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公开(公告)号：US20180032665A1
公开(公告)日：2018-02-01
申请号：US15647171
申请日：2017-07-11
Applicant: SEQUENOM, INC.
Inventor： Lin TANG , Cosmin DECIU
CPC classification number: G16B20/00 , C12Q1/6869 , C12Q1/6874 , G16B30/00 , G16B40/00 , Y02A90/26 , C12Q2537/16 , C12Q2537/165
Abstract: Provided in part herein are methods and processes that can be used for non-invasive assessment of a genetic variation which can lead to diagnosis of a particular medical condition or conditions. Such methods and processes can, for example, identify dissimiliarities or similarities for one or more features between a subject data set and a reference data set, generate a multidimensional matrix, reduce the matrix into a representation and classify the representation into one or more groups. Methods and processes described herein are applicable to data in biotechnology and other fields.
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公开(公告)号：US20180030528A1
公开(公告)日：2018-02-01
申请号：US15647148
申请日：2017-07-11
Applicant: SEQUENOM, INC.
Inventor： Dirk Johannes VAN DEN BOOM , Charles R. CANTOR , Sung Kyun KIM , Zeljko DZAKULA , Cosmin DECIU
CPC classification number: C12Q1/6869 , C12Q1/6827 , G16B20/00 , G16B30/00 , G16B40/00 , C12Q2537/16 , C12Q2537/165
Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
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3.发明申请公开(公告)号：US20170073756A1
公开(公告)日：2017-03-16
申请号：US15124324
申请日：2015-03-12
Applicant: SEQUENOM, INC.
Inventor： Taylor Jacob JENSEN , Jennifer GEIS , Sung Kyun KIM , Cosmin DECIU , Mathias EHRICH
CPC classification number: C12Q1/6883 , C12Q2537/143 , C12Q2565/627 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16 , G16B25/00 , G16B45/00 , H01J49/164
Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations. In particular the invention relates to methods and kits for detecting aneuploidy of a fetal chromosome by determining the amounts of differentially methylated regions in each of chromosomes 13, 18 and 21 in circulating cell-free nucleic acid from a human pregnant female.
Abstract translation: 本文提供的技术部分地涉及遗传变异的非侵入性评估的方法，过程和装置。 特别地，本发明涉及用于通过确定来自人类怀孕女性的循环无细胞核酸中的染色体13,18和21中的每一个中的差异甲基化区域的量来检测胎儿染色体的非整倍体的方法和试剂盒。
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公开(公告)号：US20130304392A1
公开(公告)日：2013-11-14
申请号：US13933935
申请日：2013-07-02
Applicant: SEQUENOM, INC.
Inventor： Cosmin DECIU , Zeljko Dzakula
IPC: G06F19/20
Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.
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公开(公告)号：US20250157575A1
公开(公告)日：2025-05-15
申请号：US18944368
申请日：2024-11-12
Applicant: Sequenom, Inc.
Inventor： Sung K. KIM , Cosmin DECIU
Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.
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Patent Agency Ranking
公开(公告)号：US20250006298A1
公开(公告)日：2025-01-02
申请号：US18816723
申请日：2024-08-27
Applicant: SEQUENOM, INC.
Inventor： Cosmin DECIU , Zeljko DZAKULA , Amin MAZLOOM
IPC: G16B20/10 , C12Q1/6869 , C12Q1/6883 , G16B30/00 , G16B30/10 , G16B30/20 , G16B40/00
Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations. Also provided herein are methods, processes and apparatuses for determining fetal fraction in a cell-free a sample from a pregnant subject. Also provided herein are methods, processes and apparatuses for determining fetal fraction in a cell-free a sample from a pregnant subject based on a maternal copy number variation. Also provided herein are methods, processes and apparatuses for determining fetal fraction in a cell-free a sample from a pregnant subject based on a maternal microduplication or microdeletion.
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公开(公告)号：US20190309351A1
公开(公告)日：2019-10-10
申请号：US16395658
申请日：2019-04-26
Applicant: SEQUENOM, INC.
Inventor： Cosmin DECIU , Zeljko Jovan DZAKULA , Mathias EHRICH , Sung Kyun KIM
IPC: C12Q1/6827 , G16B20/00
Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.
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公开(公告)号：US20130288244A1
公开(公告)日：2013-10-31
申请号：US13829164
申请日：2013-03-14
Applicant: Sequenom, Inc.
Inventor： Cosmin DECIU , Zeljko Dzakula , John Allen Tynan , Grant Hogg
IPC: C12Q1/68
CPC classification number: C12Q1/683 , C12Q1/6827 , C12Q2600/156 , G06F19/18 , C12Q2537/16 , C12Q2537/165
Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.
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公开(公告)号：US20130085681A1
公开(公告)日：2013-04-04
申请号：US13669136
申请日：2012-11-05
Applicant: SEQUENOM, INC.
Inventor： Cosmin DECIU , Zeljko DZAKULA , Mathias EHRICH , Sung Kyun KIM
IPC: G06F19/18
CPC classification number: C12Q1/6827 , G06F19/18 , C12Q2537/16 , C12Q2537/165
Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.
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公开(公告)号：US20220098644A1
公开(公告)日：2022-03-31
申请号：US17502842
申请日：2021-10-15
Applicant: SEQUENOM, INC.
Inventor： Mathias EHRICH , Guy DEL MISTRO , Cosmin DECIU , Yong Qing CHEN , Ron Michael McCULLOUGH , Roger Chan TIM
IPC: C12Q1/686 , G16B25/00 , C12Q1/6883 , C12Q1/6886 , G16B25/20
Abstract: Provided are methods for identifying the presence or absence of a chromosome abnormality by which a cell-free sample nucleic acid from a subject is analyzed. In certain embodiments, provided are methods for identifying the presence or absence of a fetal chromosome abnormality in a nucleic acid from cell-free maternal blood.
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