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    Fatty acid esters as anti-Malassezia agents
    7.
    发明授权
    Fatty acid esters as anti-Malassezia agents 有权

    公开(公告)号：US12274775B2

    公开(公告)日：2025-04-15

    申请号：US17428309

    申请日：2019-02-04

    Applicant: SYMRISE AG

    Inventor： Peter Mayser ,  Manuel Pesaro ,  Gerhard Schmaus ,  Jessica Grieger ,  Nikolas Bugdahn

    IPC: A61K8/37 ,  A61K8/34 ,  A61Q5/00 ,  A61Q17/00 ,  A61Q19/00

    Abstract: The present invention primarily relates to a fatty acid ester or mixture of two or more fatty acid esters or mixture comprising one or more fatty acid esters, wherein the fatty acid ester or one, two, three or more, preferably all, of the fatty acid ester(s) is/are selected from the group consisting of 3-hydroxypropyl caprylate, glyceryl monocaprylate, 3-hydroxypropyl undecylenate and glyceryl monoundecylenate, for use in the treatment of an excess of Malassezia on the skin surface of mammals, preferably of humans. The present invention further relates to particular mixtures or products, and to the cosmetic, non-therapeutic use of fatty acid esters or of mixtures or products comprising fatty acid esters as defined herein to reduce the amount of Malassezia on the skin surface of mammals, preferably of humans.

    Probiotics for altering the composition of oral biofilms
    8.
    发明授权
    Probiotics for altering the composition of oral biofilms 有权

    公开(公告)号：US11198848B2

    公开(公告)日：2021-12-14

    申请号：US16070573

    申请日：2017-01-18

    Applicant: SYMRISE AG ,  PROBI AB

    Inventor： William Wade ,  Marcus Rudolf Götz ,  Manuel Pesaro

    IPC: A61K35/747 ,  C12N1/20 ,  A61K9/00 ,  A61K9/68 ,  A61Q11/00 ,  A61K35/00 ,  C12R1/225

    Abstract: The present invention relates to a certain microorganism for altering the composition of oral biofilms, in particular for use in the treatment and/or prevention of dental caries and/or periodontal disease.
    In particular, the present invention relates to a microorganism for use as a probiotic agent for altering the bacterial composition of oral biofilms derived from saliva, preferably for reducing the proportions of Gram-negative anaerobic genera and/or increasing the proportions of aerobic or facultatively anaerobic genera.
    Furthermore, the present invention provides oral pharmaceutical compositions, oral care products or products for nutrition or pleasure comprising the microorganism as probiotic agents as well as a method of production thereof.

    Antimicrobial compositions
    9.
    发明授权
    Antimicrobial compositions 有权

    公开(公告)号：US11116710B2

    公开(公告)日：2021-09-14

    申请号：US16301854

    申请日：2016-10-11

    Applicant: SYMRISE AG

    Inventor： Manuel Pesaro ,  Bernd Hölscher ,  Benoit Join

    IPC: A61K8/37 ,  A61Q17/00 ,  A61Q15/00 ,  A61K8/49 ,  A61K8/04 ,  A61K8/06 ,  A61K8/42 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q19/10 ,  A01N37/22 ,  A01N37/24 ,  A01N37/12 ,  A01N43/08

    Abstract: The present invention is the use of a compound of formula (I) or a (pharmaceutically) acceptable salt thereof, wherein (a) X denotes CH═CH or CZ1=CZ2, wherein if Z1 is H then Z2 denotes a radical selected from the group consisting of OH, NH2, NHMe, NMe2, OMe and OEt and if Z2 is H then Z1 denotes a radical selected from the group consisting of OH, NH2, NHMe, NMe2, OMe and OEt, Y denotes a radical selected from the group consisting of NH2, NHMe, NMe2, NHEt, O—(CH2)n—OH, wherein n is 2 to 5 and R denotes a radical selected from the group consisting of H, OH, Me, Et, OMe, OEt, NH2, NHMe, NMe2, NHEt and NEt2, or (b) X denotes O, Y denotes a radical selected from the group consisting of NH2, NHMe, NMe2, NHEt, O—(CH2)n—OH and OMe, wherein n is 2 to 5 and R denotes H, OH, Me, Et, OMe, OEt, NH2, NHMe, NMe2, NHEt, NEt2 as antimicrobial agent as well as to composition comprising said agent.

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