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17 条记录 (耗时 0.051 秒)

    Intravenously administerable polyclonal immunoglobulin preparation containing IgM and method of manufacture
    2.
    发明授权
    Intravenously administerable polyclonal immunoglobulin preparation containing IgM and method of manufacture 失效
    含有IGM的生物体内免疫多核苷酸免疫球蛋白的制备及其制备方法

    公开(公告)号：US5190752A

    公开(公告)日：1993-03-02

    申请号：US380180

    申请日：1989-07-14

    申请人： Wolfgang Moller ,  Hebert Dichtelmuller ,  Norbert Kothe ,  Dieter Rudnick ,  Detlef Piechaczek

    发明人： Wolfgang Moller ,  Hebert Dichtelmuller ,  Norbert Kothe ,  Dieter Rudnick ,  Detlef Piechaczek

    IPC分类号： A61K38/00 ,  A61K39/395 ,  C07K16/12

    CPC分类号： A61K39/39591 ,  C07K16/12 ,  A61K38/00 ,  Y10S424/806 ,  Y10S530/863

    摘要： An intravenously administrable polyclonal immunoglobulin preparation for the treatment and prophylaxis of bacterial infections containing at least 50% by weight of IgM in terms of the total content of immunoglobulin, exhibiting a low anticomplementary activity, being stable in aqueous solution, and being free of viruses. It can also consist of or also contain a mixture of several monoclonal IgM antibodies. The source material for its manufacture is an immunoglobulin-containing fraction of human, animal, or bacterial provenance. The fraction is treated with an anion exchanger that is eluted with a saline or pH gradient and the eluate is optionally subjected to gel filtration, treated before or after the chromatography with .beta.-propiolactone and PEG 4000, and optionally heated. Treatment with .beta.-propiolactone and ultraviolet light, treatment with solvents and detergents, or pasteurization can also be conducted. Proteins, sugars, or mixtures of amino acids are optionally added to the preparation.

    摘要翻译： 一种静脉内施用的多克隆免疫球蛋白制剂，用于治疗和预防细菌感染，其以免疫球蛋白的总含量为基础，含有至少50重量％的IgM，表现出低抗补体活性，在水溶液中稳定，并且不含病毒。 它还可以由几种单克隆IgM抗体组成或也含有几种单克隆IgM抗体的混合物。 其制造的来源材料是人，动物或细菌来源的含免疫球蛋白的部分。 用阴离子交换剂处理级分，用阴离子交换剂用盐水或pH梯度洗脱，洗脱液任选进行凝胶过滤，在用β-丙内酯和PEG 4000进行色谱分离之前或之后进行处理，并任选加热。 也可以用β-丙内酯和紫外线处理，用溶剂和洗涤剂处理或巴氏消毒。 任选地将蛋白质，糖或氨基酸的混合物加入到制剂中。

    Method of preparing a high-purity, virus safe, biologically active transferrin preparation
    4.
    发明授权
    Method of preparing a high-purity, virus safe, biologically active transferrin preparation 失效
    制备高纯度，病毒安全，生物活性的转铁蛋白制剂的方法

    公开(公告)号：US5041537A

    公开(公告)日：1991-08-20

    申请号：US249807

    申请日：1988-09-27

    申请人： Ulf Bethke ,  Norbert Kothe ,  Dieter Rudnick ,  Wolfgang Moller ,  Michael Kloft

    发明人： Ulf Bethke ,  Norbert Kothe ,  Dieter Rudnick ,  Wolfgang Moller ,  Michael Kloft

    IPC分类号： A61K35/14 ,  A61K38/00 ,  A61K38/16 ,  A61L2/00 ,  C07K14/79 ,  C12N5/02

    CPC分类号： A61L2/0088 ,  C07K14/79 ,  A61K38/00

    摘要： To provide a simple method of preparing biologically active transferrin that can be employed on an industrial scale and that will result in extremely pure and natural transferrin containing no viruses and appropriate for both in-vitro and in-vivo applications, the .gamma.-globulins are precipitated from the fraction containing the transferrin, the precipitant is removed from the residual liquid by ultrafiltration or gel filtration, the liquid is adjusted to a prescribed ionic concentration and protein concentration and (a) treated with .beta.-propiolactone and the solution is subjected to ultraviolet radiation or (b) treated with specific detergents and subjected to ion-exchange chromatography, and the transferrin is concentrated and filtered sterile.

    摘要翻译： 为了提供一种制备生物活性转铁蛋白的简单方法，该方法可以在工业规模上使用，并且将导致非常纯的和天然的不含病毒的转铁蛋白并且适用于体外和体内应用，γ球蛋白沉淀 从含有转铁蛋白的级分中，通过超滤或凝胶过滤从残余液体中除去沉淀剂，将液体调节至规定的离子浓度和蛋白质浓度，（a）用β-丙内酯处理，并将溶液经受紫外线照射 或（b）用特定洗涤剂处理并进行离子交换层析，并将转铁蛋白浓缩并无菌过滤。

    Process for the sterile filtration of milk
    5.
    发明授权
    Process for the sterile filtration of milk 失效
    牛奶无菌过滤的方法

    公开(公告)号：US5576040A

    公开(公告)日：1996-11-19

    申请号：US282256

    申请日：1994-07-29

    申请人： Wolfgang Moller ,  Wolfgang Stephan ,  Henry Hies

    发明人： Wolfgang Moller ,  Wolfgang Stephan ,  Henry Hies

    IPC分类号： A23C7/04 ,  A23C9/142 ,  A23C9/146 ,  A23C9/20 ,  A23C9/14

    CPC分类号： A23C7/043 ,  A23C9/1422 ,  A23C9/1427 ,  A23C9/146 ,  A23C9/206 ,  A23C2210/208

    摘要： The present invention relates to a process for obtaining sterile milk, wherein the calcium ion content is reduced preferably to half of the naturally occurring amount by means, for example, of ion exchange or dialysis, and the milk is then filtered sterile, and if desired calcium ions are added again to restore the natural content.The product thus obtained has all of the biological activities as well as virtually the original composition, but it is free of bacteria, fungi and spores and will keep for a longer time.

    摘要翻译： 本发明涉及一种获得无菌奶的方法，其中通过例如离子交换或透析将钙离子含量优选降低至天然存在量的一半，然后将牛奶过滤灭菌，如果需要 再次加入钙离子以恢复天然成分。 由此获得的产品具有所有的生物活性以及实际上的原始组成，但是它没有细菌，真菌和孢子并且将保持更长的时间。

    Method for removing the bones from fish and an apparatus for carrying out the method
    8.
    发明授权
    Method for removing the bones from fish and an apparatus for carrying out the method 失效
    用于从鱼中除去骨骼的方法和用于执行该方法的装置

    公开(公告)号：US5871395A

    公开(公告)日：1999-02-16

    申请号：US744069

    申请日：1996-11-04

    申请人： Thomas Grabau ,  Ulrich Gutte ,  Wolfgang Moller

    发明人： Thomas Grabau ,  Ulrich Gutte ,  Wolfgang Moller

    IPC分类号： A22C25/16

    CPC分类号： A22C25/166

    摘要： The invention concerns a method for deboning fish of the mackerel family such as the Thunnus genus, the scomboid type and the like, and an apparatus for performing this method. Fish of this family have belly spokes extending along the full length of the backbone into the area of the belly cavity, so that conventional cutting free of the back and belly spokes will lead to a separation of the ribs from the remaining bone structure. To allow an accurate filetting of mackerel fish with their specific bone structure in the ventral cavity region, the invention suggests a slice of fish meat including the ribs to be cut free automatically by providing a computer controlled tool including a knife with a cutting edge diverging with respect to the conveying path of the fish, and a supporting element, which in combination with the knife allows the ribs to be cut away progressively while respecting the anatomical characteristics of the fish.

    摘要翻译： 本发明涉及一种鲭鱼类的de鱼类，诸如unn鱼类，id鱼类等的剔骨的方法，以及用于进行该方法的装置。 这个家庭的鱼具有沿着主干的全长延伸到腹腔区域的腹部轮辐，使得没有后腹部和腹部轮辐的常规切割将导致肋与剩余骨骼结构的分离。 为了允许在腹腔区域中具有特定骨骼结构的鲭鱼准确的捣实，本发明提出了一种鱼肉切片，包括通过提供计算机控制的工具自动切割的肋条，其包括具有与 相对于鱼的输送路径，以及支撑元件，其与刀的组合允许在相对于鱼的解剖特征的同时逐渐切除肋。

    Axial thrust bearing
    9.
    发明授权
    Axial thrust bearing 失效
    推力推力轴承

    公开(公告)号：US4241958A

    公开(公告)日：1980-12-30

    申请号：US73379

    申请日：1979-09-07

    申请人： Wolfgang Moller ,  Hans Schwarz

    发明人： Wolfgang Moller ,  Hans Schwarz

    IPC分类号： F16C17/06 ,  F16C27/08 ,  F16C37/00

    CPC分类号： F16C37/002 ,  F16C17/06 ,  F16C27/08

    摘要： An axial thrust bearing includes a plurality of circumferentially arranged segments. The segments are constrained in the circumferential direction by means of support plates disposed therebetween. The segments are elastically supported by means of individual spring elements mounted in a bearing body. The segments are provided with support ribs having tilting edges. The support ribs are supported between the support plates, and the tilting edges are supported against the spring elements. As a result, friction between the segments is minimized.

    摘要翻译： 轴向推力轴承包括多个周向布置的段。 通过设置在它们之间的支撑板，在圆周方向上限制所述段。 这些段通过安装在轴承体中的各个弹簧元件弹性支撑。 这些段设置有具有倾斜边缘的支撑肋。 支撑肋支撑在支撑板之间，并且倾斜边缘被支撑在弹簧元件上。 结果，段之间的摩擦力被最小化。