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    Diagnostics and remedies for interstitial pneumonia
    1.
    发明申请
    Diagnostics and remedies for interstitial pneumonia 审中-公开
    间质性肺炎的诊断和治疗

    公开(公告)号：US20050095242A1

    公开(公告)日：2005-05-05

    申请号：US10505980

    申请日：2003-02-28

    申请人： Ryuzo Ueda ,  Shigeki Sato ,  Takeo Yoshinouchi ,  Takashi Niimi ,  Shigeki Shimizu ,  Tadaaki Eimoto

    发明人： Ryuzo Ueda ,  Shigeki Sato ,  Takeo Yoshinouchi ,  Takashi Niimi ,  Shigeki Shimizu ,  Tadaaki Eimoto

    IPC分类号： A61P11/00 ,  C07K16/28 ,  G01N33/50 ,  G01N33/68 ,  A61K39/395

    CPC分类号： G01N33/6863 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/565 ,  G01N33/505

    摘要： A preventive agent, a diagnostic agent or a therapeutic agent for interstitial pneumonia, which comprises an anti-CCR4 antibody and/or an anti-CXCR3 antibody as an active ingredient, a diagnostic agent for discriminating between usual idiopathic interstitial pneumonia and non-specific idiopathic interstitial pneumonia which comprises an anti-CCR4 antibody and an anti-CXCR3 antibody as an active ingredient, and a method for discriminating between usual idiopathic interstitial pneumonia and non-specific idiopathic interstitial pneumonia, which comprises detecting and/or determining a Th2 cell and a Th1 cell in a sample by using an anti-CCR4 antibody and an anti-CXCR3 antibody.

    摘要翻译： 作为间质性肺炎的预防剂，诊断剂或治疗剂，其包含抗CCR4抗体和/或抗CXCR3抗体作为活性成分，用于鉴别常见特发性间质性肺炎与非特异性特发性 包含抗CCR4抗体和抗CXCR3抗体作为活性成分的间质性肺炎以及通常的特发性间质性肺炎与非特异性特发性间质性肺炎的鉴别方法，其特征在于，检测和/或测定Th2细胞和 通过使用抗CCR4抗体和抗CXCR3抗体，样品中的Th1细胞。

    Method of depleting regulatory T cell
    2.
    发明申请
    Method of depleting regulatory T cell 审中-公开
    消耗调节性T细胞的方法

    公开(公告)号：US20060034841A1

    公开(公告)日：2006-02-16

    申请号：US11144731

    申请日：2005-06-06

    申请人： Ryuzo Ueda ,  Kenya Shitara ,  Shiro Akinaga ,  Rinpei Niwa ,  Masamichi Koike

    发明人： Ryuzo Ueda ,  Kenya Shitara ,  Shiro Akinaga ,  Rinpei Niwa ,  Masamichi Koike

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  Y02A50/41 ,  Y02A50/412

    摘要： The present invention relates to the method for depleting in vivo regulatory T cell, the method for suppressing IL-10 producing activity of regulatory T cell, the method for treating diseases in which pathologic conditions are deteriorated by regulatory T cell and the method for enhancing tumor immunity which comprises administering to a patient a monoclonal antibody which specifically binds to human CC chemokine 4 (CCR4) or the antibody fragment thereof.

    摘要翻译： 本发明涉及体内调节性T细胞的消耗方法，抑制调节性T细胞的IL-10产生活性的方法，通过调节性T细胞治疗病变状态的疾病的治疗方法及增强肿瘤的方法 其包括向患者施用特异性结合人CC趋化因子4（CCR4）或其抗体片段的单克隆抗体。

    Apparatus for detecting a magnetic field having an excitation current source unit, a detection unit and a current control source unit
    5.
    发明授权
    Apparatus for detecting a magnetic field having an excitation current source unit, a detection unit and a current control source unit 失效
    用于检测具有激励电流源单元，检测单元和电流控制源单元的磁场的装置

    公开(公告)号：US4933637A

    公开(公告)日：1990-06-12

    申请号：US306203

    申请日：1989-02-02

    申请人： Ryuzo Ueda ,  Toshikatsu Sonoda ,  Toshiyuki Irisa ,  Shigeo Takata

    发明人： Ryuzo Ueda ,  Toshikatsu Sonoda ,  Toshiyuki Irisa ,  Shigeo Takata

    IPC分类号： G01R33/04

    CPC分类号： G01R33/04

    摘要： An apparatus for detecting a magnetic field includes a magnetic core, an excitation current source unit, a magnetic flux detecting unit, and a current control source unit. The excitation current source unit includes a first excitation winding disposed around the core, an amplifier having an output coupled to the first excitation winding, and a subtractor for applying to the amplifier a first difference between a voltage corresponding to a supplied excitation current and a voltage corresponding to a current passing through the first excitation winding. The magnetic flux detecting unit includes a second excitation winding disposed around the core, a waveform shaping circuit for shaping the waveform of a voltage induced in the second excitation winding, a pulse generating circuit for outputting pulses in synchronism with the shape waveform voltage, and a sample-and-hold circuit for sampling and holding the voltage corresponding to the supplied excitation current. The current control source unit includes a third excitation winding disposed around the core, a subtracter for outputting a second difference between an output of the sample-and-hold means in a predetermined output value, and a proportional-plus-integral circuit for outputting a control current command signal according to the second difference. The magnetic field detected in response to the control current command signal applied to the third excitation winding.

    摘要翻译： 用于检测磁场的装置包括磁芯，励磁电流源单元，磁通量检测单元和电流控制源单元。 激励电流源单元包括设置在芯周围的第一激励绕组，具有耦合到第一励磁绕组的输出的放大器和用于向放大器施加与所提供的励磁电流相对应的电压与电压之间的第一差值的减法器 对应于通过第一激励绕组的电流。 磁通检测单元包括设置在磁芯周围的第二励磁绕组，用于对在第二励磁绕组中感应的电压的波形进行整形的波形整形电路，与形状波形电压同步地输出脉冲的脉冲发生电路，以及 采样和保持电路，用于采样和保持与所提供的激励电流相对应的电压。 电流控制源单元包括设置在芯周围的第三激励绕组，用于以预定输出值输出采样保持装置的输出之间的第二差值的减法器和用于输出采样保持装置的比例加积分电路 根据第二个差异控制电流指令信号。 响应于施加到第三励磁绕组的控制电流指令信号而检测的磁场。