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公开(公告)号：US20090071477A1
公开(公告)日：2009-03-19
申请号：US12275836
申请日：2008-11-21
申请人： Ron L. Hale , Soonho Song , Reynaldo J. Quintana , Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Soonho Song , Reynaldo J. Quintana , Joshua D. Rabinowitz , Alejandro C. Zaffaroni
CPC分类号： A61M15/06 , A24F47/006 , A61M11/041 , A61M11/042 , A61M11/047 , A61M2205/8268 , F24V30/00
摘要： Disclosed is a method and device for rapid heating of a substance. One embodiment includes a substance including a drug to be vaporized for inhalation therapy. A sealed fuel cell containing a combustible filament is placed in a heat exchange relationship with the substance. An igniter is operatively associated with the combustible element. The substance may be vaporized inside of a housing to allow the vaporized drug to aerosolize and be inhaled by a user.
摘要翻译： 公开了一种快速加热物质的方法和装置。 一个实施方案包括包含待蒸发的药物用于吸入治疗的物质。 将含有可燃灯丝的密封燃料电池置于与物质的热交换关系中。 点火器可操作地与可燃元件相关联。 物质可以在壳体内蒸发以允许蒸发的药物雾化并被使用者吸入。
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公开(公告)号：US07987846B2
公开(公告)日：2011-08-02
申请号：US12275836
申请日：2008-11-21
申请人： Ron L. Hale , Soonho Song , Reynaldo J. Quintana , Joshua D. Rabinowitz , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Soonho Song , Reynaldo J. Quintana , Joshua D. Rabinowitz , Alejandro C. Zaffaroni
IPC分类号： A61M11/00
CPC分类号： A61M15/06 , A24F47/006 , A61M11/041 , A61M11/042 , A61M11/047 , A61M2205/8268 , F24V30/00
摘要： Disclosed is a method and device for rapid heating of a substance. One embodiment includes a substance including a drug to be vaporized for inhalation therapy. A sealed fuel cell containing a combustible filament is placed in a heat exchange relationship with the substance. An igniter is operatively associated with the combustible element. The substance may be vaporized inside of a housing to allow the vaporized drug to aerosolize and be inhaled by a user.
摘要翻译： 公开了一种快速加热物质的方法和装置。 一个实施方案包括包含待蒸发的药物用于吸入治疗的物质。 将含有可燃灯丝的密封燃料电池置于与物质的热交换关系中。 点火器可操作地与可燃元件相关联。 物质可以在壳体内蒸发以允许蒸发的药物雾化并被使用者吸入。
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公开(公告)号：US07458374B2
公开(公告)日：2008-12-02
申请号：US10146086
申请日：2002-05-13
申请人： Ron L. Hale , Soonho Song , Reynaldo J. Quintana , Alejandro C. Zaffaroni , Joshua D. Rabinowitz
发明人： Ron L. Hale , Soonho Song , Reynaldo J. Quintana , Alejandro C. Zaffaroni , Joshua D. Rabinowitz
IPC分类号： A61M11/00
CPC分类号： A61M15/06 , A24F47/006 , A61M11/041 , A61M11/042 , A61M11/047 , A61M2205/8268 , F24V30/00
摘要： Disclosed is a method and device for rapid heating of a coated substance which preferably includes a drug to vaporized for inhalation therapy. A device in accordance with the present invention preferably includes a substrate which has an interior surface surrounding an interior region and an exterior surface upon which the coated substance is to be adhered. Though the substrate is preferably metallic, it does not need to be. A combustible element is placed in the interior region of the rigid substrate and an igniter is connected to the combustible element. The igniter is for initiating oxidation of the combustible element. Preferably, the coated substance is vaporized inside of a housing to allow the vaporized drug to aerosolize and be inhaled by a user.
摘要翻译： 公开了一种用于快速加热涂覆物质的方法和装置，其优选包括用于吸入治疗的蒸发药物。 根据本发明的装置优选地包括具有包围内部区域的内表面的基板和待附着被涂物质的外表面。 虽然基材优选为金属，但不需要。 可燃元件被放置在刚性基板的内部区域中，并且点火器连接到可燃元件。 点火器用于启动可燃元件的氧化。 优选地，涂覆的物质在壳体内蒸发以允许蒸发的药物雾化并被使用者吸入。
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公开(公告)号：US07011819B2
公开(公告)日：2006-03-14
申请号：US10792096
申请日：2004-03-03
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/192 , A61K31/196 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , F24V30/00 , Y10S514/958
摘要： The present invention relates to the delivery of headache and anti-migraine compounds through an inhalation route. Specifically, it relates to aerosols containing that are used in inhalation therapy. In a method aspect of the present invention, rizatriptan or zolmitriptan is administered to a patient through an inhalation route. The method comprises: a) heating a composition, comprising rizatriptan or zolmitriptan to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol with less than 5% of the drug degradation products. In a kit aspect of the present invention, a kit for delivering rizatriptan or zolmitriptan through an inhalation route is provided which comprises: a) a thin coating of a rizatriptan or zolmitriptan composition; and, b) a device for dispending said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送头痛和抗偏头痛化合物。 具体地说，它涉及含有用于吸入治疗的气溶胶。 在本发明的方法方面，利扎曲坦或佐米曲坦通过吸入途径给予患者。 该方法包括：a）加热包含利扎曲坦或佐米曲坦的组合物以形成蒸气; 和b）允许蒸气冷却，由此形成少于药物降解产物的5％的凝结气雾剂。 在本发明的试剂盒方面，提供了用于通过吸入途径输送利扎曲坦或佐米曲坦的试剂盒，其包括：a）利扎曲坦或唑来曲坦组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。
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公开(公告)号：US20130032139A1
公开(公告)日：2013-02-07
申请号：US13569006
申请日：2012-08-07
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
IPC分类号： A61M11/04
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided, wherein the device, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Methods for use are also disclosed.
摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时快速加热涂覆有厚度为0.05至20μm的药物薄膜的基材，形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气雾剂的装置的试剂盒，其中所述装置具有用于加热药物的元件，所述元件作为膜涂覆在基底上并且当施用药物时含有治疗有效剂量的药物 气溶胶形式，以及允许蒸汽冷却以形成气溶胶的元素。 还公开了使用方法。
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公开(公告)号：US08235037B2
公开(公告)日：2012-08-07
申请号：US12117737
申请日：2008-05-08
申请人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
发明人： Ron L. Hale , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时快速加热涂覆有厚度为0.05至20μm的药物薄膜的基材，形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。 包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件 以形成气溶胶。 还公开了使用这些气溶胶和试剂盒的方法。
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公开(公告)号：US20110244020A1
公开(公告)日：2011-10-06
申请号：US13078516
申请日：2011-04-01
申请人： Ron L. HALE , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
发明人： Ron L. HALE , Craig C. Hodges , Peter M. Lloyd , Amy T. Lu , Daniel J. Myers , Joshua D. Rabinowitz , Martin J. Wensley , Jeffrey A. McKinney , Alejandro C. Zaffaroni
IPC分类号： A61K9/70 , A61K31/551 , A61K31/445 , A61K31/554 , A61K31/5415 , A61K31/519 , A61P25/04 , A61P25/00 , A61P25/18
CPC分类号： A61K9/0004 , A61K9/007 , A61K9/0078 , A61K9/12 , A61K31/4468 , A61K31/519 , A61K31/5415 , A61K31/5517 , A61K31/553 , A61M11/002 , A61M11/005 , A61M11/04 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M2207/00
摘要： The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
摘要翻译： 本发明提供用于治疗疾病和/或间歇或急性病症的新型凝结气溶胶。 这些凝结气溶胶几乎没有或没有热解降解产物，其特征在于MMAD为1-3微米。 这些气溶胶是通过在使薄膜上的气体通过膜的同时快速加热涂覆有厚度为0.05至20μm的药物薄膜的基材，以形成用于吸入的理想颗粒尺寸的颗粒。 还提供了包含药物和用于产生冷凝气溶胶的装置的试剂盒。 包含在试剂盒中的装置通常具有用于加热药物的元件，其作为膜被涂覆在基底上并且当药物以气溶胶形式施用时含有治疗有效剂量的药物，以及允许蒸气冷却的元件 以形成气溶胶。 还公开了使用这些气溶胶和试剂盒的方法。
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8.发明授权Delivery of compounds for the treatment of headache through an inhalation route 有权输送化合物用于通过吸入途径治疗头痛公开(公告)号：US07498019B2
公开(公告)日：2009-03-03
申请号：US11385992
申请日：2006-03-21
CPC分类号： A61K9/007 , A61K9/0073 , A61K31/405 , Y10S514/958
摘要： The present invention relates to the delivery of migraine headache drugs through an inhalation route. Specifically, it relates to aerosols containing migraine headache drugs that are used in inhalation therapy.
摘要翻译： 本发明涉及通过吸入途径递送偏头痛药物。 具体来说，它涉及含有用于吸入治疗的偏头痛药物的气溶胶。
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公开(公告)号：US07018621B2
公开(公告)日：2006-03-28
申请号：US10792012
申请日：2004-03-03
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/192 , A61K31/196 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , F24V30/00 , Y10S514/958
摘要： The present invention relates to the delivery of compounds for the treatment of migraine and headache through an inhalation route. Specifically, it relates to aerosols containing rizatriptan or zolmitriptan that are used in inhalation therapy. In a method aspect of the present invention, rizatriptan or zolmitriptan is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of rizatriptan or zolmitriptan on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering rizatriptan or zolmitriptan through an inhalation route is provided which comprises: a) a thin coating of a rizatriptan or zolmitriptan composition; and, b) a device for dispending said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及用于通过吸入途径治疗偏头痛和头痛的化合物的递送。 具体地说，它涉及用于吸入治疗的含有利扎曲坦或唑来曲坦的气溶胶。 在本发明的方法方面，利扎曲坦或佐米曲坦通过吸入途径给予患者。 该方法包括：a）将固体支持物上的利扎曲坦或唑来曲坦的薄层加热以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了用于通过吸入途径输送利扎曲坦或佐米曲坦的试剂盒，其包括：a）利扎曲坦或唑来曲坦组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。
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10.发明授权Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route 失效通过吸入途径递送舒马曲坦，呋喃曲坦或纳拉曲坦公开(公告)号：US07014840B2
公开(公告)日：2006-03-21
申请号：US10792239
申请日：2004-03-03
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of anti-migraine compounds through an inhalation route. Specifically, it relates to aerosols containing sumatriptan, frovatriptan, or naratriptan that are used in inhalation therapy. In a method aspect of the present invention, one of sumatriptan, frovatriptan, or naratriptan is administered to a patient through an inhalation route. The method comprises: a) heating a composition, comprising sumatriptan, frovatriptan, or naratriptan, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol with less than 5% of the drug degradation products. In a kit aspect of the present invention, a kit for delivering sumatriptan, frovatriptan, or naratriptan through an inhalation route is provided which comprises: a) a thin coating of a sumatriptan, frovatriptan, or naratriptan composition; and, b) a device for dispending said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送抗偏头痛化合物。 具体地说，它涉及用于吸入治疗的含有舒马曲坦，呋喃曲坦或纳拉曲坦的气溶胶。 在本发明的方法方面，通过吸入途径向患者施用舒马普坦，福来曲坦或纳拉曲坦中的一种。 该方法包括：a）加热组合物，其包含舒马曲坦，呋喃曲坦或纳拉曲坦，形成蒸气; 和b）允许蒸气冷却，由此形成少于药物降解产物的5％的凝结气雾剂。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送舒马曲坦，福来曲坦或纳拉曲坦的试剂盒，其包括：a）舒马曲坦，福布曲坦或纳拉曲坦组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。
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