公开(公告)号：US20210301342A1

公开(公告)日：2021-09-30

申请号：US17268732

申请日：2019-09-06

Applicant: SEQUENOM, INC.

Inventor： Roy Brian Lefkowitz ,  John Allen Tynan ,  Chen Xu

IPC: C12Q1/6881 ,  G16B30/10 ,  G16B20/20 ,  G16H10/40 ,  G16H50/30 ,  G16H10/60 ,  G16H50/70

Abstract: This application provides methods and systems for determining transplant status. In some embodiments, the method comprises obtaining a biological sample from an organ transplant recipient who has received an organ; isolating cell-free nucleic acids from the biological sample; measuring the amount of each allele of one or more polymorphic nucleic acid targets in the biological sample; identifying the donor specific allele using a computer algorithm based on the measurements of the one or more polymorphic nucleic acid targets, whereby detecting one or more donor-specific circulating cell-free nucleic acids, detecting tissue injury based on the presence or amount of said one or more donor-specific nucleic acids, thereby determining transplant status.

公开(公告)号：US20250154593A1

公开(公告)日：2025-05-15

申请号：US18921873

申请日：2024-10-21

Applicant: Sequenom, Inc.

Inventor： John Allen Tynan ,  Grant Hogg

IPC: C12Q1/6883 ,  C12Q1/6881 ,  C12Q1/6886

Abstract: Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.

公开(公告)号：US10196681B2

公开(公告)日：2019-02-05

申请号：US13829164

申请日：2013-03-14

Applicant: SEQUENOM, INC.

Inventor： Cosmin Deciu ,  Zeljko Dzakula ,  John Allen Tynan ,  Grant Hogg

IPC: C12Q1/683 ,  G06F19/18 ,  C12Q1/6827 ,  G06F19/00 ,  C12Q1/68

Abstract: Provided herein are methods, processes and apparatuses for determining the fraction of fetal nucleic acid in a test sample derived from a pregnant female with improved accuracy and/or precision. Also, provided herein are methods, processes and apparatuses for determining the presence or absence of a genetic variation in a fetus with improved accuracy and/or precision. Certain methods include using fetal fraction measurements for the determination of a fetal genetic variation.

公开(公告)号：US20170342477A1

公开(公告)日：2017-11-30

申请号：US15607235

申请日：2017-05-26

Applicant: Sequenom, Inc.

Inventor： Taylor Jacob Jensen ,  Mathias Ehrich ,  Dirk van den Boom ,  John Allen Tynan ,  Sung Kyun Kim ,  Timothy S. Burcham ,  Christopher K. Ellison ,  Youting Sun

IPC: C12Q1/68 ,  C40B30/02 ,  G06F19/22 ,  G06F19/20

CPC classification number: C12Q1/6858 ,  C12Q1/6844 ,  C12Q1/6853 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/16 ,  G16B25/00 ,  G16B30/00 ,  G16B35/00 ,  G16C20/60 ,  G16H15/00 ,  G16H50/30 ,  C12Q2537/143 ,  C12Q2537/16 ,  C12Q2537/165 ,  C12Q2545/114

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for detecting genetic variations. In some embodiments, the technology is related to non-invasive assessment of aneuploidies.

公开(公告)号：US20230060700A1

公开(公告)日：2023-03-02

申请号：US17726809

申请日：2022-04-22

Applicant: Sequenom, Inc.

Inventor： John Allen Tynan ,  Grant Hogg

IPC: C12Q1/6883 ,  C12Q1/6886 ,  C12Q1/6881

Abstract: Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.

公开(公告)号：US11492659B2

公开(公告)日：2022-11-08

申请号：US16215254

申请日：2018-12-10

Applicant: Sequenom, Inc.

Inventor： Cosmin Deciu ,  Zeljko Dzakula ,  John Allen Tynan ,  Grant Hogg

IPC: C12Q1/683 ,  G16B20/00 ,  C12Q1/6827 ,  G16B20/10 ,  G16B30/00 ,  C12Q1/6869 ,  C12Q1/6883

Abstract: Provided herein are methods for determining fetal ploidy according to nucleic acid sequence reads. Nucleic acid sequence reads may be obtained from test sample nucleic acid comprising circulating cell-free nucleic acid from the blood of a pregnant female bearing a fetus. Fetal ploidy may be determined according to genomic section levels and a fraction of fetal nucleic acid in a test sample.

公开(公告)号：US20130288244A1

公开(公告)日：2013-10-31

申请号：US13829164

申请日：2013-03-14

Applicant: Sequenom, Inc.

Inventor： Cosmin DECIU ,  Zeljko Dzakula ,  John Allen Tynan ,  Grant Hogg

IPC: C12Q1/68

CPC classification number: C12Q1/683 ,  C12Q1/6827 ,  C12Q2600/156 ,  G06F19/18 ,  C12Q2537/16 ,  C12Q2537/165

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US11332791B2

公开(公告)日：2022-05-17

申请号：US15261457

申请日：2016-09-09

Applicant: SEQUENOM, INC.

Inventor： John Allen Tynan ,  Grant Hogg

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q1/6881

Abstract: Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.

公开(公告)号：US20190276874A1

公开(公告)日：2019-09-12

申请号：US16215254

申请日：2018-12-10

Applicant: Sequenom, Inc.

Inventor： Cosmin Deciu ,  Zeljko Dzakula ,  John Allen Tynan ,  Grant Hogg

IPC: C12Q1/683 ,  G16B20/00 ,  C12Q1/6827

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.