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13 条记录 (耗时 0.019 秒)

    Processes for preparing 3,4-dihydro 2-naphthanoic acid and 2-naphthanoic acid and esters thereof
    2.
    发明授权
    Processes for preparing 3,4-dihydro 2-naphthanoic acid and 2-naphthanoic acid and esters thereof 失效
    制备3,4-二氢-2-萘甲酸和2-萘酸的方法及其酯

    公开(公告)号：US4783548A

    公开(公告)日：1988-11-08

    申请号：US97021

    申请日：1987-09-16

    申请人： Joseph R. Zoeller

    发明人： Joseph R. Zoeller

    IPC分类号： B01J23/44 ,  C07B61/00 ,  C07C51/347 ,  C07C61/13 ,  C07C61/29 ,  C07C61/39 ,  C07C61/40 ,  C07C62/06 ,  C07C62/14 ,  C07C62/34 ,  C07C63/38 ,  C07C67/30 ,  C07C69/757 ,  C07C69/76 ,  C07C149/40

    CPC分类号： C07C62/34 ,  C07C61/29 ,  C07C61/39 ,  C07C61/40 ,  C07C63/38

    摘要： A process for preparing a 3,4-dihydro 2-naphthanoic acid or an ester thereof comprises heating an alpha-vinyl cinnamic acid or a (C.sub.1 -C.sub.12)alkyl, (C.sub.6 -C.sub.12)aryl, (C.sub.6 -C.sub.12)aralkyl or (C.sub.6 -C.sub.12)alkylaryl ester thereof at a temperature effective to cyclize said acid or ester thereof and obtain the corresponding 3,4-dihydro 2-naphthanoic acid or ester thereof. The alpha-vinyl cinnamic acid or ester thereof may be obtained by contacting crotonic anhydride and a benzaldehyde substituted with halo or (C.sub.1 -C.sub.12)alkyl, acyl, acyloxy, carboxy, carbalkoxy, alkylthiol or alkoxy.A process for preparing 2-naphthanoic acid or an ester thereof comprises the above steps to prepare a 3,4-dihydro-2-naphthanoic acid, and dehydrogenating said 3,4-dihydro 2-naphthanoic acid or ester thereof to obtain the 2-naphthanoic acid.

    摘要翻译： 制备3,4-二氢-2-萘酸或其酯的方法包括加热α-乙烯基肉桂酸或（C 1 -C 12）烷基，（C 6 -C 12）芳基，（C 6 -C 12）芳烷基或（ C6-C12）烷基芳基酯在有效使所述酸或酯环化的温度下得到相应的3,4-二氢-2-萘酸或其酯。 α-乙烯基肉桂酸或其酯可以通过使巴豆酸酐和被卤素或（C 1 -C 12）烷基，酰基，酰氧基，羧基，烷氧基，烷基硫醇或烷氧基取代的苯甲醛接触来获得。 制备2-萘酸或其酯的方法包括上述步骤制备3,4-二氢-2-萘酸，并使所述3,4-二氢-2-萘酸或其酯脱氢得到2- 萘酸。

    Potassium channel opener
    9.
    发明授权
    Potassium channel opener 失效
    钾通道开启剂

    公开(公告)号：US07385083B2

    公开(公告)日：2008-06-10

    申请号：US10664165

    申请日：2003-09-17

    申请人： Yuji Imaizumi ,  Tomohiko Ohwada

    发明人： Yuji Imaizumi ,  Tomohiko Ohwada

    IPC分类号： C07C65/01 ,  C07C63/33 ,  C07C62/12 ,  C07C62/14 ,  C07C62/22

    CPC分类号： A61K31/19

    摘要： A potassium channel opener comprising a compound (e.g., pimaric acid) represented by the formula [I]: wherein R1, R2, R3, R4, R5, R6 and R7 are each independently hydrogen, alkyl, alkenyl, halogen, hydroxy, halogenated alkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, heteroaryl, acyl, carboxyl, alkoxycarbonyl, hydroxamate, sulfo, carbamoyl, sulfonamide, aldehyde, or nitrile; or R4 and R5 may be bonded to each other to form a ring; or R6 and R7 may be bonded to each other to form a ring; and all of three bonds represented by are single bonds, or one of the three bonds is double bond and the other bonds are single bonds, or a physiologically acceptable salt thereof as an effective ingredient.

    摘要翻译： 钾通道开放剂，其包含由式[I]表示的化合物（例如，海松酸）：其中R 1，R 2，R 3， >，R 4，R 5，R 6和R 7各自独立地为氢，烷基，烯基， 卤素，羟基，卤代烷基，羟基烷基，氨基烷基，烷氧基，芳基，杂芳基，酰基，羧基，烷氧基羰基，异羟肟酸酯，磺基，氨基甲酰基，磺酰胺，醛或腈; 或R 4和R 5可以彼此键合形成环; 或R 6和R 7可以彼此键合形成环; 并且由是单键，或三键之一是双键，另一个键是单键，或其生理学上可接受的盐作为有效成分。