公开(公告)号：US20150196544A1

公开(公告)日：2015-07-16

申请号：US14644012

申请日：2015-03-10

申请人： Roger D. Tung

发明人： Roger D. Tung

IPC分类号： A61K31/4525

CPC分类号： A61K31/4525 ,  C07D317/64 ,  C07D405/12

摘要： The present invention relates to an isotopologue of Compound 1 substituted with deuterium at the methylene carbon of the benzodioxol ring. The isotopologues of this invention selective serotonin reuptake inhibitors (SSRIs) and possess unique biopharmaceutical and metabolic properties compared to Compound 1. They may also be used to accurately determine the concentration of Compound 1 in biological fluids and to determine metabolic patterns of Compound 1 and its isotopologues. The invention further provides compositions comprising these deuterated isotopologues and methods of treating diseases and conditions that are responsive to increased neuronal serotonin transmission, alone and in combination with additional agents.

摘要翻译： 本发明涉及在苯并二氧杂环戊烯的亚甲基碳上被氘取代的化合物1的同位素学。 本发明的同位素学选择性5-羟色胺再摄取抑制剂（SSRIs）并且与化合物1相比具有独特的生物药物和代谢性质。它们还可用于精确测定化合物1在生物流体中的浓度并确定化合物1及其化合物1的代谢模式 同位素学。 本发明还提供包含这些氘代同位素异构体的组合物和治疗对增加的神经元血清素传递起反应的疾病和病症的方法，其单独和与另外的试剂组合。

公开(公告)号：US08987442B2

公开(公告)日：2015-03-24

申请号：US13448930

申请日：2012-04-17

申请人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

发明人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

IPC分类号： A61K31/522 ,  A61P13/12 ,  A61P43/00 ,  C07D473/06

CPC分类号： A61K31/522 ,  C07D473/06

摘要： This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

摘要翻译： 本发明涉及作为取代黄嘌呤衍生物的新化合物及其药学上可接受的盐。 例如，本发明涉及作为己酮可可碱衍生物的新型取代黄嘌呤衍生物。 本发明还提供了包含一种或多种本发明化合物和载体的组合物，以及所述化合物和组合物在治疗己酮可可碱和相关化合物有益的疾病和病症的方法中的用途。

公开(公告)号：US20130053333A1

公开(公告)日：2013-02-28

申请号：US13522795

申请日：2011-01-19

申请人： Roger D. Tung

发明人： Roger D. Tung

IPC分类号： A61K31/47 ,  A61K31/49 ,  A61K31/473 ,  A61K31/65 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/635 ,  A61K31/7056 ,  A61P33/02 ,  A61P33/08 ,  A61P11/00 ,  A61P33/06 ,  C07D215/06

CPC分类号： C07D215/40

摘要： This invention relates to novel aminoquinoline derivatives of Formula (I) or Ia, or pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an aminoquinoline derivative, such as a derivative of primaquine.

摘要翻译： 本发明涉及式（I）或Ia的新型氨基喹啉衍生物或其药学上可接受的盐。 本发明还提供了包含本发明化合物的组合物和这些组合物在治疗通过给予氨基喹啉衍生物如伯母喹衍生物有益治疗的疾病和病症的方法中的用途。

公开(公告)号：US20130012565A1

公开(公告)日：2013-01-10

申请号：US13372989

申请日：2012-02-14

申请人： Roger D. Tung ,  Adam J. Morgan ,  I. Robert Silverman

发明人： Roger D. Tung ,  Adam J. Morgan ,  I. Robert Silverman

IPC分类号： A61K31/225 ,  C07C69/34 ,  C07C69/353 ,  C07C69/40 ,  C07C69/675 ,  A61K31/19 ,  A61K31/222 ,  A61P25/00 ,  A61P29/00 ,  A61P21/00 ,  A61P25/18 ,  A61P25/32 ,  A61P25/16 ,  A61P25/30 ,  A61K31/197 ,  C07C59/01

CPC分类号： C07C59/115 ,  A61K31/19 ,  A61K31/22 ,  A61K31/225 ,  A61K45/06 ,  C07B59/001 ,  C07B2200/05 ,  C07C59/01 ,  C07C59/125 ,  C07C69/67 ,  C07C69/675 ,  C07C69/708

摘要： This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.

公开(公告)号：US20130012430A1

公开(公告)日：2013-01-10

申请号：US13534531

申请日：2012-06-27

申请人： Roger D. Tung ,  Scott L. Harbeson ,  David D. Deininger ,  Mark A. Murcko ,  Govinda R. Bhisetti ,  Luc J. Farmer

发明人： Roger D. Tung ,  Scott L. Harbeson ,  David D. Deininger ,  Mark A. Murcko ,  Govinda R. Bhisetti ,  Luc J. Farmer

IPC分类号： A61K38/07 ,  C07K7/06 ,  A61P31/14 ,  C07K5/083 ,  A61K38/06 ,  C07K5/103 ,  A61K38/08

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/1024 ,  C07K5/1027 ,  C07K7/02

摘要： The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds, and the compositions and methods that utilize them, can be used, either alone or in combination to inhibit viruses, particularly HCV virus.

公开(公告)号：US20120270934A1

公开(公告)日：2012-10-25

申请号：US13381419

申请日：2010-07-02

申请人： Craig E. Masse ,  Scott L. Harbeson ,  Roger D. Tung

发明人： Craig E. Masse ,  Scott L. Harbeson ,  Roger D. Tung

IPC分类号： A61K31/5578 ,  C07D317/40 ,  A61K31/5585 ,  A61P9/00 ,  C07C69/73 ,  A61P9/12 ,  A61P13/12 ,  A61P35/00 ,  C07C69/732 ,  C07C311/51

CPC分类号： C07C69/734 ,  C07B2200/05 ,  C07B2200/07 ,  C07C59/46 ,  C07C69/732 ,  C07C311/51 ,  C07C2601/14 ,  C07C2602/22 ,  C07D317/34 ,  C07D319/06

摘要： This invention relates to novel prostacyclin derivatives and acceptable salts thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by prostacyclin, and in particular those diseases and conditions beneficially treated by dilators of systemic and pulmonary arterial vascular beds or by platelet aggregation inhibitors.

摘要翻译： 本发明涉及新型前列环素衍生物及其可接受的盐。 本发明还提供了包含本发明化合物和这些组合物在治疗由前列环素有益治疗的疾病和病症的方法中的用途，特别是那些通过全身和肺动脉血管床的扩张器或血小板有利地治疗的疾病和病症 聚集抑制剂。

公开(公告)号：US20120202830A1

公开(公告)日：2012-08-09

申请号：US13448930

申请日：2012-04-17

申请人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

发明人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

IPC分类号： A61K31/522 ,  A61P13/12 ,  A61P43/00

CPC分类号： A61K31/522 ,  C07D473/06

摘要： This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

摘要翻译： 本发明涉及作为取代黄嘌呤衍生物的新化合物及其药学上可接受的盐。 例如，本发明涉及作为己酮可可碱衍生物的新型取代黄嘌呤衍生物。 本发明还提供了包含一种或多种本发明化合物和载体的组合物，以及所述化合物和组合物在治疗己酮可可碱和相关化合物有益的疾病和病症的方法中的用途。

公开(公告)号：US08158805B2

公开(公告)日：2012-04-17

申请号：US12755184

申请日：2010-04-06

申请人： Scott L. Harbeson ,  Roger D. Tung

发明人： Scott L. Harbeson ,  Roger D. Tung

IPC分类号： A61K31/44 ,  C07D213/00

CPC分类号： C07D213/42 ,  C07F9/58

摘要： This invention relates to novel compounds that are azapeptides, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel azapeptide compounds that are derivatives of the HIV protease inhibitor atazanavir sulfate. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering HIV protease inhibitors. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving atazanavir.

公开(公告)号：US20110082147A1

公开(公告)日：2011-04-07

申请号：US12842589

申请日：2010-07-23

申请人： Scott L. Harbeson ,  Roger D. Tung ,  Julie F. Liu

发明人： Scott L. Harbeson ,  Roger D. Tung ,  Julie F. Liu

IPC分类号： A61K31/53 ,  C07D487/04 ,  A61P25/22 ,  A61P25/08 ,  A61P25/00 ,  A61P29/00 ,  A61P25/06

CPC分类号： C07D487/04

摘要： This invention relates to novel substituted imidazotriazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a compound showing partial-agonist activity at the GABA α2, α3 and α5 subtype receptors, and antagonist activity at the al subtype receptor.

摘要翻译： 本发明涉及新的取代的咪唑并嗪及其药学上可接受的盐。 本发明还提供包含本发明化合物的组合物和这些组合物在治疗通过给予在GABAα2，α3和α5亚型受体上显示部分激动剂活性的化合物和拮抗剂有益处理的疾病和病症的方法中的用途 在亚型受体的活性。

公开(公告)号：US20110053961A1

公开(公告)日：2011-03-03

申请号：US12873991

申请日：2010-09-01

申请人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

发明人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

IPC分类号： A61K31/522 ,  C07D473/10 ,  A61P9/12 ,  A61P13/12 ,  A61P1/16 ,  A61P27/02 ,  A61P3/10 ,  A61P3/04

CPC分类号： C07D473/04

摘要： This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.