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    Cell observation device and cell observation method
    2.
    发明授权
    Cell observation device and cell observation method 有权
    细胞观察装置和细胞观察方法

    公开(公告)号：US07415144B2

    公开(公告)日：2008-08-19

    申请号：US11390419

    申请日：2006-03-28

    申请人： Yuji Imaizumi ,  Yoshitaro Nakano ,  Ichiro Sase

    发明人： Yuji Imaizumi ,  Yoshitaro Nakano ,  Ichiro Sase

    IPC分类号： G06K9/00

    CPC分类号： G01N21/253 ,  C12Q1/04

    摘要： The cell observation device and method aims to easily study the correlation between initial states of cells and their reactions without using a synchronous culture method. For this purpose, the cell observation device includes an image acquisition unit acquiring an image of a specimen including a plurality of cells; a stimulating unit applying a predetermined stimulation to the plural cells; a determining unit determining initial states of the plural cells from the image which is acquired by the image acquisition unit before the stimulating unit applies the stimulation; a finding unit finding reactions of the plural cells to the stimulation, from the image acquired by the image acquisition unit after the stimulating unit applies the stimulation; and a generating unit generating information on correlation between the initial states and the reactions of the plural cells.

    摘要翻译： 细胞观察装置和方法旨在容易地研究细胞初始状态与其反应之间的相关性，而不使用同步培养方法。 为此，细胞观察装置包括获取包含多个细胞的标本的图像的图像获取单元; 刺激单元，对所述多个细胞施加预定的刺激; 确定单元，在所述刺激单元施加所述刺激之前，从所述图像获取单元获取的图像中确定所述多个单元的初始状态; 发现单元从刺激单元施加刺激之后由图像获取单元获取的图像中发现多个单元对刺激的反应; 以及生成单元，生成关于初始状态与多个单元的反应之间的相关性的信息。

    MATERIAL FOR SCREENING FOR COMPOUND ACTING ON ION CHANNEL AND USE THEREOF
    3.
    发明申请
    MATERIAL FOR SCREENING FOR COMPOUND ACTING ON ION CHANNEL AND USE THEREOF 有权
    用于在离子通道上进行化合物的筛选的材料及其用途

    公开(公告)号：US20130183709A1

    公开(公告)日：2013-07-18

    申请号：US13807464

    申请日：2011-06-29

    申请人： Yuji Imaizumi ,  Masato Fujii ,  Susumu Ohya ,  Hisao Yamamura

    发明人： Yuji Imaizumi ,  Masato Fujii ,  Susumu Ohya ,  Hisao Yamamura

    IPC分类号： C12Q1/02

    CPC分类号： C12Q1/025 ,  C07K14/705 ,  G01N33/6872 ,  G01N2500/10 ,  G01N2510/00

    摘要： An object of the present invention is to provide a screening system that targets ion channels and has superior efficiency. The present invention provides a material for screening for compounds that act on a target ion channel, comprising cells which retain at least one first DNA encoding a voltage-dependent Na ion channel that has been inhibited from being inactivated, and in which a K ion channel has been activated so that a resting membrane potential becomes deeper in a negative direction.

    摘要翻译： 本发明的目的是提供一种靶向离子通道并具有优异效率的筛选系统。 本发明提供了用于筛选作用于靶离子通道的化合物的材料，其包含保留至少一种编码已被抑制的失活的电压依赖性Na离子通道的第一DNA的细胞，其中K离子通道 已经被激活，使得静息膜电位在负方向变深。

    Cell observation device and cell observation method
    4.
    发明申请
    Cell observation device and cell observation method 有权
    细胞观察装置和细胞观察方法

    公开(公告)号：US20060210962A1

    公开(公告)日：2006-09-21

    申请号：US11390419

    申请日：2006-03-28

    申请人： Yuji Imaizumi ,  Yoshitaro Nakano ,  Ichiro Sase

    发明人： Yuji Imaizumi ,  Yoshitaro Nakano ,  Ichiro Sase

    IPC分类号： C12Q1/00 ,  C12M1/34

    CPC分类号： G01N21/253 ,  C12Q1/04

    摘要： The cell observation device and method aims to easily study the correlation between initial states of cells and their reactions without using a synchronous culture method. For this purpose, the cell observation device includes an image acquisition unit acquiring an image of a specimen including a plurality of cells; a stimulating unit applying a predetermined stimulation to the plural cells; a determining unit determining initial states of the plural cells from the image which is acquired by the image acquisition unit before the stimulating unit applies the stimulation; a finding unit finding reactions of the plural cells to the stimulation, from the image acquired by the image acquisition unit after the stimulating unit applies the stimulation; and a generating unit generating information on correlation between the initial states and the reactions of the plural cells.

    摘要翻译： 细胞观察装置和方法旨在容易地研究细胞初始状态与其反应之间的相关性，而不使用同步培养方法。 为此，细胞观察装置包括获取包含多个细胞的标本的图像的图像获取单元; 刺激单元，对所述多个细胞施加预定的刺激; 确定单元，在所述刺激单元施加所述刺激之前，从所述图像获取单元获取的图像中确定所述多个单元的初始状态; 发现单元从刺激单元施加刺激之后由图像获取单元获取的图像中发现多个单元对刺激的反应; 以及生成单元，生成关于初始状态与多个单元的反应之间的相关性的信息。

    Potassium channel opener
    5.
    发明授权
    Potassium channel opener 失效
    钾通道开启剂

    公开(公告)号：US07495127B2

    公开(公告)日：2009-02-24

    申请号：US11353189

    申请日：2006-02-14

    申请人： Yuji Imaizumi ,  Tomohiko Ohwada

    发明人： Yuji Imaizumi ,  Tomohiko Ohwada

    IPC分类号： C07C62/02 ,  C07C62/04 ,  C07C62/06

    CPC分类号： A61K31/19

    摘要： A potassium channel opener including a compound (e.g., pimaric acid) represented by the formula [I]: wherein R1, R2, R3, R4, R5, R6 and R7 are each independently hydrogen, alkyl, alkenyl, halogen, hydroxy, halogenated alkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, heteroaryl, acyl, carboxyl, alkoxycarbonyl, hydroxamate, sulfo, carbamoyl, sulfonamide, aldehyde, or nitrile; or R4 and R5 may be bonded to each other to form a ring; or R6 and R7 may be bonded to each other to form a ring; and all of three bonds represented by are single bonds, or one of the three bonds is double bond and the other bonds are single bonds, or a physiologically acceptable salt thereof as an effective ingredient.

    摘要翻译： 钾通道开放剂，其包含由式[I]表示的化合物（例如，海松酸）：其中R1，R2，R3，R4，R5，R6和R7各自独立地为氢，烷基，烯基，卤素，羟基，卤代烷基 ，羟基烷基，氨基烷基，烷氧基，芳基，杂芳基，酰基，羧基，烷氧基羰基，异羟肟酸酯，磺基，氨基甲酰基，磺酰胺，醛或腈; 或者R 4和R 5可以彼此键合形成环; 或者R 6和R 7可以彼此键合形成环; 并且由是单键，或三键之一是双键，另一个键是单键，或其生理学上可接受的盐作为有效成分。

    Potassium channel opener
    6.
    发明授权
    Potassium channel opener 失效
    钾通道开启剂

    公开(公告)号：US07385083B2

    公开(公告)日：2008-06-10

    申请号：US10664165

    申请日：2003-09-17

    申请人： Yuji Imaizumi ,  Tomohiko Ohwada

    发明人： Yuji Imaizumi ,  Tomohiko Ohwada

    IPC分类号： C07C65/01 ,  C07C63/33 ,  C07C62/12 ,  C07C62/14 ,  C07C62/22

    CPC分类号： A61K31/19

    摘要： A potassium channel opener comprising a compound (e.g., pimaric acid) represented by the formula [I]: wherein R1, R2, R3, R4, R5, R6 and R7 are each independently hydrogen, alkyl, alkenyl, halogen, hydroxy, halogenated alkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, heteroaryl, acyl, carboxyl, alkoxycarbonyl, hydroxamate, sulfo, carbamoyl, sulfonamide, aldehyde, or nitrile; or R4 and R5 may be bonded to each other to form a ring; or R6 and R7 may be bonded to each other to form a ring; and all of three bonds represented by are single bonds, or one of the three bonds is double bond and the other bonds are single bonds, or a physiologically acceptable salt thereof as an effective ingredient.

    摘要翻译： 钾通道开放剂，其包含由式[I]表示的化合物（例如，海松酸）：其中R 1，R 2，R 3， >，R 4，R 5，R 6和R 7各自独立地为氢，烷基，烯基， 卤素，羟基，卤代烷基，羟基烷基，氨基烷基，烷氧基，芳基，杂芳基，酰基，羧基，烷氧基羰基，异羟肟酸酯，磺基，氨基甲酰基，磺酰胺，醛或腈; 或R 4和R 5可以彼此键合形成环; 或R 6和R 7可以彼此键合形成环; 并且由是单键，或三键之一是双键，另一个键是单键，或其生理学上可接受的盐作为有效成分。

    Apparatus and method for measuring intracellular reactions
    7.
    发明授权
    Apparatus and method for measuring intracellular reactions 有权
    用于测量细胞内反应的装置和方法

    公开(公告)号：US07371565B2

    公开(公告)日：2008-05-13

    申请号：US10671721

    申请日：2003-09-29

    申请人： Yuji Imaizumi ,  Takayuki Suga ,  Yoshitaro Nakano

    发明人： Yuji Imaizumi ,  Takayuki Suga ,  Yoshitaro Nakano

    IPC分类号： C12M1/34

    CPC分类号： G01N21/6458 ,  G01N2015/0065 ,  G06K9/00127 ,  G06T7/0012 ,  G06T2207/30024

    摘要： An intracellular-reaction measuring apparatus for measuring intracellular reactions by the use of a specimen in which a plurality of cell colonies are contained in a non-contact state, the apparatus includes a device that specifies the intensity of first light emitted from the specimen in accordance with the presence of a stated protein is detected to specify, of the plurality of cell colonies, a noted colony containing cells where the stated protein is present, and a device in which the intensity of second light emitted from the specimen in accordance with the intracellular reactions is detected to select, of the detected intensity of the second light, the intensity of the second light emitted from the noted colony.

    摘要翻译： 一种细胞内反应测定装置，其通过使用非接触状态下容纳多个细胞集落的样本来测定细胞内反应，所述装置包括：根据所述试样确定从所述试样发出的第一光的强度的装置 检测到所述蛋白质的存在以指定多个细胞集落中存在所述蛋白质的所述含有细胞的所述集落，以及其中根据细胞内从样品发射的第二光的强度的装置 检测到反应，以检测第二光的检测强度，从所述菌落发射的第二光的强度。

    Potassium channel opener
    9.
    发明申请
    Potassium channel opener 失效
    钾通道开启剂

    公开(公告)号：US20060235072A1

    公开(公告)日：2006-10-19

    申请号：US11353189

    申请日：2006-02-14

    申请人： Yuji Imaizumi ,  Tomohiko Ohwada

    发明人： Yuji Imaizumi ,  Tomohiko Ohwada

    IPC分类号： A61K31/325 ,  A61K31/275 ,  A61K31/18 ,  A61K31/16 ,  A61K31/045 ,  A61K31/12 ,  A61K31/19

    CPC分类号： A61K31/19

    摘要： A potassium channel opener including a compound (e.g., pimaric acid) represented by the formula [I]: wherein R1, R2, R3, R4, R5, R6 and R7 are each independently hydrogen, alkyl, alkenyl, halogen, hydroxy, halogenated alkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, heteroaryl, acyl, carboxyl, alkoxycarbonyl, hydroxamate, sulfo, carbamoyl, sulfonamide, aldehyde, or nitrile; or R4 and R5 may be bonded to each other to form a ring; or R6 and R7 may be bonded to each other to form a ring; and all of three bonds represented by are single bonds, or one of the three bonds is double bond and the other bonds are single bonds, or a physiologically acceptable salt thereof as an effective ingredient.

    摘要翻译： 钾通道开放剂，其包含由式[I]表示的化合物（例如，海松酸）：其中R 1，R 2，R 3， >，R 4，R 5，R 6和R 7各自独立地为氢，烷基，烯基， 卤素，羟基，卤代烷基，羟基烷基，氨基烷基，烷氧基，芳基，杂芳基，酰基，羧基，烷氧基羰基，异羟肟酸酯，磺基，氨基甲酰基，磺酰胺，醛或腈; 或R 4和R 5可以彼此键合形成环; 或R 6和R 7可以彼此键合形成环; 并且由是单键，或三键之一是双键，另一个键是单键，或其生理学上可接受的盐作为有效成分。