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72 条记录 (耗时 0.046 秒)

    Pyrimidine derivatives as selective inhibitors of COX-2
    9.
    发明授权
    Pyrimidine derivatives as selective inhibitors of COX-2 失效
    嘧啶衍生物作为COX-2的选择性抑制剂

    公开(公告)号：US06780870B2

    公开(公告)日：2004-08-24

    申请号：US10182788

    申请日：2002-07-31

    申请人： Malcolm Clive Carter ,  Alan Naylor ,  Jeremy John Payne ,  Neil Anthony Pegg

    发明人： Malcolm Clive Carter ,  Alan Naylor ,  Jeremy John Payne ,  Neil Anthony Pegg

    IPC分类号： C07D23942

    CPC分类号： C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

    摘要： The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: R1 and R2 are independently selected from H, or C1-6alkyl; R3 is C1-6alkyl or NH2; R4 is H or C1-6alkyl; A is a 5- or 6-membered aryl, or a 5- or 6-membered aryl substituted by one or more R5; R5 is halogen, C1-6alkyl, C1-6alkyl substituted by one ore more F, C1-6alkoxy, C1-6alkoxy substituted by one or more F, SO2NH2 or SO2C1-6alkyl; and n is 1 to 4.

    摘要翻译： 本发明提供式（I）化合物及其药学上可接受的衍生物，其中：R 1和R 2独立地选自H或C 1-6烷基; R 3是C 1-6烷基或NH 2; R 4是H或C 1-6烷基; A是5或6元芳基或被一个或多个R 5取代的5或6元芳基; R 5是卤素，C 1 -C 6烷基， 被一个或多个F，C 1-6烷氧基，被一个或多个F，SO 2 NH 2或SO 2 C 1-6烷基取代的C 1-6烷氧基取代的C 1-6烷基; andn是1到4。

    Chemical compounds
    10.
    发明授权
    Chemical compounds 失效

    公开(公告)号：US5023255A

    公开(公告)日：1991-06-11

    申请号：US493250

    申请日：1990-03-14

    申请人： Frank Ellis ,  Alan Naylor ,  Christopher J. Wallis ,  Ian Waterhouse

    发明人： Frank Ellis ,  Alan Naylor ,  Christopher J. Wallis ,  Ian Waterhouse

    IPC分类号： C12N9/99 ,  A61K31/53 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C281/02 ,  C07C281/06 ,  C07D233/64 ,  C07D253/06 ,  C07D281/02 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

    CPC分类号： C07D253/06

    摘要： Triazine derivatives of formula (I) ##STR1## or salts thereof, whereinR.sup.1 represents a halogen atom or a group selected from hydroxy; C.sub.1-8 alkyl C.sub.1-6 alkoxy; C.sub.1-3 alkoxy C.sub.1-3 alkoxy; phenoxy or phenyl C.sub.1-3 alkoxy, wherein the phenyl group is optionally substituted by a halogen atom or a group selected from C.sub.1-3 alkyl, C.sub.1-3 alkoxy, or hydroxy; fluoro C.sub.1-3 alkyl; cyano; --CO.sub.2 R.sup.3, wherein R.sup.3 represents a hydrogen atom or a C.sub.1-4 alkyl group; --CONR.sup.4 R.sup.5, wherein R.sup.4 and R.sup.5 each independently represents a hydrogen atom or a C.sub.1-4 alkyl group, or, together with the nitrogen atom to which they are attached, form a saturated 5- to 7- membered ring, which ring optionally contains one or more atoms selected from an oxygen or a sulphur atom, or a group selected from --NH-- or --N(CH.sub.3)--; andR.sup.2 represents a hydrogen or halogen atom, or a group selected from hydroxy, C.sub.1-6 alkyl or C.sub.1-6 alkoxy;are inhibitors of the enzyme 5-lipoxygenase.Processes for preparing the triazine derivatives of formula (I) and compositions containing them are also described.