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公开(公告)号：US20150140562A1
公开(公告)日：2015-05-21
申请号：US14543160
申请日：2014-11-17
CPC分类号： C12Q1/6851 , B01L3/50851 , B01L7/52 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/0819 , B01L2300/0829 , B01L2300/0851 , B01L2300/0887 , B01L2300/0893 , B01L2300/161 , B01L2300/163 , B01L2300/168 , B01L2300/1827 , C12Q1/6825 , C12Q1/686 , G01N21/01 , G01N21/0303 , G01N21/253 , G01N21/51 , G01N21/6452 , G06K9/0014 , G06T7/0012 , G06T7/0014 , G06T2207/10064 , G06T2207/20024 , G06T2207/20061 , G06T2207/30072 , Y10T29/49885
摘要： An optical analyzer, configured to receiving a cartridge for biochemical analyses including a plurality of wells, and carrying out fluorescence analysis of the cartridge, in particular of the wells. The analyzer comprises a control unit (microprocessor and memory) configured to: (a) acquiring an image associated to the fluorescence emitted by the cartridge; (b) identifying, in the image, pixels belonging to boundary lines of the wells by generating a black and white binary image; (c) recognizing, between the geometrical shapes identified in step (b), the ones that best approximate a reference geometrical shape identifying an ideal well; (d) acquiring, from the starting image, values of light intensity only in portions of the image itself that in turn correspond to the regions recognized in step (c); and (e) evaluating a state of advance and/or a result of the biochemical analysis on the basis of the values of light intensity acquired in step (d).
摘要翻译： 一种光学分析器，被配置为接收用于包括多个孔的生化分析的盒，并且对所述盒，特别是所述孔进行荧光分析。 分析器包括控制单元（微处理器和存储器），其被配置为：（a）获取与由盒发出的荧光相关联的图像; （b）通过生成黑白二进制图像在图像中识别属于孔的边界线的像素; （c）在步骤（b）中识别的几何形状之间识别最接近标识理想井的参考几何形状的几何形状; （d）仅在图像本身的部分中从起始图像获取光强值，其依次对应于步骤（c）中识别的区域; 和（e）基于步骤（d）中获得的光强度的值来评估生化分析的进展状态和/或生化分析结果。
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公开(公告)号：US20150140563A1
公开(公告)日：2015-05-21
申请号：US14543276
申请日：2014-11-17
CPC分类号： C12Q1/6851 , B01L3/50851 , B01L7/52 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/0819 , B01L2300/0829 , B01L2300/0851 , B01L2300/0887 , B01L2300/0893 , B01L2300/161 , B01L2300/163 , B01L2300/168 , B01L2300/1827 , C12Q1/6825 , C12Q1/686 , G01N21/01 , G01N21/0303 , G01N21/253 , G01N21/51 , G01N21/6452 , G06K9/0014 , G06T7/0012 , G06T7/0014 , G06T2207/10064 , G06T2207/20024 , G06T2207/20061 , G06T2207/30072 , Y10T29/49885
摘要： A cartridge for an optical analysis, including a supporting body, having a first face and a second face opposite to one another; a plurality of wells adapted to receive a biological solution to be analyzed, the wells extending in the supporting body on the first face; at least one biocompatible layer extending inside each well; an anti-reflection layer extending on the first face outside the wells; and a reflection layer extending inside each well. Methods of using same are also provided.
摘要翻译： 一种用于光学分析的盒，包括支撑体，具有彼此相对的第一面和第二面; 适于接收要分析的生物溶液的多个井，所述井在所述第一面上的所述支撑体中延伸; 在每个孔内延伸的至少一个生物相容层; 在所述孔的外部的所述第一面上延伸的防反射层; 以及在每个孔内延伸的反射层。 还提供了使用方法。
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公开(公告)号：US20140291152A1
公开(公告)日：2014-10-02
申请号：US14221033
申请日：2014-03-20
CPC分类号： B01L3/50273 , B01L3/502723 , B01L3/502784 , B01L3/5085 , B01L3/50851 , B01L2200/0642 , B01L2300/0864 , B01L2300/166 , B01L2400/0406 , B01L2400/0427 , C12Q1/6844
摘要： A microreactor includes: a substrate (2; 102; 202) made of semiconductor material; a plurality of wells (5; 105; 205) separated by walls (6; 106; 206) in the substrate (2; 102; 202); a dielectric structure (7; 107; 207a, 207b) coating at least the top of the walls (6; 106; 206); a cap (3; 103; 203), bonded to the substrate (2; 102; 202) and defining a chamber (10; 110; 210) above the wells (5; 105; 205); and a biasing structure (2, 8, 13; 102, 108, 113; 202, 208a, 208b, 213), configured for setting up a voltage (VB) between the substrate (2; 102; 202) and the chamber (10; 110; 210).
摘要翻译： 微反应器包括：由半导体材料制成的衬底（2; 102; 202） 在所述衬底（2; 102; 202）中被壁（6; 106; 206）隔开的多个孔（5; 105; 205）; 涂覆至少所述壁（6; 106; 206）的顶部的电介质结构（7; 107; 207a，207b）; 盖子（3; 103; 203），其结合到所述基底（2; 102; 202）并且在所述孔（5; 105; 205）上方限定腔室（10; 110; 210） 以及偏置结构（2,8,13; 102,108,113; 202,208a，208b，213），其被配置用于在所述基板（2; 102; 202）和所述腔室（10）之间建立电压（VB） ; 110; 210）。
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公开(公告)号：US20220327845A1
公开(公告)日：2022-10-13
申请号：US17715744
申请日：2022-04-07
摘要： A time series of face images of a human during a human activity are captured. A first artificial neural network (ANN) processing pipeline processes the captured time series of face images to provide a first attention level indicator signal. An electrophysiological signal indicative of the level of attention of the human during the activity is also captured. A second ANN processing pipeline processes the sensed electrophysiological signal to providing a second attention level indicator signal. A risk indicator signal is then generated based on at least one of the first attention level indicator and second attention level indicator. A user circuit is then triggered as a result of the risk indicator reaching or failing to reach at least one attention level threshold.
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