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公开(公告)号：US20100075891A1
公开(公告)日：2010-03-25
申请号：US11043770
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。 还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，其使用本发明的新型多肽和多核苷酸作为诊断标记。
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2.发明申请VARIANTS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) RECEPTOR AND USE THEREOF 审中-公开血管内皮生长因子（VEGF）受体及其用途的变异公开(公告)号：US20110212051A1
公开(公告)日：2011-09-01
申请号：US13037196
申请日：2011-02-28
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
IPC分类号： A61K38/19 , G01N33/53 , C07K16/28 , C07K14/535 , C07K7/06 , C07K14/715 , C07K14/47 , C07K14/735 , C07K14/475 , A61K38/17 , C07K16/24 , C07K16/22 , C12N9/66 , C07K16/40 , G01N33/573 , A61K38/48 , A61K38/18 , A61K38/08 , A61P31/00 , A61P19/08 , A61P9/00 , A61P27/02 , A61P13/12 , A61P35/00 , A61P3/04 , A61P3/10 , A61P19/10 , A61P9/10 , A61P9/04 , A61P11/00 , A61P7/02 , A61P7/04 , A61P29/00 , A61P37/06 , A61P1/18 , A61P27/14 , A61P31/10 , A61P31/20 , A61P31/22 , A61P31/18 , A61P31/14 , A61P35/04 , A61P1/16 , A61P3/00 , A61P37/02 , A61P13/00 , A61P25/00 , A61P25/28 , A61P25/16
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。 还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，其使用本发明的新型多肽和多核苷酸作为诊断标记。
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公开(公告)号：US07939634B2
公开(公告)日：2011-05-10
申请号：US11043770
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。 还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，使用本发明的新型多肽和多核苷酸作为诊断标记。
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公开(公告)号：US20110091454A1
公开(公告)日：2011-04-21
申请号：US12701651
申请日：2010-02-08
申请人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad S. Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
发明人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad S. Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
IPC分类号： A61K39/395 , C07K16/00 , G01N33/53 , A61P35/00
CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00
摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
摘要翻译： 提供多肽序列和多核苷酸序列。 还提供了关于这些序列的这些序列和用途的注释信息。
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公开(公告)号：US20060068405A1
公开(公告)日：2006-03-30
申请号：US11043860
申请日：2005-01-27
申请人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
发明人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00
摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
摘要翻译： 提供多肽序列和多核苷酸序列。 还提供了关于这些序列的这些序列和用途的注释信息。
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公开(公告)号：US20060147946A1
公开(公告)日：2006-07-06
申请号：US11051725
申请日：2005-01-27
申请人： Pinchas Akiva , Alexander Dlber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekhari , Zipi Shaged , Moshe Olshansky , Arial Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanquing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
发明人： Pinchas Akiva , Alexander Dlber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekhari , Zipi Shaged , Moshe Olshansky , Arial Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanquing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00
摘要： Novel alpha 1 subunit splice variants, including nucleic and amino acid sequences. Methods of use thereof are also described.
摘要翻译： 新的α1亚基剪接变体，包括核酸和氨基酸序列。 还描述了其使用方法。
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7.发明申请POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS 有权多肽和多核苷酸，以及作为药物和生物学药物目标的用途公开(公告)号：US20120134997A1
公开(公告)日：2012-05-31
申请号：US12676359
申请日：2008-09-03
申请人： Zurit Levine , Tania Pergam , Dalit Milo , Anat Cohen-Dayag , Amir Toporik , Yaron Kinar , Sergey Nemzer , Avi Rosenberg , Galit Rotman , Amit Novik , Cynthia Koifman , Merav Beiman , Liat Dassa , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Oler Levy , Marina Bubis
发明人： Zurit Levine , Tania Pergam , Dalit Milo , Anat Cohen-Dayag , Amir Toporik , Yaron Kinar , Sergey Nemzer , Avi Rosenberg , Galit Rotman , Amit Novik , Cynthia Koifman , Merav Beiman , Liat Dassa , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Oler Levy , Marina Bubis
IPC分类号： A61K39/395 , C07K19/00 , C12N15/11 , C12N15/62 , C12N15/63 , C12P21/02 , C12N1/21 , C12N5/10 , C12N1/19 , A61K38/00 , A61K31/7088 , A61K35/00 , A61P37/02 , A61P37/06 , A61P19/02 , A61P1/00 , A61P29/00 , C07K16/00 , C12N9/96 , A61P35/00 , A61P35/02 , A61P35/04 , G01N33/566 , C07K14/00
CPC分类号： C07K16/30 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K39/0008 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61N5/10 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K14/70503 , C07K14/82 , C07K16/28 , C07K2317/21 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C07K2319/70 , G01N33/564 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2500/04
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants which are suitable targets for immunotherapy, cancer therapy, and drug development.
摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供了针对VSIG1，ILDR1，LOC253012，AI216611，C1ORF32或FXYD3抗原的治疗性抗体，其是预测的共刺激家族成员，并且在包括肺癌，卵巢癌和结肠癌在内的癌症中差异表达， 诊断和治疗用途。 还提供了这些抗体用于调节B7共刺激和相关疗法（例如治疗自身免疫）的用途。 本发明还涉及VSIG1及其变体FXYD3及其变体ILDR1及其变体，LOC253012及其变体，AI216611及其变体和作为免疫治疗，癌症治疗的合适靶标的C1ORF32及其变体的细胞外结构域的发现 ，药物开发。
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公开(公告)号：US08415455B2
公开(公告)日：2013-04-09
申请号：US12676359
申请日：2008-09-03
申请人： Zurit Levine , Tania Pergam , Dalit Landesman-Milo , Anat Cohen-Dayag , Amir Toporik , Yaron Kinar , Sergey Nemzer , Avi Rosenberg , Galit Rotman , Amit Novik , Cynthia Koifman , Merav Beiman , Liat Dassa , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Ofer Levy , Marina Bubis
发明人： Zurit Levine , Tania Pergam , Dalit Landesman-Milo , Anat Cohen-Dayag , Amir Toporik , Yaron Kinar , Sergey Nemzer , Avi Rosenberg , Galit Rotman , Amit Novik , Cynthia Koifman , Merav Beiman , Liat Dassa , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Ofer Levy , Marina Bubis
CPC分类号： C07K16/30 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/0005 , A61K39/0008 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61N5/10 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K14/70503 , C07K14/82 , C07K16/28 , C07K2317/21 , C07K2317/76 , C07K2319/00 , C07K2319/30 , C07K2319/60 , C07K2319/70 , G01N33/564 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N2500/04
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants which are suitable targets for immunotherapy, cancer therapy, and drug development.
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9.发明申请POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS 审中-公开多肽和多核苷酸，以及作为药物和生物学药物目标的用途公开(公告)号：US20110311450A1
公开(公告)日：2011-12-22
申请号：US13131879
申请日：2009-12-08
申请人： Zurit Levine , Avi Rosenberg , Galit Rotman , Amit Novik , Amir Toporik , Yaron Kinar , Sergey Nemzer , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Liat Dassa , Merav Beiman , Anat Cohen-Dayag , Ofer Levy
发明人： Zurit Levine , Avi Rosenberg , Galit Rotman , Amit Novik , Amir Toporik , Yaron Kinar , Sergey Nemzer , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Liat Dassa , Merav Beiman , Anat Cohen-Dayag , Ofer Levy
IPC分类号： A61K49/00 , C12N9/96 , A61P35/00 , A61K39/395 , C40B30/04 , G01N33/574 , C07K16/30 , C12N5/078
CPC分类号： C07K16/28 , A61K38/00 , A61K39/39558 , A61K2039/505 , C07K14/47 , C07K16/30 , C07K16/3015 , C07K16/3038 , C07K16/3053 , C07K16/3061 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12Q1/6886 , C12Q2600/136 , G01N33/57484 , G01N33/577 , G01N2333/47
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTCAP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof.
摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供针对在癌症中差异表达的KRTCAP3，FAM26F，MGC52498，FAM70A或TMEM154抗原以及诊断和治疗用途的治疗性抗体。 本发明还涉及KRTCAP3，FAM26F，MGC52498，FAM70A和TMEM154蛋白质和变体的细胞外结构域及其治疗用途。
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