公开(公告)号：US20050119309A1

公开(公告)日：2005-06-02

申请号：US10956957

申请日：2004-09-30

申请人： Roger Papke ,  Nicole Horenstein ,  Michael Francis ,  Kyung Choi

发明人： Roger Papke ,  Nicole Horenstein ,  Michael Francis ,  Kyung Choi

IPC分类号： A61K20060101 ,  A61K31/445 ,  C07D211/36 ,  C07D211/44

CPC分类号： C07D211/44

摘要： The present invention concerns methods for treating or preventing neurological disorders characterized by dysfunction of nicotinic acetylcholine receptors by administering 2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH), or a pharmaceutically acceptable salt thereof, to the patient. In another aspect, the present invention pertains to pharmaceutical compositions containing TMPH, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. In another aspect, the present invention pertains to methods for selectively inhibiting nicotinic acetylcholine receptors that lack an α5, α6, or β3 subunit by contacting an effective amount of TMPH, or a pharmaceutically acceptable salt thereof, to the receptor. The method for selectively inhibiting nicotinic acethylcholine receptors that lack an α5 subunit can be carried out in vivo or in vitro.

摘要翻译： 本发明涉及通过向患者施用2,2,6,6-四甲基哌啶-4-基庚酸酯（TMPH）或其药学上可接受的盐来治疗或预防特征为烟碱乙酰胆碱受体功能障碍的神经障碍的方法。 另一方面，本发明涉及含有TMPH或其药学上可接受的盐和药学上可接受的载体的药物组合物。 另一方面，本发明涉及通过使有效量的TMPH或其药学上可接受的盐与受体接触来选择性地抑制缺乏α5，α6或β3亚基的烟碱乙酰胆碱受体的方法。 选择性抑制缺乏α5亚基的烟碱乙酰胆碱受体的方法可以在体内或体外进行。

公开(公告)号：US20240081804A1

公开(公告)日：2024-03-14

申请号：US18465255

申请日：2023-09-12

申请人： Michael Francis

发明人： Michael Francis

IPC分类号： A61B17/04 ,  A61F2/08

CPC分类号： A61B17/0401 ,  A61F2/0811 ,  A61B2017/0409 ,  A61B2017/0438 ,  A61B2017/0464 ,  A61F2002/0817 ,  A61F2002/0858

摘要： A soft tissue augmentation implant for surgically reinforcing soft tissue, such as a rotator cuff tendon in the shoulder. The implant comprises one or more slots for passing a suture through the implant. In a two-slot design, the suture may pass through the slots in a buckle configuration. The suture secures the implant to the target soft tissue. The bottom side of the implant has a rough surface or has one or protrusions. This feature facilitates mechanical integration of the implant to the target soft tissue. Also disclosed are soft tissue augmentation assemblies, surgical kits, and methods for reinforcing soft tissue (such as rotator cuff repair).

公开(公告)号：US20100277912A1

公开(公告)日：2010-11-04

申请号：US12799493

申请日：2010-04-26

申请人： Michael Francis

发明人： Michael Francis

IPC分类号： F21V1/00

CPC分类号： G02B27/30 ,  F41G1/54 ,  F41G1/545 ,  G02B5/10

摘要： A boresight collimating device using a novel way of achieving multiple source illumination of the pin hole/reticule using one moving part, a rotating elliptical mirror, while maintaining precision alignment of the device is disclosed.

摘要翻译： 公开了一种使用一个移动部件，旋转椭圆镜来实现针孔/网状物的多源照明的新颖方式的视轴准直装置，同时保持装置的精确对准。

公开(公告)号：US09707904B2

公开(公告)日：2017-07-18

申请号：US14011550

申请日：2013-08-27

申请人： Michael Francis ,  Donald Francis

发明人： Michael Francis ,  Donald Francis

IPC分类号： B60R11/06

CPC分类号： B60R11/06

摘要： A receptacle for attachment to a rim is disclosed, being primarily used to store wheel lug nuts into said receptacle for storage and transportation of lug nuts with their associated wheels. The receptacle comprises a lid, a container and a securing pin. The container secures the wheel lug nuts, while the lid fastens onto the container to secure its contents, and meanwhile the securing pin secures the lid onto the container and ultimately onto the rim of the wheel, such that the wheel lug nuts are easily stored with the rim. This procedure is primarily performed before the winter or summer seasons, or when the wheels are changed for wheel leasing purposes or the transportation of wheels with their associated lug nuts, to ensure that the wheel lug nuts are never misplaced or lost.

公开(公告)号：US20140054334A1

公开(公告)日：2014-02-27

申请号：US14011550

申请日：2013-08-27

申请人： Michael Francis ,  Donald Francis

发明人： Michael Francis ,  Donald Francis

IPC分类号： B60R11/06

CPC分类号： B60R11/06

摘要： A receptacle for attachment to a rim is disclosed, being primarily used to store wheel lug nuts into said receptacle for storage and transportation of lug nuts with their associated wheels. The receptacle comprises a lid, a container and a securing pin. The container secures the wheel lug nuts, while the lid fastens onto the container to secure its contents, and meanwhile the securing pin secures the lid onto the container and ultimately onto the rim of the wheel, such that the wheel lug nuts are easily stored with the rim. This procedure is primarily performed before the winter or summer seasons, or when the wheels are changed for wheel leasing purposes or the transportation of wheels with their associated lug nuts, to ensure that the wheel lug nuts are never misplaced or lost.

摘要翻译： 公开了用于附接到轮辋的接收器，其主要用于将轮辋螺母存储在所述容器中，用于存储和传送具有其相关轮的凸耳螺母。 容器包括盖，容器和固定销。 容器固定车轮螺母，同时将盖子紧固到容器上以固定其内容物，同时固定销将盖固定在容器上并最终将其固定在车轮的轮缘上，使得轮毂螺母容易地与 边缘 该程序主要在冬季或夏季之前进行，或者当轮子更换为轮式租赁目的或用相关联的凸耳螺母运输车轮时，以确保车轮螺母从未放错或丢失。

公开(公告)号：US20100125282A1

公开(公告)日：2010-05-20

申请号：US12271493

申请日：2008-11-14

申请人： James Machek ,  Michael Francis

发明人： James Machek ,  Michael Francis

IPC分类号： A61B19/00 ,  A61M5/00

CPC分类号： A61B34/30 ,  A61B18/1492 ,  A61B2017/00703 ,  A61B2034/2051 ,  A61B2034/2065 ,  A61B2034/301 ,  A61B2090/364

摘要： A distal end of a stent graft fenestration or other special purpose catheter is guided to a location in a patient's vasculature based on input from a surgeon using a pre-operatively generated image of the patient's vasculature—this can be in proximity to an already implanted device. The movement of the catheter is controlled by a robotic surgical system based upon the input from the surgeon. The distal end of the catheter, at the location, is synchronized to the patient's cardiac cycle so the robotic surgical system maintains the distal end of the catheter at the location throughout a cardiac cycle of the patient. The surgeon is not required to precisely manipulate the catheter to maintain the distal end in the proper location throughout the cardiac cycle. The surgeon can focus on performing the desired procedure such as fenestrating the stent graft, endostapling or endosuturing, for example.

摘要翻译： 基于来自外科医生的使用患者血管系统的预先产生的图像的输入，将支架移植物开窗或其它专用导管的远端导引到患者的脉管系统中的位置 - 这可以在已经植入的装置 。 导管的移动由基于外科医生的输入的机器人手术系统来控制。 在该位置的导管的远端与患者的心脏周期同步，因此机器人手术系统将导管的远端保持在患者心脏周期的位置。 外科医生不需要精确地操纵导管，以将远端保持在整个心脏周期的适当位置。 外科医生可以专注于执行所需的程序，例如开窗支架移植物，内包囊或内插管。

公开(公告)号：US20210059461A1

公开(公告)日：2021-03-04

申请号：US16958645

申请日：2018-06-26

申请人： Michael Francis ,  Suzanna Mellersh

发明人： Michael Francis ,  Suzanna Mellersh

IPC分类号： A47J27/05 ,  A47J36/20 ,  B65D81/34

摘要： Improvements in and relating to a cooking apparatus A container (201) for storing and steaming food is disclosed, together with a packaged food product, a method of packaging food items and a method of cooking food items. The container (201) comprises a first compartment (202) for containing a steam source and a second compartment (203) for containing at least one food item. The second compartment (203) is disposed above the first compartment (202). Preferably, the first compartment (202) is separated from the second compartment (203) by a partition (221) and an adjustable barrier (240), the partition (201) comprising at least one opening (223) for admitting water vapour into the second compartment (203) from the first compartment (202). Preferably, the adjustable barrier (240) is movable from a) a food storing configuration in which the adjustable barrier (240) prevents flow of at least one of i) liquid and ii) gas from the first compartment (202) to the second compartment (203), to b) a food steaming configuration in which at least one of i) liquid and ii) gas is able to flow between the first and second compartments (202, 203).

公开(公告)号：US09268831B2

公开(公告)日：2016-02-23

申请号：US12229902

申请日：2008-08-27

申请人： Michael Francis

发明人： Michael Francis

IPC分类号： G06F17/30

CPC分类号： G06F17/30569

摘要： A system and method are provided for receiving extracted data from a transaction database. Extracted data is transformed into a predefined structure and used to populate a database. A set of measures are then provided for interrogating the database and these may be displayed to the user with dimensions which maybe applied to filter the data. Data presented to a user is relevant to his or her area of activity. The data is periodically refreshed and signals are presented in the data relating to issues requiring further investigation.

公开(公告)号：US20100249898A1

公开(公告)日：2010-09-30

申请号：US12409759

申请日：2009-03-24

申请人： Adrian Gale ,  Jenine S. Vinluan ,  Jia Hua Xiao ,  Michael Francis ,  Frank Yang

发明人： Adrian Gale ,  Jenine S. Vinluan ,  Jia Hua Xiao ,  Michael Francis ,  Frank Yang

IPC分类号： A61F2/82

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2/95 ,  A61F2002/061 ,  A61F2002/067

摘要： A stent graft system includes a first stent graft having a first end and a second end opposing the first end. The system further includes a second stent graft in fluid communication with the first stent graft. The second stent graft defines a lumen a third end in fluid communication with the second end. The second stent graft further includes a fourth end opposing the third end, and at least a first sleeve and second sleeve extending radially therefrom and in fluid communication with the lumen, The first sleeve is radially offset from the second sleeve. Each of the first sleeve and second sleeve comprises a flexible material configured to evert between a first position such that the sleeve is positioned within the lumen and a second position such that the sleeve is positioned exterior to the lumen. The system further includes a third stent graft.

摘要翻译： 支架移植系统包括具有第一端和与第一端相对的第二端的第一支架移植物。 该系统还包括与第一支架移植物流体连通的第二支架移植物。 第二支架移植物限定内腔与第二端流体连通的第三端。 第二支架移植物还包括与第三端相对的第四端，以及至少第一套筒和第二套筒，其径向延伸并与内腔流体连通。第一套筒与第二套筒径向偏移。 第一套筒和第二套筒中的每一个包括柔性材料，其构造成在第一位置之间转换，使得套筒定位在内腔内，而第二位置使得套筒位于管腔的外部。 该系统还包括第三支架移植物。

公开(公告)号：US20080168078A1

公开(公告)日：2008-07-10

申请号：US10586004

申请日：2005-01-12

申请人： Michael Francis

发明人： Michael Francis

IPC分类号： G06F17/30

CPC分类号： G06F16/24539 ,  G06F16/24552 ,  G06F16/283

摘要： A system and method are provided for extracting user selected data from a database. Configuration data is stored defining how a user selected data is to be extracted in response to a user request. A database query is generated from the user request using the configuration data and data extracted in response to the query. This extracted data is supplied to the user. The database query includes data defining to be measured and displayed and data defining any dimensions for that measure selected by the user. The data defining the measure and dimensions are a portion of the configuration data. Another aspect of the invention provides a method and apparatus for supplying a set of chart data from a database to a user in response to the user input. A number of sets of chart data are stored in a cache memory and a determination is made as to whether or not a user input corresponds to a request for a set of chart data stored in the cache memory. A set of chart data is supplied from the cache memory to the user in dependence on the result of the determination.

摘要翻译： 提供了一种用于从数据库提取用户选择的数据的系统和方法。 存储定义如何响应于用户请求来提取用户选择的数据的配置数据。 使用配置数据和响应于查询提取的数据从用户请求生成数据库查询。 该提取的数据被提供给用户。 数据库查询包括定义要测量和显示的数据以及定义用户选择的该度量的任何维度的数据。 定义测量和尺寸的数据是配置数据的一部分。 本发明的另一方面提供了一种用于响应于用户输入将一组图表数据从数据库提供给用户的方法和装置。 许多图表数据集存储在高速缓冲存储器中，并且确定用户输入是否对应于存储在高速缓冲存储器中的一组图表数据的请求。 根据确定的结果，从缓存存储器向用户提供一组图表数据。