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公开(公告)号：US08093253B2
公开(公告)日：2012-01-10
申请号：US12390725
申请日：2009-02-23
申请人： Romyr Dominique , Robert Alan Goodnow, Jr. , Agnieszka Kowalczyk , Jianping Lou , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
发明人： Romyr Dominique , Robert Alan Goodnow, Jr. , Agnieszka Kowalczyk , Jianping Lou , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
IPC分类号： A01N43/54
CPC分类号： C07C317/22 , C07C317/36 , C07C2601/02 , C07C2601/16 , C07D209/12 , C07D213/34 , C07D231/12 , C07D239/26 , C07D239/38 , C07D277/26 , C07D277/62 , C07D307/80 , C07D317/46 , C07D317/56 , C07D319/18 , C07D333/18
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.
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公开(公告)号：US20090253684A1
公开(公告)日：2009-10-08
申请号：US12326349
申请日：2008-12-02
申请人： Romyr Dominique , Robert Alan Goodnow, JR. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
发明人： Romyr Dominique , Robert Alan Goodnow, JR. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
IPC分类号： A61K31/551 , C07C265/08 , A61K31/26 , C07D213/04 , A61K31/44 , C07D333/22 , A61K31/381 , C07D317/46 , A61K31/357 , C07D265/36 , A61K31/538 , C07D319/16 , A61K31/352 , C07D307/02 , A61K31/341 , C07D405/10 , A61K31/496 , C07D403/10 , A61P11/00 , A61K31/4535 , C07D409/10 , A61K31/443 , A61K31/4525 , A61K31/5377 , C07D407/10 , C07D413/10 , A61K31/495 , C07D401/10 , A61K31/4025 , C07D243/08
CPC分类号： C07D319/18 , C07C233/66 , C07C233/67 , C07C235/46 , C07D317/60
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如COPD的疾病。
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公开(公告)号：US07989454B2
公开(公告)日：2011-08-02
申请号：US12326349
申请日：2008-12-02
申请人： Romyr Dominique , Robert Alan Goodnow, Jr. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
发明人： Romyr Dominique , Robert Alan Goodnow, Jr. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
IPC分类号： A61K31/497 , C07D241/04
CPC分类号： C07D319/18 , C07C233/66 , C07C233/67 , C07C235/46 , C07D317/60
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如COPD的疾病。
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公开(公告)号：US08088936B2
公开(公告)日：2012-01-03
申请号：US12720822
申请日：2010-03-10
申请人： Romyr Dominique , Robert Alan Goodnow, Jr. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
发明人： Romyr Dominique , Robert Alan Goodnow, Jr. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
IPC分类号： C07D317/44 , A61K31/405
CPC分类号： C07C59/68 , C07C59/90 , C07D209/08 , C07D213/38 , C07D213/61 , C07D239/26 , C07D277/24 , C07D317/54 , C07D317/58 , C07D319/18 , C07D333/16 , C07D333/20 , C07D333/24
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.
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公开(公告)号：US20100240678A1
公开(公告)日：2010-09-23
申请号：US12720822
申请日：2010-03-10
申请人： Romyr Dominique , Robert Alan Goodnow, JR. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
发明人： Romyr Dominique , Robert Alan Goodnow, JR. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
IPC分类号： A61K31/505 , C07D317/46 , A61K31/357 , C07C59/31 , A61K31/194 , C07D333/10 , A61K31/381 , C07D319/14 , C07C317/14 , C07D239/24 , C07D209/04 , A61K31/404 , C07C229/34 , A61K31/195 , C07D213/55 , A61K31/44 , C07D277/62 , A61K31/428 , A61P29/00 , A61P11/06 , A61P11/00
CPC分类号： C07C59/68 , C07C59/90 , C07D209/08 , C07D213/38 , C07D213/61 , C07D239/26 , C07D277/24 , C07D317/54 , C07D317/58 , C07D319/18 , C07D333/16 , C07D333/20 , C07D333/24
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如COPD的疾病
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公开(公告)号：US08093385B2
公开(公告)日：2012-01-10
申请号：US12180738
申请日：2008-07-28
申请人： Romyr Dominique , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri
发明人： Romyr Dominique , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri
IPC分类号： C07D403/00 , C07D231/00 , C07D239/42 , C07C59/40 , A61K31/19 , A61K31/44
CPC分类号： C07C59/68 , C07C217/80 , C07C229/34 , C07C323/56 , C07D209/12 , C07D213/30 , C07D213/61 , C07D215/14 , C07D239/26 , C07D239/54 , C07D317/54 , C07D319/18 , C07D333/20 , C07D405/10 , C07D409/10 , C07D409/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如COPD。
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公开(公告)号：US20090054466A1
公开(公告)日：2009-02-26
申请号：US12180738
申请日：2008-07-28
申请人： Romyr Dominique , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri
发明人： Romyr Dominique , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri
IPC分类号： A61K31/506 , A61K31/444 , C07D401/10 , A61K31/194 , C07C59/235 , C07D403/10
CPC分类号： C07C59/68 , C07C217/80 , C07C229/34 , C07C323/56 , C07D209/12 , C07D213/30 , C07D213/61 , C07D215/14 , C07D239/26 , C07D239/54 , C07D317/54 , C07D319/18 , C07D333/20 , C07D405/10 , C07D409/10 , C07D409/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如COPD的疾病
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公开(公告)号：US06388084B1
公开(公告)日：2002-05-14
申请号：US09717684
申请日：2000-11-21
IPC分类号： C07D21172
CPC分类号： C07D213/64
摘要： Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
摘要翻译： 式I的化合物具有作为VCAM-1与表达VLA-4的细胞之间结合的抑制剂的活性，并且可用于治疗其症状和/或损伤与VCAM-1与表达VLA-4的细胞结合相关的疾病。
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公开(公告)号：US06380387B1
公开(公告)日：2002-04-30
申请号：US09717912
申请日：2000-11-21
IPC分类号： C07D23954
CPC分类号： C07D239/54 , A61K38/00 , C07K5/06165
摘要： Compounds of Formula I are disclosed, having activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
摘要翻译： 公开了具有作为VCAM-1与表达VLA-4的细胞之间结合的抑制剂的活性的式I化合物，因此可用于治疗其症状和/或损伤与VCAM-1与表达VLA-4的细胞结合相关的疾病 。
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公开(公告)号：US06916933B2
公开(公告)日：2005-07-12
申请号：US10670182
申请日：2003-09-24
IPC分类号： C07D213/64 , C07D213/70 , C07D211/72 , C07D401/00 , C07D405/00 , C07D417/00
CPC分类号： C07D213/64
摘要： Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
摘要翻译： 式I的化合物具有作为VCAM-1与表达VLA-4的细胞之间结合的抑制剂的活性，并且可用于治疗其症状和/或损伤与VCAM-1与表达VLA-4的细胞结合相关的疾病。
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