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1.发明申请HUMAN DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) FAMILY MEMBERS AND USES THEREFOR 审中-公开人类胆固醇ACYLTRANSFERASE 2（DGAT2）家族成员及其用途公开(公告)号：US20120177661A1
公开(公告)日：2012-07-12
申请号：US13424574
申请日：2012-03-20
IPC分类号： A61K39/395 , C12N5/10 , C12N1/21 , C12N1/19 , C12N9/10 , C07K16/40 , G01N33/566 , C12N9/96 , C12Q1/48 , C12Q1/68 , C12N9/99 , C12N5/071 , A61K38/45 , A61P3/04 , A61P3/06 , C12N15/54
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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2.发明授权Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor 失效人二酰基甘油酰基转移酶2（DGAT2）家族成员及其用途公开(公告)号：US07910346B2
公开(公告)日：2011-03-22
申请号：US12378703
申请日：2009-02-17
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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3.发明授权Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor 有权人二酰基甘油酰基转移酶2（DGAT2）家族成员及其用途公开(公告)号：US08334111B2
公开(公告)日：2012-12-18
申请号：US13015635
申请日：2011-01-28
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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公开(公告)号：US07527962B2
公开(公告)日：2009-05-05
申请号：US11296615
申请日：2005-12-07
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
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公开(公告)号：US20120003233A1
公开(公告)日：2012-01-05
申请号：US13015635
申请日：2011-01-28
IPC分类号： A61K39/395 , C12N9/10 , C12N9/96 , C12N1/21 , C12N1/19 , A61P3/10 , C12Q1/68 , C12Q1/48 , G01N33/573 , C07K16/40 , A61K48/00 , A61K38/02 , C12N15/54 , C12N5/10
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
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6.发明申请Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor 失效人二酰基甘油酰基转移酶2（DGAT2）家族成员及其用途公开(公告)号：US20090269332A1
公开(公告)日：2009-10-29
申请号：US12378703
申请日：2009-02-17
IPC分类号： C12Q1/68 , C07H21/04 , C12N5/10 , C07K14/00 , C07K16/00 , C12P21/02 , G01N33/53 , A61K39/395 , A61P3/04
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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公开(公告)号：US06348321B1
公开(公告)日：2002-02-19
申请号：US09232201
申请日：1999-01-14
IPC分类号： G01N3353
CPC分类号： C12N9/93 , C07K2319/02
摘要： A family of fatty acid transport proteins (FATPS) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, vectors comprising these nucleic acids, as well as the production of FATP proteins in host cells are described. Also described are methods to test FATPs for fatty acid transport function, and methods to identify inhibitors or enhancers of transport function. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP in the small intestine can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ such as the heart.
摘要翻译： 一系列脂肪酸转运蛋白（FATPS）介导长链脂肪酸（LCFAs）在细胞膜中的转运到细胞中。 这些蛋白质在哺乳动物的器官中表现出不同的表达模式。 描述了编码该家族的FATP的核酸，包含这些核酸的载体以及宿主细胞中FATP蛋白的产生。 还描述了测试脂肪酸转运功能的FATP的方法，以及鉴定转运功能的抑制剂或增强子的方法。 通过向哺乳动物施用FATP在小肠中的FATP转运功能的抑制剂或增强剂，LCFA摄取的改变可以降低或增加作为脂肪获得的卡路里，并且可以减少或增加循环脂肪酸。 FATP分布的器官特异性可以用于将药物，诊断指标等引导到诸如心脏的器官的方法中。
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公开(公告)号：US06300096B1
公开(公告)日：2001-10-09
申请号：US09232197
申请日：1999-01-14
IPC分类号： C12P2106
CPC分类号： C12N9/93 , C07K2319/02 , G01N2800/044
摘要： A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, vectors comprising these nucleic acids, as well as the production of FATP proteins in host cells are described. Also described are methods to test FATPs for fatty acid transport function, and methods to identify inhibitors or enhancers of transport function. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP in the small intestine can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ such as the heart.
摘要翻译： 一系列脂肪酸转运蛋白（FATP）介导长链脂肪酸（LCFAs）跨细胞膜转运到细胞中。 这些蛋白质在哺乳动物的器官中表现出不同的表达模式。 描述了编码该家族的FATP的核酸，包含这些核酸的载体以及宿主细胞中FATP蛋白的产生。 还描述了测试脂肪酸转运功能的FATP的方法，以及鉴定转运功能的抑制剂或增强子的方法。 通过向哺乳动物施用FATP在小肠中的FATP转运功能的抑制剂或增强剂，LCFA摄取的改变可以降低或增加作为脂肪获得的卡路里，并且可以减少或增加循环脂肪酸。 FATP分布的器官特异性可以用于将药物，诊断指标等引导到诸如心脏的器官的方法中。
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9.发明申请ADIPOCYTE SECRETED PROTEIN CCDC80 IS A POTENT STIMULATOR OF BONE FORMATION 审中-公开ADIPOCOTE分泌蛋白CCDC80是骨形成的一个重要刺激物公开(公告)号：US20080241129A1
公开(公告)日：2008-10-02
申请号：US12031265
申请日：2008-02-14
IPC分类号： A61K31/7088 , A61K38/16 , A61K31/4439 , A61P19/00 , G01N33/53 , A61K39/395
CPC分类号： A61K38/17 , C12N5/0654 , C12N2501/155 , C12N2501/998 , C12N2503/00 , C12N2799/022 , C12N2799/06 , G01N33/5026 , G01N2500/10
摘要： Disclosed herein are methods of using Ccdc80, Ccdc80 mimics, or Ccdc80 agonists or antagonists in the treatment of bone disorders.
摘要翻译： 本文公开了使用Ccdc80，Ccdc80模拟物或Ccdc80激动剂或拮抗剂治疗骨骼疾病的方法。
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10.发明授权公开(公告)号：US07033772B1
公开(公告)日：2006-04-25
申请号：US09405504
申请日：1999-09-23
CPC分类号： G01N33/92 , G01N2333/70596 , G01N2500/00 , G01N2800/044
摘要： A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, vectors comprising these nucleic acids, as well as the production of FATP proteins in host cells are described. Also described are methods to test FATPs for fatty acid transport function, and methods to identify inhibitors or enhancers of transport function. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP in the small intestine can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ such as the heart.
摘要翻译： 一系列脂肪酸转运蛋白（FATP）介导长链脂肪酸（LCFAs）跨细胞膜转运到细胞中。 这些蛋白质在哺乳动物的器官中表现出不同的表达模式。 描述了编码该家族的FATP的核酸，包含这些核酸的载体以及宿主细胞中FATP蛋白的产生。 还描述了测试脂肪酸转运功能的FATP的方法，以及鉴定转运功能的抑制剂或增强子的方法。 通过向哺乳动物施用FATP在小肠中的FATP转运功能的抑制剂或增强剂，LCFA摄取的改变可以降低或增加作为脂肪获得的卡路里，并且可以减少或增加循环脂肪酸。 FATP分布的器官特异性可以用于将药物，诊断指标等引导到诸如心脏的器官的方法中。
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