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    Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes
    2.
    发明申请
    Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes 有权
    混合库平行基因定位定量微阵列技术，用于全基因组鉴定赋予基因的性状

    公开(公告)号：US20060084098A1

    公开(公告)日：2006-04-20

    申请号：US11231018

    申请日：2005-09-20

    申请人： Ryan Gill ,  Michael Lynch ,  Tanya Warnecke

    发明人： Ryan Gill ,  Michael Lynch ,  Tanya Warnecke

    IPC分类号： C40B30/06 ,  C40B40/08

    CPC分类号： C07K14/245 ,  C12N15/1079

    摘要： The present disclosure concerns methods and compositions relating to mixed-library parallel gene trait mapping. In particular embodiments, the methods concern quantitative microarray hybridization techniques for genome-wide identification of trait conferring genes. In other embodiments, the compositions concern genetic elements that confer or are associated with a trait. In an exemplary embodiment, the trait is enhanced growth rate. In another exemplary embodiment, genetic elements that confer enhanced bacterial growth rate comprise part or all of the sequences of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4 or SEQ ID NO:5. In other embodiments, the genetic elements that confer enhanced bacterial growth rate correspond to the YliF, adrA, yeaP, yddV or ydeH genes of E. coli.

    摘要翻译： 本公开涉及与混合型库并行基因性状图谱相关的方法和组合物。 在具体实施方案中，该方法涉及定性微阵列杂交技术，用于全基因组鉴定赋予性状的基因。 在其它实施方案中，组合物涉及赋予或与性状相关的遗传元件。 在一个示例性实施例中，性状是增强的增长率。 在另一个示例性实施方案中，赋予增强的细菌生长速率的遗传元件包含SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：4或SEQ ID NO：5的部分或全部序列 。 在其他实施方案中，赋予增强的细菌生长速率的遗传元件对应于大肠杆菌的YliF，adrA，yeaP，yddV或ydeH基因。

    Broad host range vectors for shotgun and expression library cloning in Gram negative bacteria
    3.
    发明授权
    Broad host range vectors for shotgun and expression library cloning in Gram negative bacteria 有权
    用于霰弹枪和表达文库克隆的革兰氏阴性细菌的广泛宿主范围载体

    公开(公告)号：US07846688B2

    公开(公告)日：2010-12-07

    申请号：US11505147

    申请日：2006-08-15

    申请人： Ryan Gill ,  Michael Lynch

    发明人： Ryan Gill ,  Michael Lynch

    IPC分类号： C12N15/00 ,  C12N15/10

    CPC分类号： C12N15/66

    摘要： The present invention concerns methods and compositions for the construction of a series of stable vectors for genomic library construction useful in Gram negative species. In certain embodiments, the vectors contain the pBBR1 replicon, capable of to stable replication in a broad range of Gram negative species. In various embodiments, the plasmid vectors may also contain bidirectional, rho-independent transcriptional terminators flanking the multiple cloning site, which allows for greater insert stability, and thus, greater genomic representation. Each vector may vary in its selection marker region, mobilization function, and promoter used to express insert sequences. These vectors are of use in the screening of highly representational genomic libraries in a broad variety of Gram negative species.

    摘要翻译： 本发明涉及用于构建用于革兰氏阴性物种的基因组文库构建的一系列稳定载体的方法和组合物。 在某些实施方案中，载体含有能够在宽范围的革兰氏阴性物种中稳定复制的pBBR1复制子。 在各种实施方案中，质粒载体还可以包含在多克隆位点侧翼的双向，独立于转录终止子，其允许更大的插入稳定性，因此更大的基因组表示。 每个载体可以在其选择标记区，动员功能和用于表达插入序列的启动子上变化。 这些载体可用于筛选广泛种类的革兰氏阴性物种中高度代表性的基因组文库。

    Broad host range vectors for shotgun and expression library cloning in Gram negative bacteria
    4.
    发明申请
    Broad host range vectors for shotgun and expression library cloning in Gram negative bacteria 有权
    用于霰弹枪和表达文库克隆的革兰氏阴性细菌的广泛宿主范围载体

    公开(公告)号：US20070059768A1

    公开(公告)日：2007-03-15

    申请号：US11505147

    申请日：2006-08-15

    申请人： Ryan Gill ,  Michael Lynch

    发明人： Ryan Gill ,  Michael Lynch

    IPC分类号： C40B50/06 ,  C12N15/74

    CPC分类号： C12N15/66

    摘要： The present invention concerns methods and compositions for the construction of a series of stable vectors for genomic library construction useful in Gram negative species. In certain embodiments, the vectors contain the pBBR1 replicon, capable of to stable replication in a broad range of Gram negative species. In various embodiments, the plasmid vectors may also contain bidirectional, rho-independent transcriptional terminators flanking the multiple cloning site, which allows for greater insert stability, and thus, greater genomic representation. Each vector may vary in its selection marker region, mobilization function, and promoter used to express insert sequences. These vectors are of use in the screening of highly representational genomic libraries in a broad variety of Gram negative species.

    摘要翻译： 本发明涉及用于构建用于革兰氏阴性物种的基因组文库构建的一系列稳定载体的方法和组合物。 在某些实施方案中，载体含有能够在宽范围的革兰氏阴性物种中稳定复制的pBBR1复制子。 在各种实施方案中，质粒载体还可以包含在多克隆位点侧翼的双向，独立于转录终止子，其允许更大的插入稳定性，因此更大的基因组表示。 每个载体可以在其选择标记区，动员功能和用于表达插入序列的启动子上变化。 这些载体可用于筛选广泛种类的革兰氏阴性物种中高度代表性的基因组文库。

    Method and system for generating a four-chamber heart model
    6.
    发明授权
    Method and system for generating a four-chamber heart model 有权
    用于产生四室心脏模型的方法和系统

    公开(公告)号：US09275190B2

    公开(公告)日：2016-03-01

    申请号：US12082143

    申请日：2008-04-09

    申请人： Yefeng Zheng ,  Adrian Barbu ,  Bogdan Georgescu ,  Michael Lynch ,  Michael Scheuering ,  Dorin Comaniciu

    发明人： Yefeng Zheng ,  Adrian Barbu ,  Bogdan Georgescu ,  Michael Lynch ,  Michael Scheuering ,  Dorin Comaniciu

    IPC分类号： G06F19/00

    CPC分类号： G06F19/3437 ,  G06F19/00 ,  G06F19/34 ,  G06T2207/30048 ,  G16H50/50

    摘要： A method and system for building a statistical four-chamber heart model from 3D volumes is disclosed. In order to generate the four-chamber heart model, each chamber is modeled using an open mesh, with holes at the valves. Based on the image data in one or more 3D volumes, meshes are generated and edited for the left ventricle (LV), left atrium (LA), right ventricle (RV), and right atrium (RA). Resampling to enforce point correspondence is performed during mesh editing. Important anatomic landmarks in the heart are explicitly represented in the four-chamber heart model of the present invention.

    摘要翻译： 公开了一种用于从3D体积构建统计四室心脏模型的方法和系统。 为了产生四腔心脏模型，每个腔室都使用开放的网格进行建模，在阀门处有孔。 基于一个或多个3D体积中的图像数据，为左心室（LV），左心房（LA），右心室（RV）和右心房（RA）生成并编辑网格。 在网格编辑期间执行重新采样以强制点对应。 在本发明的四腔心脏模型中明确地表示心脏中的重要解剖学标志。

    Curved Instrument for the Sport of Object Manipulation
    7.
    发明申请
    Curved Instrument for the Sport of Object Manipulation 审中-公开
    对象操纵运动的弯曲仪器

    公开(公告)号：US20140117622A1

    公开(公告)日：2014-05-01

    申请号：US13665468

    申请日：2012-10-31

    申请人： David Lynch ,  Michael Lynch

    发明人： David Lynch ,  Michael Lynch

    IPC分类号： A63B67/08

    CPC分类号： A63B67/08 ,  A63B69/00

    摘要： A Curved Instrument for the Sport of Object Manipulation is described as being a solid mold made of soft plastic which is used by but not limited to whirling, twirling, spinning, tossing, grasping, catching, bumping and flipping in the air to oneself, another person and among an unlimited number of persons with virtually any portion of the body. The present invention is composed of at least two portions attached to one another by a third portion where each portion contains at least one curve. A third portion also contains at least on curve with an addition of an indention located in the center of the portion for grip and reference point. The present invention has curves and indentions which makes the instrument safer and easier to use in the sport of object manipulation as the curved instrument is safer and easier to whirl, twirl, spin, toss, grasp, catch, bump and flip with virtually any portion of the body.

    摘要翻译： 用于对象操作的弯曲仪器被描述为由软塑料制成的实心模具，其被使用但不限于在空气中旋转，旋转，旋转，折腾，抓取，碰撞，碰撞和翻转，另一个 人和无限数量的身体几乎任何部分的人。 本发明由至少两个部分组成，其中每个部分包含至少一条曲线，第三部分彼此相连。 第三部分至少在曲线上还包含位于该夹持部分和参考点部分的中心的凹槽。 本发明具有曲线和凹痕，这使得仪器在对象操作的运动中更安全和更容易地使用，因为弯曲的乐器更安全，更容易旋转，旋转，旋转，折叠，抓住，捕捉，碰撞和翻转，几乎任何部分 的身体。

    High Voltage Cable and Insulator Shield
    9.
    发明申请
    High Voltage Cable and Insulator Shield 有权
    高压电缆和绝缘体屏蔽

    公开(公告)号：US20130299230A1

    公开(公告)日：2013-11-14

    申请号：US13466778

    申请日：2012-05-08

    申请人： Michael Lynch

    发明人： Michael Lynch

    IPC分类号： H02G7/00

    CPC分类号： H01B17/00 ,  H02G7/00

    摘要： A plastic shield for a cable and insulator is described having a center section for covering the insulator. The center section has an opening at both its ends for the cable. Proximate each opening is a pivotable flange, where the flange pivots at one end of the flange. An arm extends from each of the cable openings of the center section, and each arm covers the cable exiting the center section. Each arm is pivotally attached to the other end of the associated flange. The length of the flange will typically be about 2-3 inches. The flange allows its associated arm to be moved over a wide range of lateral angles (e.g., up to 45 degrees) and allows the arms to have a lateral offset relative to the center line of the center section and insulator to accommodate a cable that is offset from the center line.

    摘要翻译： 描述了一种用于电缆和绝缘体的塑料屏蔽件，其具有用于覆盖绝缘体的中心部分。 中心部分的两端都有一个开口用于电缆。 近似每个开口是可枢转的法兰，其中法兰在凸缘的一端枢转。 臂从中心部分的每个电缆开口延伸，并且每个臂覆盖离开中心部分的电缆。 每个臂可枢转地连接到相关法兰的另一端。 凸缘的长度通常为2-3英寸。 凸缘允许其相关联的臂在宽范围的横向角度（例如，最多45度）上移动，并且允许臂相对于中心部分和绝缘体的中心线具有横向偏移，以容纳电缆 偏离中心线。

    Curved Instrument for the Sport of Object Manipulation
    10.
    发明申请
    Curved Instrument for the Sport of Object Manipulation 审中-公开
    对象操纵运动的弯曲仪器

    公开(公告)号：US20130267357A1

    公开(公告)日：2013-10-10

    申请号：US13666129

    申请日：2012-11-01

    申请人： David Lynch ,  Michael Lynch

    发明人： David Lynch ,  Michael Lynch

    IPC分类号： A63B67/08

    CPC分类号： A63B67/08

    摘要： A Curved Instrument for the Sport of Object Manipulation is described as being a solid mold made of soft plastic which is used by but not limited to whirling, twirling, spinning, tossing, grasping, catching, bumping and flipping in the air to oneself, another person or among an unlimited number of persons with virtually any portion of the body. The present invention is composed of four portions attached to one another where each portion contains at least one curve in addition to an indention located in the center of the portion for grip and reference point. Each portion is identical to the other three portions and is a minor image of its respectable opposite portion. The present invention has curves and indentions which makes the instrument safer and easier to use in the sport of object manipulation as the curved instrument is safer and easier to whirl, twirl, spin, toss, grasp, catch, bump and flip with virtually any portion of the body.

    摘要翻译： 用于对象操作的弯曲仪器被描述为由软塑料制成的实心模具，其被使用但不限于在空气中旋转，旋转，旋转，折腾，抓取，碰撞，碰撞和翻转，另一个 人或无限数量的身体几乎任何部分的人。 本发明由彼此附接的四个部分组成，其中每个部分除了位于用于抓握和参考点的部分的中心的凹槽之外还包含至少一个曲线。 每个部分与其他三个部分相同，并且是其相对相对部分的次要图像。 本发明具有曲线和凹痕，这使得仪器在对象操作的运动中更安全和更容易地使用，因为弯曲的乐器更安全并且更容易旋转，旋转，旋转，折腾，抓住，捕捉，碰撞和翻转几乎任何部分 的身体。