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公开(公告)号：US08598511B1
公开(公告)日：2013-12-03
申请号：US12398710
申请日：2009-03-05
申请人： Rudiger Schlaf , Joshua Schumacher
发明人： Rudiger Schlaf , Joshua Schumacher
IPC分类号： G21K5/04
CPC分类号： H01J49/0418 , G01N2560/00
摘要： This invention enables a sensitivity enhancement in the detection of molecular compounds. A mass spectrometry analyte support with nanotube anchors are used to concentrate MALDI samples, specifically samples prepared with water-insoluble matrix compounds, on the anchor spot. The surface structure is established through patterned carbon nanotube anchor growth, providing a nucleation center for analyte and reducing sample precipitation on the surrounding MALDI wafer. Also disclosed is a method of creating a mass spectrometry support using patterned metal catalyst to grow carbon nanotubes. The carbon nanotubes enhance nucleation on specific areas of a sample plate to concentrate analyte/matrix deposit during droplet evaporation.
摘要翻译： 本发明能够提高分子化合物的检测灵敏度。 使用纳米管锚的质谱分析物载体将MALDI样品（特别是用水不溶性基质化合物制备的样品）集中在锚点上。 表面结构通过图案化碳纳米管锚定生长建立，为分析物提供成核中心，并减少周围MALDI晶片上的样品沉淀。 还公开了使用图案化金属催化剂生长碳纳米管的质谱支持体的方法。 碳纳米管增强样品板的特定区域的成核，以在液滴蒸发期间浓缩分析物/基质沉积物。
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公开(公告)号：US10074530B1
公开(公告)日：2018-09-11
申请号：US15088843
申请日：2016-04-01
申请人： Rudiger Schlaf , Joshua Schumacher
发明人： Rudiger Schlaf , Joshua Schumacher
IPC分类号： H01J49/04 , C23C16/455 , H01J49/16
CPC分类号： H01J49/0418 , C23C16/455 , G01N2560/00 , H01J49/164
摘要： This invention enables a sensitivity enhancement in the detection of molecular compounds. A mass spectrometry analyte support with nanotube anchors are used to concentrate MALDI samples prepared with water-insoluble matrix compounds on the anchor spot. A matrix solution mixed with analyte molecules is spotted onto a specialized MALDI plate using carbon nanotubes to selectively nucleate the analyte. The spot diameter of the target is usually several orders of magnitude larger than traditional supports, and led to lateral concentration for non-aqueous based matrices and produced a final dried matrix/analyte spot that was approximately the diameter of the laser spot at the point of investigation. The carbon nanotubes enhance nucleation on specific areas of a sample plate to concentrate analyte/matrix deposit during droplet evaporation, and demonstrate an increase in signal to noise ratio and an improved detection capability of low analyte concentrations compared to the standard MALDI preparation technique.
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公开(公告)号：US06835613B2
公开(公告)日：2004-12-28
申请号：US10313886
申请日：2002-12-06
申请人： Rudiger Schlaf
发明人： Rudiger Schlaf
IPC分类号： H01L218238
CPC分类号： H01L51/0545 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/162 , C23C16/04 , C23C16/26 , C30B25/00 , C30B29/02 , C30B29/605 , G01N29/036 , G01N2291/0256 , G11C13/025 , G11C23/00 , H01L51/0048 , Y10S977/938
摘要： A method of producing an integrated circuit with a carbon nanotube is disclosed. The integrated circuit includes a source, a drain, and a gate, and the source and the drain are positioned on the gate. A catalytic material is deposited onto the source. The catalytic material is then subjected to chemical vapor deposition. This initiates growth of the carbon nanotube such that the carbon nanotube extends from the source. Next, the carbon nanotube is bent toward the integrated circuit such that the carbon nanotube extends between the source and the drain to render the circuit operable.
摘要翻译： 公开了一种制造具有碳纳米管的集成电路的方法。 集成电路包括源极，漏极和栅极，源极和漏极位于栅极上。 催化材料沉积在源上。 然后将催化材料进行化学气相沉积。 这引发碳纳米管的生长，使得碳纳米管从源极延伸。 接下来，碳纳米管朝向集成电路弯曲，使得碳纳米管在源极和漏极之间延伸以使电路可操作。
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4.发明授权Method of producing a branched carbon nanotube for use with an atomic force microscope 失效用原子力显微镜制造支链碳纳米管的方法公开(公告)号：US06871528B2
公开(公告)日：2005-03-29
申请号：US10413598
申请日：2003-04-14
申请人： Rudiger Schlaf , Zhifeng F. Ren , Jianguo Wen , David L. Carnahan
发明人： Rudiger Schlaf , Zhifeng F. Ren , Jianguo Wen , David L. Carnahan
IPC分类号： B05D5/12 , C01B31/02 , C23C8/00 , C23C16/04 , C23C16/26 , C30B25/00 , G01Q60/24 , G01Q70/12 , H01L51/30 , G01B5/28 , G01N13/16
CPC分类号： H01L51/0048 , C01B32/162 , C23C16/04 , C23C16/26 , C30B25/00 , C30B29/02 , C30B29/605 , G01Q70/12 , H01L51/0545 , Y10S977/876
摘要： A method of producing a branched carbon nanotube (CNT) is disclosed. The branched CNT is used with an atomic force microscope having a cantilever and a tip and that is able to measure a surface of a substrate as well as an undercut feature of the substrate that protrudes from the surface. A catalytic material is deposited onto the tip of the microscope, and the catalytic material is subjected to chemical vapor deposition. This initiates growth of a primary branch of the branched carbon nanotube such that the primary branch extends from the tip. A secondary branch is then introduced to extend from the primary branch and produce the branched carbon nanotube. The primary branch interacts with the surface of the substrate and the secondary branch interacts with the undercut feature.
摘要翻译： 公开了一种生产支链碳纳米管（CNT）的方法。 分支CNT与具有悬臂和尖端的原子力显微镜一起使用，并且能够测量衬底的表面以及从表面突出的衬底的底切特征。 将催化材料沉积在显微镜的尖端上，催化材料进行化学气相沉积。 这引发支链碳纳米管的主要分支的生长，使得主分支从尖端延伸。 然后引入次级分支以从主分支延伸并产生支化碳纳米管。 主分支与基底的表面相互作用，次分支与底切特征相互作用。
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公开(公告)号：US07906182B1
公开(公告)日：2011-03-15
申请号：US12353283
申请日：2009-01-14
申请人： Rudiger Schlaf
发明人： Rudiger Schlaf
IPC分类号： B05D1/04
CPC分类号： B05D1/04
摘要： A method of forming a smooth thin film on a substrate within a short deposition time, the method comprising introducing ionic substances (salts, acids, bases) to a polymeric solution to be sprayed. These ions attach to the polymer strands in solution, increasing their charge to mass ratio. This results in mutual repulsion of the strands during the spray process and produces a smooth film, even at relatively high polymeric solution concentrations. A side effect of this process is the introduction of impurities (the added ions) to the polymer thin film. The proper choice of ionic compound allows a dissolution step to be used to “clean” the polymer film after deposition, using the solubility characteristics of the thin film versus the ionic compound.
摘要翻译： 一种在短的沉积时间内在衬底上形成光滑薄膜的方法，该方法包括将离子物质（盐，酸，碱）引入待喷射的聚合物溶液中。 这些离子在溶液中附着到聚合物链上，从而增加其电荷与质量比。 这导致在喷涂过程中股线的相互排斥，即使在相对高的聚合物溶液浓度下也产生光滑的膜。 该方法的副作用是向聚合物薄膜引入杂质（添加的离子）。 离子化合物的适当选择允许溶解步骤用于沉积后的“清洁”聚合物膜，使用薄膜与离子化合物的溶解度特性。
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公开(公告)号：US20080171152A1
公开(公告)日：2008-07-17
申请号：US11841236
申请日：2007-08-20
IPC分类号： B01J19/08
CPC分类号： B05D1/60 , B05D1/04 , B05D3/0493
摘要： An electrospray (ES)-based deposition system enabling the coating an impervious substrate, such as a glass slide, with biological materials in a vacuum. Distilled water or a buffer is used as the solvent; no other solvents are used thereby eliminating hazardous waste from the process. Movement across differential pumping stages causes evaporation of the solvent occurs resulting in shrinkage of the remaining constituents with an increase of the charge density. The resulting ion beam enters a vacuum chamber and the beam impinges on the substrate, whereby a thin layer is deposited thereon. The spray can be focused to a specific area allowing patterning of the substrate if desired. The amount of coating can be controlled and a specified number of coats of the same or different molecules can be added to the surface.
摘要翻译： 基于电喷雾（ES）的沉积系统，其能够在真空中用生物材料涂覆不渗透的基底，例如载玻片。 使用蒸馏水或缓冲液作为溶剂; 不再使用其他溶剂，从而消除了该方法的危险废物。 不同泵送阶段的运动导致溶剂的蒸发发生，导致电荷密度增加导致剩余组分的收缩。 所得到的离子束进入真空室，并且光束撞击在基底上，由此在其上沉积薄层。 如果需要，喷雾可以聚焦到特定区域，允许基底图案化。 可以控制涂层的量，并且可以向表面加入指定数量的相同或不同分子的涂层。
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7.发明授权High aspect ratio tip atomic force microscopy cantilevers and method of manufacture 有权高纵横比尖端原子力显微镜悬臂梁及其制造方法公开(公告)号：US07181958B2
公开(公告)日：2007-02-27
申请号：US10905045
申请日：2004-12-13
申请人： Rudiger Schlaf
发明人： Rudiger Schlaf
IPC分类号： H21J27/00
摘要： The present invention provides a method for the selective growth of single carbon nanotubes (CNT) on the tip apex of a conventional cantilever. Selective CNT growth is established by coating the backside of a cantilever, having a through-hole at a tip apex, with a catalyst material followed by a cover layer. The exposed catalyst at the bottom of the hole at the apex of the cantilever induces growth of a single CNT at this location.
摘要翻译： 本发明提供了在常规悬臂的尖端顶端上选择性生长单碳纳米管（CNT）的方法。 选择性碳纳米管生长是通过涂覆悬臂的背面而形成的，该悬臂具有尖端顶部的通孔，催化剂材料随后是覆盖层。 在悬臂顶点处的孔底部的暴露的催化剂在该位置诱导单个CNT的生长。
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公开(公告)号：US07112816B2
公开(公告)日：2006-09-26
申请号：US10413621
申请日：2003-04-14
申请人： Rudiger Schlaf , Shekhar Bhansali
发明人： Rudiger Schlaf , Shekhar Bhansali
IPC分类号： H01L29/772
CPC分类号： H01L51/0545 , B82Y10/00 , B82Y30/00 , C23C16/26 , C23C16/56 , G01N29/036 , G01N2291/0256 , G11C13/025 , G11C23/00 , H01L51/0048 , Y10S977/748 , Y10S977/938
摘要： A carbon nanotube sensor and a method of producing the carbon nanotube sensor are disclosed. The sensor detects small particles and molecules. The sensor includes a gate, a source and a drain positioned on the gate, and a carbon nanotube grown from a catalytic material and extending from one of the source and the drain. The method includes the step of functionalizing an end of the carbon nanotube with a receptor. As such, the carbon nanotube is receptive to the small particles and molecules. The carbon nanotube is driven at a resonance, and the resonance of the carbon nanotube is measured when the end of the carbon nanotube is free of the small particles and the molecules. The method includes monitoring for a change in the resonance to detect the association of the small particles and molecules with the end of the carbon nanotube.
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公开(公告)号：US07759639B2
公开(公告)日：2010-07-20
申请号：US11841236
申请日：2007-08-20
CPC分类号： B05D1/60 , B05D1/04 , B05D3/0493
摘要： An electrospray (ES)-based deposition system enabling the coating an impervious substrate, such as a glass slide, with biological materials in a vacuum. Distilled water or a buffer is used as the solvent; no other solvents are used thereby eliminating hazardous waste from the process. Movement across differential pumping stages causes evaporation of the solvent occurs resulting in shrinkage of the remaining constituents with an increase of the charge density. The resulting ion beam enters a vacuum chamber and the beam impinges on the substrate, whereby a thin layer is deposited thereon. The spray can be focused to a specific area allowing patterning of the substrate if desired. The amount of coating can be controlled and a specified number of coats of the same or different molecules can be added to the surface.
摘要翻译： 一种基于电喷雾（ES）的沉积系统，其能够在真空中用生物材料涂覆不渗透的基底，例如载玻片。 使用蒸馏水或缓冲液作为溶剂; 不再使用其他溶剂，从而消除了该方法的危险废物。 不同泵送阶段的运动导致溶剂的蒸发发生，导致电荷密度增加导致剩余组分的收缩。 所得到的离子束进入真空室，并且光束撞击在基底上，由此在其上沉积薄层。 如果需要，喷雾可以聚焦到特定区域，允许基底图案化。 可以控制涂层的量，并且可以向表面加入指定数量的相同或不同分子的涂层。
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10.发明申请High Aspect Ratio Tip Atomic Force Microscopy Cantilevers and Method of Manufacture 有权高纵横比尖端原子力显微镜悬臂和制造方法公开(公告)号：US20050241374A1
公开(公告)日：2005-11-03
申请号：US10905045
申请日：2004-12-13
申请人： Rudiger Schlaf
发明人： Rudiger Schlaf
摘要： The present invention provides a method for the selective growth of single carbon nanotubes (CNT) on the tip apex of a conventional cantilever. Selective CNT growth is established by coating the backside of a cantilever, having a through-hole at a tip apex, with a catalyst material followed by a cover layer. The exposed catalyst at the bottom of the hole at the apex of the cantilever induces growth of a single CNT at this location.
摘要翻译： 本发明提供了在常规悬臂的尖端顶端上选择性生长单碳纳米管（CNT）的方法。 选择性碳纳米管生长是通过涂覆悬臂的背面而形成的，该悬臂具有尖端顶部的通孔，催化剂材料随后是覆盖层。 在悬臂顶点处的孔底部的暴露的催化剂在该位置诱导单个CNT的生长。
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