公开(公告)号：US20070009203A1

公开(公告)日：2007-01-11

申请号：US11532689

申请日：2006-09-18

申请人： Rogier Receveur ,  Philippe Habets ,  Ralph Danzl ,  Richard Houben ,  Michael Mattes

发明人： Rogier Receveur ,  Philippe Habets ,  Ralph Danzl ,  Richard Houben ,  Michael Mattes

IPC分类号： G02B6/26

CPC分类号： H01H59/0009 ,  B81B3/0054 ,  B81B2201/018 ,  B81B2203/051 ,  H01H2001/0042 ,  H01H2001/0078 ,  Y10T29/49105

摘要： A micro electromechanical (MEMS) switch suitable for use in medical devices is provided, along with methods of producing and using MEMS switches. In one aspect, a micro electromechanical switch including a moveable member configured to electrically cooperate with a receiving terminal is formed on a substrate. The moveable member and the receiving terminal each include an insulating layer proximate to the substrate and a conducting layer proximate to the insulating layer opposite the substrate. In various embodiments, the conducting layers of the moveable member and/or receiving terminal include a protruding region that extends outward from the substrate to switchably couple the conducting layers of the moveable member and the receiving terminal to thereby form a switch. The switch may be actuated using, for example, electrostatic energy.

摘要翻译： 提供了适用于医疗设备的微机电（MEMS）开关，以及生产和使用MEMS开关的方法。 一方面，在基板上形成包括被配置为与接收端子电配合的可移动部件的微机电开关。 可移动构件和接收端子各自包括靠近衬底的绝缘层和靠近与衬底相对的绝缘层的导电层。 在各种实施例中，可移动构件和/或接收端子的导电层包括从基板向外延伸的可突出地连接可移动构件和接收端子的导电层从而形成开关的突出区域。 可以使用例如静电能来致动开关。

公开(公告)号：US20050165324A1

公开(公告)日：2005-07-28

申请号：US10781111

申请日：2004-02-18

申请人： Rogier Receveur ,  Vincent Larik ,  Ron Van Der Kruk ,  Victor Duysens ,  Richard Houben ,  Nicolaas Lokhoff ,  John Feron

发明人： Rogier Receveur ,  Vincent Larik ,  Ron Van Der Kruk ,  Victor Duysens ,  Richard Houben ,  Nicolaas Lokhoff ,  John Feron

IPC分类号： A61B5/00 ,  A61B5/027 ,  A61B5/03 ,  A61B5/107 ,  A61B8/12 ,  A61B17/00 ,  A61B19/00 ,  A61M25/01 ,  A61N1/05 ,  A61B5/02

CPC分类号： A61N1/056 ,  A61B5/027 ,  A61B5/036 ,  A61B5/1459 ,  A61B8/12 ,  A61B34/20 ,  A61B90/06 ,  A61B90/36 ,  A61B2017/00088 ,  A61B2017/00092 ,  A61B2017/00101 ,  A61B2017/00115 ,  A61B2017/00243 ,  A61B2090/064

摘要： A sensor is provided on a lead and senses various physical parameters that are indicative of a desired anatomical target, such as the coronary sinus. The data from the sensor is used to navigate to the anatomical target and/or confirm that the anatomical target has been reached. In one embodiment, the sensor is a temperature sensor and increased temperature values in and around the coronary sinus are used for navigational purposes.

摘要翻译： 传感器设置在引线上并且感测指示期望的解剖学靶标（例如冠状窦）的各种物理参数。 来自传感器的数据用于导航到解剖目标和/或确认解剖目标已达到。 在一个实施例中，传感器是温度传感器，并且冠状窦内和周围的升高的温度值被用于导航目的。

公开(公告)号：US06572542B1

公开(公告)日：2003-06-03

申请号：US09518796

申请日：2000-03-03

申请人： Richard Houben ,  Vincent Larik

发明人： Richard Houben ,  Vincent Larik

IPC分类号： A61B500

CPC分类号： A61B5/0472 ,  A61B5/14532 ,  A61B5/7264 ,  A61M5/14244 ,  A61M2230/04 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H50/20 ,  Y10S128/92 ,  Y10S128/925

摘要： Information derived from ECG signals and EEG signals may be employed in combination to reliably predict the onset, or to indicate the presence of, hypoglycemia in a human patient. In one embodiment, ECG and EEG signals are processed and the information derived from them is combined to determine whether a patient suffering from diabetes is undergoing a hypoglycemic event, or whether such an event is imminent. Input data from the patient or a health care provider may also be used to increase the accuracy and reliability of the system. Detection of a hypoglycemic event by the system can result in the output of an alarm signal and/or the delivery or administration of a beneficial agent such as insulin, glucagon or diazoxide to the patient. The system may be implantable, external, or a combination of external and implantable components. The control strategy of the present system is preferably microprocessor based and/or implemented using dedicated electronics. In another embodiment, the glycemic state of the patient is continuously or relatively continuously monitored and controlled by the system. The system may contain any of a number of different types of feedback control systems for monitoring the glycemic state of a patient and controlling same, such as fuzzy logic systems, adaptive systems, reinforcement learning systems, and the like.

摘要翻译： 从ECG信号和EEG信号得到的信息可以组合使用以可靠地预测人类患者的发作或低血糖的存在。 在一个实施例中，处理ECG和EEG信号，并且从它们得到的信息被组合以确定患有糖尿病的患者是否正在经历低血糖事件，或者这种事件是否即将来临。 还可以使用来自患者或医疗保健提供者的输入数据来提高系统的准确性和可靠性。 通过系统检测低血糖事件可以导致警报信号的输出和/或向患者输送或施用有益剂例如胰岛素，胰高血糖素或二氮嗪。 该系统可以是可植入的，外部的或外部的和可植入的组件的组合。 本系统的控制策略优选是基于微处理器的和/或使用专用电子设备实现的。 在另一个实施方案中，患者的血糖状态由系统连续或相对连续地监测和控制。 该系统可以包含许多不同类型的反馈控制系统中的任何一种，用于监视患者的血糖状态并控制其，例如模糊逻辑系统，自适应系统，强化学习系统等。

公开(公告)号：US06605039B2

公开(公告)日：2003-08-12

申请号：US09909999

申请日：2001-07-23

申请人： Richard Houben ,  Vincent Larik

发明人： Richard Houben ,  Vincent Larik

IPC分类号： A61B500

CPC分类号： A61B5/01 ,  A61B5/14532

摘要： A sensing methodology is used based on measuring a physical response from a living structure as a result of a chemical compound stimulating this structure on the cellular level. Measurement of the heat response (calorimetry) from a group of pancreatic islets of Langerhans stimulated by glucose is proposed as a glucose biosensor. A novel biosensor concept is proposed acquiring physical response from living cells or cell clusters. In this particular case, membrane impedance of pancreatic B-cells, as a result of glucose stimulated cellular metabolism is used as physical readout. This method of physical assessment is made possible by growing genetically engineered pancreatic beta cells onto a substrate equipped with a set of interdigitated electrodes (IDEs).

摘要翻译： 基于在细胞水平上刺激该结构的化学化合物的结果，基于测量来自活体结构的物理反应的感测方法被使用。 作为葡萄糖生物传感器，提出了一组由葡萄糖刺激的朗格汉斯胰岛的热响应（量热法）的测量。 提出了一种新的生物传感器概念，从生物细胞或细胞簇获得物理反应。 在这种特殊情况下，作为葡萄糖刺激的细胞代谢的结果，胰腺B细胞的膜阻抗用作物理读数。 通过将基因工程的胰β细胞生长到配备有一组交叉电极（IDE）的基底上，这种物理评估方法成为可能。

公开(公告)号：US20060167364A1

公开(公告)日：2006-07-27

申请号：US11043584

申请日：2005-01-26

申请人： Richard Houben

发明人： Richard Houben

IPC分类号： A61B5/04

CPC分类号： A61B5/0464 ,  A61B5/046 ,  A61B5/726 ,  G06K9/00557

摘要： A method for detecting a cardiac arrhythmia from an electrocardiogram includes the steps of identifying a plurality of R-waves in the electrocardiogram during a predetermined time interval; extracting heartbeat complexes corresponding to the identified R-waves; identifying a key region within each heartbeat complex that is morphologically altered in the event of the cardiac arrhythmia; calculating a statistical measurement of an ensemble of the key regions from each of the heartbeat complexes; and determining from the statistical measurement whether the cardiac arrhythmia occurred during the predetermined time interval. An apparatus is also provided that includes a processor that is coupled to receive an electrocardiogram, and is configured in response thereof to perform the method for detecting a cardiac arrhythmia.

摘要翻译： 一种用于从心电图检测心律不齐的方法包括以下步骤：在预定的时间间隔内识别心电图中的多个R波; 提取与所识别的R波相对应的心跳复合体; 识别在心律失常的情况下在形态上改变的每个心跳复合物内的关键区域; 计算来自每个心跳复合体的关键区域的整体的统计测量; 以及从所述统计测量确定在所述预定时间间隔期间是否发生心律失常。 还提供了一种装置，其包括耦合以接收心电图的处理器，并且被配置为响应于此执行用于检测心律失常的方法。

公开(公告)号：US06329929B1

公开(公告)日：2001-12-11

申请号：US09217127

申请日：1998-12-21

申请人： Koen J. Weijand ,  Richard Houben

发明人： Koen J. Weijand ,  Richard Houben

IPC分类号： G08C1916

CPC分类号： H04L25/062 ,  A61N1/08 ,  H04L27/10 ,  Y10S128/903

摘要： There is provided a telemetry system with a receiver which enables detection of pulsed high frequency data (hf) signals in a manner which suppresses noise which may be present within the high frequency bandwidth. The transmitter carrier, which may be subject to some instability, is encoded at a symbol rate which is generated at a lower frequency than the hf, but which is reliably stable. The receiver detects the phase of each received hf pulse, and generates a phase-locked signal which is synchronized to the transmitter symbol signal. The phase-locked signal in turn is used to demodulate the received pulsed signals. In a specific DSP embodiment, the phase-lock loop has a numerically controlled oscillator which has a center frequency which corresponds to the aliased phase difference between the hf carrier phase and the phase of each pulse, thereby obtaining a signal which carries information as to the exact symbol rate. This information is used either to calculate the timing of a narrow window which gates a pulse detector coincident with each next expected symbol time, or to trigger generation of a replica signal which is used in the detect circuit, thereby providing high resolution detection of the pulses and good noise rejection.

摘要翻译： 提供了一种具有接收器的遥测系统，其能够以抑制可能存在于高频带宽内的噪声的方式检测脉冲高频数据（hf）信号。 可能受到一些不稳定性的发射机载波以以比hf低的频率产生的符号速率被编码，但是其可靠地稳定。 接收机检测每个接收到的hf脉冲的相位，并产生与发射机符号信号同步的锁相信号。 锁相信号依次用于解调所接收的脉冲信号。 在特定DSP实施例中，锁相环具有数控振荡器，其具有对应于hf载波相位和每个脉冲的相位之间的混叠相位差的中心频率，从而获得载有关于 精确符号率。 该信息用于计算与每个下一个预期符号时间一致的脉冲检测器的窄窗口的定时，或者触发在检测电路中使用的复制信号的产生，从而提供脉冲的高分辨率检测 和良好的噪音抑制。

公开(公告)号：US07069078B2

公开(公告)日：2006-06-27

申请号：US10127033

申请日：2002-04-22

申请人： Richard Houben

发明人： Richard Houben

IPC分类号： A61N1/365

CPC分类号： A61B5/14532 ,  A61B5/0031 ,  A61N1/362

摘要： An implanted medical device may detect the onset of impaired glucose tolerance or Type II diabetes. The implanted medical device may have additional functionality. For example, the implanted medical device may be a pacemaker or a pressure monitor, but may also monitor insulin-mediated glucose uptake by processing electrical signals from the heart. An implanted medical device that monitors insulin-mediated glucose uptake may be implanted in a patient who has not been diagnosed with impaired glucose tolerance or Type II diabetes, and may give the patient early warning if these conditions develop.

公开(公告)号：US5741211A

公开(公告)日：1998-04-21

申请号：US548784

申请日：1995-10-26

申请人： Alexis C. M. Renirie ,  Richard Houben ,  Frank van Leeuwen

发明人： Alexis C. M. Renirie ,  Richard Houben ,  Frank van Leeuwen

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  Y10S128/92

摘要： A system and method for sensing and providing an indication of one or more diabetes-related blood constituents of a patient, the system being based upon an ECG sensor which processes patient ECG signals, either surface, or intracardiac or epicardial, for determining a measure of a blood constituent such as insulin or glucose, or both insulin and glucose. The system has processing capability for correlating selected parameters of the ECG signal with patient blood insulin or blood glucose, to provide the insulin or glucose level. Additionally, the system is provided with input capability for enabling the patient to input data such as the time of meal intake, which is representative of glucose intake, which data is incorporated in making a determination of patient insulin need. The system can be in a first external wearable embodiment, or in a second implantable embodiment which utilizes a pacing-type lead for picking up intracardiac or epicardial signals. In either the wearable or implantable embodiment, the output response may be simply an indication of patient insulin and/or glucose need provided by an external display, and may also include automatic control of insulin injection to the patient.

摘要翻译： 一种用于感测和提供患者的一种或多种与糖尿病相关的血液成分的指示的系统和方法，所述系统基于处理患者ECG信号（表面或心内或心外膜）的ECG传感器，用于确定 血液成分如胰岛素或葡萄糖，或胰岛素和葡萄糖两者。 该系统具有将ECG信号的选定参数与患者血液胰岛素或血糖相关联的处理能力，以提供胰岛素或葡萄糖水平。 此外，该系统具有输入能力，使得患者能够输入诸如饮食时间的数据，其代表葡萄糖摄取，该数据被纳入以确定患者胰岛素需要。 该系统可以在第一外部穿戴性实施例中，或者在利用起搏型引线拾取心内或心外膜信号的第二可植入实施例中。 在可穿戴或可植入的实施例中，输出响应可以简单地是由外部显示器提供的患者胰岛素和/或葡萄糖需求的指示，并且还可以包括对患者的胰岛素注射的自动控制。

公开(公告)号：US20100010393A1

公开(公告)日：2010-01-14

申请号：US12169448

申请日：2008-07-08

申请人： Niall Duffy ,  Richard Houben ,  Ashish Varma ,  Sean Whelan

发明人： Niall Duffy ,  Richard Houben ,  Ashish Varma ,  Sean Whelan

IPC分类号： A61N7/00

CPC分类号： A61N7/02 ,  A61B17/22004 ,  A61B2017/00106 ,  A61B2017/00703

摘要： An apparatus for treating an occlusion in a vessel inside of a patient. The apparatus includes an external high intensity focused ultrasound transducer configured to be positioned outside of the vessel and to emit ultrasonic waves of energy to the occlusion and to detect ultrasonic waves of energy, an internal ultrasound transducer configured to be positioned inside of the vessel at a position adjacent to or inside the occlusion and to emit ultrasonic waves of energy for detection by the external high intensity focused ultrasound transducer, and a controller configured to control the ultrasonic waves of energy emitted by the external high intensity focused ultrasound transducer based on an electrocardiogram of the patient.

摘要翻译： 一种用于治疗患者体内血管闭塞的装置。 该装置包括外部高强度聚焦超声波换能器，其被配置为位于血管外部并且向闭塞发射能量的超声波并检测能量的超声波;内部超声波换能器被配置为定位在血管内部 位于与闭塞相邻或内部的位置，并且发射超声波能量以供外部高强度聚焦超声波换能器检测;以及控制器，被配置为基于外部高强度聚焦超声波换能器的心电图 患者。

公开(公告)号：US06484054B2

公开(公告)日：2002-11-19

申请号：US09879282

申请日：2001-06-12

申请人： Koen J. Weijand ,  Richard Houben

发明人： Koen J. Weijand ,  Richard Houben

IPC分类号： A61N100

CPC分类号： H01L29/66181 ,  A61N1/05 ,  H01L27/0805 ,  H01L29/945

摘要： Floating and non-floating on-chip capacitors are formed by vertical walls and/or large aspect ratio deep trenches disposed in semiconductor material. By optimizing the through spacing and substrate voltage, a very small parasitic to intended capacitance ratio may be obtained. Capacitors so formed may be used as on-chip charge storage and other types of on-chip capacitors, and eliminate or reduce the number of off-chip capacitors that would otherwise be required. The deep trench capacitors find particularly efficacious application in implantable medical devices where volume, cost and electrical energy consumption must be minimized, and preferably have capacitances which range between about 10 nF and about 1000 uF.

摘要翻译： 浮置和非浮动片上电容器由设置在半导体材料中的垂直壁和/或大纵横比深沟槽形成。 通过优化通过间隔和衬底电压，可以获得非常小的寄生到预期电容比。 如此形成的电容器可以用作片上电荷存储和其他类型的片上电容器，并且消除或减少否则将要求的片外电容器的数量。 深沟槽电容器在体积，成本和电能消耗必须最小化的可植入医疗设备中特别有效，并且优选地具有介于约10nF至约1000uF之间的电容。