公开(公告)号：US20120279873A1

公开(公告)日：2012-11-08

申请号：US13550176

申请日：2012-07-16

申请人： Ronald C. Chatelier ,  Dennis Rylatt

发明人： Ronald C. Chatelier ,  Dennis Rylatt

IPC分类号： C12Q1/54

CPC分类号： G01N33/54326 ,  G01N33/5438

摘要： An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.

摘要翻译： 提供了用于测量样品（例如血液）中特定成分（例如抗原）的存在或浓度的装置和方法中的粘合剂组合物。 在粘合剂组合物的一个示例性实施方案中，组合物包括粘合剂，水，泊洛沙姆和抗凝血剂。 粘合剂可以包括特定的性质，例如亲水的，压敏的，热活化的和/或水溶性的。 粘合剂是特别有用的，因为它可以帮助改善样品的流动。 例如，当该装置是免疫传感器时，粘合剂可以帮助防止血液在免疫传感器的腔室内凝结。 这样可以更有效和准确地测定样品的浓度。 提供可以使用组合物的组合物和装置的方法，以及使用该组合物的方法。

公开(公告)号：US08877034B2

公开(公告)日：2014-11-04

申请号：US12649509

申请日：2009-12-30

申请人： Ronald C. Chatelier ,  Dennis Rylatt ,  Linda Raineri ,  Alastair M. Hodges

发明人： Ronald C. Chatelier ,  Dennis Rylatt ,  Linda Raineri ,  Alastair M. Hodges

IPC分类号： G01N33/49 ,  G01N33/80 ,  G01N33/48 ,  G01N27/48

CPC分类号： G01N27/3272 ,  G01N27/3273 ,  G01N27/3274 ,  G01N27/48 ,  G01N33/49 ,  G01N33/80 ,  G01N2333/4737

摘要： Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.

摘要翻译： 用于确定血液样本的血细胞比容的方法，以及与之一起使用的装置和系统。 血细胞比容值可以单独测定，而且还可以用于确定样品中分析物的浓度。 在用于确定血液样品中的血细胞比容值的方法的一个示例性实施方案中，在具有工作和对电极的样品分析装置中提供体积的血液。 在电极之间施加电位，并计算样品进入器件的初始填充速度。 然后可以确定血液的血细胞比容，以及考虑到初始填充速度的分析物的浓度。 还提供利用初始填充速度来确定血细胞比容水平并进行分析物浓度测定的系统和装置。

公开(公告)号：US20110155584A1

公开(公告)日：2011-06-30

申请号：US12649509

申请日：2009-12-30

申请人： Ronald C. Chatelier ,  Dennis Rylatt ,  Linda Raineri ,  Alastair M. Hodges

发明人： Ronald C. Chatelier ,  Dennis Rylatt ,  Linda Raineri ,  Alastair M. Hodges

IPC分类号： G01N27/26

CPC分类号： G01N27/3272 ,  G01N27/3273 ,  G01N27/3274 ,  G01N27/48 ,  G01N33/49 ,  G01N33/80 ,  G01N2333/4737

摘要： Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.

摘要翻译： 用于确定血液样本的血细胞比容的方法，以及与之一起使用的装置和系统。 血细胞比容值可以单独测定，而且还可以用于确定样品中分析物的浓度。 在用于确定血液样品中的血细胞比容值的方法的一个示例性实施方案中，在具有工作和对电极的样品分析装置中提供体积的血液。 在电极之间施加电位，并计算样品进入器件的初始填充速度。 然后可以确定血液的血细胞比容，以及考虑到初始填充速度的分析物的浓度。 还提供利用初始填充速度来确定血细胞比容水平并进行分析物浓度测定的系统和装置。

公开(公告)号：US08758592B2

公开(公告)日：2014-06-24

申请号：US13550176

申请日：2012-07-16

申请人： Ronald C. Chatelier ,  Dennis Rylatt

发明人： Ronald C. Chatelier ,  Dennis Rylatt

IPC分类号： G01N27/327

CPC分类号： G01N33/54326 ,  G01N33/5438

摘要： An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.

摘要翻译： 提供了用于测量样品（例如血液）中特定成分（例如抗原）的存在或浓度的装置和方法中的粘合剂组合物。 在粘合剂组合物的一个示例性实施方案中，组合物包括粘合剂，水，泊洛沙姆和抗凝血剂。 粘合剂可以包括特定的性质，例如亲水的，压敏的，热活化的和/或水溶性的。 粘合剂是特别有用的，因为它可以帮助改善样品的流动。 例如，当该装置是免疫传感器时，粘合剂可以帮助防止血液在免疫传感器的腔室内凝结。 这样可以更有效和准确地测定样品的浓度。 提供可以使用组合物的组合物和装置的方法，以及使用该组合物的方法。

公开(公告)号：US08221994B2

公开(公告)日：2012-07-17

申请号：US12570268

申请日：2009-09-30

申请人： Ronald C. Chatelier ,  Dennis Rylatt

发明人： Ronald C. Chatelier ,  Dennis Rylatt

IPC分类号： G01N27/327

CPC分类号： G01N33/54326 ,  G01N33/5438

摘要： An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.

摘要翻译： 提供了用于测量样品（例如血液）中特定成分（例如抗原）的存在或浓度的装置和方法中的粘合剂组合物。 在粘合剂组合物的一个示例性实施方案中，组合物包括粘合剂，水，泊洛沙姆和抗凝血剂。 粘合剂可以包括特定的性质，例如亲水的，压敏的，热活化的和/或水溶性的。 粘合剂是特别有用的，因为它可以帮助改善样品的流动。 例如，当该装置是免疫传感器时，粘合剂可以帮助防止血液在免疫传感器的腔室内凝结。 这样可以更有效和准确地测定样品的浓度。 提供可以使用组合物的组合物和装置的方法，以及使用该组合物的方法。

公开(公告)号：US20120283358A1

公开(公告)日：2012-11-08

申请号：US13550114

申请日：2012-07-16

申请人： Ronald C. Chatelier ,  Dennis Rylatt

发明人： Ronald C. Chatelier ,  Dennis Rylatt

IPC分类号： C09J163/00 ,  C08K5/11 ,  C08K5/092 ,  C09J105/10

CPC分类号： G01N33/54326 ,  G01N33/5438

摘要： An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.

公开(公告)号：US20110073493A1

公开(公告)日：2011-03-31

申请号：US12570268

申请日：2009-09-30

申请人： Ronald C. Chatelier ,  Dennis Rylatt

发明人： Ronald C. Chatelier ,  Dennis Rylatt

IPC分类号： G01N33/50 ,  G01N27/26 ,  C09J171/00

CPC分类号： G01N33/54326 ,  G01N33/5438

摘要： An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.

摘要翻译： 提供了用于测量样品（例如血液）中特定成分（例如抗原）的存在或浓度的装置和方法中的粘合剂组合物。 在粘合剂组合物的一个示例性实施方案中，组合物包括粘合剂，水，泊洛沙姆和抗凝血剂。 粘合剂可以包括特定的性质，例如亲水的，压敏的，热活化的和/或水溶性的。 粘合剂是特别有用的，因为它可以帮助改善样品的流动。 例如，当该装置是免疫传感器时，粘合剂可以帮助防止血液在免疫传感器的腔室内凝结。 这样可以更有效和准确地测定样品的浓度。 提供可以使用组合物的组合物和装置的方法，以及使用该组合物的方法。

公开(公告)号：US09739745B2

公开(公告)日：2017-08-22

申请号：US13620448

申请日：2012-09-14

申请人： Alastair M. Hodges ,  Ronald C. Chatelier

发明人： Alastair M. Hodges ,  Ronald C. Chatelier

IPC分类号： G01N27/327

摘要： Methods for calculating an analyte concentration of a sample are provided. In one exemplary embodiment the method includes steps that are directed toward accounting for inaccuracies that occur as a result of temperature variations in a sample, a meter, or the surrounding environment. In another exemplary embodiment the method includes steps that are directed toward determining whether an adequate sample is provided in a meter because insufficient samples can result in inaccuracies. The methods that are provided can be incorporated into a variety of mechanisms, but they are primarily directed toward glucose meters for blood samples and toward meters for controls solutions.

公开(公告)号：US20130306493A1

公开(公告)日：2013-11-21

申请号：US13824308

申请日：2010-12-31

申请人： Ronald C. Chatelier ,  Alastair M. Hodges

发明人： Ronald C. Chatelier ,  Alastair M. Hodges

IPC分类号： G01N27/327

CPC分类号： G01N27/4163 ,  C12Q1/006 ,  C12Q1/025 ,  G01N27/30 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3274 ,  G01N27/413 ,  G01N33/49

摘要： Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, a sample including an analyte is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and a first analyte concentration is determined. A second analyte concentration value is calculated from the first analyte concentration value and corrected for temperature effects, fill time and capacitance to provide for a final analyte concentration value.

摘要翻译： 本文提供了用于确定样品中分析物浓度的方法以及与其一起使用的装置和系统。 在用于确定样品中分析物浓度的方法的一个示例性实施方案中，在具有工作电极和对电极的样品分析装置中提供包括分析物的样品。 在电极之间施加电位，并确定第一分析物浓度。 根据第一分析物浓度值计算第二分析物浓度值，并对温度影响，填充时间和电容进行校正以提供最终分析物浓度值。

公开(公告)号：US20130098763A1

公开(公告)日：2013-04-25

申请号：US13619241

申请日：2012-09-14

申请人： Ronald C. Chatelier ,  Alastair M. Hodges ,  Santhanagopalan Nandagopalan

发明人： Ronald C. Chatelier ,  Alastair M. Hodges ,  Santhanagopalan Nandagopalan

IPC分类号： C12Q1/00

CPC分类号： G01N27/4163 ,  C12Q1/006 ,  G01N27/3274

摘要： Methods of determining a corrected analyte concentration in view of some error source are provided herein. The methods can be utilized for the determination of various analytes and/or various sources of error. In one example, the method can be configured to determine a corrected glucose concentration in view of an extreme level of hematocrit found within the sample. In other embodiments, methods are provided for identifying various system errors and/or defects. For example, such errors can include partial-fill or double-fill situations, high track resistance, and/or sample leakage. Systems are also provided for determining a corrected analyte concentration and/or detecting some system error.