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公开(公告)号：US09867904B2
公开(公告)日：2018-01-16
申请号：US15377323
申请日：2016-12-13
CPC分类号： A61L27/3691 , A61F2/105 , A61L27/3813 , A61L27/54 , A61L27/60 , A61L2430/40
摘要： The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
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公开(公告)号：US20210355451A1
公开(公告)日：2021-11-18
申请号：US17319760
申请日：2021-05-13
摘要： The present disclosure is directed to viable bioengineered skin constructs.
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公开(公告)号：US20170339943A1
公开(公告)日：2017-11-30
申请号：US15375755
申请日：2016-12-12
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0231 , A01N1/0263 , A01N1/0273
摘要： The present invention relates generally to systems and methods for storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
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公开(公告)号：US09526811B2
公开(公告)日：2016-12-27
申请号：US14669095
申请日：2015-03-26
CPC分类号： A61L27/3691 , A61F2/105 , A61L27/3813 , A61L27/54 , A61L27/60 , A61L2430/40
摘要： The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
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公开(公告)号：US11297829B2
公开(公告)日：2022-04-12
申请号：US16122598
申请日：2018-09-05
IPC分类号： A01N1/02
摘要： The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
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公开(公告)号：US20190030130A1
公开(公告)日：2019-01-31
申请号：US16150048
申请日：2018-10-02
摘要： The present invention relates generally to compositions for treating patients that have skin cancer or have recently had skin cancers removed. More specifically, the present invention provides human skin substitutes engineered to express exogenous IL-12 and compositions and methods for making human skin substitutes engineered to express exogenous IL-12. In addition, the present invention provides methods for treatment of sites on a patient where skin cancers have been removed with human skin substitutes engineered to express exogenous IL-12.
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公开(公告)号：US20140335064A1
公开(公告)日：2014-11-13
申请号：US14335534
申请日：2014-07-18
CPC分类号： A61L27/60 , A61K35/12 , A61K35/36 , A61K38/1709 , A61K38/1825 , A61K2035/122 , A61L27/227 , A61L27/3813 , A61L27/3895 , A61L27/54 , A61L2300/252 , A61L2300/404 , C07H21/04 , C07K14/50 , C12N5/0629 , C12N5/0698 , C12N15/63 , C12N15/79 , C12N2501/117 , C12N2501/998 , C12N2502/094 , C12N2502/1323 , C12N2510/00
摘要： The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.
摘要翻译： 本发明一般涉及用于伤口闭合的组合物。 更具体地，本发明提供了用于表达外源多肽（例如抗微生物多肽和角质形成细胞生长因子2）的人皮肤当量以及用于制造人皮肤等同物的工程化以表达外源多肽的组合物和方法。 此外，本发明提供了用于表达外源多肽的用于治疗具有人皮肤当量的伤口的伤口的方法。
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公开(公告)号：US20140271583A1
公开(公告)日：2014-09-18
申请号：US14208439
申请日：2014-03-13
IPC分类号： A01N1/02
CPC分类号： A01N1/0221
摘要： The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for cryopreserving viable skin substitutes.
摘要翻译： 本发明一般涉及用于制备，储存，运输和使用由器官培养形成的皮肤等同物的系统和方法。 特别地，本发明涉及用于冷冻保存活的皮肤代用品的系统和方法。
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公开(公告)号：US08685463B2
公开(公告)日：2014-04-01
申请号：US14054445
申请日：2013-10-15
IPC分类号： A61K35/12
CPC分类号： A61L27/3691 , A61F2/105 , A61L27/3813 , A61L27/54 , A61L27/60 , A61L2430/40
摘要： The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
摘要翻译： 本发明一般涉及用于制备，储存，运输和使用由器官培养形成的皮肤等同物的系统和方法。 特别地，本发明涉及用于生产，运输，储存和使用在降低的温度，优选2-8摄氏度至环境温度下由器官培养产生的皮肤当量的系统和方法。 所述方法包括移植物的无菌包装，从而保持包装的无菌性和完整性，直至用于移植目的的使用时间为止。
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公开(公告)号：US11911444B2
公开(公告)日：2024-02-27
申请号：US16150048
申请日：2018-10-02
CPC分类号： A61K38/208 , C07K14/5434 , C12N5/0629 , A61K35/12 , A61K48/00 , C12N2501/23 , C12N2510/00
摘要： The present invention relates generally to compositions for treating patients that have skin cancer or have recently had skin cancers removed. More specifically, the present invention provides human skin substitutes engineered to express exogenous IL-12 and compositions and methods for making human skin substitutes engineered to express exogenous IL-12. In addition, the present invention provides methods for treatment of sites on a patient where skin cancers have been removed with human skin substitutes engineered to express exogenous IL-12.
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