公开(公告)号：US12016944B2

公开(公告)日：2024-06-25

申请号：US16977989

申请日：2018-03-08

Applicant: Symrise AG

Inventor： Sabine Lange ,  Martina Herrmann ,  Dominik Stuhlmann ,  Ann-Christin Weseloh ,  Adelino Nakano ,  Carolina Lourenço

IPC: A61K8/64 ,  A61K8/34 ,  A61K8/362 ,  A61K8/365 ,  A61K8/891 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00

CPC classification number: A61K8/645 ,  A61K8/34 ,  A61K8/345 ,  A61K8/362 ,  A61K8/365 ,  A61K8/891 ,  A61Q5/002 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00

Abstract: Suggested is a mixture comprising or consisting of: (a) a protein extract obtained from cereal gluten extracted by means of aqueous ethanol, said extract being characterized by a content of at least 50 wt.-% proteins having a molecular weight of at least 22 kDa; (b) at least one organic acid; and (c) at least one cosmetically acceptable carrier.

公开(公告)号：US20230293408A1

公开(公告)日：2023-09-21

申请号：US18009298

申请日：2021-12-09

Applicant: Symrise AG

Inventor： Nikolas Bugdahn ,  Sven Siegel ,  Sabine Lange ,  Dominik Stuhlmann

IPC: A61K8/34 ,  A61K47/10

CPC classification number: A61K8/345 ,  A61K47/10 ,  A61K2800/5922 ,  A61K2800/524 ,  A61K2800/49 ,  A61K2800/10 ,  A61K2800/522

Abstract: The present invention is in the field of antioxidants and relates to cosmetic or pharmaceutical, preferably dermatological, compositions or homecare product comprising or consisting of a synergistic combination of a specific antioxidant and an effective amount of 1,2-heptanediol and/or 2,3-heptanediol or of a specific alkanediol or a mixture of two or more different specific alkanediols and the use of said compositions as a cosmetic, for personal care, as a pharmaceutical or homecare product, in particular for scavenging reactive oxygen species (ROS), for inhibition matrix metalloproteinases expression and/or for inhibiting interleukin 8 (IL-8) secretion. Additionally, the present invention relates to the use of 1,2-heptanediol and/or 2,3-heptanediol or of a specific alkanediol or a mixture of two or more different specific alkanediols for enhancing the antioxidative effect of an antioxidant in a cosmetic or pharmaceutical, preferably dermatological, composition or homecare product, and/or for enhancing the antioxidative effect of a cosmetic or pharmaceutical, preferably dermatological, composition upon application.

公开(公告)号：US20230248663A1

公开(公告)日：2023-08-10

申请号：US18301072

申请日：2023-04-14

Applicant: Symrise AG

Inventor： Nikolas Bugdahn ,  Sven Siegel ,  Sabine Lange ,  Dominik Stuhlmann

IPC: A61K31/047 ,  A61K31/355 ,  A61K47/22 ,  A61K47/10 ,  A61K31/23 ,  A61K31/222 ,  A61K31/375 ,  A61K47/14 ,  A61K47/08 ,  A61K8/67 ,  A61K8/34 ,  A61K8/37 ,  A61K8/39 ,  A61K8/35 ,  A61P17/18 ,  A61K31/167 ,  A61K31/4172 ,  A61K31/00 ,  A61K36/82 ,  A61K36/9068 ,  A61K47/18 ,  A61K8/42 ,  A61K8/49 ,  A61K47/46 ,  A61K8/9789 ,  A61K8/9794 ,  A61K31/07 ,  A61K31/198 ,  A61K8/43 ,  A61Q19/08 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q5/00 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q9/02 ,  A61Q5/02

CPC classification number: A61K31/047 ,  A61K31/355 ,  A61K47/22 ,  A61K47/10 ,  A61K31/23 ,  A61K31/222 ,  A61K31/375 ,  A61K47/14 ,  A61K47/08 ,  A61K8/678 ,  A61K8/345 ,  A61K8/375 ,  A61K8/676 ,  A61K8/39 ,  A61K8/35 ,  A61P17/18 ,  A61K31/167 ,  A61K31/4172 ,  A61K31/658 ,  A61K36/82 ,  A61K36/9068 ,  A61K47/18 ,  A61K8/42 ,  A61K8/4946 ,  A61K8/347 ,  A61K47/46 ,  A61K8/9789 ,  A61K8/9794 ,  A61K31/07 ,  A61K8/671 ,  A61K31/198 ,  A61K47/183 ,  A61K8/43 ,  A61Q19/08 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/002 ,  A61Q5/006 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q9/02 ,  A61Q5/02

Abstract: The present invention is in the field of antioxidants and relates to cosmetic or pharmaceutical, preferably dermatological, compositions or homecare product comprising or consisting of a synergistic combination of a specific antioxidant and an effective amount of 1,2-heptanediol and/or 2,3-heptanediol or of a specific alkanediol or a mixture of two or more different specific alkanediols and the use of said compositions as a cosmetic, for personal care, as a pharmaceutical or homecare product, in particular for scavenging reactive oxygen species (ROS), for inhibition matrix metalloproteinases expression and/or for inhibiting interleukin 8 (IL-8) secretion. Additionally, the present invention relates to the use of 1,2-heptanediol and/or 2,3-heptanediol or of a specific alkanediol or a mixture of two or more different specific alkanediols for enhancing the antioxidative effect of an antioxidant in a cosmetic or pharmaceutical, preferably dermatological, composition or homecare product, and/or for enhancing the antioxidative effect of a cosmetic or pharmaceutical, preferably dermatological, composition upon application.

公开(公告)号：US20180042832A1

公开(公告)日：2018-02-15

申请号：US15554791

申请日：2016-02-17

Applicant: Symrise AG

Inventor： Cécile Kalem ,  Dominik Stuhlmann ,  Aurélle Trunet ,  Denis Brouard

IPC: A61K8/49 ,  A61Q19/00 ,  A61K8/42 ,  A61K8/37 ,  A61K8/34 ,  A61Q5/10 ,  A61Q5/04

CPC classification number: A61K8/498 ,  A61K8/34 ,  A61K8/345 ,  A61K8/37 ,  A61K8/375 ,  A61K8/42 ,  A61K8/4973 ,  A61K2800/244 ,  A61Q5/04 ,  A61Q5/08 ,  A61Q5/10 ,  A61Q5/12 ,  A61Q19/005

Abstract: The present invention relates to a soothing composition, comprising (a) menthol compounds, and (b) one or more cosmetically acceptable carriers.

公开(公告)号：US09820923B2

公开(公告)日：2017-11-21

申请号：US14896824

申请日：2014-06-04

Applicant: Symrise AG

Inventor： Dominik Stuhlmann ,  Imke Meyer ,  Oskar Koch ,  Helko Oertling ,  Martina Herrmann ,  Claudia Gömann

IPC: A61K8/00 ,  A61K8/42 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  C07C235/74 ,  A61K8/49 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/04

CPC classification number: A61K8/42 ,  A61K8/4926 ,  A61K2800/48 ,  A61K2800/522 ,  A61K2800/524 ,  A61K2800/591 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  C07C235/74

Abstract: The invention relates generally to new compounds of formula (I), wherein R1, R′1, R2, R′2, R3, R′3, R4 R′4, R5, R′5, R6, R7 are independently of one another and denote hydrogen, hydroxyl, C1 to C6-alkyl group or R6 and R7 form together a C5-C6 ring system, and wherein n=0, 1, 2, 3, or 4. Moreover, the invention relates to the use of one or more compounds of formula (I) in cosmetic or pharmaceutical compositions, which are preferably dermatological compositions and are preferably used topically.

公开(公告)号：US11911347B2

公开(公告)日：2024-02-27

申请号：US18301072

申请日：2023-04-14

Applicant: Symrise AG

Inventor： Nikolas Bugdahn ,  Sven Siegel ,  Sabine Lange ,  Dominik Stuhlmann

IPC: A61K31/047 ,  A61K8/34 ,  A61K8/35 ,  A61K8/37 ,  A61K8/39 ,  A61K8/42 ,  A61K8/43 ,  A61K8/49 ,  A61K8/67 ,  A61K8/9789 ,  A61K8/9794 ,  A61K31/00 ,  A61K31/07 ,  A61K31/167 ,  A61K31/198 ,  A61K31/222 ,  A61K31/23 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4172 ,  A61K36/82 ,  A61K36/9068 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/46 ,  A61P17/18 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q9/02 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08

CPC classification number: A61K31/047 ,  A61K8/345 ,  A61K8/347 ,  A61K8/35 ,  A61K8/375 ,  A61K8/39 ,  A61K8/42 ,  A61K8/43 ,  A61K8/4946 ,  A61K8/671 ,  A61K8/676 ,  A61K8/678 ,  A61K8/9789 ,  A61K8/9794 ,  A61K31/07 ,  A61K31/167 ,  A61K31/198 ,  A61K31/222 ,  A61K31/23 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4172 ,  A61K31/658 ,  A61K36/82 ,  A61K36/9068 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/183 ,  A61K47/22 ,  A61K47/46 ,  A61P17/18 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q9/02 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/002 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/08 ,  A61K2800/10 ,  A61K2800/49 ,  A61K2800/522 ,  A61K2800/524 ,  A61K2800/5922

Abstract: The present invention is in the field of antioxidants and relates to cosmetic or pharmaceutical, preferably dermatological, compositions or homecare product comprising or consisting of a synergistic combination of a specific antioxidant and an effective amount of 1,2-heptanediol and/or 2,3-heptanediol or of a specific alkanediol or a mixture of two or more different specific alkanediols and the use of said compositions as a cosmetic, for personal care, as a pharmaceutical or homecare product, in particular for scavenging reactive oxygen species (ROS), for inhibition matrix metalloproteinases expression and/or for inhibiting interleukin 8 (IL-8) secretion. Additionally, the present invention relates to the use of 1,2-heptanediol and/or 2,3-heptanediol or of a specific alkanediol or a mixture of two or more different specific alkanediols for enhancing the antioxidative effect of an antioxidant in a cosmetic or pharmaceutical, preferably dermatological, composition or homecare product, and/or for enhancing the antioxidative effect of a cosmetic or pharmaceutical, preferably dermatological, composition upon application.

公开(公告)号：US11801210B2

公开(公告)日：2023-10-31

申请号：US17042263

申请日：2019-03-29

Applicant: SYMRISE AG

Inventor： Dominik Stuhlmann ,  Ann-Christin Weseloh ,  Nicole Titze ,  Sabine Lange ,  Sebastian Bruncke ,  Benoît Join ,  Gabriele Vielhaber ,  Marielle Le Maire ,  Karima Benaissi

IPC: A61K8/37 ,  A61P17/02 ,  A61K31/01 ,  A61K31/047 ,  A61K31/198 ,  A61K31/22 ,  A61K31/225 ,  A61K31/23 ,  A61K31/232 ,  A61K31/355 ,  A61K31/357 ,  A61K36/28 ,  A61K36/886 ,  A61K36/9068 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08

CPC classification number: A61K8/37 ,  A61K31/01 ,  A61K31/047 ,  A61K31/198 ,  A61K31/22 ,  A61K31/225 ,  A61K31/23 ,  A61K31/232 ,  A61K31/355 ,  A61K31/357 ,  A61K36/28 ,  A61K36/886 ,  A61K36/9068 ,  A61P17/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08

Abstract: The present invention relates to novel cosmetic and therapeutic uses of one or more compounds of the general formula (1) as described herein. Furthermore, the present invention relates to compositions (products or, respectively, formulations), in particular for topical administration, preferably cosmetic or pharmaceutical compositions, comprising or consisting of compound(s) of formula (1) and one or more cosmetically and/or pharmaceutically acceptable carriers. The present invention also relates to novel uses of such compositions according to the invention.

公开(公告)号：US11786570B2

公开(公告)日：2023-10-17

申请号：US16976037

申请日：2019-02-27

Applicant: SYMRISE AG

Inventor： Martina Herrmann ,  Sandra Gaebler ,  Dominik Stuhlmann ,  Ann-Christin Weseloh

IPC: A61K36/05 ,  A61K8/9722 ,  A61K8/60 ,  A61K8/67 ,  A61K31/455 ,  A61K47/26 ,  A61K47/40

CPC classification number: A61K36/05 ,  A61K8/60 ,  A61K8/675 ,  A61K8/9722 ,  A61K31/455 ,  A61K47/26 ,  A61K47/40

Abstract: The present invention discloses a composition comprising sugar alcohols or a combination of sugar alcohols and a Tetraselmis extract or either of the former together with niacinamide for treating or preventing dysfunctions of the human hair or skin or as a skin or hair care product.

公开(公告)号：US09125936B2

公开(公告)日：2015-09-08

申请号：US14185157

申请日：2014-02-20

Applicant: Symrise AG

Inventor： Imke Meyer ,  Martina Herrmann ,  Dominik Stuhlmann ,  Holger Joppe

IPC: A61K36/9068 ,  A61K31/12 ,  A61K8/97 ,  A61K8/35 ,  A61Q19/00 ,  A61Q7/00 ,  A61Q19/08 ,  A61Q5/00 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q19/02 ,  A61Q19/06

CPC classification number: A61K36/9068 ,  A61K8/35 ,  A61K8/97 ,  A61K31/12 ,  A61K2236/37 ,  A61K2236/39 ,  A61K2800/75 ,  A61Q5/006 ,  A61Q5/12 ,  A61Q7/00 ,  A61Q15/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/06 ,  A61Q19/08 ,  A61K2300/00

Abstract: Ginger extract compositions containing 25 to 30% b.w. [6]-gingerol, 5 to 10% b.w. [8]-gingerol, 5 to 10% b.w. [10]-gingerol, 1.5 to 4% b.w. [6]-shogaol, 0.3 to 1.3% b.w. [8]-shogaol, 0.03 to 1% b.w. [10]-shogaol and 0.01 to 1% b.w. zingerone, with the amount of gingerols totaling 35 to 50% b.w. and the amount of shogaols totaling 1.5 to 6% b.w.

Abstract translation: 姜提取物组合物含25-30％b.w. [6] - 强啡灵，5〜10％b.w [8] - 强啡多，5至10％b.w. [10] - 烯草醇，1.5〜4％b.w。 [6] -shogaol，0.3〜1.3％b.w。 [8] -shogaol，0.03〜1％b.w。 [10] -shogaol和0.01至1％b.w。 姜油酮，姜油总量为35〜50％b.w。 和shogaols的总量为1.5到6％b.w.

公开(公告)号：US20140242020A1

公开(公告)日：2014-08-28

申请号：US14185157

申请日：2014-02-20

Applicant: Symrise AG

Inventor： Imke Meyer ,  Martina Herrmann ,  Dominik Stuhlmann ,  Holger Joppe

IPC: A61K36/9068 ,  A61Q19/00 ,  A61K8/35 ,  A61Q5/00 ,  A61K31/12 ,  A61K8/97

CPC classification number: A61K36/9068 ,  A61K8/35 ,  A61K8/97 ,  A61K31/12 ,  A61K2236/37 ,  A61K2236/39 ,  A61K2800/75 ,  A61Q5/006 ,  A61Q5/12 ,  A61Q7/00 ,  A61Q15/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/06 ,  A61Q19/08 ,  A61K2300/00

Abstract: Suggested is a ginger extract, comprising (a) 25 to 30% b.w. [6]-gingerol (b) 5 to 10% b.w. [8]-gingerol (c) 5 to 10% b.w. [10]-gingerol (d) 1.5 to 4% b.w. [6]-shogaol (e) 0.3 to 1.3% b.w. [8]-shogaol; (f) 0.03 to 1% b.w. [10]-shogaol; (g) 0.01 to 1% b.w. zingerone, on condition that the amount of gingerols sums up to 35 to 50% b.w. and the amount of shogaols sums up to 1.5 to 6% b.w.

Abstract translation: 建议是姜提取物，包括（a）25-30％b.w. [6] - er烯醇（b）5〜10％b.w。 [8]庚烯酚（c）5至10％b.w。 [10]庚烯酚（d）1.5〜4％b.w。 [6] -shogaol（e）0.3〜1.3％b.w。 [8] -shogaol; （f）0.03〜1％b.w [10] -shogaol; （g）0.01至1％b.w。 姜黄酮，条件是姜醇含量达到35〜50％b.w。 并且shogaols的总量达到1.5到6％b.w.