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公开(公告)号：US20130012430A1
公开(公告)日：2013-01-10
申请号：US13534531
申请日：2012-06-27
申请人： Roger D. Tung , Scott L. Harbeson , David D. Deininger , Mark A. Murcko , Govinda R. Bhisetti , Luc J. Farmer
发明人： Roger D. Tung , Scott L. Harbeson , David D. Deininger , Mark A. Murcko , Govinda R. Bhisetti , Luc J. Farmer
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0202 , C07K5/1024 , C07K5/1027 , C07K7/02
摘要： The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be used, either alone or in combination to inhibit viruses, particularly HCV virus.
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2.发明授权Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease 失效丝氨酸蛋白酶抑制剂，特别是丙型肝炎病毒NS3蛋白酶公开(公告)号：US08314141B2
公开(公告)日：2012-11-20
申请号：US12031486
申请日：2008-02-14
申请人： Roger D. Tung , Scott L. Harbeson , David D. Deininger , Mark A. Murcko , Govinda R. Bhisetti , Luc J. Farmer
发明人： Roger D. Tung , Scott L. Harbeson , David D. Deininger , Mark A. Murcko , Govinda R. Bhisetti , Luc J. Farmer
IPC分类号： A61K31/40
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0202 , C07K5/1024 , C07K5/1027 , C07K7/02
摘要： The present invention relates to Formula (II) compounds having the structure as well as to their use in methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases.
摘要翻译： 本发明涉及具有结构的式（II）化合物及其在抑制蛋白酶，特别是丝氨酸蛋白酶，更具体地HCV NS3蛋白酶的方法和药物组合物中的用途。
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公开(公告)号：US06617309B2
公开(公告)日：2003-09-09
申请号：US09875390
申请日：2001-06-06
申请人： Roger D Tung , Scott L. Harbeson , David D. Deininger , Mark A. Murcko , Govinda R. Bhisetti , Luc J. Farmer
发明人： Roger D Tung , Scott L. Harbeson , David D. Deininger , Mark A. Murcko , Govinda R. Bhisetti , Luc J. Farmer
IPC分类号： A61K31497
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0202 , C07K5/1024 , C07K5/1027 , C07K7/02
摘要： The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be used, either alone or in combination to inhibit viruses, particularly HCV virus.
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4.发明申请INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE 失效丝氨酸蛋白酶抑制剂，特异性丙型肝炎病毒NS3蛋白公开(公告)号：US20090143312A1
公开(公告)日：2009-06-04
申请号：US12031486
申请日：2008-02-14
申请人： Roger D. Tung , Scott L. Harbeson , David D. Deininger , Mark A. Murcko , Govinda R. Bhisetti , Luc J. Farmer
发明人： Roger D. Tung , Scott L. Harbeson , David D. Deininger , Mark A. Murcko , Govinda R. Bhisetti , Luc J. Farmer
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0202 , C07K5/1024 , C07K5/1027 , C07K7/02
摘要： The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be used, either alone or in combination to inhibit viruses, particularly HCV virus.
摘要翻译： 本发明涉及用于抑制蛋白酶，特别是丝氨酸蛋白酶，更特别是HCV NS3蛋白酶的化合物，方法和药物组合物。 化合物以及利用它们的组合物和方法可以单独使用或组合用于抑制病毒，特别是HCV病毒。
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5.发明授权Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease 有权丝氨酸蛋白酶抑制剂，特别是丙型肝炎病毒NS3蛋白酶公开(公告)号：US06265380B1
公开(公告)日：2001-07-24
申请号：US09293247
申请日：1999-04-16
申请人： Roger D. Tung , Scott L. Harbeson , David D. Deininger , Mark A. Murcko , Govinda R. Bhisetti , Luc J. Farmer
发明人： Roger D. Tung , Scott L. Harbeson , David D. Deininger , Mark A. Murcko , Govinda R. Bhisetti , Luc J. Farmer
IPC分类号： A61K31497
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0202 , C07K5/1024 , C07K5/1027 , C07K7/02
摘要： The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be used, either alone or in combination to inhibit viruses, particularly HCV virus.
摘要翻译： 本发明涉及用于抑制蛋白酶，特别是丝氨酸蛋白酶，更特别是HCV NS3蛋白酶的化合物，方法和药物组合物。 化合物以及利用它们的组合物和方法可以单独使用或组合用于抑制病毒，特别是HCV病毒。
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6.发明申请INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE 审中-公开丝氨酸蛋白酶特异性HCV NS3-NS4A蛋白的抑制剂公开(公告)号：US20100173851A1
公开(公告)日：2010-07-08
申请号：US12477581
申请日：2009-06-03
申请人： Janos Pitlik , Kevin M. Cottrell , Luc J. Farmer , Robert B. Perni , Lawrence F. Courtney , John H. van Drie , Mark A. Murcko
发明人： Janos Pitlik , Kevin M. Cottrell , Luc J. Farmer , Robert B. Perni , Lawrence F. Courtney , John H. van Drie , Mark A. Murcko
CPC分类号： C07D209/42 , C07D209/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07K5/06008 , C07K5/0812 , C07K5/1024 , C07K5/1027
摘要： The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
摘要翻译： 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的化合物。 因此，它们通过干扰丙型肝炎病毒的生命周期起作用，也可用作抗病毒剂。 本发明还涉及包含这些化合物的组合物，用于离体使用或给予患有HCV感染的患者。 本发明还涉及通过施用包含本发明化合物的组合物来治疗患者HCV感染的方法。 本发明还涉及制备这些化合物的方法。
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7.发明授权公开(公告)号：US07273885B2
公开(公告)日：2007-09-25
申请号：US10412600
申请日：2003-04-11
申请人： Janos Pitlik , Kevin M. Cottrell , Luc J. Farmer , Robert B. Perni , Lawrence F. Courtney , John H. van Drie , Mark A. Murcko
发明人： Janos Pitlik , Kevin M. Cottrell , Luc J. Farmer , Robert B. Perni , Lawrence F. Courtney , John H. van Drie , Mark A. Murcko
IPC分类号： A61K31/403 , A61K31/435 , C07D209/02 , C07D221/00
CPC分类号： C07D209/42 , C07D209/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07K5/06008 , C07K5/0812 , C07K5/1024 , C07K5/1027
摘要： The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
摘要翻译： 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的化合物。 因此，它们通过干扰丙型肝炎病毒的生命周期起作用，也可用作抗病毒剂。 本发明还涉及包含这些化合物的组合物，用于离体使用或给予患有HCV感染的患者。 本发明还涉及通过施用包含本发明化合物的组合物来治疗患者HCV感染的方法。 本发明还涉及制备这些化合物的方法。
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8.发明授权公开(公告)号：US07683033B2
公开(公告)日：2010-03-23
申请号：US11051977
申请日：2005-02-04
申请人： Kevin M. Cottrell , John J. Court , David D. Deininger , Luc J. Farmer , Janos Pitlik , Robert B. Permi
发明人： Kevin M. Cottrell , John J. Court , David D. Deininger , Luc J. Farmer , Janos Pitlik , Robert B. Permi
CPC分类号： C07K5/10 , A61K38/00 , A61K38/07 , A61K45/06 , C07K5/0202 , C07K7/02 , C07K14/005 , C12N2770/24222
摘要： The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
摘要翻译： 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐或混合物。 因此，它们通过干扰丙型肝炎病毒的生命周期起作用，也可用作抗病毒剂。 本发明还涉及包含用于离体使用或用于给予HCV感染患者的这些化合物的组合物和制备该化合物的方法。 本发明还涉及通过施用包含本发明化合物的组合物来治疗患者HCV感染的方法。 本发明还涉及制备这些化合物的方法。
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9.发明申请公开(公告)号：US20100330109A1
公开(公告)日：2010-12-30
申请号：US12639162
申请日：2009-12-16
申请人： Kevin M. Cottrell , John J. Court , David D. Deininger , Luc J. Farmer , Janos Pitlik , Robert B. Perni
发明人： Kevin M. Cottrell , John J. Court , David D. Deininger , Luc J. Farmer , Janos Pitlik , Robert B. Perni
CPC分类号： C07K5/10 , A61K38/00 , A61K38/07 , A61K45/06 , C07K5/0202 , C07K7/02 , C07K14/005 , C12N2770/24222
摘要： The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
摘要翻译： 本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒NS3-NS4A蛋白酶活性的式I化合物或其药学上可接受的盐或混合物。 因此，它们通过干扰丙型肝炎病毒的生命周期起作用，也可用作抗病毒剂。 本发明还涉及包含用于离体使用或用于给予HCV感染患者的这些化合物的组合物和制备该化合物的方法。 本发明还涉及通过施用包含本发明化合物的组合物来治疗患者HCV感染的方法。 本发明还涉及制备这些化合物的方法。
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10.发明申请INHIBITORS OF SERINE PROTEASES, PARTICULARLY HEPATITIS C VIRUS NS3 PROTEASE 审中-公开丝氨酸蛋白酶抑制剂，特异性丙型肝炎病毒NS3蛋白公开(公告)号：US20110112114A1
公开(公告)日：2011-05-12
申请号：US12797250
申请日：2010-06-09
IPC分类号： A61K31/4965 , C07D241/24 , C07C237/52 , A61K31/167 , C07D213/82 , A61K31/44 , C07C231/14 , A61P31/14
CPC分类号： C07D213/82 , C07C237/42 , C07D241/24
摘要： The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be used, either alone or in combination to inhibit viruses, particularly HCV virus.
摘要翻译： 本发明涉及用于抑制蛋白酶，特别是丝氨酸蛋白酶，更特别是HCV NS3蛋白酶的化合物，方法和药物组合物。 化合物以及利用它们的组合物和方法可以单独使用或组合用于抑制病毒，特别是HCV病毒。
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