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13 条记录 (耗时 0.033 秒)

    DNA encoding galanin receptor activating peptide
    5.
    发明授权
    DNA encoding galanin receptor activating peptide 失效
    编码甘丙肽受体激活肽的DNA

    公开(公告)号：US07374910B2

    公开(公告)日：2008-05-20

    申请号：US11376694

    申请日：2006-03-15

    申请人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    IPC分类号： C01N15/11 ,  C01N15/63 ,  C01N5/10

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/72

    摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof.An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.

    摘要翻译： 本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与 由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。 本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物 具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。

    Antiobestic agents methods for screening antiobestic agents and kits comprising same
    6.
    发明授权
    Antiobestic agents methods for screening antiobestic agents and kits comprising same 失效
    用于筛选抗生物剂的抗生物剂方法和包含其的试剂盒

    公开(公告)号：US06991908B1

    公开(公告)日：2006-01-31

    申请号：US09869540

    申请日：1999-12-27

    申请人： Masaaki Mori ,  Yukio Shimomura ,  Shiro Takekawa ,  Tsukasa Sugo ,  Yoshihiro Ishibashi ,  Chieko Kitada ,  Nobuhiro Suzuki

    发明人： Masaaki Mori ,  Yukio Shimomura ,  Shiro Takekawa ,  Tsukasa Sugo ,  Yoshihiro Ishibashi ,  Chieko Kitada ,  Nobuhiro Suzuki

    IPC分类号： G01N33/53

    CPC分类号： C07K7/08 ,  A61K38/10 ,  G01N33/74 ,  G01N2333/575 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2500/02 ,  Y10S436/808

    摘要： The present invention provides a method for screening a compound or its salt that alters the binding property between MCH or its salt and SLC-1 or its salt, characterized by using MCH or its derivative or a salt thereof and SLC-1 or its salt is useful for screening an SLC-1 agonist which can be used not only as an appetite (eating) promoting agent but also as a prophylactic/therapeutic agent for weak pains, atonic bleeding, before and after expulsion, subinvolution of uterus, cesarean section, induced abortion, galactostasis, and the like, and an SLC-1 antagonist which can be used not only as an antiobestic agents (drug), an appetite (eating) modulator, and the like, but also as a prophylactic/therapeutic agent for hyperstimulation, ankylosing uterine contractions, fetal distress, uterine rupture, cervical laceration, preterm delivery, Prader-Wili syndrome and the like.

    摘要翻译： 本发明提供一种筛选化合物或其盐的方法，其改变MCH或其盐与SLC-1或其盐之间的结合性质，其特征在于使用MCH或其衍生物或其盐，SLC-1或其盐是 可用于筛选SLC-1激动剂，其不仅可以用作食欲（进食）促进剂，而且可用作弱疼痛，无症状出血，驱除前后，子宫切除，剖宫产，诱导 流产，半乳糖淀粉酶等，以及不仅可以用作抗生素（药物），食欲调节剂等的SLC-1拮抗剂，而且可以用作过度刺激的预防/治疗剂， 强直性子宫收缩，胎儿窘迫，子宫破裂，子宫颈撕裂，早产，Prader-Wili综合征等。

    PACAP receptor protein, method for preparing said protein, and use thereof
    7.
    发明授权
    PACAP receptor protein, method for preparing said protein, and use thereof 失效
    PACAP受体蛋白质，所述蛋白质的制备方法及其用途

    公开(公告)号：US06399316B1

    公开(公告)日：2002-06-04

    申请号：US09201474

    申请日：1998-11-30

    申请人： Haruo Onda ,  Tetsuya Ohtaki ,  Yasushi Masuda ,  Chieko Kitada ,  Yoshihiro Ishibashi ,  Masaki Hosoya ,  Kazuhiro Ogi ,  Yasunori Miyamoto ,  Yugo Habata ,  Norio Shimamoto

    发明人： Haruo Onda ,  Tetsuya Ohtaki ,  Yasushi Masuda ,  Chieko Kitada ,  Yoshihiro Ishibashi ,  Masaki Hosoya ,  Kazuhiro Ogi ,  Yasunori Miyamoto ,  Yugo Habata ,  Norio Shimamoto

    IPC分类号： G01N3353

    CPC分类号： C07K14/72 ,  A61K38/00 ,  A61K48/00

    摘要： This invention discloses a PACAP receptor protein or a salt thereof, a DNA comprising a DNA fragment coding for the protein, a method for preparing the protein, antibody against the protein, and use of the protein, DNA, and antibodies. A PACAP receptor protein was purified from the bovine cerebrum. DNAs coding for PACAP receptor proteins were isolated from bovine, rat and human cDNA libraries, and their nucleotide sequences were determined. Further, amino acid sequences deduced from the nucleotide sequences were determined. The PACAP receptor proteins and the DNAs coding for the proteins of the present invention can be used for (1) acquisition of antibodies and antisera, (2) construction of expression systems of recombinant receptor proteins, (3) development of receptor binding assay systems using said expression systems and screening of potential compounds for drugs, (4) execution of drug design based on the comparison of ligands and receptors which are structurally similar to each other, (5) preparation of probes and PCR primers in gene diagnosis, and the like.

    摘要翻译： 本发明公开了一种PACAP受体蛋白或其盐，包含编码该蛋白质的DNA片段的DNA，该蛋白质的制备方法，针对该蛋白质的抗体以及该蛋白质，DNA及抗体的用途。 从牛大脑中纯化PACAP受体蛋白。 从牛，大鼠和人类cDNA文库中分离编码PACAP受体蛋白的DNA，测定其核苷酸序列。 此外，确定从核苷酸序列推导的氨基酸序列。 PACAP受体蛋白和编码本发明蛋白的DNA可用于（1）获得抗体和抗血清，（2）构建重组受体蛋白质的表达系统，（3）开发受体结合测定系统，使用 表达系统和药物潜在化合物的筛选，（4）基于结构相似的配体和受体的比较来执行药物设计，（5）基因诊断中探针和PCR引物的制备等 。

    Novel physiologically active peptide and its use
    10.
    发明申请
    Novel physiologically active peptide and its use 失效
    新型生理活性肽及其用途

    公开(公告)号：US20060155109A1

    公开(公告)日：2006-07-13

    申请号：US11376694

    申请日：2006-03-15

    申请人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hideki Matsui ,  Yoshihiro Ishibashi ,  Kazuhiro Ogi ,  Chieko Kitada

    IPC分类号： A61K38/22 ,  C07K14/575

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/72

    摘要： The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof. An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.

    摘要翻译： 本发明涉及一种肽，其包含与SEQ ID NO：35所示的氨基酸序列相同或基本相同的氨基酸序列，并且具有与受体蛋白结合的能力，所述受体蛋白包含与 由SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3表示的氨基酸序列，或其前体，其酰胺或酯或其盐。 本发明的编码编码DNA的DNA或等同物可以用于（1）使用重组受体蛋白质的表达系统和药物候选化合物的筛选的受体结合测定系统的开发，和（2）药物 具有减少的副作用，例如记忆功能改善剂，食欲改善剂，子宫，肾，前列腺，睾丸或骨骼肌功能调节剂。