y10S977/895 ,  Y10S977/957 ,  Y10T428/2918 ,  Y10T428/2975

    摘要： Nanotubes and nanotube-based devices are implemented in a variety of applications. According to an example embodiment of the present invention, a nanotube device is manufactured having a nanotube extending between two conductive elements. In one implementation, each conductive element includes a catalyst portion, wherein electrical connection is made to opposite ends of the nanotube at each of the catalyst portions. In one implementation, the conductive elements are coupled to circuitry for detecting an electrical characteristic of the nanotube, such as the response of the nanotube to exposure to one or more of a variety of materials. In another implementation, the nanotube device is adapted for chemical and biological sensing. In still another implementation, a particular functionality is imparted to the nanotube using one or more of a variety of materials coupled to the nanotube, such as metal particles, biological particles and/or layers of the same.

    摘要翻译： 纳米管和基于纳米管的器件可以在各种应用中实现。 根据本发明的示例性实施例，制造具有在两个导电元件之间延伸的纳米管的纳米管器件。 在一个实施方案中，每个导电元件包括​​催化剂部分，其中在每个催化剂部分处对纳米管的相对端进行电连接。 在一个实施方案中，导电元件耦合到用于检测纳米管的电特性的电路，例如纳米管暴露于多种材料中的一种或多种的响应。 在另一个实施方案中，纳米管装置适用于化学和生物感测。 在另一个实施方案中，使用耦合到纳米管的各种材料中的一种或多种，​​例如金属颗粒，生物颗粒和/或其层，向纳米管赋予特定的功能。