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公开(公告)号：US4474757A
公开(公告)日：1984-10-02
申请号：US335574
申请日：1981-12-29
Applicant: Ruth Arnon , Michal Shapira , Gunhild Muller
Inventor： Ruth Arnon , Michal Shapira , Gunhild Muller
IPC: A61K39/145 , C07K14/11 , A61K39/00 , A61K37/02 , C07C103/52 , C07G7/00
CPC classification number: C07K14/005 , A61K39/12 , A61K39/145 , A61K39/385 , A61K2039/55566 , A61K2039/6037 , A61K2039/6093 , C12N2760/16022 , C12N2760/16034 , C12N2760/16134 , Y10S514/888 , Y10S530/806 , Y10S530/807 , Y10S530/826 , Y10S930/29
Abstract: There is provided a synthetic vaccine against influenza virus infections consisting of a synthetic peptide corresponding to a relevant antigenic fragment of the virus, which fragment is attached to a suitable carrier, such as a macromolecule. Effective vaccinations against a plurality of strains can be obtained when the antigenic fragment is one common to such strains. Such synthetic vaccines are produced by synthesizing peptides corresponding to such relevant antigenic fragments and coupling same to a suitable carrier, such as a macromolecule. There is also provided a process for the vaccination of mammals against influenza which comprises applying to said mammals an effective quantity of a vaccine according to the invention.
Abstract translation: 提供了针对流感病毒感染的合成疫苗，其由对应于病毒的相关抗原性片段的合成肽组成，该片段连接到合适的载体，例如大分子。 当抗原片段是这些菌株共有的时，可以获得针对多种菌株的有效疫苗接种。 通过合成对应于这些相关抗原片段的肽并将其与合适的载体如大分子偶联来制备这样的合成疫苗。 还提供了一种针对流感的哺乳动物接种疫苗的方法，其包括向所述哺乳动物施用有效量的根据本发明的疫苗。
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公开(公告)号：US08357789B2
公开(公告)日：2013-01-22
申请号：US12585600
申请日：2009-09-18
Applicant: Ruth Arnon , Sung-Ho Jeon , Basak Kayhan , Tamar Ben-Yedidia
Inventor： Ruth Arnon , Sung-Ho Jeon , Basak Kayhan , Tamar Ben-Yedidia
CPC classification number: C07H21/04 , C12N15/115 , C12N2310/16 , C12N2310/322 , G01N33/56983 , G01N2333/11
Abstract: Polynucleotides and polypeptides which participate in influenza virus infection of cells and nucleic acid molecules, which include a polynucleotide sequence capable of specifically binding the polypeptides of the present invention. Also provided are methods of using such nucleic acid molecules, polynucleotides and antibodies directed thereagainst for diagnosing, treating and preventing influenza virus infection.
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3.发明申请Synthetic Peptide Copolymers for Treatment and Prevention of Cardiovascular Disorders 审中-公开用于治疗和预防心血管疾病的合成肽共聚物公开(公告)号：US20090130121A1
公开(公告)日：2009-05-21
申请号：US11883734
申请日：2006-02-02
Applicant: Ruth Arnon , Arkady-Avi Kotlyar , Aviv Shayish , Dror Haratz
Inventor： Ruth Arnon , Arkady-Avi Kotlyar , Aviv Shayish , Dror Haratz
CPC classification number: C12N15/1136 , A61K31/785 , A61K38/02 , C12N15/111 , C12N2320/31 , A61K2300/00
Abstract: The present invention relates to the use of random or ordered copolymers including the known copolymer glatiramer (also known as Copolymer 1) and Copolymer 1-related heteropolymers or ordered peptides, for treating or preventing cardiovascular diseases and disorders.
Abstract translation: 本发明涉及随机或有序共聚物的用途，包括已知的共聚物格拉美姆（也称为共聚物1）和共聚物1相关的杂多聚物或有序肽，用于治疗或预防心血管疾病和病症。
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公开(公告)号：US07514086B2
公开(公告)日：2009-04-07
申请号：US11672429
申请日：2007-02-07
Applicant: Ruth Arnon , Tamar Ben-Yedidia , Raphael Levi
Inventor： Ruth Arnon , Tamar Ben-Yedidia , Raphael Levi
IPC: A61K39/145
CPC classification number: C12N7/00 , A61K39/12 , A61K39/145 , A61K39/385 , A61K2039/543 , A61K2039/58 , A61K2039/6068 , C12N2760/16134
Abstract: A human synthetic peptide-based influenza vaccine for intranasal administration comprises a mixture of flagella containing at least four epitopes of influenza virus reactive with human cells, each expressed individually in Salmonella flagellin, said influenza virus epitopes being selected from the group consisting of: (i) one B-cell hemagglutinin (HA) epitope; (ii) one T-helper hemagglutinin (HA) or nucleo-protein (NP) epitope that can bind to many HLA molecules; and (iii) at least two cytotoxic lymphocyte (CTL) nucleoprotein (NP) or matrix protein (M) epitopes that are restricted to the most prevalent HLA molecules in different human populations.
Abstract translation: 用于鼻内给药的基于人的基于合成肽的流感疫苗包含含有至少四种与人类细胞反应的流感病毒表位的鞭毛的混合物，每种表达单独在沙门氏菌鞭毛蛋白中表达，所述流感病毒表位选自：（i ）一个B细胞血凝素（HA）表位; （ii）可以结合许多HLA分子的一种T辅助血凝素（HA）或核蛋白（NP）表位; 和（iii）限于不同人群中最流行的HLA分子的至少两种细胞毒性淋巴细胞（CTL）核蛋白（NP）或基质蛋白（M）表位。
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公开(公告)号：US20050171286A1
公开(公告)日：2005-08-04
申请号：US11098432
申请日：2005-04-05
Applicant: Eliezer Konfino , Michael Sela , Dvora Teitelbaum , Ruth Arnon
Inventor： Eliezer Konfino , Michael Sela , Dvora Teitelbaum , Ruth Arnon
IPC: A61K31/785 , A01N37/18 , A61K20060101 , A61K31/74 , A61K38/00 , A61K38/03 , A61K38/16 , A61P25/00 , A61P25/28 , A61P37/00 , A61P43/00 , C07G20060101 , C07K20060101 , C07K14/00 , C07K14/47 , C08G69/08 , C08G69/10 , C08G69/46 , C08G69/48 , C08L77/06 , C08L23/00
CPC classification number: A61K38/1703 , C07K14/4713 , C08G69/10 , Y10S514/903
Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
Abstract translation: 本发明涉及共聚物-1的改进组合物，其包括基本上不含分子量超过40千道尔顿的物质的共聚物-1。
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Patent Agency Ranking
公开(公告)号：US06620847B2
公开(公告)日：2003-09-16
申请号：US10014477
申请日：2001-12-14
Applicant: Eliezer Konfino , Michael Sela , Dvora Teitelbaum , Ruth Arnon
Inventor： Eliezer Konfino , Michael Sela , Dvora Teitelbaum , Ruth Arnon
IPC: A61K31195
CPC classification number: A61K38/1703 , C07K14/4713 , C08G69/10 , Y10S514/903
Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
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公开(公告)号：US5800808A
公开(公告)日：1998-09-01
申请号：US447146
申请日：1995-05-22
Applicant: Eliezer Konfino , Michael Sela , Dvora Teitelbaum , Ruth Arnon
Inventor： Eliezer Konfino , Michael Sela , Dvora Teitelbaum , Ruth Arnon
IPC: A61K31/785 , A01N37/18 , A61K20060101 , A61K31/74 , A61K38/00 , A61K38/03 , A61K38/16 , A61P25/00 , A61P25/28 , A61P37/00 , A61P43/00 , C07G20060101 , C07K20060101 , C07K14/00 , C07K14/47 , C08G69/08 , C08G69/10 , C08G69/46 , C08G69/48 , C08L77/06 , A61K27/00
CPC classification number: A61K38/1703 , C07K14/4713 , C08G69/10 , Y10S514/903
Abstract: The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
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公开(公告)号：US07914797B2
公开(公告)日：2011-03-29
申请号：US12096322
申请日：2006-12-06
Applicant: Ruth Arnon , Tamar Ben-Yedidia
Inventor： Ruth Arnon , Tamar Ben-Yedidia
IPC: A61K39/145
CPC classification number: C07K14/005 , A61K39/12 , A61K39/145 , A61K39/385 , A61K2039/5252 , A61K2039/543 , A61K2039/545 , A61K2039/58 , A61K2039/6068 , A61K2039/70 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , Y02A50/412
Abstract: The present invention relates to influenza vaccines for human and veterinary use. In particular, the present invention provides a vaccine able to effect long term and cross-strain protection by including at least two influenza virus epitopes expressed as a chimeric polypeptide wherein at least one epitope is influenza A virus matrix protein epitope and the second epitope is a haemagglutinin peptide epitope.
Abstract translation: 本发明涉及用于人类和兽医用途的流感疫苗。 特别地，本发明提供了能够通过包括表达为嵌合多肽的至少两种流感病毒表位来实现长期和交叉应变保护的疫苗，其中至少一个表位是甲型流感病毒基质蛋白表位，第二表位是 血凝素肽表位。
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9.发明申请Induction Of Neurogenesis And Stem Cell Therapy In Combination With Copolymer 1 审中-公开诱导神经发生和干细胞治疗与共聚物组合1公开(公告)号：US20090191173A1
公开(公告)日：2009-07-30
申请号：US11791681
申请日：2005-11-29
Applicant: Michal Eisenbach-Schwartz , Ruth Arnon , Oleg Butovsky , Yaniv Ziv , Jonathan Kipnis , Noga Ron , Raya Eilam , Rina Aharoni
Inventor： Michal Eisenbach-Schwartz , Ruth Arnon , Oleg Butovsky , Yaniv Ziv , Jonathan Kipnis , Noga Ron , Raya Eilam , Rina Aharoni
Abstract: A method for inducing and enhancing neurogenesis and/or oligodendrogenesis from endogenous as well as from exogenously administered stem cells comprises administering to an individual in need thereof an agent selected from the group consisting of Copolymer 1, a Copolymer 1-related polypeptide, a Copolymer 1-related peptide, and activated T cells which have been activated by Copolymer 1, a Copolymer 1-related polypeptide, or a Copolymer 1-related peptide. The method is particularly useful for stem cell therapy in combination with the agent.
Abstract translation: 从内源性和外源性干细胞诱导和增强神经发生和/或少突起发生的方法包括向有需要的个体施用选自共聚物1，共聚物1相关多肽，共聚物1 相关肽和已经被共聚物1，共聚物1相关多肽或共聚物1相关肽激活的活化的T细胞。 该方法对于与该药剂组合的干细胞治疗特别有用。
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公开(公告)号：US20090124557A1
公开(公告)日：2009-05-14
申请号：US12081482
申请日：2008-04-16
Applicant: Nathalie Moyal-Amsellem , Ruth Arnon
Inventor： Nathalie Moyal-Amsellem , Ruth Arnon
CPC classification number: C07K14/4727 , A61K38/00 , A61K39/0011 , A61K2039/55566 , A61K2039/6068 , C07K2319/40
Abstract: A composition which comprises a chimeric polypeptide is provided. The chimeric polypeptide having a flagellin amino acid sequence and a mucin 1 amino acid sequence which includes at least a 7 amino acid sequence of the mucin 1 tandem repeat which can be used to elicit an immune response against MUC1—expressing cancerous cells. Also provided is a method of treating cancer such as a cancer of a glandular epithelium in which MUC1 is overexpressed using the composition of the present invention.
Abstract translation: 提供了包含嵌合多肽的组合物。 具有鞭毛蛋白氨基酸序列和粘蛋白1氨基酸序列的嵌合多肽包括可用于引发对表达MUC1的癌细胞的免疫应答的粘蛋白1串联重复序列的至少7个氨基酸序列。 还提供了使用本发明的组合物治疗癌症的方法，例如其中MUC1过表达的腺上皮癌。
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