公开(公告)号：US20190041379A1

公开(公告)日：2019-02-07

申请号：US16074587

申请日：2016-11-14

Applicant: Sony Corporation

Inventor： Kenzo Machida ,  Shinji Omori ,  Yoshihito Hayashi ,  Marcaurele Brun

IPC: G01N33/49 ,  G01N27/12 ,  G01N33/86

Abstract: To provide a technique which is useful in verification of measurement accuracy before measurement in the measurement of electric characteristics of a blood sample.There is provided a sample for measurement of electric characteristics at least including a liquid containing a blood coagulation factor, and micro particles. The density of each of the micro particles is different from the density of the liquid containing the blood coagulation factor. In addition, there is provided an electric characteristic measuring apparatus and an electric characteristic measuring method as well each using the sample for measurement of electric characteristics.

公开(公告)号：US08999243B2

公开(公告)日：2015-04-07

申请号：US14201051

申请日：2014-03-07

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  MarcAurele Brun ,  Shinji Omori ,  Yoichi Katsumoto ,  Kazumasa Sato

IPC: G01N33/86 ,  G01N33/48 ,  G01N33/49 ,  G01N27/22

CPC classification number: G01N33/86 ,  G01N27/221 ,  G01N33/4905

Abstract: A blood coagulation analysis device and method in which information relating to the coagulability of blood is evaluated based on a change generated in a permittivity measured in a coagulation process of the blood due to addition of a substance that activates or inactivates platelets to the blood.

Abstract translation: 一种血液凝固分析装置和方法，其中基于由于将血小板活化或灭活的物质添加到血液中而在血液的凝固过程中测量的介电常数产生的变化来评估与血液的凝固性有关的信息。

公开(公告)号：US10794896B2

公开(公告)日：2020-10-06

申请号：US16071663

申请日：2016-11-16

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Shinji Omori

IPC: G01N33/86 ,  G01N33/49 ,  G01N27/22

Abstract: Disclosed are a blood coagulation system examination module, a blood coagulation system examination system, and a blood coagulation system examination method, all of which enable to simply and easily measure thrombin potential with a whole blood sample.The blood coagulation system examination module includes a thrombin potential examination unit configured to examine thrombin potential on the basis of an electrical property of blood as measured at a specific frequency and predetermined time intervals in a predetermined period after reversal of an anticoagulation action working on the blood.

公开(公告)号：US10962495B2

公开(公告)日：2021-03-30

申请号：US16087438

申请日：2017-02-17

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida ,  Aya Murata ,  Shinji Omori ,  Seungmin Lee ,  Kaori Kawaguchi

IPC: G01N33/86 ,  G01N27/22 ,  G01N33/49

Abstract: To provide a system capable of evaluating a deficiency and/or a lowered function of extrinsic coagulation factors or intrinsic coagulation factors with high sensitivity by adding new procedures and apparatuses to a blood coagulation system analysis procedure, an apparatus, or the like.
A blood coagulation system analysis system includes a blood coagulation system measurement apparatus that performs blood coagulation system measurement of a blood sample; and a blood coagulation system analysis apparatus including a coagulation parameter extraction unit that extracts a coagulation parameter from a measurement result by the blood coagulation system measurement apparatus, and a blood coagulation evaluation unit that evaluates a level of blood coagulation of the blood sample on the basis of the coagulation parameter, the measurement by the blood coagulation system measurement apparatus being performed under an extrinsic system acceleration condition and an intrinsic system acceleration condition.

公开(公告)号：US20190162690A1

公开(公告)日：2019-05-30

申请号：US16087438

申请日：2017-02-17

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Marcaurele Brun ,  Kenzo Machida ,  Aya Murata ,  Shinji Omori ,  Seungmin Lee ,  Kaori Kawaguchi

IPC: G01N27/22 ,  G01N33/86

Abstract: To provide a system capable of evaluating a deficiency and/or a lowered function of extrinsic coagulation factors or intrinsic coagulation factors with high sensitivity by adding new procedures and apparatuses to a blood coagulation system analysis procedure, an apparatus, or the like.A blood coagulation system analysis system includes a blood coagulation system measurement apparatus that performs blood coagulation system measurement of a blood sample; and a blood coagulation system analysis apparatus including a coagulation parameter extraction unit that extracts a coagulation parameter from a measurement result by the blood coagulation system measurement apparatus, and a blood coagulation evaluation unit that evaluates a level of blood coagulation of the blood sample on the basis of the coagulation parameter, the measurement by the blood coagulation system measurement apparatus being performed under an extrinsic system acceleration condition and an intrinsic system acceleration condition.

公开(公告)号：US09915599B2

公开(公告)日：2018-03-13

申请号：US14763980

申请日：2013-12-26

Applicant: Sony Corporation

Inventor： Marcaurele Brun ,  Kazumasa Sato ,  Shinji Omori ,  Yoichi Katsumoto

IPC: G01N15/10 ,  G01N27/22 ,  G01N33/487 ,  G01N15/12 ,  G01N15/00

CPC classification number: G01N15/1031 ,  G01N15/1218 ,  G01N27/221 ,  G01N33/48728 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1037 ,  G01N2015/1081 ,  G01N2015/1087 ,  G01N2015/1254 ,  G01N2015/129

Abstract: There is provided a microparticle analysis apparatus including a sample channel configured to receive liquid containing a plurality of microparticles, a first pair of electrodes configured to form an alternating electric field in at least a part of the sample channel, a measuring part configured to measure impedance between the first pair of electrodes, an analyzing part configured to calculate property values of the microparticles from the impedance measured in the measuring part, and a determining part configured to determine whether data of the impedance measured in the measuring part is derived from the microparticles.

公开(公告)号：US09250296B2

公开(公告)日：2016-02-02

申请号：US13734011

申请日：2013-01-04

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  Shinji Omori ,  Ikuya Oshige

IPC: G01R27/08 ,  G01R27/26 ,  G01R31/36 ,  G01N27/22

CPC classification number: G01R31/36 ,  G01N27/221

Abstract: A transmission line substrate includes at least an insulating layer of a predetermined thickness, a pair of conductor layers arranged in a state of being opposed to each other such that the insulating layer is interposed between the conductor layers, the pair of conductor layers functioning as a high-frequency transmission line, and a fault part formed so as to make the conductor layer on one side disconnected, into which a sample to be measured can be introduced.

公开(公告)号：US20140186217A1

公开(公告)日：2014-07-03

申请号：US14201051

申请日：2014-03-07

Applicant: Sony Corporation

Inventor： Yoshihito Hayashi ,  MarcAurele Brun ,  Shinji Omori ,  Yoichi Katsumoto ,  Kazumasa Sato

IPC: G01N33/86

CPC classification number: G01N33/86 ,  G01N27/221 ,  G01N33/4905

Abstract: A blood coagulation analysis device and method in which information relating to the coagulability of blood is evaluated based on a change generated in a permittivity measured in a coagulation process of the blood due to addition of a substance that activates or inactivates platelets to the blood.

Abstract translation: 一种血液凝固分析装置和方法，其中基于由于将血小板活化或灭活的物质添加到血液中而在血液的凝固过程中测量的介电常数产生的变化来评估与血液的凝固性有关的信息。

公开(公告)号：US20190072540A1

公开(公告)日：2019-03-07

申请号：US16087443

申请日：2016-12-22

Applicant: Sony Corporation

Inventor： Marcaurele Brun ,  Isao Hidaka ,  Shinji Omori

IPC: G01N33/49 ,  G01N27/02 ,  G01N33/86 ,  G01N33/487

Abstract: The main purpose of the present technology is to provide a technology capable of reducing the risk of erroneous determination while ensuring real-time properties in the measurement of electrical characteristics of a biological sample.In this regard, the present technology provides an electrical characteristics measurement apparatus including: at least a measurement unit that measures electrical characteristics of a biological sample over time; an analysis unit that reviews, in real time during the measurement, data related to a temporal change in the electrical characteristics and analyzes a change in state of the biological sample; and a notification unit that issues notification of an analysis result in the analysis unit at a specific time point, in which the analysis unit detects a predetermined feature point from the data related to the temporal change in the electrical characteristics to use data related to the temporal change in a period before and/or after the predetermined feature point.

公开(公告)号：US20150377763A1

公开(公告)日：2015-12-31

申请号：US14763980

申请日：2013-12-26

Applicant: SONY CORPORATION

Inventor： Marcaurele Brun ,  Kazumasa Sato ,  Shinji Omori ,  Yoichi Katsumoto

IPC: G01N15/10 ,  G01N33/487 ,  G01N27/22

CPC classification number: G01N15/1031 ,  G01N15/1218 ,  G01N27/221 ,  G01N33/48728 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1037 ,  G01N2015/1081 ,  G01N2015/1087 ,  G01N2015/1254 ,  G01N2015/129

Abstract: There is provided a microparticle analysis apparatus including a sample channel configured to receive liquid containing a plurality of microparticles, a first pair of electrodes configured to form an alternating electric field in at least a part of the sample channel, a measuring part configured to measure impedance between the first pair of electrodes, an analyzing part configured to calculate property values of the microparticles from the impedance measured in the measuring part, and a determining part configured to determine whether data of the impedance measured in the measuring part is derived from the microparticles.

Abstract translation: 提供了一种微粒分析装置，其包括被配置为接收含有多个微粒的液体的样品通道，第一对电极构造成在至少一部分样品通道中形成交变电场;测量部件，被配置为测量阻抗 在第一对电极之间，分析部件被配置为根据在测量部件中测量的阻抗计算微粒的特性值，以及确定部件，被配置为确定在测量部件中测量的阻抗的数据是否从微粒导出。