公开(公告)号：US20120279873A1

公开(公告)日：2012-11-08

申请号：US13550176

申请日：2012-07-16

申请人： Ronald C. Chatelier ,  Dennis Rylatt

发明人： Ronald C. Chatelier ,  Dennis Rylatt

IPC分类号： C12Q1/54

CPC分类号： G01N33/54326 ,  G01N33/5438

摘要： An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.

摘要翻译： 提供了用于测量样品（例如血液）中特定成分（例如抗原）的存在或浓度的装置和方法中的粘合剂组合物。 在粘合剂组合物的一个示例性实施方案中，组合物包括粘合剂，水，泊洛沙姆和抗凝血剂。 粘合剂可以包括特定的性质，例如亲水的，压敏的，热活化的和/或水溶性的。 粘合剂是特别有用的，因为它可以帮助改善样品的流动。 例如，当该装置是免疫传感器时，粘合剂可以帮助防止血液在免疫传感器的腔室内凝结。 这样可以更有效和准确地测定样品的浓度。 提供可以使用组合物的组合物和装置的方法，以及使用该组合物的方法。

公开(公告)号：US08877034B2

公开(公告)日：2014-11-04

申请号：US12649509

申请日：2009-12-30

申请人： Ronald C. Chatelier ,  Dennis Rylatt ,  Linda Raineri ,  Alastair M. Hodges

发明人： Ronald C. Chatelier ,  Dennis Rylatt ,  Linda Raineri ,  Alastair M. Hodges

IPC分类号： G01N33/49 ,  G01N33/80 ,  G01N33/48 ,  G01N27/48

CPC分类号： G01N27/3272 ,  G01N27/3273 ,  G01N27/3274 ,  G01N27/48 ,  G01N33/49 ,  G01N33/80 ,  G01N2333/4737

摘要： Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.

摘要翻译： 用于确定血液样本的血细胞比容的方法，以及与之一起使用的装置和系统。 血细胞比容值可以单独测定，而且还可以用于确定样品中分析物的浓度。 在用于确定血液样品中的血细胞比容值的方法的一个示例性实施方案中，在具有工作和对电极的样品分析装置中提供体积的血液。 在电极之间施加电位，并计算样品进入器件的初始填充速度。 然后可以确定血液的血细胞比容，以及考虑到初始填充速度的分析物的浓度。 还提供利用初始填充速度来确定血细胞比容水平并进行分析物浓度测定的系统和装置。

公开(公告)号：US20110155584A1

公开(公告)日：2011-06-30

申请号：US12649509

申请日：2009-12-30

申请人： Ronald C. Chatelier ,  Dennis Rylatt ,  Linda Raineri ,  Alastair M. Hodges

发明人： Ronald C. Chatelier ,  Dennis Rylatt ,  Linda Raineri ,  Alastair M. Hodges

IPC分类号： G01N27/26

CPC分类号： G01N27/3272 ,  G01N27/3273 ,  G01N27/3274 ,  G01N27/48 ,  G01N33/49 ,  G01N33/80 ,  G01N2333/4737

摘要： Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.

摘要翻译： 用于确定血液样本的血细胞比容的方法，以及与之一起使用的装置和系统。 血细胞比容值可以单独测定，而且还可以用于确定样品中分析物的浓度。 在用于确定血液样品中的血细胞比容值的方法的一个示例性实施方案中，在具有工作和对电极的样品分析装置中提供体积的血液。 在电极之间施加电位，并计算样品进入器件的初始填充速度。 然后可以确定血液的血细胞比容，以及考虑到初始填充速度的分析物的浓度。 还提供利用初始填充速度来确定血细胞比容水平并进行分析物浓度测定的系统和装置。

公开(公告)号：US08758592B2

公开(公告)日：2014-06-24

申请号：US13550176

申请日：2012-07-16

申请人： Ronald C. Chatelier ,  Dennis Rylatt

发明人： Ronald C. Chatelier ,  Dennis Rylatt

IPC分类号： G01N27/327

CPC分类号： G01N33/54326 ,  G01N33/5438

摘要： An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.

摘要翻译： 提供了用于测量样品（例如血液）中特定成分（例如抗原）的存在或浓度的装置和方法中的粘合剂组合物。 在粘合剂组合物的一个示例性实施方案中，组合物包括粘合剂，水，泊洛沙姆和抗凝血剂。 粘合剂可以包括特定的性质，例如亲水的，压敏的，热活化的和/或水溶性的。 粘合剂是特别有用的，因为它可以帮助改善样品的流动。 例如，当该装置是免疫传感器时，粘合剂可以帮助防止血液在免疫传感器的腔室内凝结。 这样可以更有效和准确地测定样品的浓度。 提供可以使用组合物的组合物和装置的方法，以及使用该组合物的方法。

公开(公告)号：US08221994B2

公开(公告)日：2012-07-17

申请号：US12570268

申请日：2009-09-30

申请人： Ronald C. Chatelier ,  Dennis Rylatt

发明人： Ronald C. Chatelier ,  Dennis Rylatt

IPC分类号： G01N27/327

CPC分类号： G01N33/54326 ,  G01N33/5438

摘要： An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.

摘要翻译： 提供了用于测量样品（例如血液）中特定成分（例如抗原）的存在或浓度的装置和方法中的粘合剂组合物。 在粘合剂组合物的一个示例性实施方案中，组合物包括粘合剂，水，泊洛沙姆和抗凝血剂。 粘合剂可以包括特定的性质，例如亲水的，压敏的，热活化的和/或水溶性的。 粘合剂是特别有用的，因为它可以帮助改善样品的流动。 例如，当该装置是免疫传感器时，粘合剂可以帮助防止血液在免疫传感器的腔室内凝结。 这样可以更有效和准确地测定样品的浓度。 提供可以使用组合物的组合物和装置的方法，以及使用该组合物的方法。

公开(公告)号：US20120283358A1

公开(公告)日：2012-11-08

申请号：US13550114

申请日：2012-07-16

申请人： Ronald C. Chatelier ,  Dennis Rylatt

发明人： Ronald C. Chatelier ,  Dennis Rylatt

IPC分类号： C09J163/00 ,  C08K5/11 ,  C08K5/092 ,  C09J105/10

CPC分类号： G01N33/54326 ,  G01N33/5438

摘要： An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.

公开(公告)号：US20110073493A1

公开(公告)日：2011-03-31

申请号：US12570268

申请日：2009-09-30

申请人： Ronald C. Chatelier ,  Dennis Rylatt

发明人： Ronald C. Chatelier ,  Dennis Rylatt

IPC分类号： G01N33/50 ,  G01N27/26 ,  C09J171/00

CPC分类号： G01N33/54326 ,  G01N33/5438

摘要： An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.

摘要翻译： 提供了用于测量样品（例如血液）中特定成分（例如抗原）的存在或浓度的装置和方法中的粘合剂组合物。 在粘合剂组合物的一个示例性实施方案中，组合物包括粘合剂，水，泊洛沙姆和抗凝血剂。 粘合剂可以包括特定的性质，例如亲水的，压敏的，热活化的和/或水溶性的。 粘合剂是特别有用的，因为它可以帮助改善样品的流动。 例如，当该装置是免疫传感器时，粘合剂可以帮助防止血液在免疫传感器的腔室内凝结。 这样可以更有效和准确地测定样品的浓度。 提供可以使用组合物的组合物和装置的方法，以及使用该组合物的方法。

公开(公告)号：US20120090998A1

公开(公告)日：2012-04-19

申请号：US13316006

申请日：2011-12-09

申请人： Dennis Rylatt ,  Sharon Leong

发明人： Dennis Rylatt ,  Sharon Leong

IPC分类号： G01N33/559 ,  G01N27/26

CPC分类号： B01D57/02 ,  G01N27/447 ,  G01N27/44756

摘要： A process for separating a cell type from a mixture of cell types by electrophoresis comprising providing a sample containing a mixture of cell types to a sample chamber of a membrane-based electrophoresis apparatus adapted to separate cells and applying an electric potential causing at least one cell type in the sample to be separated from other cells in the sample.

摘要翻译： 一种通过电泳从细胞类型混合物中分离细胞类型的方法，其包括将含有细胞类型混合物的样品提供到适于分离细胞并施加导致至少一个细胞的电势的基于膜的电泳装置的样品室 键入要与样品中其他细胞分离的样品。

公开(公告)号：US20110111425A1

公开(公告)日：2011-05-12

申请号：US13003752

申请日：2009-07-10

申请人： Dennis Rylatt ,  Alastair Hodges

发明人： Dennis Rylatt ,  Alastair Hodges

IPC分类号： G01N33/53 ,  C12M1/34 ,  G01N30/00

CPC分类号： G01N33/54366 ,  B01L3/5027 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0694 ,  C12Q1/001 ,  C12Q1/004 ,  C12Q1/005 ,  C12Q1/006 ,  C12Q1/26 ,  C12Q1/32 ,  G01N33/53 ,  G01N33/5302 ,  G01N33/5306 ,  G01N33/537 ,  G01N33/538 ,  G01N33/539 ,  G01N33/541 ,  G01N33/54393 ,  G01N33/558 ,  G01N33/581 ,  G01N33/66

摘要： Disclosed herein are devices for detecting the presence of a target analyte in a fluid sample. The biosensor device can comprise at least a reaction chamber and a detection chamber. The device can comprise a amplifying mechanism such that one target analyte molecule present in the fluid sample can lead to generation/activation of multiple detection agent molecules, and therefore, an amplified signal. Also disclosed are the methods of manufacturing and using such a biosensor device.

摘要翻译： 本文公开了用于检测流体样品中目标分析物的存在的装置。 生物传感器装置可以至少包括反应室和检测室。 该装置可以包括放大机制，使得存在于流体样品中的一个目标分析物分子可以导致多个检测剂分子的产生/激活，并因此导致放大的信号。 还公开了制造和使用这种生物传感器装置的方法。

公开(公告)号：US20100006452A1

公开(公告)日：2010-01-14

申请号：US12563091

申请日：2009-09-18

申请人： Alastair McIndoe Hodges ,  Ronald Chatelier ,  Dennis Rylatt

发明人： Alastair McIndoe Hodges ,  Ronald Chatelier ,  Dennis Rylatt

IPC分类号： C12Q1/00 ,  G01N27/26 ,  H05K3/00

CPC分类号： G01N33/5438 ,  G01N33/53 ,  G01N33/543 ,  G01N33/54326 ,  Y10T29/49124

摘要： Disclosed herein are methods and devices for detecting the presence of an analyte of interest. A biosensor device can include a reaction chamber and an electrochemical detection chamber. The reaction chamber can include at least one immobilized binding site and a probe conjugate adapted to bind to at least one of the target analyte and the immobilized binding site while the detection chamber can include electrodes for detecting an electrochemical reaction. If present, the target analyte in the fluid sample results in a change in the amount of probe conjugate bound in the reaction chamber, which can be detected electrochemically in the detection chamber.

摘要翻译： 本文公开了用于检测感兴趣的分析物的存在的方法和装置。 生物传感器装置可以包括反应室和电化学检测室。 反应室可以包括至少一个固定的结合位点和适于结合至少一种目标分析物和固定的结合位点的探针共轭体，同时检测室可以包括用于检测电化学反应的电极。 如果存在，则流体样品中的目标分析物导致在反应室中结合的探针结合物的量的变化，其可以在检测室中电化学检测。