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1.发明申请"Polyunsaturated Fatty Acid-Containing Oil Product and Uses and Production Thereof" 审中-公开“多不饱和脂肪酸含油产品及其用途及其生产”公开(公告)号：US20080107791A1
公开(公告)日：2008-05-08
申请号：US11470996
申请日：2006-09-07
申请人： Jaouad Fichtali , Neil Francis Leininger , Jesus Ruben Abril , Naseer Ahmed , S.P. Janaka Namal Senanayake
发明人： Jaouad Fichtali , Neil Francis Leininger , Jesus Ruben Abril , Naseer Ahmed , S.P. Janaka Namal Senanayake
IPC分类号： A23D7/00
CPC分类号： A23D7/04 , A23D7/06 , A23D9/013 , A23D9/04 , A23D9/06 , A61K47/12 , C11B1/025 , C11B1/10 , C11B3/001 , C11B3/008 , C11B3/08 , C11B3/10 , C11B5/0092 , C11B7/0075 , C11B15/00
摘要： The present invention includes a solid fat composition that includes an oil having saturated fat and a microbial oil having a long chain polyunsaturated fatty acid and an emulsifier. In particular, the solid fat composition can have high levels of long chain polyunsaturated fatty acid and low amounts of emulsifiers. In preferred embodiments, the polyunsaturated oil is an unwinterized microbial oil. The invention also relates to methods for making such compositions and food, nutritional, and pharmaceutical products comprising said compositions. The present invention also includes a microbial oil product prepared by extracting an oil-containing fraction comprising at least one LC-PUFA from a microbial biomass, and treating the fraction by a process of vacuum evaporation, wherein the oil product has not been subject to one or more of a solvent winterization step, a caustic refining process, a chill filtration process, or a bleaching process.
摘要翻译： 本发明包括具有饱和脂肪的油和具有长链多不饱和脂肪酸和乳化剂的微生物油的固体脂肪组合物。 特别地，固体脂肪组合物可以具有高水平的长链多不饱和脂肪酸和少量的乳化剂。 在优选的实施方案中，多不饱和的油是未连续的微生物油。 本发明还涉及制备这种组合物的方法以及包含所述组合物的食品，营养和药物产品。 本发明还包括通过从微生物生物质提取包含至少一种LC-PUFA的含油馏分制备的微生物油产物，并通过真空蒸发处理该馏分，其中该油产品未被一个 或更多的溶剂冬季化步骤，苛性碱精炼方法，冷却过滤方法或漂白方法。
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2.发明申请Polyunsaturated Fatty Acid-Containing Solid Fat Compositions and Uses and Production Thereof 审中-公开多不饱和脂肪酸固体脂肪组合物及其用途及其生产公开(公告)号：US20090099260A1
公开(公告)日：2009-04-16
申请号：US12201728
申请日：2008-08-29
CPC分类号： A61K47/44 , A21D2/165 , A23D7/001 , A23D7/003 , A23D7/0053 , A23D7/0056 , A23D9/00 , A23D9/007 , A23K20/158 , A23L33/30 , C11B1/025 , C11B1/10 , C11B5/00
摘要： The present invention provides a solid fat composition that includes an oil having saturated fat and an oil having at least one long chain polyunsaturated fatty acid. In particular, the solid fat composition can have high levels of long chain polyunsaturated fatty acid and low to no presence of emulsifiers. In preferred embodiments, the polyunsaturated oil is an unwinterized microbial oil. The invention also relates to methods for making such compositions and food, nutritional, and pharmaceutical products comprising said compositions.
摘要翻译： 本发明提供一种固体脂肪组合物，其包含具有饱和脂肪的油和具有至少一种长链多不饱和脂肪酸的油。 特别地，固体脂肪组合物可以具有高水平的长链多不饱和脂肪酸，并且低至无乳化剂存在。 在优选的实施方案中，多不饱和的油是未连续的微生物油。 本发明还涉及制备这种组合物的方法以及包含所述组合物的食品，营养和药物产品。
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3.发明授权Polyunsaturated fatty acid-containing oil product and uses and production thereof 有权多不饱和脂肪酸油产品及其用途及生产公开(公告)号：US08753707B2
公开(公告)日：2014-06-17
申请号：US11748330
申请日：2007-05-14
IPC分类号： A23D9/02
CPC分类号： A23D7/04 , A23D7/06 , A23D9/013 , A23D9/04 , A23D9/06 , A61K47/12 , C11B1/025 , C11B1/10 , C11B3/001 , C11B3/008 , C11B3/08 , C11B3/10 , C11B5/0092 , C11B7/0075 , C11B15/00
摘要： The present invention includes a solid fat composition that includes an oil having saturated fat and a microbial oil having a long chain polyunsaturated fatty acid and an emulsifier. In particular, the solid fat composition can have high levels of long chain polyunsaturated fatty acid and low amounts of emulsifiers. In preferred embodiments, the polyunsaturated oil is an unwinterized microbial oil. The invention also relates to methods for making such compositions and food, nutritional, and pharmaceutical products comprising said compositions. The present invention also includes a microbial oil product prepared by extracting an oil-containing fraction comprising at least one LC-PUFA from a microbial biomass, and treating the fraction by a process of vacuum evaporation, wherein the oil product has not been subject to one or more of a solvent winterization step, a caustic refining process, a chill filtration process, or a bleaching process.
摘要翻译： 本发明包括具有饱和脂肪的油和具有长链多不饱和脂肪酸和乳化剂的微生物油的固体脂肪组合物。 特别地，固体脂肪组合物可以具有高水平的长链多不饱和脂肪酸和少量的乳化剂。 在优选的实施方案中，多不饱和的油是未连续的微生物油。 本发明还涉及制备这种组合物的方法以及包含所述组合物的食品，营养和药物产品。 本发明还包括通过从微生物生物质提取包含至少一种LC-PUFA的含油馏分制备的微生物油产物，并通过真空蒸发处理该馏分，其中该油产品未被一个 或更多的溶剂冬季化步骤，苛性碱精炼方法，冷却过滤方法或漂白方法。
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4.发明申请Polyunsaturated Fatty Acid-Containing Oil Product and Uses and Production Thereof 有权多不饱和脂肪酸含油产品及其用途及其生产公开(公告)号：US20080026103A1
公开(公告)日：2008-01-31
申请号：US11748330
申请日：2007-05-14
IPC分类号： A23D9/007
CPC分类号： A23D7/04 , A23D7/06 , A23D9/013 , A23D9/04 , A23D9/06 , A61K47/12 , C11B1/025 , C11B1/10 , C11B3/001 , C11B3/008 , C11B3/08 , C11B3/10 , C11B5/0092 , C11B7/0075 , C11B15/00
摘要： The present invention includes a solid fat composition that includes an oil having saturated fat and a microbial oil having a long chain polyunsaturated fatty acid and an emulsifier. In particular, the solid fat composition can have high levels of long chain polyunsaturated fatty acid and low amounts of emulsifiers. In preferred embodiments, the polyunsaturated oil is an unwinterized microbial oil. The invention also relates to methods for making such compositions and food, nutritional, and pharmaceutical products comprising said compositions. The present invention also includes a microbial oil product prepared by extracting an oil-containing fraction comprising at least one LC-PUFA from a microbial biomass, and treating the fraction by a process of vacuum evaporation, wherein the oil product has not been subject to one or more of a solvent winterization step, a caustic refining process, a chill filtration process, or a bleaching process.
摘要翻译： 本发明包括具有饱和脂肪的油和具有长链多不饱和脂肪酸和乳化剂的微生物油的固体脂肪组合物。 特别地，固体脂肪组合物可以具有高水平的长链多不饱和脂肪酸和少量的乳化剂。 在优选的实施方案中，多不饱和的油是未连续的微生物油。 本发明还涉及制备这种组合物的方法以及包含所述组合物的食品，营养和药物产品。 本发明还包括通过从微生物生物质提取包含至少一种LC-PUFA的含油馏分制备的微生物油产物，并通过真空蒸发处理该馏分，其中该油产品未被一个 或更多的溶剂冬季化步骤，苛性碱精炼方法，冷却过滤方法或漂白方法。
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5.发明申请Polyunsaturated Fatty Acid-Containing Oil Product and Uses and Production Thereof 有权多不饱和脂肪酸含油产品及其用途及其生产公开(公告)号：US20070003686A1
公开(公告)日：2007-01-04
申请号：US11428277
申请日：2006-06-30
IPC分类号： A23D7/00
CPC分类号： A23D7/04 , A23D7/06 , A23D9/013 , A23D9/04 , A23D9/06 , A61K47/12 , C11B1/025 , C11B1/10 , C11B3/001 , C11B3/008 , C11B3/08 , C11B3/10 , C11B5/0092 , C11B7/0075 , C11B15/00
摘要： The present invention includes a solid fat composition that includes an oil having saturated fat and a microbial oil having a long chain polyunsaturated fatty acid and an emulsifier. In particular, the solid fat composition can have high levels of long chain polyunsaturated fatty acid and low amounts of emulsifiers. In preferred embodiments, the polyunsaturated oil is an unwinterized microbial oil. The invention also relates to methods for making such compositions and food, nutritional, and pharmaceutical products comprising said compositions. The present invention also includes a microbial oil product prepared by extracting an oil-containing fraction comprising at least one LC-PUFA from a microbial biomass, and treating the fraction by a process of vacuum evaporation, wherein the oil product has not been subject to one or more of a solvent winterization step, a caustic refining process, a chill filtration process, or a bleaching process.
摘要翻译： 本发明包括具有饱和脂肪的油和具有长链多不饱和脂肪酸和乳化剂的微生物油的固体脂肪组合物。 特别地，固体脂肪组合物可以具有高水平的长链多不饱和脂肪酸和少量的乳化剂。 在优选的实施方案中，多不饱和的油是未连续的微生物油。 本发明还涉及制备这种组合物的方法以及包含所述组合物的食品，营养和药物产品。 本发明还包括通过从微生物生物质提取包含至少一种LC-PUFA的含油馏分制备的微生物油产物，并通过真空蒸发处理该馏分，其中该油产品未被一个 或更多的溶剂冬季化步骤，苛性碱精炼方法，冷却过滤方法或漂白方法。
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6.发明授权Production of DHA in microalgae in medium having modified amounts of potassium 有权在具有改性量的钾的培养基中，在微藻中生产DHA公开(公告)号：US07824892B2
公开(公告)日：2010-11-02
申请号：US11738425
申请日：2007-04-20
申请人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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公开(公告)号：US20080032353A1
公开(公告)日：2008-02-07
申请号：US11738414
申请日：2007-04-20
申请人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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公开(公告)号：US20060100279A1
公开(公告)日：2006-05-11
申请号：US11313524
申请日：2005-12-20
申请人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
IPC分类号： C12P7/64 , A61K31/202
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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9.发明授权公开(公告)号：US07745183B2
公开(公告)日：2010-06-29
申请号：US11738414
申请日：2007-04-20
申请人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
摘要翻译： 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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公开(公告)号：US07678931B2
公开(公告)日：2010-03-16
申请号：US11255787
申请日：2005-10-21
IPC分类号： C11B1/00
摘要： The present invention relates to a process for preparing a biomass, such as from a microbial fermentation, for an extraction process to separate desired chemicals, nutritional products, bioactive components, proteins, carbohydrates, and lipids, from the biomass. Particularly preferred substances to extract include docosahexaenoic acid, docosapentaenoic acid, and arachidonic acid. The present invention also includes extracting the prepared biomass. Biomasses to be treated in accordance with the methods of the invention include plant, animal, and microbial biomass, particularly a microorganism such as Crypthecodinium cohnii and a fungus such as Mortierella alpina.
摘要翻译： 本发明涉及从微生物发酵制备生物质的方法，用于从生物质中分离所需化学品，营养产品，生物活性成分，蛋白质，碳水化合物和脂质的提取方法。 特别优选的提取物质包括二十二碳六烯酸，二十二碳五烯酸和花生四烯酸。 本发明还包括提取制备的生物质。 根据本发明的方法处理的生物质包括植物，动物和微生物生物质，特别是微生物如隐孢子虫（Crypthecodinium cohnii）和真菌如高山被孢霉（Mortierella alpina）。
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